标题
CAR T cells in solid tumors: challenges and opportunities
作者
关键词
-
出版物
Stem Cell Research & Therapy
Volume 12, Issue 1, Pages -
出版商
Springer Science and Business Media LLC
发表日期
2021-01-25
DOI
10.1186/s13287-020-02128-1
参考文献
相关参考文献
注意：仅列出部分参考文献，下载原文获取全部文献信息。- Use of chimeric antigen receptor NK-92 cells to target mesothelin in ovarian cancer
- (2020) Bihui Cao et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Tumor microenvironment differences between primary tumor and brain metastases
- (2020) Bernardo Cacho-Díaz et al. Journal of Translational Medicine
- Brain interstitial fluid drainage and extracellular space affected by inhalational isoflurane: in comparison with intravenous sedative dexmedetomidine and pentobarbital sodium
- (2020) Guomei Zhao et al. Science China-Life Sciences
- Glypican-3–Specific CAR T Cells Coexpressing IL15 and IL21 Have Superior Expansion and Antitumor Activity against Hepatocellular Carcinoma
- (2020) Sai Arun Batra et al. Cancer Immunology Research
- DDIAS promotes STAT3 activation by preventing STAT3 recruitment to PTPRM in lung cancer cells
- (2020) Joo-Young Im et al. Oncogenesis
- Chimeric cytokine receptor enhancing PSMA-CAR-T cell-mediated prostate cancer regression
- (2020) Shao Weimin et al. CANCER BIOLOGY & THERAPY
- IL7-IL12 Engineered Mesenchymal Stem Cells (MSCs) Improve A CAR T Cell Attack Against Colorectal Cancer Cells
- (2020) Andreas A. Hombach et al. Cells
- Combined DLL3-targeted bispecific antibody with PD-1 inhibition is efficient to suppress small cell lung cancer growth
- (2020) Xin Chen et al. Journal for ImmunoTherapy of Cancer
- Chimeric Antigen Receptor T Cell Therapy Targeting ICAM-1 in Gastric Cancer
- (2020) Minkyu Jung et al. Molecular Therapy-Oncolytics
- The Landscape of CAR-T Cell Clinical Trials against Solid Tumors—A Comprehensive Overview
- (2020) Niels Schaft Cancers
- The Emergence of Universal Immune Receptor T Cell Therapy for Cancer
- (2019) Nicholas G. Minutolo et al. Frontiers in Oncology
- Chimeric antigen receptor T cell targeting EGFRvIII for metastatic lung cancer therapy
- (2019) Zhao Zhang et al. Frontiers of Medicine
- Mesothelin is a target of chimeric antigen receptor T cells for treating gastric cancer
- (2019) Jiang Lv et al. Journal of Hematology & Oncology
- Killing Mechanisms of Chimeric Antigen Receptor (CAR) T Cells
- (2019) Mohamed-Reda Benmebarek et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Antitumor Responses in the Absence of Toxicity in Solid Tumors by Targeting B7-H3 via Chimeric Antigen Receptor T Cells
- (2019) Hongwei Du et al. CANCER CELL
- CAR T-Cells Targeting the Integrin αvβ6 and Co-Expressing the Chemokine Receptor CXCR2 Demonstrate Enhanced Homing and Efficacy against Several Solid Malignancies
- (2019) Lynsey M. Whilding et al. Cancers
- HITM-SIR: phase Ib trial of intraarterial chimeric antigen receptor T-cell therapy and selective internal radiation therapy for CEA+ liver metastases
- (2019) Steven C. Katz et al. CANCER GENE THERAPY
- Manufacturing and preclinical validation of CAR T cells targeting ICAM-1 for advanced thyroid cancer therapy
- (2019) Yogindra Vedvyas et al. Scientific Reports
- Human CAR NK Cells: A New Non-viral Method Allowing High Efficient Transfection and Strong Tumor Cell Killing
- (2019) Tiziano Ingegnere et al. Frontiers in Immunology
- CAR T Cells Targeting the Tumor MUC1 Glycoprotein Reduce Triple-Negative Breast Cancer Growth
- (2019) Ru Zhou et al. Frontiers in Immunology
- Clinical investigation of CAR T cells for solid tumors: Lessons learned and future directions
- (2019) Stephen J. Bagley et al. PHARMACOLOGY & THERAPEUTICS
- Engineered T Cell Therapy for Cancer in the Clinic
- (2019) Lijun Zhao et al. Frontiers in Immunology
- PD-1 disrupted CAR-T cells in the treatment of solid tumors: Promises and challenges
- (2019) Eileen McGowan et al. BIOMEDICINE & PHARMACOTHERAPY
- DCLK1 Monoclonal Antibody-Based CAR-T Cells as a Novel Treatment Strategy against Human Colorectal Cancers
- (2019) Sripathi M. Sureban et al. Cancers
- The Immune Revolution: A Case for Priming, Not Checkpoint
- (2018) Robert H. Vonderheide CANCER CELL
- The siRNA-mediated downregulation of PD-1 alone or simultaneously with CTLA-4 shows enhanced in vitro CAR-T-cell functionality for further clinical development towards the potential use in immunotherapy of melanoma
- (2018) Bianca Simon et al. EXPERIMENTAL DERMATOLOGY
- Chimeric antigen receptor-engineered T-cell therapy for liver cancer
- (2018) Yang Chen et al. Hepatobiliary & Pancreatic Diseases International
- Development of Anti-Human Mesothelin-Targeted Chimeric Antigen Receptor Messenger RNA–Transfected Peripheral Blood Lymphocytes for Ovarian Cancer Therapy
- (2018) Chien-Fu Hung et al. HUMAN GENE THERAPY
- Lambertianic Acid Sensitizes Non-Small Cell Lung Cancers to TRAIL-Induced Apoptosis via Inhibition of XIAP/NF-κB and Activation of Caspases and Death Receptor 4
- (2018) Deok Ahn et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Chimeric antigen receptor T cell (CAR-T) immunotherapy for solid tumors: lessons learned and strategies for moving forward
- (2018) Jian Li et al. Journal of Hematology & Oncology
- Control of triple-negative breast cancer using ex vivo self-enriched, costimulated NKG2D CAR T cells
- (2018) Yali Han et al. Journal of Hematology & Oncology
- Preclinical Assessment of CAR T-Cell Therapy Targeting the Tumor Antigen 5T4 in Ovarian Cancer
- (2018) Gemma L. Owens et al. JOURNAL OF IMMUNOTHERAPY
- OUP accepted manuscript
- (2018) JNCI-Journal of the National Cancer Institute
- MicroRNA-494 promotes cancer progression and targets adenomatous polyposis coli in colorectal cancer
- (2018) Ying Zhang et al. Molecular Cancer
- Understanding the tumor immune microenvironment (TIME) for effective therapy
- (2018) Mikhail Binnewies et al. NATURE MEDICINE
- Chimeric Antigen Receptor-Modified T Cells Redirected to EphA2 for the Immunotherapy of Non-Small Cell Lung Cancer
- (2018) Ning Li et al. Translational Oncology
- OUP accepted manuscript
- (2018) JNCI-Journal of the National Cancer Institute
- Human GUCY2C-Targeted Chimeric Antigen Receptor (CAR)-Expressing T Cells Eliminate Colorectal Cancer Metastases
- (2018) Michael S. Magee et al. Cancer Immunology Research
- CD133-directed CAR T cells for advanced metastasis malignancies: A phase I trial
- (2018) Yao Wang et al. OncoImmunology
- Development of NKG2D-based chimeric antigen receptor-T cells for gastric cancer treatment
- (2018) Kelong Tao et al. CANCER CHEMOTHERAPY AND PHARMACOLOGY
- Correction: Identification of neoepitopes recognized by tumor-infiltrating lymphocytes (TILs) from patients with glioma
- (2018) Davide Valentini et al. Oncotarget
- Expanding the Therapeutic Window for CAR T Cell Therapy in Solid Tumors: The Knowns and Unknowns of CAR T Cell Biology
- (2018) Keisuke Watanabe et al. Frontiers in Immunology
- Effective Targeting of TAG72+ Peritoneal Ovarian Tumors via Regional Delivery of CAR-Engineered T Cells
- (2018) John P. Murad et al. Frontiers in Immunology
- Human CD3+ T-Cells with the Anti-ERBB2 Chimeric Antigen Receptor Exhibit Efficient Targeting and Induce Apoptosis in ERBB2 Overexpressing Breast Cancer Cells
- (2017) Rusheni Munisvaradass et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Modification of cytokine-induced killer cells with folate receptor alpha (FRα)-specific chimeric antigen receptors enhances their antitumor immunity toward FRα-positive ovarian cancers
- (2017) Shuguang Zuo et al. MOLECULAR IMMUNOLOGY
- A single dose of peripherally infused EGFRvIII-directed CAR T cells mediates antigen loss and induces adaptive resistance in patients with recurrent glioblastoma
- (2017) Donald M. O’Rourke et al. Science Translational Medicine
- CD19-negative relapse of pediatric B-cell precursor acute lymphoblastic leukemia following blinatumomab treatment
- (2017) E. Mejstríková et al. Blood Cancer Journal
- Proteomic profiling of antibody-inducing immunogens in tumor tissue identifies PSMA1, LAP3, ANXA3, and maspin as colon cancer markers
- (2017) Qian Yang et al. Oncotarget
- CRISPR/Cas9-mediated PD-1 disruption enhances anti-tumor efficacy of human chimeric antigen receptor T cells
- (2017) Levi J. Rupp et al. Scientific Reports
- Effective and persistent antitumor activity of HER2-directed CAR-T cells against gastric cancer cells in vitro and xenotransplanted tumors in vivo
- (2017) Yanjing Song et al. Protein & Cell
- High-Affinity GD2-Specific CAR T Cells Induce Fatal Encephalitis in a Preclinical Neuroblastoma Model
- (2017) Sarah A. Richman et al. Cancer Immunology Research
- Transgenic Expression of IL15 Improves Antiglioma Activity of IL13Rα2-CAR T Cells but Results in Antigen Loss Variants
- (2017) Giedre Krenciute et al. Cancer Immunology Research
- Identification and Characterization of Neoantigens As Well As Respective Immune Responses in Cancer Patients
- (2017) Eva Bräunlein et al. Frontiers in Immunology
- An Analysis of Natural T Cell Responses to Predicted Tumor Neoepitopes
- (2017) Anne-Mette Bjerregaard et al. Frontiers in Immunology
- CRISPR-Cas9 mediated LAG-3 disruption in CAR-T cells
- (2017) Yongping Zhang et al. Frontiers of Medicine
- PSCA and MUC1 in non-small-cell lung cancer as targets of chimeric antigen receptor T cells
- (2017) Xinru Wei et al. OncoImmunology
- Safety, tumor trafficking and immunogenicity of chimeric antigen receptor (CAR)-T cells specific for TAG-72 in colorectal cancer
- (2017) Kristen M. Hege et al. Journal for ImmunoTherapy of Cancer
- Chimeric antigen receptor (CAR+) modified T cells targeting prostate-specific membrane antigen (PSMA) in patients (pts) with castrate metastatic prostate cancer (CMPC).
- (2017) Susan F. Slovin et al. JOURNAL OF CLINICAL ONCOLOGY
- Micromolar affinity CAR T cells to ICAM-1 achieves rapid tumor elimination while avoiding systemic toxicity
- (2017) Spencer Park et al. Scientific Reports
- Development of T cells carrying two complementary chimeric antigen receptors against glypican-3 and asialoglycoprotein receptor 1 for the treatment of hepatocellular carcinoma
- (2016) Cheng Chen et al. CANCER IMMUNOLOGY IMMUNOTHERAPY
- Prospects for chimeric antigen receptor (CAR) γδ T cells: A potential game changer for adoptive T cell cancer immunotherapy
- (2016) Hamid Reza Mirzaei et al. CANCER LETTERS
- Retroviral vectors and transposons for stable gene therapy: advances, current challenges and perspectives
- (2016) José Eduardo Vargas et al. Journal of Translational Medicine
- Ionic immune suppression within the tumour microenvironment limits T cell effector function
- (2016) Robert Eil et al. NATURE
- Regression of Glioblastoma after Chimeric Antigen Receptor T-Cell Therapy
- (2016) Christine E. Brown et al. NEW ENGLAND JOURNAL OF MEDICINE
- Phase I Trial of Anti-PSMA Designer CAR-T Cells in Prostate Cancer: Possible Role for Interacting Interleukin 2-T Cell Pharmacodynamics as a Determinant of Clinical Response
- (2016) Richard P. Junghans et al. PROSTATE
- Chimeric antigen receptor T cells secreting anti-PD-L1 antibodies more effectively regress renal cell carcinoma in a humanized mouse model
- (2016) Eloah Rabello Suarez et al. Oncotarget
- Augmentation of CAR T-cell Trafficking and Antitumor Efficacy by Blocking Protein Kinase A Localization
- (2016) K. Newick et al. Cancer Immunology Research
- An MHC-restricted antibody-based chimeric antigen receptor requires TCR-like affinity to maintain antigen specificity
- (2016) Marcela V Maus et al. Molecular Therapy-Oncolytics
- Catch me if you can: Leukemia Escape after CD19-Directed T Cell Immunotherapies
- (2016) Marco Ruella et al. Computational and Structural Biotechnology Journal
- Chimeric Antigen Receptor-Engineered T Cells for the Treatment of Metastatic Prostate Cancer
- (2015) Victoria Hillerdal et al. BIODRUGS
- Liver myeloid-derived suppressor cells expand in response to liver metastases in mice and inhibit the anti-tumor efficacy of anti-CEA CAR-T
- (2015) Rachel A. Burga et al. CANCER IMMUNOLOGY IMMUNOTHERAPY
- Exclusion of T Cells From Pancreatic Carcinomas in Mice Is Regulated by Ly6Clow F4/80+ Extratumoral Macrophages
- (2015) Gregory L. Beatty et al. GASTROENTEROLOGY
- Isolation of neoantigen-specific T cells from tumor and peripheral lymphocytes
- (2015) Cyrille J. Cohen et al. JOURNAL OF CLINICAL INVESTIGATION
- Corrigendum to “Chimeric Receptors Containing CD137 Signal Transduction Domains Mediate Enhanced Survival of T Cells and Increased Antileukemic Efficacy In Vivo ”
- (2015) MOLECULAR THERAPY
- Melanoma-intrinsic β-catenin signalling prevents anti-tumour immunity
- (2015) Stefani Spranger et al. NATURE
- Heparanase promotes tumor infiltration and antitumor activity of CAR-redirected T lymphocytes
- (2015) Ignazio Caruana et al. NATURE MEDICINE
- Armed Oncolytic Virus Enhances Immune Functions of Chimeric Antigen Receptor-Modified T Cells in Solid Tumors
- (2014) N. Nishio et al. CANCER RESEARCH
- Regional delivery of mesothelin-targeted CAR T cell therapy generates potent and long-lasting CD4-dependent tumor immunity
- (2014) P. S. Adusumilli et al. Science Translational Medicine
- Alpharetroviral Vectors: From a Cancer-Causing Agent to a Useful Tool for Human Gene Therapy
- (2014) Julia Suerth et al. Viruses-Basel
- Using immunoproteomics to identify tumor-associated antigens (TAAs) as biomarkers in cancer immunodiagnosis
- (2013) Qing Zhu et al. AUTOIMMUNITY REVIEWS
- Fc-dependent depletion of tumor-infiltrating regulatory T cells co-defines the efficacy of anti–CTLA-4 therapy against melanoma
- (2013) Tyler R. Simpson et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Immune targeting of fibroblast activation protein triggers recognition of multipotent bone marrow stromal cells and cachexia
- (2013) Eric Tran et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Microenvironmental regulation of tumor progression and metastasis
- (2013) Daniela F Quail et al. NATURE MEDICINE
- The Basic Principles of Chimeric Antigen Receptor Design
- (2013) Michel Sadelain et al. Cancer Discovery
- CD20-specific adoptive immunotherapy for lymphoma using a chimeric antigen receptor with both CD28 and 4-1BB domains: pilot clinical trial results
- (2012) B. G. Till et al. BLOOD
- Mesothelin, a novel immunotherapy target for triple negative breast cancer
- (2012) Julia Tchou et al. BREAST CANCER RESEARCH AND TREATMENT
- Accessories to the Crime: Functions of Cells Recruited to the Tumor Microenvironment
- (2012) Douglas Hanahan et al. CANCER CELL
- Matrix architecture defines the preferential localization and migration of T cells into the stroma of human lung tumors
- (2012) Hélène Salmon et al. JOURNAL OF CLINICAL INVESTIGATION
- Chimeric antigen receptors for T cell immunotherapy: current understanding and future directions
- (2012) Kevin J. Curran et al. JOURNAL OF GENE MEDICINE
- Retroviral Integrations in Gene Therapy Trials
- (2012) Luca Biasco et al. MOLECULAR THERAPY
- CD28 costimulation improves expansion and persistence of chimeric antigen receptor–modified T cells in lymphoma patients
- (2011) Barbara Savoldo et al. JOURNAL OF CLINICAL INVESTIGATION
- A human memory T cell subset with stem cell–like properties
- (2011) Luca Gattinoni et al. NATURE MEDICINE
- Program death-1 signaling and regulatory T cells collaborate to resist the function of adoptively transferred cytotoxic T lymphocytes in advanced acute myeloid leukemia
- (2010) Q. Zhou et al. BLOOD
- Tumor-Specific CD8+ T Cells Expressing Interleukin-12 Eradicate Established Cancers in Lymphodepleted Hosts
- (2010) S. P. Kerkar et al. CANCER RESEARCH
- Successful Eradication of Established Peritoneal Ovarian Tumors in SCID-Beige Mice following Adoptive Transfer of T Cells Genetically Targeted to the MUC16 Antigen
- (2010) A. A. Chekmasova et al. CLINICAL CANCER RESEARCH
- Enhanced Tumor Trafficking of GD2 Chimeric Antigen Receptor T Cells by Expression of the Chemokine Receptor CCR2b
- (2010) John A. Craddock et al. JOURNAL OF IMMUNOTHERAPY
- Case Report of a Serious Adverse Event Following the Administration of T Cells Transduced With a Chimeric Antigen Receptor Recognizing ERBB2
- (2010) Richard A Morgan et al. MOLECULAR THERAPY
- HER2 overexpression correlates with survival after curative resection of pancreatic cancer
- (2009) Masahiro Komoto et al. CANCER SCIENCE
- 4-1BB and CD28 Signaling Plays a Synergistic Role in Redirecting Umbilical Cord Blood T Cells Against B-Cell Malignancies
- (2009) Syam Tammana et al. HUMAN GENE THERAPY
- Chimeric Antigen Receptors Combining 4-1BB and CD28 Signaling Domains Augment PI3kinase/AKT/Bcl-XL Activation and CD8+ T Cell–mediated Tumor Eradication
- (2009) Xiao-Song Zhong et al. MOLECULAR THERAPY
- Control of large, established tumor xenografts with genetically retargeted human T cells containing CD28 and CD137 domains
- (2009) C. Carpenito et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Tumor immunotherapy across MHC barriers using allogeneic T-cell precursors
- (2008) Johannes L Zakrzewski et al. NATURE BIOTECHNOLOGY
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExploreAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started