DNA damage response(DDR): a link between cellular senescence and human cytomegalovirus

Molecular characterization of human cytomegalovirus infection with single-cell transcriptomics

(2023) Michal Schwartz et al.   Nature Microbiology

Cytotoxic CD4+ T cells eliminate senescent cells by targeting cytomegalovirus antigen

(2023) Tatsuya Hasegawa et al.   CELL

Inflammation and DNA damage: cause, effect or both

(2023) Antonio Pezone et al.   Nature Reviews Rheumatology

Senotherapeutics: An emerging approach to the treatment of viral infectious diseases in the elderly

(2023) Zhiqiang Li et al.   Frontiers in Cellular and Infection Microbiology

Human cytomegalovirus hijacks host stress response fueling replication stress and genome instability

(2022) Joanna Maria Merchut-Maya et al.   CELL DEATH AND DIFFERENTIATION

Dual inhibition of innate immunity and apoptosis by human cytomegalovirus protein UL37x1 enables efficient virus replication

(2022) Yujie Ren et al.   Nature Microbiology

Suppressive effects of pterostilbene on human cytomegalovirus (HCMV) infection and HCMV-induced cellular senescence

(2022) Sanying Wang et al.   Virology Journal

Functional regulation of the structure-specific endonuclease FEN1 by the human cytomegalovirus protein IE1 suggests a role for the re-initiation of stalled viral replication forks

(2021) Eva-Maria Schilling et al.   PLoS Pathogens

Virus-induced senescence is driver and therapeutic target in COVID-19

(2021) Soyoung Lee et al.   NATURE

Human Cytomegalovirus UL138 Protein Inhibits the STING Pathway and Reduces Interferon Beta mRNA Accumulation during Lytic and Latent Infections

(2021) Emily R. Albright et al.   mBio

Virus–host protein interactions as footprints of human cytomegalovirus replication

(2021) Matthew D Tyl et al.   Current Opinion in Virology

Cell Senescence, DNA Damage, and Metabolism

(2020) Riva Shmulevich et al.   ANTIOXIDANTS & REDOX SIGNALING

Human Cytomegalovirus Protein UL94 Targets MITA to Evade the Antiviral Immune Response

(2020) Hong-Mei Zou et al.   JOURNAL OF VIROLOGY

The Cytomegalovirus Tegument Protein UL35 Antagonizes Pattern Recognition Receptor-Mediated Type I IFN Transcription

(2020) Markus Fabits et al.   Microorganisms

Protein S-nitrosylation of Human Cytomegalovirus pp71 inhibits its ability to limit STING antiviral responses

(2020) Masatoshi Nukui et al.   JOURNAL OF VIROLOGY

Senescence in Monocytes Facilitates Dengue Virus Infection by Increasing Infectivity

(2020) Tzu-Han Hsieh et al.   Frontiers in Cellular and Infection Microbiology

Cellular senescence in ageing: from mechanisms to therapeutic opportunities

(2020) Raffaella Di Micco et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

HIV TAT-mediated microglial senescence: Role of SIRT3-dependent mitochondrial oxidative stress

(2020) Annadurai Thangaraj et al.   Redox Biology

Human cytomegalovirus protein UL42 antagonizes cGAS/MITA-mediated innate antiviral response

(2019) Yu-Zhi Fu et al.   PLoS Pathogens

DNA sensing by the cGAS–STING pathway in health and disease

(2019) Mona Motwani et al.   NATURE REVIEWS GENETICS

A Review of the Potential Role of Human Cytomegalovirus (HCMV) Infections in Breast Cancer Carcinogenesis and Abnormal Immunity

(2019) Jürgen Geisler et al.   Cancers

Human Cytomegalovirus Protein UL31 Inhibits DNA Sensing of cGAS to Mediate Immune Evasion

(2018) Zhe-Fu Huang et al.   Cell Host & Microbe

The senescent bystander effect is caused by ROS-activated NF-κB signalling

(2018) Glyn Nelson et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Human cytomegalovirus-encoded US9 targets MAVS and STING signaling to evade type I interferon immune responses

(2018) Hyun jin Choi et al.   Nature Communications

New therapies for human cytomegalovirus infections

(2018) William J. Britt et al.   ANTIVIRAL RESEARCH

Persistent repair intermediates induce senescence

(2018) F. M. Feringa et al.   Nature Communications

Impaired immune surveillance accelerates accumulation of senescent cells and aging

(2018) Yossi Ovadya et al.   Nature Communications

Restriction of Human Cytomegalovirus Replication by ISG15, a Host Effector Regulated by cGAS-STING Double-Stranded-DNA Sensing

(2017) Christopher Bianco et al.   JOURNAL OF VIROLOGY

Human Cytomegalovirus Tegument Protein pp65 (pUL83) Dampens Type I Interferon Production by Inactivating the DNA Sensor cGAS without Affecting STING

(2017) Matteo Biolatti et al.   JOURNAL OF VIROLOGY

Cytoplasmic chromatin triggers inflammation in senescence and cancer

(2017) Zhixun Dou et al.   NATURE

Innate immune sensing of cytosolic chromatin fragments through cGAS promotes senescence

(2017) Selene Glück et al.   NATURE CELL BIOLOGY

The control of DNA repair by the cell cycle

(2017) Nicole Hustedt et al.   NATURE CELL BIOLOGY

Census and evaluation of p53 target genes

(2017) M Fischer   ONCOGENE

cGAS is essential for cellular senescence

(2017) Hui Yang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Characterization of the EBV-Induced Persistent DNA Damage Response

(2017) et al.   Viruses-Basel

Essential role of HCMV deubiquitinase in promoting oncogenesis by targeting anti-viral innate immune signaling pathways

(2017) Puja Kumari et al.   Cell Death & Disease

Human Cytomegalovirus IE2 86 kDa Protein Induces STING Degradation and Inhibits cGAMP-Mediated IFN-β Induction

(2017) Jung-Eun Kim et al.   Frontiers in Microbiology

Mitochondria in Cell Senescence: Is Mitophagy the Weakest Link?

(2017) Viktor I. Korolchuk et al.   EBioMedicine

Innate immune signaling and regulation in cancer immunotherapy

(2016) Leticia Corrales et al.   CELL RESEARCH

Suppressive effects of sirtinol on human cytomegalovirus (hCMV) infection and hCMV-induced activation of molecular mechanisms of senescence and production of reactive oxygen species

(2016) Genxiang Mao et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Cytomegalovirus driven immunosenescence—An immune phenotype with or without clinical impact?

(2016) Cecilia Söderberg-Nauclér et al.   MECHANISMS OF AGEING AND DEVELOPMENT

ROS, Cell Senescence, and Novel Molecular Mechanisms in Aging and Age-Related Diseases

(2016) Pierpaola Davalli et al.   Oxidative Medicine and Cellular Longevity

Induction of DNA double-strand breaks and cellular senescence by human respiratory syncytial virus

(2016) Isidoro Martínez et al.   Virulence

cGAS Senses Human Cytomegalovirus and Induces Type I Interferon Responses in Human Monocyte-Derived Cells

(2016) Jennifer Paijo et al.   PLoS Pathogens

Writers, Readers, and Erasers of Histone Ubiquitylation in DNA Double-Strand Break Repair

(2016) Godelieve Smeenk et al.   Frontiers in Genetics

Cell senescence is an antiviral defense mechanism

(2016) Maite Baz-Martínez et al.   Scientific Reports

MacroH2A1 and ATM Play Opposing Roles in Paracrine Senescence and the Senescence-Associated Secretory Phenotype

(2015) Hongshan Chen et al.   MOLECULAR CELL

Gene expression analysis identifies global gene dosage sensitivity in cancer

(2015) Rudolf S N Fehrmann et al.   NATURE GENETICS

Cellular senescence in aging and age-related disease: from mechanisms to therapy

(2015) Bennett G Childs et al.   NATURE MEDICINE

Hydrogen Peroxide Induce Human Cytomegalovirus Replication through the Activation of p38-MAPK Signaling Pathway

(2015) Jun Xiao et al.   Viruses-Basel

DNA damage response (DDR) and senescence: shuttled inflamma-miRNAs on the stage of inflamm-aging

(2015) Fabiola Olivieri et al.   Oncotarget

DNA-Damage-Induced Type I Interferon Promotes Senescence and Inhibits Stem Cell Function

(2015) Qiujing Yu et al.   Cell Reports

Maintenance and Replication of the Human Cytomegalovirus Genome during Latency

(2014) Margaret Tarrant-Elorza et al.   Cell Host & Microbe

Stable Cellular Senescence Is Associated with Persistent DDR Activation

(2014) Marzia Fumagalli et al.   PLoS One

Modulation of Homology-Directed Repair in T98G Glioblastoma Cells Due to Interactions between Wildtype p53, Rad51 and HCMV IE1-72

(2014) Amit Kulkarni et al.   Viruses-Basel

The DNA Damage Response Induced by Infection with Human Cytomegalovirus and Other Viruses

(2014) Xiaofei E et al.   Viruses-Basel

Cell fusion induced by ERVWE1 or measles virus causes cellular senescence

(2013) A. Chuprin et al.   GENES & DEVELOPMENT

RIF1 Counteracts BRCA1-mediated End Resection during DNA Repair

(2013) Lin Feng et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Cell Cycle-Dependent Regulatory Circuit Composed of 53BP1-RIF1 and BRCA1-CtIP Controls DNA Repair Pathway Choice

(2013) Cristina Escribano-Díaz et al.   MOLECULAR CELL

A key role for mitochondrial gatekeeper pyruvate dehydrogenase in oncogene-induced senescence

(2013) Joanna Kaplon et al.   NATURE

Human Cytomegalovirus Gene UL76 Induces IL-8 Expression through Activation of the DNA Damage Response

(2013) Helena Costa et al.   PLoS Pathogens

Cyclic GMP-AMP Synthase Is a Cytosolic DNA Sensor That Activates the Type I Interferon Pathway

(2012) L. Sun et al.   SCIENCE

HCMV-Infected Cells Maintain Efficient Nucleotide Excision Repair of the Viral Genome while Abrogating Repair of the Host Genome

(2012) John M. O'Dowd et al.   PLoS Pathogens

The immunoregulatory effects of CMV-infection in human fibroblasts and the impact on cellular senescence

(2012) Juliane Wolf et al.   Immunity & Ageing

Double-Strand Break End Resection and Repair Pathway Choice

(2011) Lorraine S. Symington et al.   Annual Review of Genetics

Senescent cells develop a PARP-1 and nuclear factor- B-associated secretome (PNAS)

(2011) M. Ohanna et al.   GENES & DEVELOPMENT

Enterovirus 71 induces integrin β1/EGFR-Rac1-dependent oxidative stress in SK-N-SH cells: Role of HO-1/CO in viral replication

(2011) Wei-Hsuan Tung et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Gain and Loss of T Cell Subsets in Old Age—Age-Related Reshaping of the T Cell Repertoire

(2011) Christoph R. Arnold et al.   JOURNAL OF CLINICAL IMMUNOLOGY

Stimulation of Homology-Directed Repair at I-SceI-Induced DNA Breaks during the Permissive Life Cycle of Human Cytomegalovirus

(2011) A. S. Kulkarni et al.   JOURNAL OF VIROLOGY

Adenovirus Type 5 Rupture of Lysosomes Leads to Cathepsin B-Dependent Mitochondrial Stress and Production of Reactive Oxygen Species

(2011) K. A. McGuire et al.   JOURNAL OF VIROLOGY

Human Cytomegalovirus Induces Multiple Means To Combat Reactive Oxygen Species

(2011) C. Tilton et al.   JOURNAL OF VIROLOGY

Human cytomegalovirus infection increases mitochondrial biogenesis

(2011) Mari Kaarbø et al.   MITOCHONDRION

An E2F1-Mediated DNA Damage Response Contributes to the Replication of Human Cytomegalovirus

(2011) Xiaofei E et al.   PLoS Pathogens

Nuclear initiated NF-κB signaling: NEMO and ATM take center stage

(2010) Shigeki Miyamoto   CELL RESEARCH

The ubiquitous role of ubiquitin in the DNA damage response

(2010) Abdallah Al-Hakim et al.   DNA REPAIR

Multiple DNA Damage Signaling and Repair Pathways Deregulated by Simian Virus 40 Large T Antigen

(2010) S. Boichuk et al.   JOURNAL OF VIROLOGY

Is HCMV a tumor promoter?

(2010) Liliana Soroceanu et al.   VIRUS RESEARCH

Senescence: an antiviral defense that is tumor suppressive?

(2009) R. R. Reddel   CARCINOGENESIS

The Presence of p53 Influences the Expression of Multiple Human Cytomegalovirus Genes at Early Times Postinfection

(2009) H. Hannemann et al.   JOURNAL OF VIROLOGY

Human Cytomegalovirus IE1-72 Protein Interacts with p53 and Inhibits p53-Dependent Transactivation by a Mechanism Different from That of IE2-86 Protein

(2009) E.-S. Hwang et al.   JOURNAL OF VIROLOGY

Homologous Recombinational Repair Factors Are Recruited and Loaded onto the Viral DNA Genome in Epstein-Barr Virus Replication Compartments

(2009) A. Kudoh et al.   JOURNAL OF VIROLOGY

STING regulates intracellular DNA-mediated, type I interferon-dependent innate immunity

(2009) Hiroki Ishikawa et al.   NATURE

Persistent DNA damage signalling triggers senescence-associated inflammatory cytokine secretion

(2009) Francis Rodier et al.   NATURE CELL BIOLOGY

Oncogene-Induced Senescence Relayed by an Interleukin-Dependent Inflammatory Network

(2008) Thomas Kuilman et al.   CELL

Chemokine Signaling via the CXCR2 Receptor Reinforces Senescence

(2008) Juan C. Acosta et al.   CELL

ATR signaling can drive cells into senescence in the absence of DNA breaks

(2008) L. I. Toledo et al.   GENES & DEVELOPMENT

Human Cytomegalovirus UL97 Kinase Activity Is Required for the Hyperphosphorylation of Retinoblastoma Protein and Inhibits the Formation of Nuclear Aggresomes

(2008) M. N. Prichard et al.   JOURNAL OF VIROLOGY

Colocalization of Sensors Is Sufficient to Activate the DNA Damage Checkpoint in the Absence of Damage

(2008) Carla Yaneth Bonilla et al.   MOLECULAR CELL

Phosphorylation of Retinoblastoma Protein by Viral Protein with Cyclin-Dependent Kinase Function

(2008) A. J. Hume et al.   SCIENCE

An Oncogene-Induced DNA Damage Model for Cancer Development

(2008) T. D. Halazonetis et al.   SCIENCE

Apoptosis: controlled demolition at the cellular level

(2007) Rebecca C. Taylor et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY