A Novel Recombinant Influenza Virus Neuraminidase Vaccine Candidate Stabilized by a Measles Virus Phosphoprotein Tetramerization Domain Provides Robust Protection from Virus Challenge in the Mouse Model

Introduction of Cysteines in the Stalk Domain of Recombinant Influenza Virus N1 Neuraminidase Enhances Protein Stability and Immunogenicity in Mice

(2021) Shirin Strohmeier et al.   Vaccines

Human Antibodies Targeting Influenza B Virus Neuraminidase Active Site Are Broadly Protective

(2020) Anders Madsen et al.   IMMUNITY

Correctly folded - but not necessarily functional - influenza virus neuraminidase is required to induce protective antibody responses in mice

(2020) Meagan McMahon et al.   VACCINE

Safety and immunogenicity of co-administration of meningococcal type A and measles–rubella vaccines with typhoid conjugate vaccine in children aged 15–23 months in Burkina Faso

(2020) Sodiomon B. Sirima et al.   INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES

Influenza Virus Neuraminidase Structure and Functions

(2019) Julie L. McAuley et al.   Frontiers in Microbiology

Mucosal Immunity against Neuraminidase Prevents Influenza B Virus Transmission in Guinea Pigs

(2019) Meagan McMahon et al.   mBio

Pre-existing anti-neuraminidase antibodies are associated with shortened duration of influenza A (H1N1)pdm virus shedding and illness in naturally infected adults

(2019) Hannah E Maier et al.   CLINICAL INFECTIOUS DISEASES

Paradoxical clade- and age-specific vaccine effectiveness during the 2018/19 influenza A(H3N2) epidemic in Canada: potential imprint-regulated effect of vaccine (I-REV)

(2019) Danuta M Skowronski et al.   Eurosurveillance

Broadly protective human antibodies that target the active site of influenza virus neuraminidase

(2019) Daniel Stadlbauer et al.   SCIENCE

Structural Basis of Protection against H7N9 Influenza Virus by Human Anti-N9 Neuraminidase Antibodies

(2019) Xueyong Zhu et al.   Cell Host & Microbe

Influenza Infection in Humans Induces Broadly Cross-Reactive and Protective Neuraminidase-Reactive Antibodies

(2018) Yao-Qing Chen et al.   CELL

A conserved leucine zipper-like motif accounts for strong tetramerization capabilities of SEPALLATA-like MADS-domain transcription factors

(2018) Florian Rümpler et al.   JOURNAL OF EXPERIMENTAL BOTANY

NAction! How Can Neuraminidase-Based Immunity Contribute to Better Influenza Virus Vaccines?

(2018) Florian Krammer et al.   mBio

Influenza

(2018) Florian Krammer et al.   Nature Reviews Disease Primers

Antibodies to the Glycoprotein GP2 Subunit Cross-React between Old and New World Arenaviruses

(2018) Fatima Amanat et al.   mSphere

MolProbity: More and better reference data for improved all-atom structure validation

(2017) Christopher J. Williams et al.   PROTEIN SCIENCE

Analysis of Anti-Influenza Virus Neuraminidase Antibodies in Children, Adults, and the Elderly by ELISA and Enzyme Inhibition: Evidence for Original Antigenic Sin

(2017) Madhusudan Rajendran et al.   mBio

Evaluation of Antihemagglutinin and Antineuraminidase Antibodies as Correlates of Protection in an Influenza A/H1N1 Virus Healthy Human Challenge Model

(2016) Matthew J. Memoli et al.   mBio

Antibody to Influenza Virus Neuraminidase: An Independent Correlate of Protection

(2015) Arnold S. Monto et al.   JOURNAL OF INFECTIOUS DISEASES

Cross-Reactive Neuraminidase-Inhibiting Antibodies Elicited by Immunization with Recombinant Neuraminidase Proteins of H5N1 and Pandemic H1N1 Influenza A Viruses

(2015) Wen-Chun Liu et al.   JOURNAL OF VIROLOGY

Advances in the development of influenza virus vaccines

(2015) Florian Krammer et al.   NATURE REVIEWS DRUG DISCOVERY

Vaccination with Adjuvanted Recombinant Neuraminidase Induces Broad Heterologous, but Not Heterosubtypic, Cross-Protection against Influenza Virus Infection in Mice

(2015) Teddy John Wohlbold et al.   mBio

H3N2 Mismatch of 2014–15 Northern Hemisphere Influenza Vaccines and Head-to-head Comparison between Human and Ferret Antisera derived Antigenic Maps

(2015) Hang Xie et al.   Scientific Reports

Identification of Hemagglutinin Residues Responsible for H3N2 Antigenic Drift during the 2014–2015 Influenza Season

(2015) Benjamin S. Chambers et al.   Cell Reports

Impact of Influenza B Lineage-Level Mismatch Between Trivalent Seasonal Influenza Vaccines and Circulating Viruses, 1999–2012

(2014) Terho Heikkinen et al.   CLINICAL INFECTIOUS DISEASES

Low 2012–13 Influenza Vaccine Effectiveness Associated with Mutation in the Egg-Adapted H3N2 Vaccine Strain Not Antigenic Drift in Circulating Viruses

(2014) Danuta M. Skowronski et al.   PLoS One

A Beneficiary Role for Neuraminidase in Influenza Virus Penetration through the Respiratory Mucus

(2014) Xiaoyun Yang et al.   PLoS One

In the Shadow of Hemagglutinin: A Growing Interest in Influenza Viral Neuraminidase and Its Role as a Vaccine Antigen

(2014) Teddy Wohlbold et al.   Viruses-Basel

Antibody Correlates and Predictors of Immunity to Naturally Occurring Influenza in Humans and the Importance of Antibody to the Neuraminidase

(2013) Robert B. Couch et al.   JOURNAL OF INFECTIOUS DISEASES

Molecular Basis for Broad Neuraminidase Immunity: Conserved Epitopes in Seasonal and Pandemic H1N1 as Well as H5N1 Influenza Viruses

(2013) H. Wan et al.   JOURNAL OF VIROLOGY

Structure of the Tetramerization Domain of Measles Virus Phosphoprotein

(2013) G. Communie et al.   JOURNAL OF VIROLOGY

Influenza A penetrates host mucus by cleaving sialic acids with neuraminidase

(2013) Miriam Cohen et al.   Virology Journal

Expression of Functional Recombinant Hemagglutinin and Neuraminidase Proteins from the Novel H7N9 Influenza Virus Using the Baculovirus Expression System

(2013) Irina Margine et al.   Jove-Journal of Visualized Experiments

Assembly of Subtype 1 Influenza Neuraminidase Is Driven by Both the Transmembrane and Head Domains

(2012) Diogo V. da Silva et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Carboxy-Terminal Trimerization Domain Stabilizes Conformational Epitopes on the Stalk Domain of Soluble Recombinant Hemagglutinin Substrates

(2012) Florian Krammer et al.   PLoS One

Randomized comparative study of the serum antihemagglutinin and antineuraminidase antibody responses to six licensed trivalent influenza vaccines

(2012) Robert B. Couch et al.   VACCINE

Protection against a lethal H5N1 influenza challenge by intranasal immunization with virus-like particles containing 2009 pandemic H1N1 neuraminidase in mice

(2012) Judith D. Easterbrook et al.   VIROLOGY

A Contributing Role for Anti-Neuraminidase Antibodies on Immunity to Pandemic H1N1 2009 Influenza A Virus

(2011) Glendie Marcelin et al.   PLoS One

Discordant antigenic drift of neuraminidase and hemagglutinin in H1N1 and H3N2 influenza viruses

(2011) M. R. Sandbulte et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Features and development ofCoot

(2010) P. Emsley et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

PHENIX: a comprehensive Python-based system for macromolecular structure solution

(2010) Paul D. Adams et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

The 2009 pandemic H1N1 neuraminidase N1 lacks the 150-cavity in its active site

(2010) Qing Li et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structural Characterization of the 1918 Influenza Virus H1N1 Neuraminidase

(2008) X. Xu et al.   JOURNAL OF VIROLOGY