Michael acceptor-dependent pro-oxidative intervention against angiogenesis by [6]-dehydroshogaol, a pungent constituent of ginger

6-Shogaol from ginger shows anti-tumor effect in cervical carcinoma via PI3K/Akt/mTOR pathway

(2021) Xiao-Dong Pei et al.   EUROPEAN JOURNAL OF NUTRITION

Reconciling VEGF With VPF: The Importance of Increased Vascular Permeability for Stroma Formation in Tumors, Healing Wounds, and Chronic Inflammation

(2021) Harold F. Dvorak   Frontiers in Cell and Developmental Biology

Benefits of Ginger and Its Constituent 6-Shogaol in Inhibiting Inflammatory Processes

(2021) Iris Bischoff-Kont et al.   Pharmaceuticals

Reactive oxygen species (ROS) as pleiotropic physiological signalling agents

(2020) Helmut Sies et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

6-Shogaol suppresses the growth of breast cancer cells by inducing apoptosis and suppressing autophagy via targeting notch signaling pathway

(2020) Azizah S. Bawadood et al.   BIOMEDICINE & PHARMACOTHERAPY

Oxidative Stress in Cancer

(2020) John D. Hayes et al.   CANCER CELL

Precision Research on Ginger: The Type of Ginger Matters

(2020) Shengmin Sang et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

The role of microenvironment in tumor angiogenesis

(2020) Xianjie Jiang et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Dual EGFR/VEGF pathway inhibition: a promising strategy for patients with EGFR-mutant NSCLC

(2020) Xiuning Le et al.   Journal of Thoracic Oncology

Small molecules regulating reactive oxygen species homeostasis for cancer therapy

(2020) Junmin Zhang et al.   MEDICINAL RESEARCH REVIEWS

Rational design of an ESIPT-based fluorescent probe for selectively monitoring glutathione in live cells and zebrafish

(2020) Ya-Long Zheng et al.   SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY

Targeting the Thioredoxin System as a Strategy for Cancer Therapy

(2019) Mianli Bian et al.   JOURNAL OF MEDICINAL CHEMISTRY

Applying an Electrophilicity-Based Strategy to Develop a Novel Nrf2 Activator Inspired from Dietary [6]-Shogaol

(2018) Yu-Ting Du et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

A Catechol-Type Resveratrol Analog Manifests Antiangiogenic Action by Constructing an Efficient Catalytic Redox Cycle with Intracellular Copper Ions and NQO1

(2018) Yi-Hua Wang et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Occurrence, biological activity and metabolism of 6-shogaol

(2018) Xingran Kou et al.   Food & Function

Small molecules targeting the selenoprotein thioredoxin reductase

(2018) Baoxin Zhang et al.   Chemistry-An Asian Journal

Enzymes involved in tumor-driven angiogenesis: A valuable target for anticancer therapy

(2017) Biagio Ricciuti et al.   SEMINARS IN CANCER BIOLOGY

Synthesis, evaluation, and metabolism of novel [6]-shogaol derivatives as potent Nrf2 activators

(2016) Yingdong Zhu et al.   FREE RADICAL BIOLOGY AND MEDICINE

Designing piperlongumine-directed anticancer agents by an electrophilicity-based prooxidant strategy: A mechanistic investigation

(2016) Wen-Jing Yan et al.   FREE RADICAL BIOLOGY AND MEDICINE

Reactive oxygen species and synthetic antioxidants as angiogenesis modulators: Clinical implications

(2016) Dorota M. Radomska-Leśniewska et al.   Pharmacological Reports

Insights into the importance for designing curcumin-inspired anticancer agents by a prooxidant strategy: The case of diarylpentanoids

(2015) Fang Dai et al.   FREE RADICAL BIOLOGY AND MEDICINE

6-Shogaol, an Active Constituent of Dietary Ginger, Impairs Cancer Development and Lung Metastasis by Inhibiting the Secretion of CC-Chemokine Ligand 2 (CCL2) in Tumor-Associated Dendritic Cells

(2015) Ya-Ling Hsu et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Oxidative stress inhibits distant metastasis by human melanoma cells

(2015) Elena Piskounova et al.   NATURE

Influence of side chain structure changes on antioxidant potency of the [6]-gingerol related compounds

(2014) Dong-Liang Lu et al.   FOOD CHEMISTRY

Tetrandrine induces G1/S cell cycle arrest through the ROS/Akt pathway in EOMA cells and inhibits angiogenesis in vivo

(2014) WENKAI XIAO et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Antioxidants Accelerate Lung Cancer Progression in Mice

(2014) V. I. Sayin et al.   Science Translational Medicine

Oxidative stress in angiogenesis and vascular disease

(2013) Y.-W. Kim et al.   BLOOD

Glutathione conjugation attenuates biological activities of 6-dehydroshogaol from ginger

(2013) Guodong Zhang et al.   FOOD CHEMISTRY

Highly Selective Off–On Fluorescent Probe for Imaging Thioredoxin Reductase in Living Cells

(2013) Liangwei Zhang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Thioredoxin System in Cell Death Progression

(2012) Jun Lu et al.   ANTIOXIDANTS & REDOX SIGNALING

Molecular mechanism inhibiting human hepatocarcinoma cell invasion by 6-shogaol and 6-gingerol

(2012) Chia-Jui Weng et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Electrophilic natural products and their biological targets

(2012) Malte Gersch et al.   NATURAL PRODUCT REPORTS

6-Shogaol, an active constituent of ginger, inhibits breast cancer cell invasion by reducing matrix metalloproteinase-9 expression via blockade of nuclear factor-κB activation

(2010) H Ling et al.   BRITISH JOURNAL OF PHARMACOLOGY

[6]-Dehydroshogaol, a minor component in ginger rhizome, exhibits quinone reductase inducing and anti-inflammatory activities that rival those of curcumin

(2010) Jeeyoung Imm et al.   FOOD RESEARCH INTERNATIONAL

6-Shogaol is more effective than 6-gingerol and curcumin in inhibiting 12-O-tetradecanoylphorbol 13-acetate-induced tumor promotion in mice

(2010) Hou Wu et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Increased Growth Inhibitory Effects on Human Cancer Cells and Anti-inflammatory Potency of Shogaols from Zingiber officinale Relative to Gingerols

(2009) Shengmin Sang et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Comparative antioxidant and anti-inflammatory effects of [6]-gingerol, [8]-gingerol, [10]-gingerol and [6]-shogaol

(2009) Swarnalatha Dugasani et al.   JOURNAL OF ETHNOPHARMACOLOGY

Specific reaction of α,β-unsaturated carbonyl compounds such as 6-shogaol with sulfhydryl groups in tubulin leading to microtubule damage

(2008) Kazuhiro Ishiguro et al.   FEBS LETTERS