Prolyl hydroxylase domain enzyme 2 is the major player in regulating hypoxic responses in rheumatoid arthritis

Angiogenesis and blood vessel stability in inflammatory arthritis

(2010) Aisling Kennedy et al.   ARTHRITIS AND RHEUMATISM

2010 Rheumatoid arthritis classification criteria: An American College of Rheumatology/European League Against Rheumatism collaborative initiative

(2010) Daniel Aletaha et al.   ARTHRITIS AND RHEUMATISM

Inhibition of Hypoxia-inducible Factor-targeting Prolyl Hydroxylase Domain-containing Protein 2 (PHD2) Enhances Matrix Synthesis by Human Chondrocytes

(2010) Brendan L. Thoms et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Human inflammatory synovial fibroblasts induce enhanced myeloid cell recruitment and angiogenesis through a hypoxia-inducible transcription factor 1α/vascular endothelial growth factor-mediated pathway in immunodeficient mice

(2009) Manuel J. del Rey et al.   ARTHRITIS AND RHEUMATISM

Synovial fibroblasts spread rheumatoid arthritis to unaffected joints

(2009) Stephanie Lefèvre et al.   NATURE MEDICINE

Immature Blood Vessels in Rheumatoid Synovium Are Selectively Depleted in Response to Anti-TNF Therapy

(2009) Elena Izquierdo et al.   PLoS One

Synovial Hypoxia as a Cause of Tendon Rupture in Rheumatoid Arthritis

(2008) Branavan Sivakumar et al.   JOURNAL OF HAND SURGERY-AMERICAN VOLUME

PHDs overactivation during chronic hypoxia "desensitizes" HIF  and protects cells from necrosis

(2008) A. Ginouves et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulation of adult erythropoiesis by prolyl hydroxylase domain proteins

(2007) K. Takeda et al.   BLOOD