IL-1  and TNF -initiated IL-6-STAT3 pathway is critical in mediating inflammatory cytokines and RANKL expression in inflammatory arthritis

Local microbleeding facilitates IL-6– and IL-17–dependent arthritis in the absence of tissue antigen recognition by activated T cells

(2011) Masaaki Murakami et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Modulation of Innate and Adaptive Immune Responses by Tofacitinib (CP-690,550)

(2011) Kamran Ghoreschi et al.   JOURNAL OF IMMUNOLOGY

META060 inhibits osteoclastogenesis and matrix metalloproteinases in vitro and reduces bone and cartilage degradation in a mouse model of rheumatoid arthritis

(2010) Veera Reddy Konda et al.   ARTHRITIS AND RHEUMATISM

Effects of a Janus kinase inhibitor, pyridone 6, on airway responses in a murine model of asthma

(2010) Yuko Matsunaga et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Selective Inhibition of JAK1 and JAK2 Is Efficacious in Rodent Models of Arthritis: Preclinical Characterization of INCB028050

(2010) J. S. Fridman et al.   JOURNAL OF IMMUNOLOGY

Anti-inflammatory activity and neutrophil reductions mediated by the JAK1/JAK3 inhibitor, CP-690,550, in rat adjuvant-induced arthritis

(2010) Debra M Meyer et al.   Journal of Inflammation-London

Rheumatoid arthritis

(2010) David L Scott et al.   LANCET

STAT3 is a substrate of SYK tyrosine kinase in B-lineage leukemia/lymphoma cells exposed to oxidative stress

(2010) F. M. Uckun et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Improved pain, physical functioning and health status in patients with rheumatoid arthritis treated with CP-690,550, an orally active Janus kinase (JAK) inhibitor: results from a randomised, double-blind, placebo-controlled trial

(2009) J H Coombs et al.   ANNALS OF THE RHEUMATIC DISEASES

Animal models of rheumatoid arthritis

(2009) Darren L. Asquith et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

A Novel Distal Enhancer Mediates Cytokine Induction of MouseRanklGene Expression

(2009) Kathleen A. Bishop et al.   MOLECULAR ENDOCRINOLOGY

Interleukin-17 Promotes Autoimmunity by Triggering a Positive-Feedback Loop via Interleukin-6 Induction

(2008) Hideki Ogura et al.   IMMUNITY

BMP2 Regulates Osterix through Msx2 and Runx2 during Osteoblast Differentiation

(2008) Takuma Matsubara et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cartilage preservation by inhibition of Janus kinase 3 in two rodent models of rheumatoid arthritis

(2008) Anthony J Milici et al.   ARTHRITIS RESEARCH & THERAPY