Influenza vaccine format mediates distinct cellular and antibody responses in human immune organoids

An inactivated multivalent influenza A virus vaccine is broadly protective in mice and ferrets

(2022) Jaekeun Park et al.   Science Translational Medicine

Modeling human adaptive immune responses with tonsil organoids

(2021) Lisa E. Wagar et al.   NATURE MEDICINE

Single-cell analysis of human B cell maturation predicts how antibody class switching shapes selection dynamics

(2021) Hamish W. King et al.   Science Immunology

Integrated analysis of multimodal single-cell data

(2021) Yuhan Hao et al.   CELL

Intranasal vaccination with a recombinant protein CTA1-DD-RBF protects mice against hRSV infection

(2021) Hai Li et al.   Scientific Reports

Broadly neutralizing antibodies target a haemagglutinin anchor epitope

(2021) Jenna J. Guthmiller et al.   NATURE

Intranasal priming induces local lung-resident B cell populations that secrete protective mucosal antiviral IgA

(2021) Ji Eun Oh et al.   Science Immunology

An analysis of abnormalities in the B cell receptor repertoire in patients with systemic sclerosis using high-throughput sequencing

(2020) Xiaodong Shi et al.   PeerJ

Heterologous viral protein interactions within licensed seasonal influenza virus vaccines

(2020) Marina Koroleva et al.   npj Vaccines

Human germinal centres engage memory and naive B cells after influenza vaccination

(2020) Jackson S. Turner et al.   NATURE

Pre‐existing influenza‐specific nasal IgA or nasal viral infection does not affect live attenuated influenza vaccine immunogenicity in children

(2020) M. E. Cole et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

A chimeric hemagglutinin-based universal influenza virus vaccine approach induces broad and long-lasting immunity in a randomized, placebo-controlled phase I trial

(2020) Raffael Nachbagauer et al.   NATURE MEDICINE

Preexisting immunity shapes distinct antibody landscapes after influenza virus infection and vaccination in humans

(2020) Haley L. Dugan et al.   Science Translational Medicine

The adjuvant GLA-SE promotes human Tfh cell expansion and emergence of public TCRβ clonotypes

(2019) Danika L. Hill et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Tfh cell response in influenza vaccines in humans: what is visible and what is invisible

(2019) Hideki Ueno   CURRENT OPINION IN IMMUNOLOGY

Fast, sensitive and accurate integration of single-cell data with Harmony

(2019) Ilya Korsunsky et al.   NATURE METHODS

A spectral clustering-based method for identifying clones from high-throughput B cell repertoire sequencing data

(2018) Nima Nouri et al.   BIOINFORMATICS

Influenza Infection in Humans Induces Broadly Cross-Reactive and Protective Neuraminidase-Reactive Antibodies

(2018) Yao-Qing Chen et al.   CELL

A Universal Influenza Vaccine: The Strategic Plan for the National Institute of Allergy and Infectious Diseases

(2018) Emily J Erbelding et al.   JOURNAL OF INFECTIOUS DISEASES

Circulating T FH cells, serological memory, and tissue compartmentalization shape human influenza-specific B cell immunity

(2018) Marios Koutsakos et al.   Science Translational Medicine

NAction! How Can Neuraminidase-Based Immunity Contribute to Better Influenza Virus Vaccines?

(2018) Florian Krammer et al.   mBio

Protein Microarray Analysis of the Specificity and Cross-Reactivity of Influenza Virus Hemagglutinin-Specific Antibodies

(2018) Rie Nakajima et al.   mSphere

CCR6 Defines Memory B Cell Precursors in Mouse and Human Germinal Centers, Revealing Light-Zone Location and Predominant Low Antigen Affinity

(2017) Dan Suan et al.   IMMUNITY

Analysis of Anti-Influenza Virus Neuraminidase Antibodies in Children, Adults, and the Elderly by ELISA and Enzyme Inhibition: Evidence for Original Antigenic Sin

(2017) Madhusudan Rajendran et al.   mBio

Antibodies with ‘Original Antigenic Sin’ Properties Are Valuable Components of Secondary Immune Responses to Influenza Viruses

(2016) Susanne L. Linderman et al.   PLoS Pathogens

Correlates of Immunity to Influenza as Determined by Challenge of Children with Live, Attenuated Influenza Vaccine

(2016) Peter F. Wright et al.   Open Forum Infectious Diseases

Change-O: a toolkit for analyzing large-scale B cell immunoglobulin repertoire sequencing data: Table 1.

(2015) Namita T. Gupta et al.   BIOINFORMATICS

Anti-HA Glycoforms Drive B Cell Affinity Selection and Determine Influenza Vaccine Efficacy

(2015) Taia T. Wang et al.   CELL

Novel oral anti-influenza drug candidate AV5080

(2014) Alexandre V. Ivachtchenko et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Circulating CXCR5+PD-1+Response Predicts Influenza Vaccine Antibody Responses in Young Adults but not Elderly Adults

(2014) Ramin Sedaghat Herati et al.   JOURNAL OF IMMUNOLOGY

Live Attenuated and Inactivated Influenza Vaccines in Children

(2014) Natalia A. Ilyushina et al.   JOURNAL OF INFECTIOUS DISEASES

Flow Cytometry Reveals that H5N1 Vaccination Elicits Cross-Reactive Stem-Directed Antibodies from Multiple Ig Heavy-Chain Lineages

(2014) J. R. R. Whittle et al.   JOURNAL OF VIROLOGY

Rapid development of broadly influenza neutralizing antibodies through redundant mutations

(2014) Leontios Pappas et al.   NATURE

Induction of ICOS+CXCR3+CXCR5+ TH Cells Correlates with Antibody Responses to Influenza Vaccination

(2013) S.-E. Bentebibel et al.   Science Translational Medicine

Correlates of protection to influenza virus, where do we go from here?

(2013) Rebecca Cox   Human Vaccines & Immunotherapeutics

Live and Inactivated Influenza Vaccines Induce Similar Humoral Responses, but Only Live Vaccines Induce Diverse T-Cell Responses in Young Children

(2011) Daniel F. Hoft et al.   JOURNAL OF INFECTIOUS DISEASES

Innate immune evasion strategies of influenza viruses

(2009) Benjamin G Hale et al.   Future Microbiology

Structural and functional bases for broad-spectrum neutralization of avian and human influenza A viruses

(2009) Jianhua Sui et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Comparative Efficacy of Inactivated and Live Attenuated Influenza Vaccines

(2009) Arnold S. Monto et al.   NEW ENGLAND JOURNAL OF MEDICINE

Antibody Recognition of a Highly Conserved Influenza Virus Epitope

(2009) D. C. Ekiert et al.   SCIENCE