标题
Heterogeneity of the tumor immune microenvironment and clinical interventions
作者
关键词
-
出版物
Frontiers of Medicine
Volume 17, Issue 4, Pages 617-648
出版商
Springer Science and Business Media LLC
发表日期
2023-09-20
DOI
10.1007/s11684-023-1015-9
参考文献
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注意:仅列出部分参考文献,下载原文获取全部文献信息。- Tumor-informed or tumor-agnostic circulating tumor DNA as a biomarker for risk of recurrence in resected colorectal cancer patients
- (2023) Hiu Ting Chan et al. Frontiers in Oncology
- Next steps for clinical translation of adenosine pathway inhibition in cancer immunotherapy
- (2022) Ryan C. Augustin et al. Journal for ImmunoTherapy of Cancer
- Immune phenotypic linkage between colorectal cancer and liver metastasis
- (2022) Yedan Liu et al. CANCER CELL
- COAST: An Open-Label, Phase II, Multidrug Platform Study of Durvalumab Alone or in Combination With Oleclumab or Monalizumab in Patients With Unresectable, Stage III Non–Small-Cell Lung Cancer
- (2022) Roy S. Herbst et al. JOURNAL OF CLINICAL ONCOLOGY
- Artificial Intelligence–Powered Spatial Analysis of Tumor-Infiltrating Lymphocytes as Complementary Biomarker for Immune Checkpoint Inhibition in Non–Small-Cell Lung Cancer
- (2022) Sehhoon Park et al. JOURNAL OF CLINICAL ONCOLOGY
- Breast Cancer Molecular Subtype Prediction on Pathological Images with Discriminative Patch Selection and Multi-Instance Learning
- (2022) Hong Liu et al. Frontiers in Oncology
- Spatially mapping the immune landscape of melanoma using imaging mass cytometry
- (2022) Dan Moldoveanu et al. Science Immunology
- Heterogeneity of the tumor immune microenvironment and its clinical relevance
- (2022) Qingzhu Jia et al. Experimental Hematology & Oncology
- Therapeutic targeting of macrophage plasticity remodels the tumor-immune microenvironment
- (2022) Hee-Jin Jang et al. CANCER RESEARCH
- Cancer as microenvironmental, systemic and environmental diseases: opportunity for transdisciplinary microbiomics science
- (2022) Kentaro Inamura et al. GUT
- Atezolizumab, vemurafenib, and cobimetinib in patients with melanoma with CNS metastases (TRICOTEL): a multicentre, open-label, single-arm, phase 2 study
- (2022) Reinhard Dummer et al. LANCET ONCOLOGY
- EGFR Inhibition Strongly Modulates the Tumour Immune Microenvironment in EGFR-Driven Non-Small-Cell Lung Cancer
- (2022) Carolin Selenz et al. Cancers
- Neoantigen-targeted TCR-T cell therapy for solid tumors: How far from clinical application
- (2022) Ruihan Xu et al. CANCER LETTERS
- New insights into antiangiogenic therapy resistance in cancer: Mechanisms and therapeutic aspects
- (2022) Maohua Huang et al. DRUG RESISTANCE UPDATES
- Clinical advances and ongoing trials of mRNA vaccines for cancer treatment
- (2022) Cathrine Lund Lorentzen et al. LANCET ONCOLOGY
- PARP-inhibition reprograms macrophages toward an anti-tumor phenotype
- (2022) Lin Wang et al. Cell Reports
- Personalized neoantigen vaccine combined with PD-1 blockade increases CD8+ tissue-resident memory T-cell infiltration in preclinical hepatocellular carcinoma models
- (2022) Hengkai Chen et al. Journal for ImmunoTherapy of Cancer
- Tumor Infiltrating Lymphocyte (TIL) Therapy for Solid Tumor Treatment: Progressions and Challenges
- (2022) Yueshui Zhao et al. Cancers
- Healthy and unhealthy plant‐based diets in relation to the incidence of colorectal cancer overall and by molecular subtypes
- (2022) Fenglei Wang et al. Clinical and Translational Medicine
- Overall survival with first-line atezolizumab in combination with vemurafenib and cobimetinib in BRAFV600 mutation-positive advanced melanoma (IMspire150): second interim analysis of a multicentre, randomised, phase 3 study
- (2022) Paolo A Ascierto et al. LANCET ONCOLOGY
- Liver tumour immune microenvironment subtypes and neutrophil heterogeneity
- (2022) Ruidong Xue et al. NATURE
- Prognostic role of inflammatory diets in colorectal cancer overall and in strata of tumor‐infiltrating lymphocyte levels
- (2022) Tomotaka Ugai et al. Clinical and Translational Medicine
- Personal neoantigen vaccines induce persistent memory T cell responses and epitope spreading in patients with melanoma
- (2021) Zhuting Hu et al. NATURE MEDICINE
- Pan-cancer circulating tumor DNA detection in over 10,000 Chinese patients
- (2021) Yongliang Zhang et al. Nature Communications
- CAR T cells in solid tumors: challenges and opportunities
- (2021) Faroogh Marofi et al. Stem Cell Research & Therapy
- Insights Gained from Single-Cell Analysis of Immune Cells in the Tumor Microenvironment
- (2021) Xianwen Ren et al. Annual Review of Immunology
- Biomarker Discovery in Patients with Immunotherapy-Treated Melanoma with Imaging Mass Cytometry
- (2021) Sandra Martinez-Morilla et al. CLINICAL CANCER RESEARCH
- Fecal microbiota transplant overcomes resistance to anti–PD-1 therapy in melanoma patients
- (2021) Diwakar Davar et al. SCIENCE
- Turning tumors from cold to inflamed to improve immunotherapy response
- (2021) C.L. Gerard et al. CANCER TREATMENT REVIEWS
- Bintrafusp Alfa, a Bifunctional Fusion Protein Targeting TGF-β and PD-L1, in Patients with Esophageal Adenocarcinoma: Results from a Phase 1 Cohort
- (2021) Benjamin Tan et al. Targeted Oncology
- Liquid Biopsy: From Discovery to Clinical Application
- (2021) Catherine Alix-Panabières et al. Cancer Discovery
- Obstacles and Coping Strategies of CAR-T Cell Immunotherapy in Solid Tumors
- (2021) Lele Miao et al. Frontiers in Immunology
- Multiplexed Immunohistochemistry and Digital Pathology as the Foundation for Next-Generation Pathology in Melanoma: Methodological Comparison and Future Clinical Applications
- (2021) Yannick Van Herck et al. Frontiers in Oncology
- Metastatic Colorectal Cancer Patient With Microsatellite Stability and BRAFV600E Mutation Showed a Complete Metabolic Response to PD-1 Blockade and Bevacizumab: A Case Report
- (2021) Chongkai Fang et al. Frontiers in Oncology
- Exploring tissue architecture using spatial transcriptomics
- (2021) Anjali Rao et al. NATURE
- A single-cell and spatially resolved atlas of human breast cancers
- (2021) Sunny Z. Wu et al. NATURE GENETICS
- Tumor-infiltrating lymphocyte treatment for anti-PD-1-resistant metastatic lung cancer: a phase 1 trial
- (2021) Benjamin C. Creelan et al. NATURE MEDICINE
- Spatial omics and multiplexed imaging to explore cancer biology
- (2021) Sabrina M. Lewis et al. NATURE METHODS
- Understanding and overcoming resistance to PARP inhibitors in cancer therapy
- (2021) Mariana Paes Dias et al. Nature Reviews Clinical Oncology
- Spatiotemporal Immune Landscape of Colorectal Cancer Liver Metastasis at Single-Cell Level
- (2021) Yingcheng Wu et al. Cancer Discovery
- Niraparib exhibits a synergistic anti-tumor effect with PD-L1 blockade by inducing an immune response in ovarian cancer
- (2021) Jinyu Meng et al. Journal of Translational Medicine
- Circulating tumor DNA profiling for childhood brain tumors: Technical challenges and evidence for utility
- (2021) Anthony Pak-Yin Liu et al. LABORATORY INVESTIGATION
- Digital pathology and artificial intelligence in translational medicine and clinical practice
- (2021) Vipul Baxi et al. MODERN PATHOLOGY
- Therapeutic efficacy of cancer vaccine adjuvanted with nanoemulsion loaded with TLR7/8 agonist in lung cancer model
- (2021) Jiae Koh et al. Nanomedicine-Nanotechnology Biology and Medicine
- Pan-cancer single-cell landscape of tumor-infiltrating T cells
- (2021) Liangtao Zheng et al. SCIENCE
- Vascular Microenvironment, Tumor Immunity and Immunotherapy
- (2021) Zachary Lamplugh et al. Frontiers in Immunology
- Final Overall Survival and Molecular Analysis in IMmotion151, a Phase 3 Trial Comparing Atezolizumab Plus Bevacizumab vs Sunitinib in Patients With Previously Untreated Metastatic Renal Cell Carcinoma
- (2021) Robert J. Motzer et al. JAMA Oncology
- Multicenter, double-blind, placebo-controlled trial of seviprotimut-L polyvalent melanoma vaccine in patients with post-resection melanoma at high risk of recurrence
- (2021) Craig L Slingluff et al. Journal for ImmunoTherapy of Cancer
- Front-Line ICI-Based Combination Therapy Post-TKI Resistance May Improve Survival in NSCLC Patients With EGFR Mutation
- (2021) Tian Tian et al. Frontiers in Oncology
- Impact of EGFR-TKI Treatment on the Tumor Immune Microenvironment in EGFR Mutation–Positive Non–Small Cell Lung Cancer
- (2020) Kohsuke Isomoto et al. CLINICAL CANCER RESEARCH
- Predicting survival after hepatocellular carcinoma resection using deep‐learning on histological slides
- (2020) Charlie Saillard et al. HEPATOLOGY
- Integrating microarray-based spatial transcriptomics and single-cell RNA-seq reveals tissue architecture in pancreatic ductal adenocarcinomas
- (2020) Reuben Moncada et al. NATURE BIOTECHNOLOGY
- Lessons from the A2A Adenosine Receptor Antagonist–Enabled Tumor Regression and Survival in Patients with Treatment-Refractory Renal Cell Cancer
- (2020) Michail V. Sitkovsky Cancer Discovery
- Relevance of immune cell and tumor microenvironment imaging in the new era of immunotherapy
- (2020) Filippo Galli et al. JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
- Tracking Neoantigens by Personalized Circulating Tumor DNA Sequencing during Checkpoint Blockade Immunotherapy in Non‐Small Cell Lung Cancer
- (2020) Qingzhu Jia et al. Advanced Science
- The Society for Immunotherapy in Cancer statement on best practices for multiplex immunohistochemistry (IHC) and immunofluorescence (IF) staining and validation
- (2020) Janis M Taube et al. Journal for ImmunoTherapy of Cancer
- Overview of multiplex immunohistochemistry/immunofluorescence techniques in the era of cancer immunotherapy
- (2020) Wei Chang Colin Tan et al. Cancer Communications
- Identification of a subpopulation of long-term tumor-initiating cells in colon cancer
- (2020) Linglong Peng et al. BIOSCIENCE REPORTS
- Multimodal Analysis of Composition and Spatial Architecture in Human Squamous Cell Carcinoma
- (2020) Andrew L. Ji et al. CELL
- The history and advances in cancer immunotherapy: understanding the characteristics of tumor-infiltrating immune cells and their therapeutic implications
- (2020) Yuanyuan Zhang et al. Cellular & Molecular Immunology
- A single-cell landscape of high-grade serous ovarian cancer
- (2020) Benjamin Izar et al. NATURE MEDICINE
- A deep learning model to predict RNA-Seq expression of tumours from whole slide images
- (2020) Benoît Schmauch et al. Nature Communications
- Oncolytic Viruses and the Immune System: The Dynamic Duo
- (2020) Ana Lemos de Matos et al. Molecular Therapy-Methods & Clinical Development
- Combination of anti-angiogenic therapy and immune checkpoint blockade normalizes vascular-immune crosstalk to potentiate cancer immunity
- (2020) Won Suk Lee et al. EXPERIMENTAL AND MOLECULAR MEDICINE
- Mechanisms of immune escape in the cancer immune cycle
- (2020) Sha Tang et al. INTERNATIONAL IMMUNOPHARMACOLOGY
- Personalized Cancer Vaccines: Clinical Landscape, Challenges, and Opportunities
- (2020) Colby S. Shemesh et al. MOLECULAR THERAPY
- Cancer SLC43A2 alters T cell methionine metabolism and histone methylation
- (2020) Yingjie Bian et al. NATURE
- Modulation of the Gut Microbiota Alters the Tumour-Suppressive Efficacy of Tim-3 Pathway Blockade in a Bacterial Species- and Host Factor-Dependent Manner
- (2020) Bokyoung Lee et al. Microorganisms
- Rising incidence of early-onset colorectal cancer — a call to action
- (2020) Naohiko Akimoto et al. Nature Reviews Clinical Oncology
- Fecal microbiota transplant promotes response in immunotherapy-refractory melanoma patients
- (2020) Erez N. Baruch et al. SCIENCE
- Recent progress in TGF-β inhibitors for cancer therapy
- (2020) Cheng-Yi Huang et al. BIOMEDICINE & PHARMACOTHERAPY
- Indoleamine Dioxygenase Inhibitors: Clinical Rationale and Current Development
- (2019) Mayanne M. T. Zhu et al. Current Oncology Reports
- Slide-seq: A scalable technology for measuring genome-wide expression at high spatial resolution
- (2019) Samuel G. Rodriques et al. SCIENCE
- Pembrolizumab plus Axitinib versus Sunitinib for Advanced Renal-Cell Carcinoma
- (2019) Brian I. Rini et al. NEW ENGLAND JOURNAL OF MEDICINE
- Neoantigen-directed immune escape in lung cancer evolution
- (2019) Rachel Rosenthal et al. NATURE
- IDO1 inhibition potentiates vaccine-induced immunity against pancreatic adenocarcinoma
- (2019) Alex B. Blair et al. JOURNAL OF CLINICAL INVESTIGATION
- Breast cancer outcome prediction with tumour tissue images and machine learning
- (2019) Riku Turkki et al. BREAST CANCER RESEARCH AND TREATMENT
- Efficacy and Safety Analysis of Nelipepimut-S Vaccine to Prevent Breast Cancer Recurrence: A Randomized, Multicenter, Phase III Clinical Trial
- (2019) Elizabeth A. Mittendorf et al. CLINICAL CANCER RESEARCH
- Atezolizumab plus bevacizumab versus sunitinib in patients with previously untreated metastatic renal cell carcinoma (IMmotion151): a multicentre, open-label, phase 3, randomised controlled trial
- (2019) Brian I Rini et al. LANCET
- Niraparib monotherapy for late-line treatment of ovarian cancer (QUADRA): a multicentre, open-label, single-arm, phase 2 trial
- (2019) Kathleen N Moore et al. LANCET ONCOLOGY
- Applications of machine learning in drug discovery and development
- (2019) Jessica Vamathevan et al. NATURE REVIEWS DRUG DISCOVERY
- Oncolytic Viruses: Priming Time for Cancer Immunotherapy
- (2019) Luke Russell et al. BIODRUGS
- Single-cell RNA-seq highlights intra-tumoral heterogeneity and malignant progression in pancreatic ductal adenocarcinoma
- (2019) Junya Peng et al. CELL RESEARCH
- The influence of microenvironment on tumor immunotherapy
- (2019) Jieying Zhang et al. FEBS Journal
- Current best practices in single‐cell RNA‐seq analysis: a tutorial
- (2019) Malte D Luecken et al. Molecular Systems Biology
- CAR-T cells secreting BiTEs circumvent antigen escape without detectable toxicity
- (2019) Bryan D. Choi et al. NATURE BIOTECHNOLOGY
- Atezolizumab plus cobimetinib and vemurafenib in BRAF-mutated melanoma patients
- (2019) Ryan J. Sullivan et al. NATURE MEDICINE
- Deep learning can predict microsatellite instability directly from histology in gastrointestinal cancer
- (2019) Jakob Nikolas Kather et al. NATURE MEDICINE
- Combined BRAF and MEK inhibition with PD-1 blockade immunotherapy in BRAF-mutant melanoma
- (2019) Antoni Ribas et al. NATURE MEDICINE
- Clonal replacement of tumor-specific T cells following PD-1 blockade
- (2019) Kathryn E. Yost et al. NATURE MEDICINE
- A phase I study of the PD-L1 inhibitor, durvalumab, in combination with a PARP inhibitor, olaparib, and a VEGFR1–3 inhibitor, cediranib, in recurrent women’s cancers with biomarker analyses
- (2019) Alexandra S. Zimmer et al. Journal for ImmunoTherapy of Cancer
- CD40 Agonist Antibodies in Cancer Immunotherapy
- (2019) Robert H. Vonderheide Annual Review of Medicine
- Dual PD ‐1 and VEGFR ‐2 blockade promotes vascular normalization and enhances anti‐tumor immune responses in HCC
- (2019) Kohei Shigeta et al. HEPATOLOGY
- Epacadostat plus pembrolizumab versus placebo plus pembrolizumab in patients with unresectable or metastatic melanoma (ECHO-301/KEYNOTE-252): a phase 3, randomised, double-blind study
- (2019) Georgina V Long et al. LANCET ONCOLOGY
- Artificial intelligence in digital pathology — new tools for diagnosis and precision oncology
- (2019) Kaustav Bera et al. Nature Reviews Clinical Oncology
- Clinical investigation of CAR T cells for solid tumors: Lessons learned and future directions
- (2019) Stephen J. Bagley et al. PHARMACOLOGY & THERAPEUTICS
- Magnitude of Therapeutic STING Activation Determines CD8+ T Cell-Mediated Anti-tumor Immunity
- (2019) Kelsey E. Sivick et al. Cell Reports
- Mass Cytometry Imaging for the Study of Human Diseases—Applications and Data Analysis Strategies
- (2019) Heeva Baharlou et al. Frontiers in Immunology
- VEGF-A drives TOX-dependent T cell exhaustion in anti–PD-1–resistant microsatellite stable colorectal cancers
- (2019) Chang Gon Kim et al. Science Immunology
- Engineering strategies to overcome the current roadblocks in CAR T cell therapy
- (2019) Sarwish Rafiq et al. Nature Reviews Clinical Oncology
- Integrative analysis of exogenous, endogenous, tumour and immune factors for precision medicine
- (2018) Shuji Ogino et al. GUT
- Therapeutic cancer vaccines: From initial findings to prospects
- (2018) Qian Song et al. IMMUNOLOGY LETTERS
- Phase 1/2 Study of the Safety and Tolerability of Nivolumab Plus Crizotinib for the First-Line Treatment of Anaplastic Lymphoma Kinase Translocation — Positive Advanced Non–Small Cell Lung Cancer (CheckMate 370)
- (2018) David R. Spigel et al. Journal of Thoracic Oncology
- MAGE-A3 immunotherapeutic as adjuvant therapy for patients with resected, MAGE-A3-positive, stage III melanoma (DERMA): a double-blind, randomised, placebo-controlled, phase 3 trial
- (2018) Brigitte Dreno et al. LANCET ONCOLOGY
- Using deep convolutional neural networks to identify and classify tumor-associated stroma in diagnostic breast biopsies
- (2018) Babak Ehteshami Bejnordi et al. MODERN PATHOLOGY
- Single-cell RNA sequencing: Technical advancements and biological applications
- (2018) Eva Hedlund et al. MOLECULAR ASPECTS OF MEDICINE
- Targeting tumour microenvironment by tyrosine kinase inhibitor
- (2018) Hor-Yue Tan et al. Molecular Cancer
- TGFβ drives immune evasion in genetically reconstituted colon cancer metastasis
- (2018) Daniele V. F. Tauriello et al. NATURE
- Global characterization of T cells in non-small-cell lung cancer by single-cell sequencing
- (2018) Xinyi Guo et al. NATURE MEDICINE
- Understanding the tumor immune microenvironment (TIME) for effective therapy
- (2018) Mikhail Binnewies et al. NATURE MEDICINE
- Enhancer mapping uncovers phenotypic heterogeneity and evolution in patients with luminal breast cancer
- (2018) Darren K. Patten et al. NATURE MEDICINE
- Noninvasive detection of macrophage activation with single-cell resolution through machine learning
- (2018) Nicolas Pavillon et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Antitumor Benefits of Antiviral Immunity: An Underappreciated Aspect of Oncolytic Virotherapies
- (2018) Shashi Gujar et al. TRENDS IN IMMUNOLOGY
- Spatial maps of prostate cancer transcriptomes reveal an unexplored landscape of heterogeneity
- (2018) Emelie Berglund et al. Nature Communications
- Immune Landscape of Colorectal Cancer Tumor Microenvironment from Different Primary Tumor Location
- (2018) Longhui Zhang et al. Frontiers in Immunology
- Characterizing the Role of Monocytes in T Cell Cancer Immunotherapy Using a 3D Microfluidic Model
- (2018) Sharon Wei Ling Lee et al. Frontiers in Immunology
- M7824, a novel bifunctional anti-PD-L1/TGFβ Trap fusion protein, promotes anti-tumor efficacy as monotherapy and in combination with vaccine
- (2018) Karin M. Knudson et al. OncoImmunology
- EGFR–TKI-Associated Interstitial Pneumonitis in Nivolumab-Treated Patients With Non–Small Cell Lung Cancer
- (2018) Yasuo Oshima et al. JAMA Oncology
- Targeting adenosine for cancer immunotherapy
- (2018) Robert D. Leone et al. Journal for ImmunoTherapy of Cancer
- Quality of life with talazoparib versus physician’s choice of chemotherapy in patients with advanced breast cancer and germline BRCA1/2 mutation: patient-reported outcomes from the EMBRACA phase III trial
- (2018) J Ettl et al. ANNALS OF ONCOLOGY
- Insights into Pathogenic Interactions Among Environment, Host, and Tumor at the Crossroads of Molecular Pathology and Epidemiology
- (2018) Shuji Ogino et al. Annual Review of Pathology-Mechanisms of Disease
- A radiomics approach to assess tumour-infiltrating CD8 cells and response to anti-PD-1 or anti-PD-L1 immunotherapy: an imaging biomarker, retrospective multicohort study
- (2018) Roger Sun et al. LANCET ONCOLOGY
- Classification and mutation prediction from non–small cell lung cancer histopathology images using deep learning
- (2018) Nicolas Coudray et al. NATURE MEDICINE
- SD-101 in Combination with Pembrolizumab in Advanced Melanoma: Results of a Phase Ib, Multicenter Study
- (2018) Antoni Ribas et al. Cancer Discovery
- Latest development of liquid biopsy
- (2018) Alvin Ho-Kwan Cheung et al. Journal of Thoracic Disease
- Long-term outcomes of a phase I study of agonist CD40 antibody and CTLA-4 blockade in patients with metastatic melanoma
- (2018) David L. Bajor et al. OncoImmunology
- Phase I/II clinical trial of a Wilms’ tumor 1-targeted dendritic cell vaccination-based immunotherapy in patients with advanced cancer
- (2018) Wen Zhang et al. CANCER IMMUNOLOGY IMMUNOTHERAPY
- Single Cell Transcriptomics of Pancreatic Cancer Precursors Demonstrates Epithelial and Microenvironmental Heterogeneity as an Early Event in Neoplastic Progression
- (2018) Vincent Bernard et al. CLINICAL CANCER RESEARCH
- High PD-L1 expression correlates with primary resistance to EGFR-TKIs in treatment naïve advanced EGFR-mutant lung adenocarcinoma patients
- (2018) Kuo-Hsuan Hsu et al. LUNG CANCER
- Lineage tracking reveals dynamic relationships of T cells in colorectal cancer
- (2018) Lei Zhang et al. NATURE
- Liquid biopsy in ovarian cancer: the potential of circulating miRNAs and exosomes
- (2018) Lydia Giannopoulou et al. Translational Research
- PARP Inhibition Elicits STING-Dependent Antitumor Immunity in Brca1-Deficient Ovarian Cancer
- (2018) Liya Ding et al. Cell Reports
- Single-cell sequencing in ovarian cancer
- (2018) Boris Winterhoff et al. CURRENT OPINION IN OBSTETRICS & GYNECOLOGY
- A Practical Guide to Whole Slide Imaging: A White Paper From the Digital Pathology Association
- (2018) Mark D. Zarella et al. ARCHIVES OF PATHOLOGY & LABORATORY MEDICINE
- Diagnosis and Treatment of Anaplastic Lymphoma Kinase–Positive Non–Small Cell Lung Cancer
- (2017) Kathryn C. Arbour et al. HEMATOLOGY-ONCOLOGY CLINICS OF NORTH AMERICA
- Targeting the adenosine 2A receptor enhances chimeric antigen receptor T cell efficacy
- (2017) Paul A. Beavis et al. JOURNAL OF CLINICAL INVESTIGATION
- Wnt/beta-catenin pathway: modulating anticancer immune response
- (2017) Sachin Gopalkrishna Pai et al. Journal of Hematology & Oncology
- Soluble CD73 as biomarker in patients with metastatic melanoma patients treated with nivolumab
- (2017) Silvana Morello et al. Journal of Translational Medicine
- Rucaparib maintenance treatment for recurrent ovarian carcinoma after response to platinum therapy (ARIEL3): a randomised, double-blind, placebo-controlled, phase 3 trial
- (2017) Robert L Coleman et al. LANCET
- An immunogenic personal neoantigen vaccine for patients with melanoma
- (2017) Patrick A. Ott et al. NATURE
- Tumour heterogeneity and resistance to cancer therapies
- (2017) Ibiayi Dagogo-Jack et al. Nature Reviews Clinical Oncology
- Olaparib for Metastatic Breast Cancer in Patients with a Germline BRCA Mutation
- (2017) Mark Robson et al. NEW ENGLAND JOURNAL OF MEDICINE
- Tumor Mutational Burden and Response Rate to PD-1 Inhibition
- (2017) Mark Yarchoan et al. NEW ENGLAND JOURNAL OF MEDICINE
- cGAS is essential for the antitumor effect of immune checkpoint blockade
- (2017) Hua Wang et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Epigenetic plasticity and the hallmarks of cancer
- (2017) William A. Flavahan et al. SCIENCE
- Spatial computation of intratumoral T cells correlates with survival of patients with pancreatic cancer
- (2017) Julienne L. Carstens et al. Nature Communications
- Role of tumor microenvironment in tumorigenesis
- (2017) Maonan Wang et al. Journal of Cancer
- Liver Metastasis and Treatment Outcome with Anti-PD-1 Monoclonal Antibody in Patients with Melanoma and NSCLC
- (2017) Paul C. Tumeh et al. Cancer Immunology Research
- Classification of breast cancer histology images using Convolutional Neural Networks
- (2017) Teresa Araújo et al. PLoS One
- Regular Aspirin Use Associates With Lower Risk of Colorectal Cancers With Low Numbers of Tumor-Infiltrating Lymphocytes
- (2016) Yin Cao et al. GASTROENTEROLOGY
- Body mass index and risk of colorectal cancer according to tumor lymphocytic infiltrate
- (2016) Akiko Hanyuda et al. INTERNATIONAL JOURNAL OF CANCER
- Tandem CAR T cells targeting HER2 and IL13Rα2 mitigate tumor antigen escape
- (2016) Meenakshi Hegde et al. JOURNAL OF CLINICAL INVESTIGATION
- Efficacy of the MAGE-A3 cancer immunotherapeutic as adjuvant therapy in patients with resected MAGE-A3-positive non-small-cell lung cancer (MAGRIT): a randomised, double-blind, placebo-controlled, phase 3 trial
- (2016) Johan F Vansteenkiste et al. LANCET ONCOLOGY
- Overexpression of CD39 in hepatocellular carcinoma is an independent indicator of poor outcome after radical resection
- (2016) Xiao-Yan Cai et al. MEDICINE
- Spatial intratumoral heterogeneity and temporal clonal evolution in esophageal squamous cell carcinoma
- (2016) Jia-Jie Hao et al. NATURE GENETICS
- T cell fate and clonality inference from single-cell transcriptomes
- (2016) Michael J T Stubbington et al. NATURE METHODS
- T-Cell Transfer Therapy Targeting Mutant KRAS in Cancer
- (2016) Eric Tran et al. NEW ENGLAND JOURNAL OF MEDICINE
- Visualization and analysis of gene expression in tissue sections by spatial transcriptomics
- (2016) P. L. Stahl et al. SCIENCE
- Short-term EGFR blockade enhances immune-mediated cytotoxicity of EGFR mutant lung cancer cells: rationale for combination therapies
- (2016) Charli Dominguez et al. Cell Death & Disease
- High expression of CD39 in gastric cancer reduces patient outcome following radical resection
- (2016) Xiao-Yan Cai et al. Oncology Letters
- Clinical Applications of Circulating Tumor Cells and Circulating Tumor DNA as Liquid Biopsy
- (2016) C. Alix-Panabieres et al. Cancer Discovery
- Antitumor Activity of cGAMP via Stimulation of cGAS-cGAMP-STING-IRF3 Mediated Innate Immune Response
- (2016) Tiejun Li et al. Scientific Reports
- A Metabolic Immune Checkpoint: Adenosine in Tumor Microenvironment
- (2016) Akio Ohta Frontiers in Immunology
- CD73-adenosine reduces immune responses and survival in ovarian cancer patients
- (2016) Pierre-Olivier Gaudreau et al. OncoImmunology
- Multiplexed Epitope-Based Tissue Imaging for Discovery and Healthcare Applications
- (2016) Bernd Bodenmiller Cell Systems
- Assessing the clinical value of targeted massively parallel sequencing in a longitudinal, prospective population-based study of cancer patients
- (2015) S Q Wong et al. BRITISH JOURNAL OF CANCER
- DNA Methylation and Somatic Mutations Converge on the Cell Cycle and Define Similar Evolutionary Histories in Brain Tumors
- (2015) Tali Mazor et al. CANCER CELL
- Droplet Barcoding for Single-Cell Transcriptomics Applied to Embryonic Stem Cells
- (2015) Allon M. Klein et al. CELL
- Highly Parallel Genome-wide Expression Profiling of Individual Cells Using Nanoliter Droplets
- (2015) Evan Z. Macosko et al. CELL
- CD73 Expression Is an Independent Prognostic Factor in Prostate Cancer
- (2015) B. G. Leclerc et al. CLINICAL CANCER RESEARCH
- ESR1 Mutations in Circulating Plasma Tumor DNA from Metastatic Breast Cancer Patients
- (2015) D. Chu et al. CLINICAL CANCER RESEARCH
- Clinical and Biological Effects of an Agonist Anti-CD40 Antibody: A Cancer Research UK Phase I Study
- (2015) P. Johnson et al. CLINICAL CANCER RESEARCH
- Bias-Corrected Targeted Next-Generation Sequencing for Rapid, Multiplexed Detection of Actionable Alterations in Cell-Free DNA from Advanced Lung Cancer Patients
- (2015) C. P. Paweletz et al. CLINICAL CANCER RESEARCH
- Diagnostic Accuracy of Noninvasive Genotyping of EGFR in Lung Cancer Patients by Deep Sequencing of Plasma Cell-Free DNA
- (2015) J. Uchida et al. CLINICAL CHEMISTRY
- Targeting cancer with kinase inhibitors
- (2015) Stefan Gross et al. JOURNAL OF CLINICAL INVESTIGATION
- Olaparib Monotherapy in Patients With Advanced Cancer and a GermlineBRCA1/2Mutation
- (2015) Bella Kaufman et al. JOURNAL OF CLINICAL ONCOLOGY
- Talimogene Laherparepvec Improves Durable Response Rate in Patients With Advanced Melanoma
- (2015) Robert H.I. Andtbacka et al. JOURNAL OF CLINICAL ONCOLOGY
- CD47 blockade triggers T cell–mediated destruction of immunogenic tumors
- (2015) Xiaojuan Liu et al. NATURE MEDICINE
- Neoantigens in cancer immunotherapy
- (2015) T. N. Schumacher et al. SCIENCE
- Tumor-Expressed IDO Recruits and Activates MDSCs in a Treg-Dependent Manner
- (2015) Rikke B. Holmgaard et al. Cell Reports
- Characterization of the immunophenotypes and antigenomes of colorectal cancers reveals distinct tumor escape mechanisms and novel targets for immunotherapy
- (2015) Mihaela Angelova et al. GENOME BIOLOGY
- PhyloWGS: Reconstructing subclonal composition and evolution from whole-genome sequencing of tumors
- (2015) Amit G Deshwar et al. GENOME BIOLOGY
- Neoepitopes of Cancers: Looking Back, Looking Ahead
- (2015) P. K. Srivastava Cancer Immunology Research
- CD39: A complementary target to immune checkpoints to counteract tumor-mediated immunosuppression
- (2015) Nathalie Bonnefoy et al. OncoImmunology
- Multispectral imaging of formalin-fixed tissue predicts ability to generate tumor-infiltrating lymphocytes from melanoma
- (2015) Zipei Feng et al. Journal for ImmunoTherapy of Cancer
- Trafficking of T Cells into Tumors
- (2014) C. Y. Slaney et al. CANCER RESEARCH
- Antimetastatic Effects of Blocking PD-1 and the Adenosine A2A Receptor
- (2014) D. Mittal et al. CANCER RESEARCH
- A Recombinant Modified Vaccinia Ankara Vaccine Encoding Epstein-Barr Virus (EBV) Target Antigens: A Phase I Trial in UK Patients with EBV-Positive Cancer
- (2014) G. S. Taylor et al. CLINICAL CANCER RESEARCH
- The Human Agonistic CD40 Antibody ADC-1013 Eradicates Bladder Tumors and Generates T-cell-Dependent Tumor Immunity
- (2014) S. M. Mangsbo et al. CLINICAL CANCER RESEARCH
- STING-Dependent Cytosolic DNA Sensing Promotes Radiation-Induced Type I Interferon-Dependent Antitumor Immunity in Immunogenic Tumors
- (2014) Liufu Deng et al. IMMUNITY
- ISCOMATRIX Adjuvant Induces Efficient Cross-Presentation of Tumor Antigen by Dendritic Cells via Rapid Cytosolic Antigen Delivery and Processing via Tripeptidyl Peptidase II
- (2014) M. Schnurr et al. JOURNAL OF IMMUNOLOGY
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- (2014) Yuankai Shi et al. Journal of Thoracic Oncology
- Highly multiplexed imaging of tumor tissues with subcellular resolution by mass cytometry
- (2014) Charlotte Giesen et al. NATURE METHODS
- Chimeric Antigen Receptor T Cells for Sustained Remissions in Leukemia
- (2014) Shannon L. Maude et al. NEW ENGLAND JOURNAL OF MEDICINE
- Immune Activation and a 9-Year Ongoing Complete Remission Following CD40 Antibody Therapy and Metastasectomy in a Patient with Metastatic Melanoma
- (2014) D. L. Bajor et al. Cancer Immunology Research
- Toll-Like Receptor Signaling Pathways
- (2014) Takumi Kawasaki et al. Frontiers in Immunology
- Mechanism of tumor rejection with doublets of CTLA-4, PD-1/PD-L1, or IDO blockade involves restored IL-2 production and proliferation of CD8+ T cells directly within the tumor microenvironment
- (2014) Stefani Spranger et al. Journal for ImmunoTherapy of Cancer
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- (2013) K. Pantel et al. CANCER RESEARCH
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- (2013) Cesare Gridelli et al. CANCER TREATMENT REVIEWS
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- (2013) Daniel S. Chen et al. IMMUNITY
- Indoleamine 2,3-dioxygenase is a critical resistance mechanism in antitumor T cell immunotherapy targeting CTLA-4
- (2013) Rikke B. Holmgaard et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Anti-Human CD73 Monoclonal Antibody Inhibits Metastasis Formation in Human Breast Cancer by Inducing Clustering and Internalization of CD73 Expressed on the Surface of Cancer Cells
- (2013) M. G. Terp et al. JOURNAL OF IMMUNOLOGY
- The causes and consequences of genetic heterogeneity in cancer evolution
- (2013) Rebecca A. Burrell et al. NATURE
- Innate and adaptive immune cells in the tumor microenvironment
- (2013) Thomas F Gajewski et al. NATURE IMMUNOLOGY
- In situ sequencing for RNA analysis in preserved tissue and cells
- (2013) Rongqin Ke et al. NATURE METHODS
- Liquid biopsy: monitoring cancer-genetics in the blood
- (2013) Emily Crowley et al. Nature Reviews Clinical Oncology
- CD73 promotes anthracycline resistance and poor prognosis in triple negative breast cancer
- (2013) S. Loi et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- DNA Methylation Alterations Exhibit Intraindividual Stability and Interindividual Heterogeneity in Prostate Cancer Metastases
- (2013) M. J. Aryee et al. Science Translational Medicine
- Immunological monitoring of anticancer vaccines in clinical trials
- (2013) Chizuru Ogi et al. OncoImmunology
- Ways to Enhance Lymphocyte Trafficking into Tumors and Fitness of Tumor Infiltrating Lymphocytes
- (2013) Matteo Bellone et al. Frontiers in Oncology
- Increased CD39 expression on CD4+ T lymphocytes has clinical and prognostic significance in chronic lymphocytic leukemia
- (2012) Chava Perry et al. ANNALS OF HEMATOLOGY
- Remote frozen section examination of breast sentinel lymph nodes by telepathology
- (2012) Andrew J. Gifford et al. ANZ JOURNAL OF SURGERY
- Uptake routes of tumor-antigen MAGE-A3 by dendritic cells determine priming of naïve T-cell subtypes
- (2012) Ines Moeller et al. CANCER IMMUNOLOGY IMMUNOTHERAPY
- CD73-Deficient Mice Are Resistant to Carcinogenesis
- (2012) J. Stagg et al. CANCER RESEARCH
- Genomic Landscape of Non-Small Cell Lung Cancer in Smokers and Never-Smokers
- (2012) Ramaswamy Govindan et al. CELL
- Quantifying heterogeneity in human tumours using MRI and PET
- (2012) Marie-Claude Asselin et al. EUROPEAN JOURNAL OF CANCER
- High expression of CD73 as a poor prognostic biomarker in human colorectal cancer
- (2012) Xian-Rui Wu et al. JOURNAL OF SURGICAL ONCOLOGY
- The clonal and mutational evolution spectrum of primary triple-negative breast cancers
- (2012) Sohrab P. Shah et al. NATURE
- Clonal selection drives genetic divergence of metastatic medulloblastoma
- (2012) Xiaochong Wu et al. NATURE
- Intratumor Heterogeneity and Branched Evolution Revealed by Multiregion Sequencing
- (2012) Marco Gerlinger et al. NEW ENGLAND JOURNAL OF MEDICINE
- Heterogeneity and Tumor History
- (2012) D. Shibata SCIENCE
- Cross-talk between myeloid-derived suppressor cells (MDSC), macrophages, and dendritic cells enhances tumor-induced immune suppression
- (2012) Suzanne Ostrand-Rosenberg et al. SEMINARS IN CANCER BIOLOGY
- Toll-like receptor 3 agonist complexed with cationic liposome augments vaccine-elicited antitumor immunity by enhancing TLR3–IRF3 signaling and type I interferons in dendritic cells
- (2012) Ce Wang et al. VACCINE
- TIL therapy broadens the tumor-reactive CD8+T cell compartment in melanoma patients
- (2012) Pia Kvistborg et al. OncoImmunology
- Digital Imaging in Pathology: Whole-Slide Imaging and Beyond
- (2011) Farzad Ghaznavi et al. Annual Review of Pathology-Mechanisms of Disease
- Safety and persistence of adoptively transferred autologous CD19-targeted T cells in patients with relapsed or chemotherapy refractory B-cell leukemias
- (2011) R. J. Brentjens et al. BLOOD
- Immune modulation with weekly dosing of an agonist CD40 antibody in a phase I study of patients with advanced solid tumors
- (2011) Jens Rüter et al. CANCER BIOLOGY & THERAPY
- Molecular Pathways: Hypoxia Response in Immune Cells Fighting or Promoting Cancer
- (2011) Asis Palazón et al. CLINICAL CANCER RESEARCH
- The Complex Intratumoral Heterogeneity of Colon Cancer Highlighted by Laser Microdissection
- (2011) David Buob et al. DIGESTIVE DISEASES AND SCIENCES
- Type I interferon is selectively required by dendritic cells for immune rejection of tumors
- (2011) Mark S. Diamond et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Chimeric Antigen Receptor–Modified T Cells in Chronic Lymphoid Leukemia
- (2011) David L. Porter et al. NEW ENGLAND JOURNAL OF MEDICINE
- Autophagy-Dependent Anticancer Immune Responses Induced by Chemotherapeutic Agents in Mice
- (2011) M. Michaud et al. SCIENCE
- CD39/ENTPD1 Expression by CD4+Foxp3+ Regulatory T Cells Promotes Hepatic Metastatic Tumor Growth in Mice
- (2010) Xiaofeng Sun et al. GASTROENTEROLOGY
- Molecular pathological epidemiology of colorectal neoplasia: an emerging transdisciplinary and interdisciplinary field
- (2010) S. Ogino et al. GUT
- Distant metastasis occurs late during the genetic evolution of pancreatic cancer
- (2010) Shinichi Yachida et al. NATURE
- Improved Survival with Ipilimumab in Patients with Metastatic Melanoma
- (2010) F. Stephen Hodi et al. NEW ENGLAND JOURNAL OF MEDICINE
- Mast Cells Mobilize Myeloid-Derived Suppressor Cells and Treg Cells in Tumor Microenvironment via IL-17 Pathway in Murine Hepatocarcinoma Model
- (2010) Zhuoshun Yang et al. PLoS One
- Anti-CD73 antibody therapy inhibits breast tumor growth and metastasis
- (2010) J. Stagg et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- TGF-β and immune cells: an important regulatory axis in the tumor microenvironment and progression
- (2010) Li Yang et al. TRENDS IN IMMUNOLOGY
- Systematic RNA interference reveals that oncogenic KRAS-driven cancers require TBK1
- (2009) David A. Barbie et al. NATURE
- Copy number analysis indicates monoclonal origin of lethal metastatic prostate cancer
- (2009) Wennuan Liu et al. NATURE MEDICINE
- Vaccination against HPV-16 Oncoproteins for Vulvar Intraepithelial Neoplasia
- (2009) Gemma G. Kenter et al. NEW ENGLAND JOURNAL OF MEDICINE
- Systemic Spread Is an Early Step in Breast Cancer
- (2008) Yves Hüsemann et al. CANCER CELL
- WT1 peptide vaccine for the treatment of cancer
- (2008) Yoshihiro Oka et al. CURRENT OPINION IN IMMUNOLOGY
- Adoptive Cell Therapy for Patients With Metastatic Melanoma: Evaluation of Intensive Myeloablative Chemoradiation Preparative Regimens
- (2008) Mark E. Dudley et al. JOURNAL OF CLINICAL ONCOLOGY
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