标题
Applications of CRISPR technologies in research and beyond
作者
关键词
-
出版物
NATURE BIOTECHNOLOGY
Volume 34, Issue 9, Pages 933-941
出版商
Springer Nature
发表日期
2016-09-09
DOI
10.1038/nbt.3659
参考文献
相关参考文献
注意：仅列出部分参考文献，下载原文获取全部文献信息。- Crystal Structure of Cpf1 in Complex with Guide RNA and Target DNA
- (2016) Takashi Yamano et al. CELL
- Exploiting CRISPR–Cas immune systems for genome editing in bacteria
- (2016) Rodolphe Barrangou et al. CURRENT OPINION IN BIOTECHNOLOGY
- Identifying and Visualizing Functional PAM Diversity across CRISPR-Cas Systems
- (2016) Ryan T. Leenay et al. MOLECULAR CELL
- In Vivo CRISPR/Cas9 Gene Editing Corrects Retinal Dystrophy in the S334ter-3 Rat Model of Autosomal Dominant Retinitis Pigmentosa
- (2016) Benjamin Bakondi et al. MOLECULAR THERAPY
- Streptococcus thermophilus CRISPR-Cas9 Systems Enable Specific Editing of the Human Genome
- (2016) Maximilian Müller et al. MOLECULAR THERAPY
- The crystal structure of Cpf1 in complex with CRISPR RNA
- (2016) De Dong et al. NATURE
- Gene-edited CRISPR mushroom escapes US regulation
- (2016) Emily Waltz NATURE
- High-fidelity CRISPR–Cas9 nucleases with no detectable genome-wide off-target effects
- (2016) Benjamin P. Kleinstiver et al. NATURE
- CRISPR knockout screening outperforms shRNA and CRISPRi in identifying essential genes
- (2016) Bastiaan Evers et al. NATURE BIOTECHNOLOGY
- Estimating the biotech sector's contribution to the US economy
- (2016) Robert Carlson NATURE BIOTECHNOLOGY
- Multiplexed labeling of genomic loci with dCas9 and engineered sgRNAs using CRISPRainbow
- (2016) Hanhui Ma et al. NATURE BIOTECHNOLOGY
- Enhancing homology-directed genome editing by catalytically active and inactive CRISPR-Cas9 using asymmetric donor DNA
- (2016) Christopher D Richardson et al. NATURE BIOTECHNOLOGY
- High-throughput mapping of regulatory DNA
- (2016) Nisha Rajagopal et al. NATURE BIOTECHNOLOGY
- Functional genetic screens for enhancer elements in the human genome using CRISPR-Cas9
- (2016) Gozde Korkmaz et al. NATURE BIOTECHNOLOGY
- Molecular recordings by directed CRISPR spacer acquisition
- (2016) Seth L. Shipman et al. SCIENCE
- Self-Assembled DNA Nanoclews for the Efficient Delivery of CRISPR-Cas9 for Genome Editing
- (2015) Wujin Sun et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- From Genomics to Gene Therapy: Induced Pluripotent Stem Cells Meet Genome Editing
- (2015) Akitsu Hotta et al. Annual Review of Genetics
- Targeting hepatitis B virus cccDNA by CRISPR/Cas9 nuclease efficiently inhibits viral replication
- (2015) Chunsheng Dong et al. ANTIVIRAL RESEARCH
- Genome-wide CRISPR Screen in a Mouse Model of Tumor Growth and Metastasis
- (2015) Sidi Chen et al. CELL
- Crystal Structure of Staphylococcus aureus Cas9
- (2015) Hiroshi Nishimasu et al. CELL
- High-Resolution CRISPR Screens Reveal Fitness Genes and Genotype-Specific Cancer Liabilities
- (2015) Traver Hart et al. CELL
- A Genome-wide CRISPR Screen in Primary Immune Cells to Dissect Regulatory Networks
- (2015) Oren Parnas et al. CELL
- Cpf1 Is a Single RNA-Guided Endonuclease of a Class 2 CRISPR-Cas System
- (2015) Bernd Zetsche et al. CELL
- Small Molecules Enhance CRISPR Genome Editing in Pluripotent Stem Cells
- (2015) Chen Yu et al. Cell Stem Cell
- CRISPR-Cas9-based Photoactivatable Transcription System
- (2015) Yuta Nihongaki et al. CHEMISTRY & BIOLOGY
- Editing plant genomes with CRISPR/Cas9
- (2015) Khaoula Belhaj et al. CURRENT OPINION IN BIOTECHNOLOGY
- The structural biology of CRISPR-Cas systems
- (2015) Fuguo Jiang et al. CURRENT OPINION IN STRUCTURAL BIOLOGY
- Harnessing the clustered regularly interspaced short palindromic repeat (CRISPR)/CRISPR-associated Cas9 system to disrupt the hepatitis B virus
- (2015) S Zhen et al. GENE THERAPY
- High Efficiency, Homology-Directed Genome Editing in Caenorhabditis elegans Using CRISPR-Cas9 Ribonucleoprotein Complexes
- (2015) A. Paix et al. GENETICS
- Enabling functional genomics with genome engineering
- (2015) Isaac B. Hilton et al. GENOME RESEARCH
- The Bacterial Origins of the CRISPR Genome-Editing Revolution
- (2015) Erik J. Sontheimer et al. HUMAN GENE THERAPY
- CRISPR/Cas9-Mediated Genome Editing of Epigenetic Factors for Cancer Therapy
- (2015) Shaohua Yao et al. HUMAN GENE THERAPY
- Adenovirus-Mediated Somatic Genome Editing ofPtenby CRISPR/Cas9 in Mouse Liver in Spite of Cas9-Specific Immune Responses
- (2015) Dan Wang et al. HUMAN GENE THERAPY
- Dimeric CRISPR RNA-Guided FokI-dCas9 Nucleases Directed by Truncated gRNAs for Highly Specific Genome Editing
- (2015) Nicolas Wyvekens et al. HUMAN GENE THERAPY
- Fanconi Anemia Gene Editing by the CRISPR/Cas9 System
- (2015) Mark J. Osborn et al. HUMAN GENE THERAPY
- Functional disruption of the dystrophin gene in rhesus monkey using CRISPR/Cas9
- (2015) Yongchang Chen et al. HUMAN MOLECULAR GENETICS
- Genomic Engineering and the Future of Medicine
- (2015) Jennifer A. Doudna JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
- Systematic analysis of CRISPR–Cas9 mismatch tolerance reveals low levels of off-target activity
- (2015) Emily M. Anderson et al. JOURNAL OF BIOTECHNOLOGY
- CRISPR-Based Technologies and the Future of Food Science
- (2015) Kurt Selle et al. JOURNAL OF FOOD SCIENCE
- Inhibition of hepatitis B virus by the CRISPR/Cas9 system via targeting the conserved regions of the viral genome
- (2015) Xing Liu et al. JOURNAL OF GENERAL VIROLOGY
- Inhibition of HIV-1 infection of primary CD4+ T-cells by gene editing of CCR5 using adenovirus-delivered CRISPR/Cas9
- (2015) Chang Li et al. JOURNAL OF GENERAL VIROLOGY
- Expanding the Biologist’s Toolkit with CRISPR-Cas9
- (2015) Samuel H. Sternberg et al. MOLECULAR CELL
- Discovery and Functional Characterization of Diverse Class 2 CRISPR-Cas Systems
- (2015) Sergey Shmakov et al. MOLECULAR CELL
- Efficient Virus-Mediated Genome Editing in Plants Using the CRISPR/Cas9 System
- (2015) Zahir Ali et al. Molecular Plant
- CRISPR, the disruptor
- (2015) Heidi Ledford NATURE
- CRISPR-Cas immunity in prokaryotes
- (2015) Luciano A. Marraffini NATURE
- Engineered CRISPR-Cas9 nucleases with altered PAM specificities
- (2015) Benjamin P. Kleinstiver et al. NATURE
- Conformational control of DNA target cleavage by CRISPR–Cas9
- (2015) Samuel H. Sternberg et al. NATURE
- Genome-scale transcriptional activation by an engineered CRISPR-Cas9 complex
- (2015) Silvana Konermann et al. NATURE
- In vivo genome editing using Staphylococcus aureus Cas9
- (2015) F. Ann Ran et al. NATURE
- Increasing the efficiency of precise genome editing with CRISPR-Cas9 by inhibition of nonhomologous end joining
- (2015) Takeshi Maruyama et al. NATURE BIOTECHNOLOGY
- Gene-edited pigs are protected from porcine reproductive and respiratory syndrome virus
- (2015) Kristin M Whitworth et al. NATURE BIOTECHNOLOGY
- Safeguarding CRISPR-Cas9 gene drives in yeast
- (2015) James E DiCarlo et al. NATURE BIOTECHNOLOGY
- Chemically modified guide RNAs enhance CRISPR-Cas genome editing in human primary cells
- (2015) Ayal Hendel et al. NATURE BIOTECHNOLOGY
- DNA-free genome editing in plants with preassembled CRISPR-Cas9 ribonucleoproteins
- (2015) Je Wook Woo et al. NATURE BIOTECHNOLOGY
- Inducible in vivo genome editing with CRISPR-Cas9
- (2015) Lukas E Dow et al. NATURE BIOTECHNOLOGY
- Increasing the efficiency of homology-directed repair for CRISPR-Cas9-induced precise gene editing in mammalian cells
- (2015) Van Trung Chu et al. NATURE BIOTECHNOLOGY
- Orthogonal gene knockout and activation with a catalytically active Cas9 nuclease
- (2015) James E Dahlman et al. NATURE BIOTECHNOLOGY
- A split-Cas9 architecture for inducible genome editing and transcription modulation
- (2015) Bernd Zetsche et al. NATURE BIOTECHNOLOGY
- Discovery of cancer drug targets by CRISPR-Cas9 screening of protein domains
- (2015) Junwei Shi et al. NATURE BIOTECHNOLOGY
- CRISPR germline engineering—the community speaks
- (2015) Katrine S Bosley et al. NATURE BIOTECHNOLOGY
- Epigenome editing by a CRISPR-Cas9-based acetyltransferase activates genes from promoters and enhancers
- (2015) Isaac B Hilton et al. NATURE BIOTECHNOLOGY
- A CRISPR-Cas9 gene drive system targeting female reproduction in the malaria mosquito vector Anopheles gambiae
- (2015) Andrew Hammond et al. NATURE BIOTECHNOLOGY
- Photoactivatable CRISPR-Cas9 for optogenetic genome editing
- (2015) Yuta Nihongaki et al. NATURE BIOTECHNOLOGY
- DNA-binding-domain fusions enhance the targeting range and precision of Cas9
- (2015) Mehmet Fatih Bolukbasi et al. NATURE METHODS
- Functional annotation of native enhancers with a Cas9–histone demethylase fusion
- (2015) Nicola A Kearns et al. NATURE METHODS
- MMEJ-assisted gene knock-in using TALENs and CRISPR-Cas9 with the PITCh systems
- (2015) Tetsushi Sakuma et al. Nature Protocols
- High-throughput functional genomics using CRISPR–Cas9
- (2015) Ophir Shalem et al. NATURE REVIEWS GENETICS
- Applications of CRISPR–Cas systems in neuroscience
- (2015) Matthias Heidenreich et al. NATURE REVIEWS NEUROSCIENCE
- Advances in CRISPR-Cas9 genome engineering: lessons learned from RNA interference
- (2015) Rodolphe Barrangou et al. NUCLEIC ACIDS RESEARCH
- Cas9-Guide RNA Directed Genome Editing in Soybean
- (2015) Zhongsen Li et al. PLANT PHYSIOLOGY
- Targeted Mutagenesis, Precise Gene Editing, and Site-Specific Gene Insertion in Maize Using Cas9 and Guide RNA
- (2015) Sergei Svitashev et al. PLANT PHYSIOLOGY
- Next-generation libraries for robust RNA interference-based genome-wide screens
- (2015) Martin Kampmann et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Generation of knock-in primary human T cells using Cas9 ribonucleoproteins
- (2015) Kathrin Schumann et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Rational design of a split-Cas9 enzyme complex
- (2015) Addison V. Wright et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- CRISPR-based screening of genomic island excision events in bacteria
- (2015) Kurt Selle et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Highly efficient Cas9-mediated gene drive for population modification of the malaria vector mosquitoAnopheles stephensi
- (2015) Valentino M. Gantz et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- CRISPR/Cas9 somatic multiplex-mutagenesis for high-throughput functional cancer genomics in mice
- (2015) Julia Weber et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- A prudent path forward for genomic engineering and germline gene modification
- (2015) D. Baltimore et al. SCIENCE
- A Cas9-guide RNA complex preorganized for target DNA recognition
- (2015) F. Jiang et al. SCIENCE
- Rationally engineered Cas9 nucleases with improved specificity
- (2015) I. M. Slaymaker et al. SCIENCE
- Dynamics of CRISPR-Cas9 genome interrogation in living cells
- (2015) Spencer C. Knight et al. SCIENCE
- Genome-wide inactivation of porcine endogenous retroviruses (PERVs)
- (2015) L. Yang et al. SCIENCE
- Postnatal genome editing partially restores dystrophin expression in a mouse model of muscular dystrophy
- (2015) C. Long et al. SCIENCE
- In vivo gene editing in dystrophic mouse muscle and muscle stem cells
- (2015) M. Tabebordbar et al. SCIENCE
- In vivo genome editing improves muscle function in a mouse model of Duchenne muscular dystrophy
- (2015) C. E. Nelson et al. SCIENCE
- Identification and characterization of essential genes in the human genome
- (2015) T. Wang et al. SCIENCE
- Identification of potential drug targets for tuberous sclerosis complex by synthetic screens combining CRISPR-based knockouts with RNAi
- (2015) Benjamin E. Housden et al. Science Signaling
- Improved Hematopoietic Differentiation Efficiency of Gene-Corrected Beta-Thalassemia Induced Pluripotent Stem Cells by CRISPR/Cas9 System
- (2015) Bing Song et al. STEM CELLS AND DEVELOPMENT
- Tailored Pig Models for Preclinical Efficacy and Safety Testing of Targeted Therapies
- (2015) Nikolai Klymiuk et al. TOXICOLOGIC PATHOLOGY
- Harnessing CRISPR–Cas systems for bacterial genome editing
- (2015) Kurt Selle et al. TRENDS IN MICROBIOLOGY
- Suppression of hepatitis B virus DNA accumulation in chronically infected cells using a bacterial CRISPR/Cas RNA-guided DNA endonuclease
- (2015) Edward M. Kennedy et al. VIROLOGY
- Efficient human immunodeficiency virus (HIV-1) infection of cells lacking PDZD8
- (2015) Shijian Zhang et al. VIROLOGY
- Bacterial CRISPR/Cas DNA endonucleases: A revolutionary technology that could dramatically impact viral research and treatment
- (2015) Edward M. Kennedy et al. VIROLOGY
- Dual gRNAs guided CRISPR/Cas9 system inhibits hepatitis B virus replication
- (2015) Jie Wang WORLD JOURNAL OF GASTROENTEROLOGY
- Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies
- (2015) Xueyan Li et al. Nature Communications
- Use of the CRISPR/Cas9 system as an intracellular defense against HIV-1 infection in human cells
- (2015) Hsin-Kai Liao et al. Nature Communications
- Multiplex CRISPR/Cas9-based genome editing for correction of dystrophin mutations that cause Duchenne muscular dystrophy
- (2015) David G. Ousterout et al. Nature Communications
- Modelling kidney disease with CRISPR-mutant kidney organoids derived from human pluripotent epiblast spheroids
- (2015) Benjamin S. Freedman et al. Nature Communications
- CRISPR/Cas9 cleavage of viral DNA efficiently suppresses hepatitis B virus
- (2015) Vyas Ramanan et al. Scientific Reports
- Production of Human Albumin in Pigs Through CRISPR/Cas9-Mediated Knockin of Human cDNA into Swine Albumin Locus in the Zygotes
- (2015) Jin Peng et al. Scientific Reports
- Both TALENs and CRISPR/Cas9 directly target the HBB IVS2–654 (C > T) mutation in β-thalassemia-derived iPSCs
- (2015) Peng Xu et al. Scientific Reports
- Genome editing of CXCR4 by CRISPR/cas9 confers cells resistant to HIV-1 infection
- (2015) Panpan Hou et al. Scientific Reports
- Functional Gene Correction for Cystic Fibrosis in Lung Epithelial Cells Generated from Patient iPSCs
- (2015) Amy L. Firth et al. Cell Reports
- CRISPR/Cas9-mediated gene editing in human tripronuclear zygotes
- (2015) Puping Liang et al. Protein & Cell
- Naïve Induced Pluripotent Stem Cells Generated From β-Thalassemia Fibroblasts Allow Efficient Gene Correction With CRISPR/Cas9
- (2015) Yuanyuan Yang et al. Stem Cells Translational Medicine
- CRISPR/Cas9-mediated heterozygous knockout of the autism gene CHD8 and characterization of its transcriptional networks in neurodevelopment
- (2015) Ping Wang et al. Molecular Autism
- Identification of potential drug targets for tuberous sclerosis complex by synthetic screens combining CRISPR-based knockouts with RNAi
- (2015) Benjamin E. Housden et al. Science Signaling
- Genomic impact of CRISPR immunization against bacteriophages
- (2015) Rodolphe Barrangou et al. BIOCHEMICAL SOCIETY TRANSACTIONS
- Crystal Structure of Cas9 in Complex with Guide RNA and Target DNA
- (2014) Hiroshi Nishimasu et al. CELL
- Genome-Scale CRISPR-Mediated Control of Gene Repression and Activation
- (2014) Luke A. Gilbert et al. CELL
- Development and Applications of CRISPR-Cas9 for Genome Engineering
- (2014) Patrick D. Hsu et al. CELL
- Generation of Gene-Modified Cynomolgus Monkey via Cas9/RNA-Mediated Gene Targeting in One-Cell Embryos
- (2014) Yuyu Niu et al. CELL
- Permanent Alteration of PCSK9 With In Vivo CRISPR-Cas9 Genome Editing
- (2014) Qiurong Ding et al. CIRCULATION RESEARCH
- Unraveling the potential of CRISPR-Cas9 for gene therapy
- (2014) Rodolphe Barrangou et al. EXPERT OPINION ON BIOLOGICAL THERAPY
- Seamless gene correction of β-thalassemia mutations in patient-specific iPSCs using CRISPR/Cas9 andpiggyBac
- (2014) Fei Xie et al. GENOME RESEARCH
- Highly efficient RNA-guided genome editing in human cells via delivery of purified Cas9 ribonucleoproteins
- (2014) S. Kim et al. GENOME RESEARCH
- Inactivation of the Human Papillomavirus E6 or E7 Gene in Cervical Carcinoma Cells by Using a Bacterial CRISPR/Cas RNA-Guided Endonuclease
- (2014) E. M. Kennedy et al. JOURNAL OF VIROLOGY
- Precision genome engineering in lactic acid bacteria
- (2014) Jan Peter van Pijkeren et al. Microbial Cell Factories
- Guide RNA Functional Modules Direct Cas9 Activity and Orthogonality
- (2014) Alexandra E. Briner et al. MOLECULAR CELL
- CRISPR-Cas Systems: Prokaryotes Upgrade to Adaptive Immunity
- (2014) Rodolphe Barrangou et al. MOLECULAR CELL
- Structural basis of PAM-dependent target DNA recognition by the Cas9 endonuclease
- (2014) Carolin Anders et al. NATURE
- CRISPR-mediated direct mutation of cancer genes in the mouse liver
- (2014) Wen Xue et al. NATURE
- Sequence-specific antimicrobials using efficiently delivered RNA-guided nucleases
- (2014) Robert J Citorik et al. NATURE BIOTECHNOLOGY
- In vivo interrogation of gene function in the mammalian brain using CRISPR-Cas9
- (2014) Lukasz Swiech et al. NATURE BIOTECHNOLOGY
- Cationic lipid-mediated delivery of proteins enables efficient protein-based genome editing in vitro and in vivo
- (2014) John A Zuris et al. NATURE BIOTECHNOLOGY
- Improving CRISPR-Cas nuclease specificity using truncated guide RNAs
- (2014) Yanfang Fu et al. NATURE BIOTECHNOLOGY
- Dimeric CRISPR RNA-guided FokI nucleases for highly specific genome editing
- (2014) Shengdar Q Tsai et al. NATURE BIOTECHNOLOGY
- CRISPR-Cas systems for editing, regulating and targeting genomes
- (2014) Jeffry D Sander et al. NATURE BIOTECHNOLOGY
- Exploiting CRISPR-Cas nucleases to produce sequence-specific antimicrobials
- (2014) David Bikard et al. NATURE BIOTECHNOLOGY
- Genome editing with Cas9 in adult mice corrects a disease mutation and phenotype
- (2014) Hao Yin et al. NATURE BIOTECHNOLOGY
- Functional genomics platform for pooled screening and generation of mammalian genetic interaction maps
- (2014) Martin Kampmann et al. Nature Protocols
- CRISPR–Cas9-assisted recombineering in Lactobacillus reuteri
- (2014) Jee-Hwan Oh et al. NUCLEIC ACIDS RESEARCH
- CCR5 Gene Disruption via Lentiviral Vectors Expressing Cas9 and Single Guided RNA Renders Cells Resistant to HIV-1 Infection
- (2014) Weiming Wang et al. PLoS One
- RNA-guided endonuclease provides a therapeutic strategy to cure latent herpesviridae infection
- (2014) J. Wang et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Seamless modification of wild-type induced pluripotent stem cells to the natural CCR5Δ32 mutation confers resistance to HIV infection
- (2014) Lin Ye et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- RNA-directed gene editing specifically eradicates latent and prevents new HIV-1 infection
- (2014) W. Hu et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Direct observation of R-loop formation by single RNA-guided Cas9 and Cascade effector complexes
- (2014) Mark D. Szczelkun et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Cas9 Targeting and the CRISPR Revolution
- (2014) R. Barrangou SCIENCE
- Prevention of muscular dystrophy in mice by CRISPR/Cas9-mediated editing of germline DNA
- (2014) C. Long et al. SCIENCE
- The new frontier of genome engineering with CRISPR-Cas9
- (2014) J. A. Doudna et al. SCIENCE
- Structures of Cas9 Endonucleases Reveal RNA-Mediated Conformational Activation
- (2014) M. Jinek et al. SCIENCE
- Efficient generation of genetically distinct pigs in a single pregnancy using multiplexed single-guide RNA and carbohydrate selection
- (2014) Ping Li et al. XENOTRANSPLANTATION
- Programmable Removal of Bacterial Strains by Use of Genome-Targeting CRISPR-Cas Systems
- (2014) A. A. Gomaa et al. mBio
- Functional genetics for all: engineered nucleases, CRISPR and the gene editing revolution
- (2014) Anna F Gilles et al. EvoDevo
- Concerning RNA-guided gene drives for the alteration of wild populations
- (2014) Kevin M Esvelt et al. eLife
- Selection of chromosomal DNA libraries using a multiplex CRISPR system
- (2014) Owen W Ryan et al. eLife
- The CRISPR/Cas9 System Facilitates Clearance of the Intrahepatic HBV Templates In Vivo
- (2014) Su-Ru Lin et al. Molecular Therapy-Nucleic Acids
- Characterization of Human Induced Pluripotent Stem Cell-Derived Retinal Pigment Epithelium Cell Sheets Aiming for Clinical Application
- (2014) Hiroyuki Kamao et al. Stem Cell Reports
- Repurposing CRISPR as an RNA-Guided Platform for Sequence-Specific Control of Gene Expression
- (2013) Lei S. Qi et al. CELL
- Dynamic Imaging of Genomic Loci in Living Human Cells by an Optimized CRISPR/Cas System
- (2013) Baohui Chen et al. CELL
- CRISPR-Mediated Modular RNA-Guided Regulation of Transcription in Eukaryotes
- (2013) Luke A. Gilbert et al. CELL
- Functional Repair of CFTR by CRISPR/Cas9 in Intestinal Stem Cell Organoids of Cystic Fibrosis Patients
- (2013) Gerald Schwank et al. Cell Stem Cell
- Correction of a Genetic Disease in Mouse via Use of CRISPR-Cas9
- (2013) Yuxuan Wu et al. Cell Stem Cell
- In vitro reconstitution of Cascade-mediated CRISPR immunity in Streptococcus thermophilus
- (2013) Tomas Sinkunas et al. EMBO JOURNAL
- Genome-wide recessive genetic screening in mammalian cells with a lentiviral CRISPR-guide RNA library
- (2013) Hiroko Koike-Yusa et al. NATURE BIOTECHNOLOGY
- CAS9 transcriptional activators for target specificity screening and paired nickases for cooperative genome engineering
- (2013) Prashant Mali et al. NATURE BIOTECHNOLOGY
- Targeted genome engineering in human cells with the Cas9 RNA-guided endonuclease
- (2013) Seung Woo Cho et al. NATURE BIOTECHNOLOGY
- Efficient genome editing in zebrafish using a CRISPR-Cas system
- (2013) Woong Y Hwang et al. NATURE BIOTECHNOLOGY
- RNA-guided editing of bacterial genomes using CRISPR-Cas systems
- (2013) Wenyan Jiang et al. NATURE BIOTECHNOLOGY
- Orthogonal Cas9 proteins for RNA-guided gene regulation and editing
- (2013) Kevin M Esvelt et al. NATURE METHODS
- CRISPR interference (CRISPRi) for sequence-specific control of gene expression
- (2013) Matthew H Larson et al. Nature Protocols
- Genome engineering using the CRISPR-Cas9 system
- (2013) F Ann Ran et al. Nature Protocols
- Phylogeny of Cas9 determines functional exchangeability of dual-RNA and Cas9 among orthologous type II CRISPR-Cas systems
- (2013) Ines Fonfara et al. NUCLEIC ACIDS RESEARCH
- The CRISPR Craze
- (2013) E. Pennisi SCIENCE
- RNA-Guided Human Genome Engineering via Cas9
- (2013) P. Mali et al. SCIENCE
- Genetic Screens in Human Cells Using the CRISPR-Cas9 System
- (2013) Tim Wang et al. SCIENCE
- Multiplex Genome Engineering Using CRISPR/Cas Systems
- (2013) L. Cong et al. SCIENCE
- ZFN, TALEN, and CRISPR/Cas-based methods for genome engineering
- (2013) Thomas Gaj et al. TRENDS IN BIOTECHNOLOGY
- RNA-programmed genome editing in human cells
- (2013) Martin Jinek et al. eLife
- Alternative end-joining mechanisms: a historical perspective
- (2013) Anabelle Decottignies Frontiers in Genetics
- DNA Repair and Genome Maintenance in Bacillus subtilis
- (2012) J. S. Lenhart et al. MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS
- RNA-mediated programmable DNA cleavage
- (2012) Rodolphe Barrangou NATURE BIOTECHNOLOGY
- Cas9-crRNA ribonucleoprotein complex mediates specific DNA cleavage for adaptive immunity in bacteria
- (2012) G. Gasiunas et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Mechanism of substrate selection by a highly specific CRISPR endoribonuclease
- (2012) S. H. Sternberg et al. RNA
- A Programmable Dual-RNA-Guided DNA Endonuclease in Adaptive Bacterial Immunity
- (2012) M. Jinek et al. SCIENCE
- CRISPR: New Horizons in Phage Resistance and Strain Identification
- (2012) Rodolphe Barrangou et al. Annual Review of Food Science and Technology
- Cas3 is a single-stranded DNA nuclease and ATP-dependent helicase in the CRISPR/Cas immune system
- (2011) Tomas Sinkunas et al. EMBO JOURNAL
- CRISPR RNA maturation by trans-encoded small RNA and host factor RNase III
- (2011) Elitza Deltcheva et al. NATURE
- The CRISPR/Cas bacterial immune system cleaves bacteriophage and plasmid DNA
- (2010) Josiane E. Garneau et al. NATURE
- Group II Introns: Mobile Ribozymes that Invade DNA
- (2010) A. M. Lambowitz et al. Cold Spring Harbor Perspectives in Biology
- RNA-Guided RNA Cleavage by a CRISPR RNA-Cas Protein Complex
- (2009) Caryn R. Hale et al. CELL
- Short motif sequences determine the targets of the prokaryotic CRISPR defence system
- (2009) MICROBIOLOGY-SGM
- CRISPR-based adaptive and heritable immunity in prokaryotes
- (2009) John van der Oost et al. TRENDS IN BIOCHEMICAL SCIENCES
- Small CRISPR RNAs Guide Antiviral Defense in Prokaryotes
- (2008) S. J. J. Brouns et al. SCIENCE
- CRISPR Interference Limits Horizontal Gene Transfer in Staphylococci by Targeting DNA
- (2008) Luciano A. Marraffini et al. SCIENCE
- Alternative-NHEJ Is a Mechanistically Distinct Pathway of Mammalian Chromosome Break Repair
- (2008) Nicole Bennardo et al. PLoS Genetics
Discover Peeref hubs
Discuss science. Find collaborators. Network.
Join a conversationFind the ideal target journal for your manuscript
Explore over 38,000 international journals covering a vast array of academic fields.
Search