Anticancer perspective of 6-shogaol: anticancer properties, mechanism of action, synergism and delivery system

6-Shogaol Overcomes Gefitinib Resistance via ER Stress in Ovarian Cancer Cells

(2023) Tae Woo Kim et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

6-Shogaol Inhibits Oxidative Stress-Induced Rat Vascular Smooth Muscle Cell Apoptosis by Regulating OXR1-p53 Axis

(2022) Jing Liu et al.   Frontiers in Molecular Biosciences

Michael acceptor-dependent pro-oxidative intervention against angiogenesis by [6]-dehydroshogaol, a pungent constituent of ginger

(2022) Xuefeng Liu et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Epithelial–Mesenchymal Transition (EMT) 2021

(2022) Guidalberto Manfioletti et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Ultrasound and nanomaterial: an efficient pair to fight cancer

(2022) Edouard Alphandéry   JOURNAL OF NANOBIOTECHNOLOGY

Ginger Constituent 6-Shogaol Inhibits Inflammation- and Angiogenesis-Related Cell Functions in Primary Human Endothelial Cells

(2022) Iris Bischoff-Kont et al.   Frontiers in Pharmacology

[6]-Shogaol Attenuates Oxaliplatin-Induced Allodynia through Serotonergic Receptors and GABA in the Spinal Cord in Mice

(2022) Suyong Kim et al.   Pharmaceuticals

Involvement of the p53/p21 complex in p53-dependent gene expression

(2022) Ukjin Kim et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

A comprehensive review on methotrexate containing nanoparticles; an appropriate tool for cancer treatment

(2022) Hanifeh Shariatifar et al.   MOLECULAR BIOLOGY REPORTS

Cyclodextrin inclusion complex of a multi-component natural product by hot-melt extrusion

(2022) Rhayssa de Oliveira Nonato et al.   Drug Delivery and Translational Research

6-Shogaol from ginger shows anti-tumor effect in cervical carcinoma via PI3K/Akt/mTOR pathway

(2021) Xiao-Dong Pei et al.   EUROPEAN JOURNAL OF NUTRITION

Targeting Akt in Hepatocellular Carcinoma and Its Tumor Microenvironment

(2021) Mariam Mroweh et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Cytotoxic effect of 6-Shogaol in Imatinib sensitive and resistant K562 cells

(2021) Tulin Ozkan et al.   MOLECULAR BIOLOGY REPORTS

Targeting cell-cycle machinery in cancer

(2021) Jan M. Suski et al.   CANCER CELL

6‐Shogaol induces apoptosis in acute lymphoblastic leukaemia cells by targeting p53 signalling pathway and generation of reactive oxygen species

(2021) Somayeh Najafi Dorcheh et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Multifunctional polymeric micellar nanomedicine in the diagnosis and treatment of cancer

(2021) Nidhi Raval et al.   Materials Science & Engineering C-Materials for Biological Applications

Orally Administered Natural Lipid Nanoparticle-Loaded 6-Shogaol Shapes the Anti-Inflammatory Microbiota and Metabolome

(2021) Chunhua Yang et al.   Pharmaceutics

Benefits of Ginger and Its Constituent 6-Shogaol in Inhibiting Inflammatory Processes

(2021) Iris Bischoff-Kont et al.   Pharmaceuticals

Application of glutathione depletion in cancer therapy: Enhanced ROS-based therapy, ferroptosis, and chemotherapy

(2021) Boyi Niu et al.   BIOMATERIALS

Solid Lipid Nanoparticles: An Approach to Improve Oral Drug Delivery

(2021) Nestor Mendoza-Muñoz et al.   JOURNAL OF PHARMACY AND PHARMACEUTICAL SCIENCES

Protective Effects of 6-Shogaol, an Active Compound of Ginger, in a Murine Model of Cisplatin-Induced Acute Kidney Injury

(2021) Mi-Gyeong Gwon et al.   MOLECULES

The Hippo Signaling Pathway in Cancer: A Cell Cycle Perspective

(2021) Yi Xiao et al.   Cancers

6-Shogaol Antagonizes the Adipocyte-Conditioned Medium-Initiated 5-Fluorouracil Resistance in Human Colorectal Cancer Cells through Controlling the SREBP-1 Level

(2021) Ko-Chao Lee et al.   Life-Basel

ROS in cancer therapy: the bright side of the moon

(2020) Bruno Perillo et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

Autophagy and autophagy-related proteins in cancer

(2020) Xiaohua Li et al.   Molecular Cancer

Chronic myeloid leukemia: 2020 update on diagnosis, therapy and monitoring

(2020) Elias Jabbour et al.   AMERICAN JOURNAL OF HEMATOLOGY

Therapeutic Nanoparticles and Their Targeted Delivery Applications

(2020) Abuzer Alp Yetisgin et al.   MOLECULES

Targeting apoptosis in cancer therapy

(2020) Benedito A. Carneiro et al.   Nature Reviews Clinical Oncology

Life, death, and autophagy in cancer: NF-κB turns up everywhere

(2020) Daniela Verzella et al.   Cell Death & Disease

Ultrasound-Augmented Phase Transition Nanobubbles for Targeted Treatment of Paclitaxel-Resistant Cancer

(2020) Yi Zhu et al.   BIOCONJUGATE CHEMISTRY

6-Shogaol suppresses the growth of breast cancer cells by inducing apoptosis and suppressing autophagy via targeting notch signaling pathway

(2020) Azizah S. Bawadood et al.   BIOMEDICINE & PHARMACOTHERAPY

Natural-lipid nanoparticle-based therapeutic approach to deliver 6-shogaol and its metabolites M2 and M13 to the colon to treat ulcerative colitis

(2020) Chunhua Yang et al.   JOURNAL OF CONTROLLED RELEASE

Anti-Survival and Pro-Apoptotic Effects of 6-Shogaol on SW872 Human Liposarcoma Cells via Control of the Intrinsic Caspase Pathway, STAT-3, AMPK, and ER Stress

(2020) Anil Kumar Yadav et al.   Biomolecules

Circular RNA MCTP2 inhibits cisplatin resistance in gastric cancer by miR-99a-5p-mediated induction of MTMR3 expression

(2020) Guangli Sun et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Nutritional implications of ginger: chemistry, biological activities and signaling pathways

(2020) Ryoiti Kiyama   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Localized Delivery of Cisplatin to Cervical Cancer Improves Its Therapeutic Efficacy and Minimizes Its Side Effect Profile

(2020) Cinzia Federico et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

AZD1208, a Pan-Pim Kinase Inhibitor, Has Anti-Growth Effect on 93T449 Human Liposarcoma Cells via Control of the Expression and Phosphorylation of Pim-3, mTOR, 4EBP-1, S6, STAT-3 and AMPK

(2019) Anil Yadav et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Enhanced Oral Bioavailability, Anti-Tumor Activity and Hepatoprotective Effect of 6-Shogaol Loaded in a Type of Novel Micelles of Polyethylene Glycol and Linoleic Acid Conjugate

(2019) Huiyun Zhang et al.   Pharmaceutics

Signal Transducer and Activator of Transcription (STATs) Proteins in Cancer and Inflammation: Functions and Therapeutic Implication

(2019) Chin-Yap Loh et al.   Frontiers in Oncology

Apoptosis: A mammalian cell bioprocessing perspective

(2019) Antonio L. Grilo et al.   BIOTECHNOLOGY ADVANCES

Anti-hyperuricemic property of 6-shogaol via self-micro emulsifying drug delivery system in model rats: formulation design, in vitro and in vivo evaluation

(2019) Qiuxuan Yang et al.   DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY

Cisplatin: The first metal based anticancer drug

(2019) Sumit Ghosh   BIOORGANIC CHEMISTRY

[6]-shogaol/β-CDs inclusion complex: Preparation, characterization, in vivo pharmacokinetics and in situ intestinal perfusion study

(2019) Ran Li et al.   JOURNAL OF MICROENCAPSULATION

Methotrexate overdose in clinical practice

(2019) Ashok Kumar Pannu   CURRENT DRUG METABOLISM

Targeting Autophagy in Cancer: Recent Advances and Future Directions

(2019) Ravi K. Amaravadi et al.   Cancer Discovery

Molecular Mechanisms of Resistance to Tyrosine Kinase Inhibitors

(2019) Marjan Yaghmaie et al.   Current Hematologic Malignancy Reports

Direct impact of cisplatin on mitochondria induces ROS production that dictates cell fate of ovarian cancer cells

(2019) Markus Kleih et al.   Cell Death & Disease

6-Shogaol Suppresses 2-Amino-1-Methyl-6-Phenylimidazo [4,5-b] Pyridine (PhIP)-Induced Human 786-O Renal Cell Carcinoma Osteoclastogenic Activity and Metastatic Potential

(2019) I-Jeng Yeh et al.   Nutrients

Naturally occurring anti-cancer compounds: shining from Chinese herbal medicine

(2019) Hua Luo et al.   Chinese Medicine

Overview of cisplatin-induced neurotoxicity and ototoxicity, and the protective agents

(2019) Neife Aparecida Guinaim dos Santos et al.   FOOD AND CHEMICAL TOXICOLOGY

[6]-Shogaol attenuates inflammation, cell proliferation via modulate NF-κB and AP-1 oncogenic signaling in 7,12-dimethylbenz[ a ]anthracene induced oral carcinogenesis

(2018) Govindhan Annamalai et al.   BIOMEDICINE & PHARMACOTHERAPY

6-Shogaol induces caspase-independent paraptosis in cancer cells via proteasomal inhibition

(2018) Divya Nedungadi et al.   EXPERIMENTAL CELL RESEARCH

Occurrence, biological activity and metabolism of 6-shogaol

(2018) Xingran Kou et al.   Food & Function

Enhanced oral bioavailability and anti-gout activity of [6]-shogaol-loaded solid lipid nanoparticles

(2018) Qilong Wang et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Anti-Cancer Natural Products and Their Bioactive Compounds Inducing ER Stress-Mediated Apoptosis: A Review

(2018) Changmin Kim et al.   Nutrients

Apoptosis and apoptotic body: disease message and therapeutic target potentials

(2018) Xuebo Xu et al.   BIOSCIENCE REPORTS

Efficient dehydration of 6-gingerol to 6-shogaol catalyzed by an acidic ionic liquid under ultrasound irradiation

(2017) Xingran Kou et al.   FOOD CHEMISTRY

Interindividual Variability in Metabolism of [6]-Shogaol by Gut Microbiota

(2017) Pei Wang et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Oral Delivery of Nanoparticles Loaded With Ginger Active Compound, 6-Shogaol, Attenuates Ulcerative Colitis and Promotes Wound Healing in a Murine Model of Ulcerative Colitis

(2017) Mingzhen Zhang et al.   Journal of Crohns & Colitis

Ginger Phytochemicals Inhibit Cell Growth and Modulate Drug Resistance Factors in Docetaxel Resistant Prostate Cancer Cell

(2017) Chi-Ming Liu et al.   MOLECULES

Prospectives of Solid Self-microemulsifying Systems in Novel Drug Delivery

(2017) Kanav Midha et al.   Current Drug Delivery

Edible ginger-derived nanoparticles: A novel therapeutic approach for the prevention and treatment of inflammatory bowel disease and colitis-associated cancer

(2016) Mingzhen Zhang et al.   BIOMATERIALS

[6]-Shogaol, a dietary phenolic compound, induces oxidative stress mediated mitochondrial dependant apoptosis through activation of proapoptotic factors in Hep-2 cells

(2016) Govindhan Annamalai et al.   BIOMEDICINE & PHARMACOTHERAPY

Revealing the effect of 6-gingerol, 6-shogaol and curcumin on mPGES-1, GSK-3β and β-catenin pathway in A549 cell line

(2016) Demirpolat Eren et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Herbal remedies use by breast cancer patients in the West Bank of Palestine

(2016) Nidal Amin Jaradat et al.   JOURNAL OF ETHNOPHARMACOLOGY

Complementary and alternative medicine use among cancer patients in Palestine with special reference to safety-related concerns

(2016) Mohammed S. Ali-Shtayeh et al.   JOURNAL OF ETHNOPHARMACOLOGY

6-Gingerol Mediates its Anti Tumor Activities in Human Oral and Cervical Cancer Cell Lines through Apoptosis and Cell Cycle Arrest

(2016) Vaishali Kapoor et al.   PHYTOTHERAPY RESEARCH

Anti-Colon Cancer Effects of 6-Shogaol Through G2/M Cell Cycle Arrest by p53/p21-cdc2/cdc25A Crosstalk

(2015) Lian-Wen Qi et al.   AMERICAN JOURNAL OF CHINESE MEDICINE

6-Shogaol enhances renal carcinoma Caki cells to TRAIL-induced apoptosis through reactive oxygen species-mediated cytochrome c release and down-regulation of c-FLIP(L) expression

(2015) Min Ae Han et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Effects of inhaled ginger aromatherapy on chemotherapy-induced nausea and vomiting and health-related quality of life in women with breast cancer

(2015) Pei Lin Lua et al.   COMPLEMENTARY THERAPIES IN MEDICINE

6-Shogaol induces cell cycle arrest and apoptosis in human hepatoma cells through pleiotropic mechanisms

(2015) Jung-Ju Wu et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

6-Shogaol, an Active Constituent of Dietary Ginger, Impairs Cancer Development and Lung Metastasis by Inhibiting the Secretion of CC-Chemokine Ligand 2 (CCL2) in Tumor-Associated Dendritic Cells

(2015) Ya-Ling Hsu et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Microwave-assisted decomposition coupled with acidic food condiment as an efficient technology for ginger (Zingiber officinale Roscoe) processing

(2015) Jing-bo Guo et al.   SEPARATION AND PURIFICATION TECHNOLOGY

6-Shogaol exerts anti-proliferative and pro-apoptotic effects through the modulation of STAT3 and MAPKs signaling pathways

(2015) Sung-Moo Kim et al.   MOLECULAR CARCINOGENESIS

Anticancer Effect of Ginger Extract against Pancreatic Cancer Cells Mainly through Reactive Oxygen Species-Mediated Autotic Cell Death

(2015) Miho Akimoto et al.   PLoS One

6-Shogaol Inhibits Breast Cancer Cells and Stem Cell-Like Spheroids by Modulation of Notch Signaling Pathway and Induction of Autophagic Cell Death

(2015) Anasuya Ray et al.   PLoS One

Antitumor Activity of Gemcitabine Can Be Potentiated in Pancreatic Cancer through Modulation of TLR4/NF-κB signaling by 6-Shogaol

(2014) Ling Zhou et al.   AAPS Journal

6-Shogaol from Dried Ginger Inhibits Growth of Prostate Cancer Cells Both In Vitro and In Vivo through Inhibition of STAT3 and NF- B Signaling

(2014) A. Saha et al.   Cancer Prevention Research

Enterohepatic recirculation of bioactive ginger phytochemicals is associated with enhanced tumor growth-inhibitory activity of ginger extract

(2014) Sushma R. Gundala et al.   CARCINOGENESIS

Self-microemulsifying drug delivery system (SMEDDS) – challenges and road ahead

(2014) Shambhu Dokania et al.   DRUG DELIVERY

Induction of Lung Cancer Cell Apoptosis through a p53 Pathway by [6]-Shogaol and Its Cysteine-Conjugated Metabolite M2

(2014) Renaud F. Warin et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Ethnobotanical survey of usage of fresh medicinal plants in Singapore

(2014) Yin-Yin Siew et al.   JOURNAL OF ETHNOPHARMACOLOGY

Modulation of Cytochrome P450 Metabolism and Transport across Intestinal Epithelial Barrier by Ginger Biophenolics

(2014) Rao Mukkavilli et al.   PLoS One

6-Shogaol inhibits breast and colon cancer cell proliferation through activation of peroxisomal proliferator activated receptor γ (PPARγ)

(2013) Boon Shing Tan et al.   CANCER LETTERS

[6]-Shogaol inhibits growth and induces apoptosis of non-small cell lung cancer cells by directly regulating Akt1/2

(2013) Myoung Ok Kim et al.   CARCINOGENESIS

Cysteine-Conjugated Metabolite of Ginger Component [6]-Shogaol Serves as a Carrier of [6]-Shogaol in Cancer Cells and in Mice

(2013) Huadong Chen et al.   CHEMICAL RESEARCH IN TOXICOLOGY

6-Shogaol induces apoptosis in human leukemia cells through a process involving caspase-mediated cleavage of eIF2α

(2013) Qun Liu et al.   Molecular Cancer

Metabolites of Ginger Component [6]-Shogaol Remain Bioactive in Cancer Cells and Have Low Toxicity in Normal Cells: Chemical Synthesis and Biological Evaluation

(2013) Yingdong Zhu et al.   PLoS One

[6]-Shogaol inhibits melanogenesis in B16 mouse melanoma cells through activation of the ERK pathway

(2012) Cheng Yao et al.   ACTA PHARMACOLOGICA SINICA

Cyclodextrins

(2012) Sergey V. Kurkov et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Identification of phase II metabolites of thiol-conjugated [6]-shogaol in mouse urine using high-performance liquid chromatography tandem mass spectrometry

(2012) Huadong Chen et al.   JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

Molecular mechanism inhibiting human hepatocarcinoma cell invasion by 6-shogaol and 6-gingerol

(2012) Chia-Jui Weng et al.   MOLECULAR NUTRITION & FOOD RESEARCH

6-Shogaol Induces Apoptosis in Human Hepatocellular Carcinoma Cells and Exhibits Anti-Tumor Activity In Vivo through Endoplasmic Reticulum Stress

(2012) Rong Hu et al.   PLoS One

Shogaols at proapoptotic concentrations induce G2/M arrest and aberrant mitotic cell death associated with tubulin aggregation

(2011) Fei-Fei Gan et al.   APOPTOSIS

Steamed ginger (Zingiber officinale): Changed chemical profile and increased anticancer potential

(2011) Xiao-Lan Cheng et al.   FOOD CHEMISTRY

6-Shogaol, an active constituent of ginger, inhibits breast cancer cell invasion by reducing matrix metalloproteinase-9 expression via blockade of nuclear factor-κB activation

(2010) H Ling et al.   BRITISH JOURNAL OF PHARMACOLOGY

6-Shogaol, an Active Constituent of Dietary Ginger, Induces Autophagy by Inhibiting the AKT/mTOR Pathway in Human Non-Small Cell Lung Cancer A549 Cells

(2009) Jen-Yu Hung et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Pharmacokinetics of 6-Gingerol, 8-Gingerol, 10-Gingerol, and 6-Shogaol and Conjugate Metabolites in Healthy Human Subjects

(2008) S. M. Zick et al.   CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION

Specific reaction of α,β-unsaturated carbonyl compounds such as 6-shogaol with sulfhydryl groups in tubulin leading to microtubule damage

(2008) Kazuhiro Ishiguro et al.   FEBS LETTERS