Census and evaluation of p53 target genes

Expanding the p53 regulatory network: LncRNAs take up the challenge

(2016) Elena Grossi et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

p21 governs p53's repressive side

(2016) Martin Fischer   CELL CYCLE

p53 directly regulates the glycosidase FUCA1 to promote chemotherapy-induced cell death

(2016) Alice D. Baudot et al.   CELL CYCLE

Multiplex enhancer-reporter assays uncover unsophisticated TP53 enhancer logic

(2016) Annelien Verfaillie et al.   GENOME RESEARCH

CerS6Is a Novel Transcriptional Target of p53 Protein Activated by Non-genotoxic Stress

(2016) Baharan Fekry et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Integration of TP53, DREAM, MMB-FOXM1 and RB-E2F target gene analyses identifies cell cycle gene regulatory networks

(2016) Martin Fischer et al.   NUCLEIC ACIDS RESEARCH

TRIMming p53’s anticancer activity

(2016) S Elabd et al.   ONCOGENE

p53 downregulates the Fanconi anaemia DNA repair pathway

(2016) Sara Jaber et al.   Nature Communications

IER5 generates a novel hypo-phosphorylated active form of HSF1 and contributes to tumorigenesis

(2016) Yoshinori Asano et al.   Scientific Reports

Whole-genome cartography of p53 response elements ranked on transactivation potential

(2015) Toma Tebaldi et al.   BMC GENOMICS

ChIP bias as a function of cross-linking time

(2015) Laura Baranello et al.   CHROMOSOME RESEARCH

Ferroptosis as a p53-mediated activity during tumour suppression

(2015) Le Jiang et al.   NATURE

p53 in survival, death and metabolic health: a lifeguard with a licence to kill

(2015) Flore Kruiswijk et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Integrative genomic analysis reveals widespread enhancer regulation by p53 in response to DNA damage

(2015) Scott T. Younger et al.   NUCLEIC ACIDS RESEARCH

The p53-p21-DREAM-CDE/CHR pathway regulates G2/M cell cycle genes

(2015) Martin Fischer et al.   NUCLEIC ACIDS RESEARCH

p53 regulates the mevalonate pathway in human glioblastoma multiforme

(2015) C Laezza et al.   Cell Death & Disease

Genome-wide profiling of p53-regulated enhancer RNAs uncovers a subset of enhancers controlled by a lncRNA

(2015) Nicolas Léveillé et al.   Nature Communications

Gene amplification during differentiation of mammalian neural stem cells in vitro and in vivo

(2015) Ulrike Fischer et al.   Oncotarget

p53 attenuates AKT signaling by modulating membrane phospholipid composition

(2015) Natalia Rueda-Rincon et al.   Oncotarget

Tumor suppressor p53 negatively regulates glycolysis stimulated by hypoxia through its target RRAD

(2015) Cen Zhang et al.   Oncotarget

p53-Dependent Nestin Regulation Links Tumor Suppression to Cellular Plasticity in Liver Cancer

(2014) Darjus F. Tschaharganeh et al.   CELL

The transcription factor p53: Not a repressor, solely an activator

(2014) Martin Fischer et al.   CELL CYCLE

Integrated high-throughput analysis identifies Sp1 as a crucial determinant of p53-mediated apoptosis

(2014) H Li et al.   CELL DEATH AND DIFFERENTIATION

DRAGO (KIAA0247), a New DNA Damage–Responsive, p53-Inducible Gene That Cooperates With p53 as Oncosuppressor

(2014) Federica Polato et al.   JNCI-Journal of the National Cancer Institute

LincRNA-p21 Activates p21 In cis to Promote Polycomb Target Gene Expression and to Enforce the G1/S Checkpoint

(2014) Nadya Dimitrova et al.   MOLECULAR CELL

Discovery and saturation analysis of cancer genes across 21 tumour types

(2014) Michael S. Lawrence et al.   NATURE

Genome-wide characterization reveals complex interplay between TP53 and TP63 in response to genotoxic stress

(2014) S. S. McDade et al.   NUCLEIC ACIDS RESEARCH

Parallel Profiling of the Transcriptome, Cistrome, and Epigenome in the Cellular Response to Ionizing Radiation

(2014) S. Rashi-Elkeles et al.   Science Signaling

P53-regulated long non-coding RNA TUG1 affects cell proliferation in human non-small cell lung cancer, partly through epigenetically regulating HOXB7 expression

(2014) E-b Zhang et al.   Cell Death & Disease

A Comprehensive and High-Resolution Genome-wide Response of p53 to Stress

(2014) Gue Su Chang et al.   Cell Reports

iRegulon: From a Gene List to a Gene Regulatory Network Using Large Motif and Track Collections

(2014) Rekin's Janky et al.   PLoS Computational Biology

Global analysis of p53-regulated transcription identifies its direct targets and unexpected regulatory mechanisms

(2014) Mary Ann Allen et al.   eLife

A Polymorphic p53 Response Element in KIT Ligand Influences Cancer Risk and Has Undergone Natural Selection

(2013) Jorge Zeron-Medina et al.   CELL

H3K4me3 Interactions with TAF3 Regulate Preinitiation Complex Assembly and Selective Gene Activation

(2013) Shannon M. Lauberth et al.   CELL

Rap2b, a novel p53 target, regulates p53-mediated pro-survival function

(2013) Xinyue Zhang et al.   CELL CYCLE

p53-dependent regulation of metabolic function through transcriptional activation of pantothenate kinase-1 gene

(2013) Shang-Jui Wang et al.   CELL CYCLE

Type 2 cGMP-dependent protein kinase regulates homeostasis by blocking c-Jun N-terminal kinase in the colon epithelium

(2013) R Wang et al.   CELL DEATH AND DIFFERENTIATION

Depletion of the novel p53-target gene carnitine palmitoyltransferase 1C delays tumor growth in the neurofibromatosis type I tumor model

(2013) N Sanchez-Macedo et al.   CELL DEATH AND DIFFERENTIATION

p53 Suppresses E2F1-dependent PLK1 expression upon DNA damage by forming p53–E2F1–DNA complex

(2013) Zhe Zhou et al.   EXPERIMENTAL CELL RESEARCH

Global genomic profiling reveals an extensive p53-regulated autophagy program contributing to key p53 responses

(2013) D. Kenzelmann Broz et al.   GENES & DEVELOPMENT

Local Depletion of DNA Methylation Identifies a Repressive p53 Regulatory Region in theNEK2Promoter

(2013) Nancy H. Nabilsi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Reciprocal regulation of p53 and malic enzymes modulates metabolism and senescence

(2013) Peng Jiang et al.   NATURE

Polo-like kinase 4 transcription is activated via CRE and NRF1 elements, repressed by DREAM through CDE/CHR sites and deregulated by HPV E7 protein

(2013) Martin Fischer et al.   NUCLEIC ACIDS RESEARCH

Diverse stresses dramatically alter genome-wide p53 binding and transactivation landscape in human cancer cells

(2013) Daniel Menendez et al.   NUCLEIC ACIDS RESEARCH

p53-dependent gene repression through p21 is mediated by recruitment of E2F4 repression complexes

(2013) E K Benson et al.   ONCOGENE

p53 and Cell Cycle Dependent Transcription of kinesin family member 23 (KIF23) Is Controlled Via a CHR Promoter Element Bound by DREAM and MMB Complexes

(2013) Martin Fischer et al.   PLoS One

CD44 Expression in Intestinal Epithelium and Colorectal Cancer Is Independent of p53 Status

(2013) Jurrit Zeilstra et al.   PLoS One

CSF1 Is a Novel p53 Target Gene Whose Protein Product Functions in a Feed-Forward Manner to Suppress Apoptosis and Enhance p53-Mediated Growth Arrest

(2013) Gregory Azzam et al.   PLoS One

Measuring Chromatin Interaction Dynamics on the Second Time Scale at Single-Copy Genes

(2013) K. Poorey et al.   SCIENCE

Characterization of the p53 Cistrome – DNA Binding Cooperativity Dissects p53's Tumor Suppressor Functions

(2013) Katharina Schlereth et al.   PLoS Genetics

p53 induces transcriptional and translational programs to suppress cell proliferation and growth

(2013) Fabricio Loayza-Puch et al.   GENOME BIOLOGY

Pint lincRNA connects the p53 pathway with epigenetic silencing by the Polycomb repressive complex 2

(2013) Oskar Marín-Béjar et al.   GENOME BIOLOGY

p53 can repress transcription of cell cycle genes through a p21WAF1/CIP1-dependent switch from MMB to DREAM protein complex binding at CHR promoter elements

(2012) Marianne Quaas et al.   CELL CYCLE

Insights into p53 transcriptional function via genome-wide chromatin occupancy and gene expression analysis

(2012) F Nikulenkov et al.   CELL DEATH AND DIFFERENTIATION

E2F7, a novel target, is up-regulated by p53 and mediates DNA damage-dependent transcriptional repression

(2012) L. A. Carvajal et al.   GENES & DEVELOPMENT

Importin 7 and Exportin 1 Link c-Myc and p53 to Regulation of Ribosomal Biogenesis

(2012) Lior Golomb et al.   MOLECULAR CELL

Distinct Regulatory Mechanisms and Functions for p53-Activated and p53-Repressed DNA Damage Response Genes in Embryonic Stem Cells

(2012) Mangmang Li et al.   MOLECULAR CELL

eRNAs Are Required for p53-Dependent Enhancer Activity and Gene Transcription

(2012) Carlos A. Melo et al.   MOLECULAR CELL

Genome-wide protein–DNA binding dynamics suggest a molecular clutch for transcription factor function

(2012) Colin R. Lickwar et al.   NATURE

p53 Dimers Associate with a Head-to-Tail Response Element to Repress Cyclin B Transcription

(2012) Robert Lipski et al.   PLoS One

p53 Dynamics Control Cell Fate

(2012) J. E. Purvis et al.   SCIENCE

Intact p53-Dependent Responses in miR-34–Deficient Mice

(2012) Carla P. Concepcion et al.   PLoS Genetics

Mad2 Is a Critical Mediator of the Chromosome Instability Observed upon Rb and p53 Pathway Inhibition

(2011) Juan-Manuel Schvartzman et al.   CANCER CELL

Distinct p53 Transcriptional Programs Dictate Acute DNA-Damage Responses and Tumor Suppression

(2011) Colleen A. Brady et al.   CELL

The p53 response element and transcriptional repression

(2011) Bei Wang et al.   CELL CYCLE

Upregulation of human autophagy-initiation kinase ULK1 by tumor suppressor p53 contributes to DNA-damage-induced cell death

(2011) W Gao et al.   CELL DEATH AND DIFFERENTIATION

p53 directly suppresses BNIP3 expression to protect against hypoxia-induced cell death

(2011) Xi Feng et al.   EMBO JOURNAL

Activation of v-Myb avian myeloblastosis viral oncogene homolog-like2 (MYBL2)-LIN9 complex contributes to human hepatocarcinogenesis and identifies a subset of hepatocellular carcinoma with mutant p53

(2011) Diego F. Calvisi et al.   HEPATOLOGY

One Function—Multiple Mechanisms: The Manifold Activities of p53 as a Transcriptional Repressor

(2011) Levin Böhlig et al.   JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY

p53, a novel regulator of lipid metabolism pathways

(2011) Ido Goldstein et al.   JOURNAL OF HEPATOLOGY

SPATA18, a Spermatogenesis-Associated Gene, Is a Novel Transcriptional Target of p53 and p63

(2011) C. Bornstein et al.   MOLECULAR AND CELLULAR BIOLOGY

ROS-Mediated p53 Induction of Lpin1 Regulates Fatty Acid Oxidation in Response to Nutritional Stress

(2011) Wissam Assaily et al.   MOLECULAR CELL

Transcriptional modulation induced by ionizing radiation: p53 remains a central player

(2011) Sharon Rashi-Elkeles et al.   Molecular Oncology

Extensive and coordinated transcription of noncoding RNAs within cell-cycle promoters

(2011) Tiffany Hung et al.   NATURE GENETICS

Reciprocal repression between P53 and TCTP

(2011) Robert Amson et al.   NATURE MEDICINE

E2F7 represses a network of oscillating cell cycle genes to control S-phase progression

(2011) Bart Westendorp et al.   NUCLEIC ACIDS RESEARCH

Cdc25B is negatively regulated by p53 through Sp1 and NF-Y transcription factors

(2011) M Dalvai et al.   ONCOGENE

Role of p53 Serine 46 in p53 Target Gene Regulation

(2011) Leonie Smeenk et al.   PLoS One

Tumor Suppressor Protein p53 Recruits Human Sin3B/HDAC1 Complex for Down-Regulation of Its Target Promoters in Response to Genotoxic Stress

(2011) Nidhi Bansal et al.   PLoS One

Parkin, a p53 target gene, mediates the role of p53 in glucose metabolism and the Warburg effect

(2011) C. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

p53 Directly Represses Id2 to Inhibit the Proliferation of Neural Progenitor Cells

(2011) Brenton R. Paolella et al.   STEM CELLS

To repress or not to repress: This is the guardian's question

(2011) John L. Rinn et al.   TRENDS IN CELL BIOLOGY

The Toll-Like Receptor Gene Family Is Integrated into Human DNA Damage and p53 Networks

(2011) Daniel Menendez et al.   PLoS Genetics

A Large Intergenic Noncoding RNA Induced by p53 Mediates Global Gene Repression in the p53 Response

(2010) Maite Huarte et al.   CELL

p53-dependent repression of polo-like kinase-1 (PLK1)

(2010) Lynsey McKenzie et al.   CELL CYCLE

DNA Binding Cooperativity of p53 Modulates the Decision between Cell-Cycle Arrest and Apoptosis

(2010) Katharina Schlereth et al.   MOLECULAR CELL

p53 activates the PANK1/ miRNA-107 gene leading to downregulation of CDK6 and p130 cell cycle proteins

(2010) Levin Böhlig et al.   NUCLEIC ACIDS RESEARCH

Phosphate-activated glutaminase (GLS2), a p53-inducible regulator of glutamine metabolism and reactive oxygen species

(2010) S. Suzuki et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Glutaminase 2, a novel p53 target gene regulating energy metabolism and antioxidant function

(2010) W. Hu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Transcriptional Regulation by P53

(2010) R. Beckerman et al.   Cold Spring Harbor Perspectives in Biology

Active transcription of the human FAS/CD95/TNFRSF6 gene involves the p53 family

(2009) Tobias Schilling et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The G Protein-Coupled Receptor 87 Is Necessary for p53-Dependent Cell Survival in Response to Genotoxic Stress

(2009) Y. Zhang et al.   CANCER RESEARCH

Transcriptional Regulation of Estrogen Receptor-  by p53 in Human Breast Cancer Cells

(2009) S. H. Shirley et al.   CANCER RESEARCH

Regulation of Protein Citrullination through p53/PADI4 Network in DNA Damage Response

(2009) C. Tanikawa et al.   CANCER RESEARCH

Identification of SULF2 as a Novel Transcriptional Target of p53 by Use of Integrated Genomic Analyses

(2009) B. Nelson Chau et al.   CANCER RESEARCH

B-MYB Is Required for Recovery from the DNA Damage-Induced G2 Checkpoint in p53 Mutant Cells

(2009) M. Mannefeld et al.   CANCER RESEARCH

Blinded by the Light: The Growing Complexity of p53

(2009) Karen H. Vousden et al.   CELL

PH Domain-Only Protein PHLDA3 Is a p53-Regulated Repressor of Akt

(2009) Tatsuya Kawase et al.   CELL

Wip1 confers G2 checkpoint recovery competence by counteracting p53-dependent transcriptional repression

(2009) Arne Lindqvist et al.   EMBO JOURNAL

Regulation of the p53 transcriptional response by structurally diverse core promoters

(2009) J. M. Morachis et al.   GENES & DEVELOPMENT

Division and apoptosis of E2f-deficient retinal progenitors

(2009) Danian Chen et al.   NATURE

DNA damage induced p53 downregulates Cdc20 by direct binding to its promoter causing chromatin remodeling

(2009) Taraswi Banerjee et al.   NUCLEIC ACIDS RESEARCH

XEDAR as a putative colorectal tumor suppressor that mediates p53-regulated anoikis pathway

(2009) C Tanikawa et al.   ONCOGENE

DNA methylation inhibits p53-mediated survivin repression

(2009) N H Nabilsi et al.   ONCOGENE

Redefining the p53 response element

(2009) B. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Many human large intergenic noncoding RNAs associate with chromatin-modifying complexes and affect gene expression

(2009) Ahmad M. Khalil et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

p53 induces distinct epigenetic states at its direct target promoters

(2008) Lukas Vrba et al.   BMC GENOMICS

Growth-Inhibitory and Tumor- Suppressive Functions of p53 Depend on Its Repression of CD44 Expression

(2008) Samuel Godar et al.   CELL

p53 Target Genes Sestrin1 and Sestrin2 Connect Genotoxic Stress and mTOR Signaling

(2008) Andrei V. Budanov et al.   CELL

LIM and SH3 protein 1 (Lasp1) is a novel p53 transcriptional target involved in hepatocellular carcinoma

(2008) Bei Wang et al.   JOURNAL OF HEPATOLOGY

p53 Regulates Toll-Like Receptor 3 Expression and Function in Human Epithelial Cell Lines

(2008) M. Taura et al.   MOLECULAR AND CELLULAR BIOLOGY

Recurrent Initiation: A Mechanism for Triggering p53 Pulses in Response to DNA Damage

(2008) Eric Batchelor et al.   MOLECULAR CELL

p53 regulates glucose metabolism through an IKK-NF-κB pathway and inhibits cell transformation

(2008) Keiko Kawauchi et al.   NATURE CELL BIOLOGY

Regulation of autophagy by cytoplasmic p53

(2008) Ezgi Tasdemir et al.   NATURE CELL BIOLOGY

Transcriptional control of human p53-regulated genes

(2008) Todd Riley et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Induction of PPM1D following DNA-damaging treatments through a conserved p53 response element coincides with a shift in the use of transcription initiation sites

(2008) Matteo Rossi et al.   NUCLEIC ACIDS RESEARCH

p53 target gene AEN is a nuclear exonuclease required for p53-dependent apoptosis

(2008) T Kawase et al.   ONCOGENE

New p53 target, phosphatase of regenerating liver 1 (PRL-1) downregulates p53

(2008) S-H Min et al.   ONCOGENE

De novo N-palmitoylsphingosine synthesis is the major biochemical mechanism of ceramide accumulation following p53 up-regulation

(2008) Shoghag Panjarian et al.   PROSTAGLANDINS & OTHER LIPID MEDIATORS

Noncanonical DNA Motifs as Transactivation Targets by Wild Type and Mutant p53

(2008) Jennifer J. Jordan et al.   PLoS Genetics