Profiling Germinal Center-like B Cell Responses to Conjugate Vaccines Using Synthetic Immune Organoids

Engineering early memory B‐cell‐like phenotype in hydrogel‐based immune organoids

(2022) Pamela L. Graney et al.   JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A

Modeling human adaptive immune responses with tonsil organoids

(2021) Lisa E. Wagar et al.   NATURE MEDICINE

On-demand biomanufacturing of protective conjugate vaccines

(2021) Jessica C. Stark et al.   Science Advances

Shotgun scanning glycomutagenesis: A simple and efficient strategy for constructing and characterizing neoglycoproteins

(2021) Mingji Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Total Synthesis of Polysaccharides by Automated Glycan Assembly

(2020) A. Abragam Joseph et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Organoid Polymer Functionality and Mode of Klebsiella pneumoniae Membrane Antigen Presentation Regulates Ex Vivo Germinal Center Epigenetics in Young and Aged B Cells

(2020) Pamela L. Graney et al.   ADVANCED FUNCTIONAL MATERIALS

Improving protein glycan coupling technology (PGCT) for glycoconjugate vaccine production

(2020) Jennifer Mhairi Dow et al.   Expert Review of Vaccines

Synthetic Glycobiology: Parts, Systems, and Applications

(2020) Weston Kightlinger et al.   ACS Synthetic Biology

Cell-Free Synthetic Glycobiology: Designing and Engineering Glycomolecules Outside of Living Cells

(2020) Thapakorn Jaroentomeechai et al.   Frontiers in Chemistry

Glycoconjugate vaccine using a genetically modified O antigen induces protective antibodies to Francisella tularensis

(2019) Giuseppe Stefanetti et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

B Cell Responses: Cell Interaction Dynamics and Decisions

(2019) Jason G. Cyster et al.   CELL

Multiscale engineering of immune cells and lymphoid organs

(2019) Sungwoong Kim et al.   Nature Reviews Materials

Recent advances in the production of recombinant glycoconjugate vaccines

(2019) Emily Kay et al.   npj Vaccines

B cell signaling in context

(2019) Kihyuck Kwak et al.   NATURE IMMUNOLOGY

Ex vivo synthetic immune tissues with T cell signals for differentiating antigen-specific, high affinity germinal center B cells

(2018) Alberto Purwada et al.   BIOMATERIALS

Single-pot glycoprotein biosynthesis using a cell-free transcription-translation system enriched with glycosylation machinery

(2018) Thapakorn Jaroentomeechai et al.   Nature Communications

Glycoconjugate vaccines: Principles and mechanisms

(2018) Rino Rappuoli   Science Translational Medicine

On the mechanisms of conjugate vaccines

(2018) Rino Rappuoli et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An O-Antigen Glycoconjugate Vaccine Produced Using Protein Glycan Coupling Technology Is Protective in an Inhalational Rat Model of Tularemia

(2018) Laura E. Marshall et al.   Journal of Immunology Research

EZH2 enables germinal centre formation through epigenetic silencing of CDKN1A and an Rb-E2F1 feedback loop

(2017) Wendy Béguelin et al.   Nature Communications

Therapeutic Antibodies to Ganglioside GD2 Evolved from Highly Selective Germline Antibodies

(2017) Eric Sterner et al.   Cell Reports

Modular Immune Organoids with Integrin Ligand Specificity Differentially Regulate Ex Vivo B Cell Activation

(2017) Alberto Purwada et al.   ACS Biomaterials-Science & Engineering

Modular Immune Organoids with Integrin Ligand Specificity Differentially Regulate Ex Vivo B Cell Activation

(2017) Alberto Purwada et al.   ACS Biomaterials Science & Engineering

Germinal Center B Cell Dynamics

(2016) Luka Mesin et al.   IMMUNITY

Immuno-engineered organoids for regulating the kinetics of B-cell development and antibody production

(2016) Alberto Purwada et al.   Nature Protocols

Outer membrane vesicles displaying engineered glycotopes elicit protective antibodies

(2016) Linxiao Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ex vivo engineered immune organoids for controlled germinal center reactions

(2015) Alberto Purwada et al.   BIOMATERIALS

Escherichia coli Maltose-Binding Protein Induces M1 Polarity of RAW264.7 Macrophage Cells via a TLR2- and TLR4-Dependent Manner

(2015) Wan Wang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

MiXCR: software for comprehensive adaptive immunity profiling

(2015) Dmitriy A Bolotin et al.   NATURE METHODS

Principles and application of antibody libraries for infectious diseases

(2014) Bee Nar Lim et al.   BIOTECHNOLOGY LETTERS

Transcription Factor IRF4 Regulates Germinal Center Cell Formation through a B Cell-Intrinsic Mechanism

(2014) S. N. Willis et al.   JOURNAL OF IMMUNOLOGY

Glycoconjugate Vaccine Containing Escherichia coli O157:H7 O-Antigen Linked with Maltose-Binding Protein Elicits Humoral and Cellular Responses

(2014) Zhongrui Ma et al.   PLoS One

EZH2 Is Required for Germinal Center Formation and Somatic EZH2 Mutations Promote Lymphoid Transformation

(2013) Wendy Béguelin et al.   CANCER CELL

Transcriptional Regulation of Germinal Center B and Plasma Cell Fates by Dynamical Control of IRF4

(2013) Kyoko Ochiai et al.   IMMUNITY

In Vivo Neutralization of α-Cobratoxin with High-Affinity Llama Single-Domain Antibodies (VHHs) and a VHH-Fc Antibody

(2013) Gabrielle Richard et al.   PLoS One

Exploitation of bacterial N-linked glycosylation to develop a novel recombinant glycoconjugate vaccine against Francisella tularensis

(2013) J. Cuccui et al.   Open Biology

Germinal Centers

(2012) Gabriel D. Victora et al.   Annual Review of Immunology

STAR: ultrafast universal RNA-seq aligner

(2012) Alexander Dobin et al.   BIOINFORMATICS

In-vitro derived germinal centre B cells differentially generate memory B or plasma cells in vivo

(2011) Takuya Nojima et al.   Nature Communications

Production of Secretory and Extracellular N-Linked Glycoproteins inEscherichia coli

(2010) Adam C. Fisher et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Monoclonal antibodies isolated without screening by analyzing the variable-gene repertoire of plasma cells

(2010) Sai T Reddy et al.   NATURE BIOTECHNOLOGY

Carbohydrate vaccines: developing sweet solutions to sticky situations?

(2010) Rena D. Astronomo et al.   NATURE REVIEWS DRUG DISCOVERY

An improved yeast transformation method for the generation of very large human antibody libraries

(2010) Lorenzo Benatuil et al.   PROTEIN ENGINEERING DESIGN & SELECTION

How Bacterial Carbohydrates Influence the Adaptive Immune System

(2009) Fikri Y. Avci et al.   Annual Review of Immunology

VarScan: variant detection in massively parallel sequencing of individual and pooled samples

(2009) Daniel C. Koboldt et al.   BIOINFORMATICS