Leveraging human immune organoids for rational vaccine design

Profiling Germinal Center-like B Cell Responses to Conjugate Vaccines Using Synthetic Immune Organoids

(2023) Tyler D. Moeller et al.   ACS Central Science

Influenza vaccine format mediates distinct cellular and antibody responses in human immune organoids

(2023) Jenna M. Kastenschmidt et al.   Immunity

Human anti-N1 monoclonal antibodies elicited by pandemic H1N1 virus infection broadly inhibit HxN1 viruses in vitro and in vivo

(2023) Lena Hansen et al.   Immunity

Novel Epitopes of the Influenza Virus N1 Neuraminidase Targeted by Human Monoclonal Antibodies

(2022) Ericka Kirkpatrick Roubidoux et al.   JOURNAL OF VIROLOGY

Pan-vaccine analysis reveals innate immune endotypes predictive of antibody responses to vaccination

(2022) Slim Fourati et al.   NATURE IMMUNOLOGY

Transcriptional atlas of the human immune response to 13 vaccines reveals a common predictor of vaccine-induced antibody responses

(2022) Thomas Hagan et al.   NATURE IMMUNOLOGY

Distinct immunological and molecular signatures underpinning influenza vaccine responsiveness in the elderly

(2022) Peggy Riese et al.   Nature Communications

Antibodies targeting the neuraminidase active site inhibit influenza H3N2 viruses with an S245N glycosylation site

(2022) Daniel Stadlbauer et al.   Nature Communications

Modeling human adaptive immune responses with tonsil organoids

(2021) Lisa E. Wagar et al.   NATURE MEDICINE

Modeling Immunity In Vitro: Slices, Chips, and Engineered Tissues

(2021) Jennifer H. Hammel et al.   Annual Review of Biomedical Engineering

Tissues, not blood, are where immune cells function

(2021) Donna L. Farber   NATURE

Broadly neutralizing antibodies target a haemagglutinin anchor epitope

(2021) Jenna J. Guthmiller et al.   NATURE

A Novel Recombinant Influenza Virus Neuraminidase Vaccine Candidate Stabilized by a Measles Virus Phosphoprotein Tetramerization Domain Provides Robust Protection from Virus Challenge in the Mouse Model

(2021) Shirin Strohmeier et al.   mBio

Human germinal centres engage memory and naive B cells after influenza vaccination

(2020) Jackson S. Turner et al.   NATURE

A chimeric hemagglutinin-based universal influenza virus vaccine approach induces broad and long-lasting immunity in a randomized, placebo-controlled phase I trial

(2020) Raffael Nachbagauer et al.   NATURE MEDICINE

Circulating T FH cells, serological memory, and tissue compartmentalization shape human influenza-specific B cell immunity

(2018) Marios Koutsakos et al.   Science Translational Medicine

Immune responses after live attenuated influenza vaccination

(2018) Kristin G.-I. Mohn et al.   Human Vaccines & Immunotherapeutics

CCR6 Defines Memory B Cell Precursors in Mouse and Human Germinal Centers, Revealing Light-Zone Location and Predominant Low Antigen Affinity

(2017) Dan Suan et al.   IMMUNITY

EZH2 enables germinal centre formation through epigenetic silencing of CDKN1A and an Rb-E2F1 feedback loop

(2017) Wendy Béguelin et al.   Nature Communications

Live Attenuated Influenza Vaccine in Children Induces B-Cell Responses in Tonsils

(2016) Kristin Greve-Isdahl Mohn et al.   JOURNAL OF INFECTIOUS DISEASES

IL-17RA Is Essential for Optimal Localization of Follicular Th Cells in the Germinal Center Light Zone To Promote Autoantibody-Producing B Cells

(2013) Y. Ding et al.   JOURNAL OF IMMUNOLOGY

Induction of ICOS+CXCR3+CXCR5+ TH Cells Correlates with Antibody Responses to Influenza Vaccination

(2013) S.-E. Bentebibel et al.   Science Translational Medicine

The Transcriptional Repressor Bcl-6 Directs T Follicular Helper Cell Lineage Commitment

(2009) Di Yu et al.   IMMUNITY

Comparative Efficacy of Inactivated and Live Attenuated Influenza Vaccines

(2009) Arnold S. Monto et al.   NEW ENGLAND JOURNAL OF MEDICINE

Bcl6 and Blimp-1 Are Reciprocal and Antagonistic Regulators of T Follicular Helper Cell Differentiation

(2009) R. J. Johnston et al.   SCIENCE

Bcl6 Mediates the Development of T Follicular Helper Cells

(2009) R. I. Nurieva et al.   SCIENCE