Hypoxia, mitochondrial dysfunction and synovial invasiveness in rheumatoid arthritis

The Roles of Mitochondrial Damage-Associated Molecular Patterns in Diseases

(2015) Kiichi Nakahira et al.   ANTIOXIDANTS & REDOX SIGNALING

HIF-1  and PFKFB3 Mediate a Tight Relationship Between Proinflammatory Activation and Anerobic Metabolism in Atherosclerotic Macrophages

(2015) A. Tawakol et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Maintaining Ancient Organelles: Mitochondrial Biogenesis and Maturation

(2015) R. B. Vega et al.   CIRCULATION RESEARCH

Monocytes from patients with rheumatoid arthritis and type 2 diabetes mellitus display an increased production of interleukin (IL)-1β via the nucleotide-binding domain and leucine-rich repeat containing family pyrin 3(NLRP3)-inflammasome activation: a pos

(2015) P. Ruscitti et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

HMGB1 induces angiogenesis in rheumatoid arthritis via HIF-1α activation

(2015) So Youn Park et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Targeted delivery of the hydroxylase inhibitor DMOG provides enhanced efficacy with reduced systemic exposure in a murine model of colitis

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Polyfunctional, Pathogenic CD161+Th17 Lineage Cells Are Resistant to Regulatory T Cell–Mediated Suppression in the Context of Autoimmunity

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The protective effects of chronic intermittent hypobaric hypoxia pretreatment against collagen-induced arthritis in rats

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Lactate Regulates Metabolic and Pro-inflammatory Circuits in Control of T Cell Migration and Effector Functions

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Reactive oxygen species induce Cox-2 expression via TAK1 activation in synovial fibroblast cells

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Cartilage-specific deletion of mTOR upregulates autophagy and protects mice from osteoarthritis

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Hypoxia and STAT3 signalling interactions regulate pro-inflammatory pathways in rheumatoid arthritis

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A formyl peptide receptor agonist suppresses inflammation and bone damage in arthritis

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Oxidative modification enhances the immunostimulatory effects of extracellular mitochondrial DNA on plasmacytoid dendritic cells

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Tumor-Secreted Lactic Acid Promotes IL-23/IL-17 Proinflammatory Pathway

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Metformin Attenuates Experimental Autoimmune Arthritis through Reciprocal Regulation of Th17/Treg Balance and Osteoclastogenesis

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Mitochondrial dysfunction promotes and aggravates the inflammatory response in normal human synoviocytes

(2014) Marta N. Valcárcel-Ares et al.   RHEUMATOLOGY

CTGF increases vascular endothelial growth factor-dependent angiogenesis in human synovial fibroblasts by increasing miR-210 expression

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Redox-Mediated Angiogenesis in the Hypoxic Joint of Inflammatory Arthritis

(2014) Monika Biniecka et al.   Arthritis & Rheumatology

Hypoxia and hypoxia-inducible factor-1α provoke toll-like receptor signalling-induced inflammation in rheumatoid arthritis

(2013) Fanlei Hu et al.   ANNALS OF THE RHEUMATIC DISEASES

Chronic hypoxia reprograms human immature dendritic cells by inducing a proinflammatory phenotype and TREM-1 expression

(2013) Daniele Pierobon et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Avastin Exhibits Therapeutic Effects on Collagen-Induced Arthritis in Rat Model

(2013) Yong Wang et al.   INFLAMMATION

Molecular biology for formyl peptide receptors in human diseases

(2013) Yongsheng Li et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Sensing hypoxia: physiology, genetics and epigenetics

(2013) Nanduri R. Prabhakar   JOURNAL OF PHYSIOLOGY-LONDON

Pathogenic conversion of Foxp3+ T cells into TH17 cells in autoimmune arthritis

(2013) Noriko Komatsu et al.   NATURE MEDICINE

Dual Role of Autophagy in Stress-Induced Cell Death in Rheumatoid Arthritis Synovial Fibroblasts

(2013) Masaru Kato et al.   Arthritis & Rheumatology

IL-17 and tumour necrosis factor α combination induces a HIF-1α-dependent invasive phenotype in synoviocytes

(2012) Arnaud Hot et al.   ANNALS OF THE RHEUMATIC DISEASES

Prolyl hydroxylase domain enzyme 2 is the major player in regulating hypoxic responses in rheumatoid arthritis

(2012) Barbara Muz et al.   ARTHRITIS AND RHEUMATISM

Notch-1 mediates hypoxia-induced angiogenesis in rheumatoid arthritis

(2012) Wei Gao et al.   ARTHRITIS AND RHEUMATISM

Mitochondrial dysfunction increases inflammatory responsiveness to cytokines in normal human chondrocytes

(2012) Carlos Vaamonde-García et al.   ARTHRITIS AND RHEUMATISM

Polarizing Macrophages through Reprogramming of Glucose Metabolism

(2012) Julianna Blagih et al.   Cell Metabolism

An N-Terminal Mutation of the Foxp3 Transcription Factor Alleviates Arthritis but Exacerbates Diabetes

(2012) Jaime Darce et al.   IMMUNITY

The hypoxic environment reprograms the cytokine/chemokine expression profile of human mature dendritic cells

(2012) Fabiola Blengio et al.   IMMUNOBIOLOGY

Enhanced Th17 Differentiation and Aggravated Arthritis in IEX-1-Deficient Mice by Mitochondrial Reactive Oxygen Species-Mediated Signaling

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Interleukin-17A promotes rheumatoid arthritis synoviocytes migration and invasion under hypoxia by increasing MMP2 and MMP9 expression through NF-κB/HIF-1α pathway

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Pyruvate kinase M2 activators promote tetramer formation and suppress tumorigenesis

(2012) Dimitrios Anastasiou et al.   Nature Chemical Biology

Hypoxia Enhances the Proliferative Response of Macrophages to CSF-1 and Their Pro-Survival Response to TNF

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Hypoxia-inducible factor-1 alpha-dependent induction of FoxP3 drives regulatory T-cell abundance and function during inflammatory hypoxia of the mucosa

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Hypoxia-inducible factors: mediators of cancer progression and targets for cancer therapy

(2012) Gregg L. Semenza   TRENDS IN PHARMACOLOGICAL SCIENCES

Human monocytes and macrophages differ in their mechanisms of adaptation to hypoxia

(2012) Monique Fangradt et al.   ARTHRITIS RESEARCH & THERAPY

Differential effects of Th1 versus Th2 cytokines in combination with hypoxia on HIFs and angiogenesis in RA

(2012) Helene Larsen et al.   ARTHRITIS RESEARCH & THERAPY

Mitochondrial mutagenesis correlates with the local inflammatory environment in arthritis

(2011) Leonard C Harty et al.   ANNALS OF THE RHEUMATIC DISEASES

Autophagy activation by rapamycin reduces severity of experimental osteoarthritis

(2011) Beatriz Caramés et al.   ANNALS OF THE RHEUMATIC DISEASES

Hypoxia induces mitochondrial mutagenesis and dysfunction in inflammatory arthritis

(2011) Monika Biniecka et al.   ARTHRITIS AND RHEUMATISM

Tumor necrosis factor blocking therapy alters joint inflammation and hypoxia

(2011) Aisling Kennedy et al.   ARTHRITIS AND RHEUMATISM

Control of TH17/Treg Balance by Hypoxia-Inducible Factor 1

(2011) Eric V. Dang et al.   CELL

HIF-1α is critical for hypoxia-mediated maintenance of glioblastoma stem cells by activating Notch signaling pathway

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NFκB and HIF display synergistic behaviour during hypoxic inflammation

(2011) Ulrike Bruning et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

IL-1  and TNF -initiated IL-6-STAT3 pathway is critical in mediating inflammatory cytokines and RANKL expression in inflammatory arthritis

(2011) T. Mori et al.   INTERNATIONAL IMMUNOLOGY

Glycolysis and rheumatoid arthritis

(2011) Xiaotian CHANG et al.   International Journal of Rheumatic Diseases

Hypoxia-inducible Factor-1α Enhances Haptoglobin Gene Expression by Improving Binding of STAT3 to the Promoter

(2011) Mi-Kyung Oh et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mitochondrial reactive oxygen species promote production of proinflammatory cytokines and are elevated in TNFR1-associated periodic syndrome (TRAPS)

(2011) Ariel C. Bulua et al.   JOURNAL OF EXPERIMENTAL MEDICINE

HIF1α–dependent glycolytic pathway orchestrates a metabolic checkpoint for the differentiation of TH17 and Tregcells

(2011) Lewis Z. Shi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Toll-Like Receptor 2 Induced Angiogenesis and Invasion Is Mediated through the Tie2 Signalling Pathway in Rheumatoid Arthritis

(2011) Tajvur Saber et al.   PLoS One

IL-17A Expression Is Localised to Both Mononuclear and Polymorphonuclear Synovial Cell Infiltrates

(2011) Ellen M. Moran et al.   PLoS One

Hypoxia differentially affects IL-1 -stimulated MMP-1 and MMP-13 expression of fibroblast-like synoviocytes in an HIF-1 -dependent manner

(2011) Y.-A. Lee et al.   RHEUMATOLOGY

A highly selective, orally active inhibitor of Janus kinase 2, CEP-33779, ablates disease in two mouse models of rheumatoid arthritis

(2011) Kristine L Stump et al.   ARTHRITIS RESEARCH & THERAPY

Successful tumour necrosis factor (TNF) blocking therapy suppresses oxidative stress and hypoxia-induced mitochondrial mutagenesis in inflammatory arthritis

(2011) Monika Biniecka et al.   ARTHRITIS RESEARCH & THERAPY

The Role of the P2X7 Receptor in Infectious Diseases

(2011) Catherine M. Miller et al.   PLoS Pathogens

Synovial tissue hypoxia and inflammation in vivo

(2010) C. T. Ng et al.   ANNALS OF THE RHEUMATIC DISEASES

From Vessel Sprouting to Normalization

(2010) Cathy Coulon et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Angiogenesis and blood vessel stability in inflammatory arthritis

(2010) Aisling Kennedy et al.   ARTHRITIS AND RHEUMATISM

Bone loss caused by iron overload in a murine model: importance of oxidative stress

(2010) J. Tsay et al.   BLOOD

Hypoxia modulates the gene expression profile of immunoregulatory receptors in human mature dendritic cells: identification of TREM-1 as a novel hypoxic marker in vitro and in vivo

(2010) M. C. Bosco et al.   BLOOD

Redox signalling and the inflammatory response in rheumatoid arthritis

(2010) L. I. Filippin et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Angiogenesis and vasculogenesis in rheumatoid arthritis

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Inhibition of Hypoxia-inducible Factor-targeting Prolyl Hydroxylase Domain-containing Protein 2 (PHD2) Enhances Matrix Synthesis by Human Chondrocytes

(2010) Brendan L. Thoms et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Oxidant conditioning protects cartilage from mechanically induced damage

(2010) Prem Ramakrishnan et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

A role for mitochondria in NLRP3 inflammasome activation

(2010) Rongbin Zhou et al.   NATURE

Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome

(2010) Kiichi Nakahira et al.   NATURE IMMUNOLOGY

Hypoxia Inactivates the VHL Tumor Suppressor through PIASy-Mediated SUMO Modification

(2010) Qiliang Cai et al.   PLoS One

Regulation of the Angiopoietin-Tie ligand-receptor system with a novel splice variant of Tie1 reduces the severity of murine arthritis

(2010) N. M. Malik et al.   RHEUMATOLOGY

Oxidative damage in synovial tissue is associated with in vivo hypoxic status in the arthritic joint

(2009) M. Biniecka et al.   ANNALS OF THE RHEUMATIC DISEASES

Hypoxia Activates NF-κB–Dependent Gene Expression Through the Canonical Signaling Pathway

(2009) Kathryn M. Oliver et al.   ANTIOXIDANTS & REDOX SIGNALING

Human inflammatory synovial fibroblasts induce enhanced myeloid cell recruitment and angiogenesis through a hypoxia-inducible transcription factor 1α/vascular endothelial growth factor-mediated pathway in immunodeficient mice

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STAT3 inhibits the degradation of HIF-1α by pVHL-mediated ubiquitination

(2009) Joo Eun Jung et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

Jagged1 regulates the activation of astrocytes via modulation of NFκB and JAK/STAT/SOCS pathways

(2009) Eleonora Morga et al.   GLIA

mTOR: taking cues from the immune microenvironment

(2009) Greg M. Delgoffe et al.   IMMUNOLOGY

Hypoxia skews dendritic cells to a T helper type 2-stimulating phenotype and promotes tumour cell migration by dendritic cell-derived osteopontin

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Adaptation of Human CD4+ T Cells to Pathophysiological Hypoxia: A Transcriptome Analysis

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Notch Signal Activates Hypoxia Pathway through HES1-Dependent SRC/Signal Transducers and Activators of Transcription 3 Pathway

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Characterization of synovial tissue from arthritis patients: a proton magnetic resonance spectroscopic investigation

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Mitochondrial depolarisation and oxidative stress in rheumatoid arthritis patients

(2008) Devapragasan Moodley et al.   CLINICAL BIOCHEMISTRY

Synovial Hypoxia as a Cause of Tendon Rupture in Rheumatoid Arthritis

(2008) Branavan Sivakumar et al.   JOURNAL OF HAND SURGERY-AMERICAN VOLUME

Human dendritic cells differentiated in hypoxia down-modulate antigen uptake and change their chemokine expression profile

(2008) Angela Rita Elia et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Effects of hypoxia on glucose transport in primary equine chondrocytesin vitroand evidence of reduced GLUT1 gene expression in pathologic cartilagein vivo

(2008) Siriporn Peansukmanee et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Transcriptome of Hypoxic Immature Dendritic Cells: Modulation of Chemokine/Receptor Expression

(2008) A. Ricciardi et al.   MOLECULAR CANCER RESEARCH

Oxygen Sensing by Metazoans: The Central Role of the HIF Hydroxylase Pathway

(2008) William G. Kaelin et al.   MOLECULAR CELL

Enhancement of Angiogenesis Through Stabilization of Hypoxia-inducible Factor-1 by Silencing Prolyl Hydroxylase Domain-2 Gene

(2008) Shourong Wu et al.   MOLECULAR THERAPY

IL-4 inhibits TGF-β-induced Foxp3+ T cells and, together with TGF-β, generates IL-9+ IL-10+ Foxp3− effector T cells

(2008) Valérie Dardalhon et al.   NATURE IMMUNOLOGY

Interaction with factor inhibiting HIF-1 defines an additional mode of cross-coupling between the Notch and hypoxia signaling pathways

(2008) X. Zheng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mucosal Protection by Hypoxia-Inducible Factor Prolyl Hydroxylase Inhibition

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