Tumor Infiltrating Lymphocyte (TIL) Therapy for Solid Tumor Treatment: Progressions and Challenges
出版年份 2022 全文链接
标题
Tumor Infiltrating Lymphocyte (TIL) Therapy for Solid Tumor Treatment: Progressions and Challenges
作者
关键词
-
出版物
Cancers
Volume 14, Issue 17, Pages 4160
出版商
MDPI AG
发表日期
2022-08-29
DOI
10.3390/cancers14174160
参考文献
相关参考文献
注意：仅列出部分参考文献，下载原文获取全部文献信息。- Tumor-associated high endothelial venules mediate lymphocyte entry into tumors and predict response to PD-1 plus CTLA-4 combination immunotherapy
- (2022) Assia Asrir et al. CANCER CELL
- TCR-T Immunotherapy: The Challenges and Solutions
- (2022) Yating Liu et al. Frontiers in Oncology
- IL-2 regulates tumor-reactive CD8+ T cell exhaustion by activating the aryl hydrocarbon receptor
- (2021) Yuying Liu et al. NATURE IMMUNOLOGY
- Lifileucel, a Tumor-Infiltrating Lymphocyte Therapy, in Metastatic Melanoma
- (2021) Amod A. Sarnaik et al. JOURNAL OF CLINICAL ONCOLOGY
- A cytokine receptor-masked IL2 prodrug selectively activates tumor-infiltrating lymphocytes for potent antitumor therapy
- (2021) Eric J. Hsu et al. Nature Communications
- Comparison of non-myeloablative lymphodepleting preconditioning regimens in patients undergoing adoptive T cell therapy
- (2021) Abraham Nissani et al. Journal for ImmunoTherapy of Cancer
- Tumor-infiltrating lymphocyte treatment for anti-PD-1-resistant metastatic lung cancer: a phase 1 trial
- (2021) Benjamin C. Creelan et al. NATURE MEDICINE
- NK Cell Therapy: A Rising Star in Cancer Treatment
- (2021) Nawen Du et al. Cancers
- CTLA-4 blockade boosts the expansion of tumor-reactive CD8+ tumor-infiltrating lymphocytes in ovarian cancer
- (2020) Christina Friese et al. Scientific Reports
- Enhanced Phenotype Definition for Precision Isolation of Precursor Exhausted Tumor-Infiltrating CD8 T Cells
- (2020) Amaia Martinez-Usatorre et al. Frontiers in Immunology
- Oncolytic adenovirus shapes the ovarian tumor microenvironment for potent tumor-infiltrating lymphocyte tumor reactivity
- (2020) João Manuel Santos et al. Journal for ImmunoTherapy of Cancer
- Dendritic cells dictate responses to PD-L1 blockade cancer immunotherapy
- (2020) Maud Mayoux et al. Science Translational Medicine
- Oncolytic virus promotes tumor-reactive infiltrating lymphocytes for adoptive cell therapy
- (2020) Mathilde Feist et al. CANCER GENE THERAPY
- Adoptive cell therapy in combination with checkpoint inhibitors in ovarian cancer
- (2020) Anders Handrup Kverneland et al. Oncotarget
- CD39 identifies the CD4+ tumor-specific T cell population in human cancer
- (2020) Kim E Kortekaas et al. Cancer Immunology Research
- Tumor infiltrating lymphocytes (TIL) therapy in metastatic melanoma: boosting of neoantigen-specific T cell reactivity and long-term follow-up
- (2020) Joost H van den Berg et al. Journal for ImmunoTherapy of Cancer
- Reinvigorating exhausted CD8 + cytotoxic T lymphocytes in the tumor microenvironment and current strategies in cancer immunotherapy
- (2020) Md Amir Hossain et al. MEDICINAL RESEARCH REVIEWS
- PD-L1 on dendritic cells attenuates T cell activation and regulates response to immune checkpoint blockade
- (2020) Qi Peng et al. Nature Communications
- BRAF and MEK inhibition in melanoma patients enables reprogramming of tumor infiltrating lymphocytes
- (2020) Lukas Peiffer et al. CANCER IMMUNOLOGY IMMUNOTHERAPY
- Adoptive transfer of TILs plus anti-PD1 therapy: An alternative combination therapy for treating metastatic osteosarcoma
- (2020) Chao Wang et al. Journal of Bone Oncology
- Targeting the ERK Signaling Pathway in Melanoma
- (2019) Paola Savoia et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Phase II clinical trial of adoptive cell therapy for patients with metastatic melanoma with autologous tumor-infiltrating lymphocytes and low-dose interleukin-2
- (2019) Linh T. Nguyen et al. CANCER IMMUNOLOGY IMMUNOTHERAPY
- An introduction to chimeric antigen receptor (CAR) T-cell immunotherapy for human cancer
- (2019) Steven Feins et al. AMERICAN JOURNAL OF HEMATOLOGY
- CD8 T Cell Exhaustion During Chronic Viral Infection and Cancer
- (2019) Laura M. McLane et al. Annual Review of Immunology
- A Single-Cell Atlas of the Tumor and Immune Ecosystem of Human Breast Cancer
- (2019) Johanna Wagner et al. CELL
- Safety and efficacy of adoptive cell transfer using autologous tumor infiltrating lymphocytes (LN-145) for treatment of recurrent, metastatic, or persistent cervical carcinoma.
- (2019) Amir A. Jazaeri et al. JOURNAL OF CLINICAL ONCOLOGY
- An Historical Overview: The Discovery of How NK Cells Can Kill Enemies, Recruit Defense Troops, and More
- (2019) Massimo Vitale et al. Frontiers in Immunology
- Translating gammadelta (γδ) T cells and their receptors into cancer cell therapies
- (2019) Zsolt Sebestyen et al. NATURE REVIEWS DRUG DISCOVERY
- Efficacy of adoptive therapy with tumor-infiltrating lymphocytes and recombinant interleukin-2 in advanced cutaneous melanoma: a systematic review and meta-analysis
- (2019) U Dafni et al. ANNALS OF ONCOLOGY
- CD103+ T and Dendritic Cells Indicate a Favorable Prognosis in Oral Cancer
- (2019) Y. Xiao et al. JOURNAL OF DENTAL RESEARCH
- Personalized neoantigen-pulsed dendritic cell vaccines show superior immunogenicity to neoantigen-adjuvant vaccines in mouse tumor models
- (2019) Rui Zhang et al. CANCER IMMUNOLOGY IMMUNOTHERAPY
- T-cell responses toTP53"hotspot" mutations and unique neoantigens expressed by human ovarian cancers
- (2018) Drew C Deniger et al. CLINICAL CANCER RESEARCH
- Utilizing T-cell Activation Signals 1, 2, and 3 for Tumor-infiltrating Lymphocytes (TIL) Expansion
- (2018) René J. Tavera et al. JOURNAL OF IMMUNOTHERAPY
- Adenovirus Coding for Interleukin-2 and Tumor Necrosis Factor Alpha Replaces Lymphodepleting Chemotherapy in Adoptive T Cell Therapy
- (2018) João Manuel Santos et al. MOLECULAR THERAPY
- Immune recognition of somatic mutations leading to complete durable regression in metastatic breast cancer
- (2018) Nikolaos Zacharakis et al. NATURE MEDICINE
- Co-expression of CD39 and CD103 identifies tumor-reactive CD8 T cells in human solid tumors
- (2018) Thomas Duhen et al. Nature Communications
- Combination of Ipilimumab and Adoptive Cell Therapy with Tumor-Infiltrating Lymphocytes for Patients with Metastatic Melanoma
- (2018) John E. Mullinax et al. Frontiers in Oncology
- Improving CLL Vγ9Vδ2-T cell fitness for cellular therapy by ex vivo activation and ibrutinib
- (2018) Iris de Weerdt et al. BLOOD
- Bystander CD8+ T cells are abundant and phenotypically distinct in human tumour infiltrates
- (2018) Yannick Simoni et al. NATURE
- Immunomodulatory effects of BRAF and MEK inhibitors: Implications for Melanoma therapy
- (2018) Marvin Kuske et al. PHARMACOLOGICAL RESEARCH
- PPAR-induced fatty acid oxidation in T cells increases the number of tumor-reactive CD8+ T cells and facilitates anti-PD-1 therapy
- (2018) Partha S. Chowdhury et al. Cancer Immunology Research
- Expansion of tumor infiltrating lymphocytes (TIL) from bladder cancer
- (2018) Michael Poch et al. OncoImmunology
- A phase II study of tumor-infiltrating lymphocyte therapy for human papillomavirus-associated epithelial cancers
- (2018) Sanja Stevanovic et al. CLINICAL CANCER RESEARCH
- Regulation of Effector and Memory CD8 T Cell Differentiation by IL-2—A Balancing Act
- (2018) Vandana Kalia et al. Frontiers in Immunology
- Dendritic Cell Cancer Therapy: Vaccinating the Right Patient at the Right Time
- (2018) Wouter W. van Willigen et al. Frontiers in Immunology
- High-dose interleukin-2 (IL-2) for the treatment of melanoma: safety considerations and future directions
- (2017) Stephen Marabondo et al. Expert Opinion On Drug Safety
- Treatment of metastatic uveal melanoma with adoptive transfer of tumour-infiltrating lymphocytes: a single-centre, two-stage, single-arm, phase 2 study
- (2017) Smita S Chandran et al. LANCET ONCOLOGY
- PD-1 expression by tumour-associated macrophages inhibits phagocytosis and tumour immunity
- (2017) Sydney R. Gordon et al. NATURE
- Landscape of immunogenic tumor antigens in successful immunotherapy of virally induced epithelial cancer
- (2017) Sanja Stevanović et al. SCIENCE
- Expansion of tumor-infiltrating lymphocytes and their potential for application as adoptive cell transfer therapy in human breast cancer
- (2017) Hee Jin Lee et al. Oncotarget
- Selection of Shared and Neoantigen-Reactive T Cells for Adoptive Cell Therapy Based on CD137 Separation
- (2017) Sivan Seliktar-Ofir et al. Frontiers in Immunology
- A bispecific nanobody approach to leverage the potent and widely applicable tumor cytolytic capacity of Vγ9Vδ2-T cells
- (2017) Renée C. G. de Bruin et al. OncoImmunology
- Tumor-infiltrating lymphocytes (TILs) from patients with glioma
- (2017) Zhenjiang Liu et al. OncoImmunology
- A Distinct Gene Module for Dysfunction Uncoupled from Activation in Tumor-Infiltrating T Cells
- (2016) Meromit Singer et al. CELL
- Long-Lasting Complete Responses in Patients with Metastatic Melanoma after Adoptive Cell Therapy with Tumor-Infiltrating Lymphocytes and an Attenuated IL2 Regimen
- (2016) R. Andersen et al. CLINICAL CANCER RESEARCH
- Isolation of T-Cell Receptors Specifically Reactive with Mutated Tumor-Associated Antigens from Tumor-Infiltrating Lymphocytes Based on CD137 Expression
- (2016) Maria Parkhurst et al. CLINICAL CANCER RESEARCH
- A Pilot Trial of the Combination of Vemurafenib with Adoptive Cell Therapy in Patients with Metastatic Melanoma
- (2016) Drew C. Deniger et al. CLINICAL CANCER RESEARCH
- Randomized, Prospective Evaluation Comparing Intensity of Lymphodepletion Before Adoptive Transfer of Tumor-Infiltrating Lymphocytes for Patients With Metastatic Melanoma
- (2016) Stephanie L. Goff et al. JOURNAL OF CLINICAL ONCOLOGY
- Expansion of Tumor-reactive T Cells From Patients With Pancreatic Cancer
- (2016) Qingda Meng et al. JOURNAL OF IMMUNOTHERAPY
- BRAF inhibition for advanced locoregional BRAF V600E mutant melanoma
- (2016) Sarah Sloot et al. MELANOMA RESEARCH
- Emerging concepts of T cell metabolism as a target of immunotherapy
- (2016) Chih-Hao Chang et al. NATURE IMMUNOLOGY
- T-Cell Transfer Therapy Targeting Mutant KRAS in Cancer
- (2016) Eric Tran et al. NEW ENGLAND JOURNAL OF MEDICINE
- Durable Complete Response from Metastatic Melanoma after Transfer of Autologous T Cells Recognizing 10 Mutated Tumor Antigens
- (2016) T. D. Prickett et al. Cancer Immunology Research
- Expansion of tumor-infiltrating lymphocytes (TIL) from human pancreatic tumors
- (2016) MacLean Hall et al. Journal for ImmunoTherapy of Cancer
- Immune Checkpoint Blockade to Improve Tumor Infiltrating Lymphocytes for Adoptive Cell Therapy
- (2016) Krithika N. Kodumudi et al. PLoS One
- Adoptive T cell therapy combined with intralesional administrations of TG1042 (adenovirus expressing interferon-γ) in metastatic melanoma patients
- (2015) Amir Khammari et al. CANCER IMMUNOLOGY IMMUNOTHERAPY
- Cancer immunotherapy: harnessing the immune system to battle cancer
- (2015) Yiping Yang JOURNAL OF CLINICAL INVESTIGATION
- Complete Regression of Metastatic Cervical Cancer After Treatment With Human Papillomavirus–Targeted Tumor-Infiltrating T Cells
- (2015) Sanja Stevanović et al. JOURNAL OF CLINICAL ONCOLOGY
- Tumor-infiltrating lymphocytes for the treatment of metastatic cancer
- (2015) M.H. Geukes Foppen et al. Molecular Oncology
- Neoantigens in cancer immunotherapy
- (2015) T. N. Schumacher et al. SCIENCE
- PD-1 and CD103 Are Widely Coexpressed on Prognostically Favorable Intraepithelial CD8 T Cells in Human Ovarian Cancer
- (2015) J. R. Webb et al. Cancer Immunology Research
- Manipulating the Tumor Microenvironment Ex Vivo for Enhanced Expansion of Tumor-Infiltrating Lymphocytes for Adoptive Cell Therapy
- (2014) Jessica Ann Chacon et al. CLINICAL CANCER RESEARCH
- PD-1 identifies the patient-specific CD8+ tumor-reactive repertoire infiltrating human tumors
- (2014) Alena Gros et al. JOURNAL OF CLINICAL INVESTIGATION
- Effects of BRAF Mutations and BRAF Inhibition on Immune Responses to Melanoma
- (2014) K. M. Ilieva et al. MOLECULAR CANCER THERAPEUTICS
- Cancer Immunotherapy Based on Mutation-Specific CD4+ T Cells in a Patient with Epithelial Cancer
- (2014) E. Tran et al. SCIENCE
- Adoptive Transfer of Tumor-Infiltrating Lymphocytes in Patients with Metastatic Melanoma: Intent-to-Treat Analysis and Efficacy after Failure to Prior Immunotherapies
- (2013) M. J. Besser et al. CLINICAL CANCER RESEARCH
- CD137 Accurately Identifies and Enriches for Naturally Occurring Tumor-Reactive T Cells in Tumor
- (2013) Q. Ye et al. CLINICAL CANCER RESEARCH
- Mining exomic sequencing data to identify mutated antigens recognized by adoptively transferred tumor-reactive T cells
- (2013) Paul F Robbins et al. NATURE MEDICINE
- Engineered Drug Resistant γδ T Cells Kill Glioblastoma Cell Lines during a Chemotherapy Challenge: A Strategy for Combining Chemo- and Immunotherapy
- (2013) Lawrence S. Lamb et al. PLoS One
- BRAF inhibition is associated with increased clonality in tumor-infiltrating lymphocytes
- (2013) Zachary A Cooper et al. OncoImmunology
- CXCR1 as a novel target for directing reactive T cells toward melanoma: implications for adoptive cell transfer immunotherapy
- (2012) Sivan Sapoznik et al. CANCER IMMUNOLOGY IMMUNOTHERAPY
- Adoptive T-Cell Therapy Using Autologous Tumor-Infiltrating Lymphocytes for Metastatic Melanoma
- (2012) Richard Wu et al. CANCER JOURNAL
- Specific Lymphocyte Subsets Predict Response to Adoptive Cell Therapy Using Expanded Autologous Tumor-Infiltrating Lymphocytes in Metastatic Melanoma Patients
- (2012) L. G. Radvanyi et al. CLINICAL CANCER RESEARCH
- Simplified Method of the Growth of Human Tumor Infiltrating Lymphocytes in Gas-permeable Flasks to Numbers Needed for Patient Treatment
- (2012) Jianjian Jin et al. JOURNAL OF IMMUNOTHERAPY
- Adoptive cell therapy with autologous tumor infiltrating lymphocytes and low-dose Interleukin-2 in metastatic melanoma patients
- (2012) Eva Ellebaek et al. Journal of Translational Medicine
- Survival in BRAF V600–Mutant Advanced Melanoma Treated with Vemurafenib
- (2012) Jeffrey A. Sosman et al. NEW ENGLAND JOURNAL OF MEDICINE
- TIL therapy broadens the tumor-reactive CD8+T cell compartment in melanoma patients
- (2012) Pia Kvistborg et al. OncoImmunology
- Adoptive T-cell therapy for malignant melanoma patients with TILs obtained by ultrasound-guided needle biopsy
- (2011) Gustav J. Ullenhag et al. CANCER IMMUNOLOGY IMMUNOTHERAPY
- Durable Complete Responses in Heavily Pretreated Patients with Metastatic Melanoma Using T-Cell Transfer Immunotherapy
- (2011) S. A. Rosenberg et al. CLINICAL CANCER RESEARCH
- Establishment and Large-scale Expansion of Minimally cultured “Young” Tumor Infiltrating Lymphocytes for Adoptive Transfer Therapy
- (2011) Orit Itzhaki et al. JOURNAL OF IMMUNOTHERAPY
- Characterization and Comparison of ‘Standard’ and ‘Young’ Tumour-Infiltrating Lymphocytes for Adoptive Cell Therapy at a Danish Translational Research Institution
- (2011) M. Donia et al. SCANDINAVIAN JOURNAL OF IMMUNOLOGY
- CD8+ Enriched "Young" Tumor Infiltrating Lymphocytes Can Mediate Regression of Metastatic Melanoma
- (2010) M. E. Dudley et al. CLINICAL CANCER RESEARCH
- Clinical Responses in a Phase II Study Using Adoptive Transfer of Short-term Cultured Tumor Infiltration Lymphocytes in Metastatic Melanoma Patients
- (2010) M. J. Besser et al. CLINICAL CANCER RESEARCH
- Blockade of Programmed Death Ligand 1 Enhances the Therapeutic Efficacy of Combination Immunotherapy against Melanoma
- (2010) S. Pilon-Thomas et al. JOURNAL OF IMMUNOLOGY
- Selection of CD8+PD-1+ Lymphocytes in Fresh Human Melanomas Enriches for Tumor-reactive T Cells
- (2010) Takashi Inozume et al. JOURNAL OF IMMUNOTHERAPY
- Expansion and Characterization of Human Melanoma Tumor-Infiltrating Lymphocytes (TILs)
- (2010) Linh T. Nguyen et al. PLoS One
- Tumor antigen-specific CD8 T cells infiltrating the tumor express high levels of PD-1 and are functionally impaired
- (2009) M. Ahmadzadeh et al. BLOOD
- Dendritic cell recovery post-lymphodepletion: a potential mechanism for anti-cancer adoptive T cell therapy and vaccination
- (2009) Mohamed Labib Salem et al. CANCER IMMUNOLOGY IMMUNOTHERAPY
- Toxicity and Activity of a Twice Daily High-dose Bolus Interleukin 2 Regimen in Patients With Metastatic Melanoma and Metastatic Renal Cell Cancer
- (2009) Nicolas Acquavella et al. JOURNAL OF IMMUNOTHERAPY
- Increased Intensity Lymphodepletion Enhances Tumor Treatment Efficacy of Adoptively Transferred Tumor-specific T Cells
- (2009) Claudia Wrzesinski et al. JOURNAL OF IMMUNOTHERAPY
- IL-2 and IL-21 confer opposing differentiation programs to CD8+ T cells for adoptive immunotherapy
- (2008) C. S. Hinrichs et al. BLOOD
- Adoptive Cell Therapy for Patients with Melanoma, Using Tumor-Infiltrating Lymphocytes Genetically Engineered to Secrete Interleukin-2
- (2008) Bianca Heemskerk et al. HUMAN GENE THERAPY
- Adoptive Cell Therapy for Patients With Metastatic Melanoma: Evaluation of Intensive Myeloablative Chemoradiation Preparative Regimens
- (2008) Mark E. Dudley et al. JOURNAL OF CLINICAL ONCOLOGY
- Minimally Cultured Tumor-infiltrating Lymphocytes Display Optimal Characteristics for Adoptive Cell Therapy
- (2008) Khoi Q. Tran et al. JOURNAL OF IMMUNOTHERAPY
Discover Peeref hubs
Discuss science. Find collaborators. Network.
Join a conversationPublish scientific posters with Peeref
Peeref publishes scientific posters from all research disciplines. Our Diamond Open Access policy means free access to content and no publication fees for authors.
Learn More