Regulatory circular RNAs in viral diseases: applications in diagnosis and therapy

A virus-induced circular RNA maintains latent infection of Kaposi’s sarcoma herpesvirus

(2023) Takanobu Tagawa et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Expanding uncapped translation and emerging function of circular RNA in carcinomas and noncarcinomas

(2022) Yan Wang et al.   Molecular Cancer

CAR T cells produced in vivo to treat cardiac injury

(2022) Joel G. Rurik et al.   SCIENCE

Biogenesis and Regulatory Roles of Circular RNAs

(2022) Li Yang et al.   Annual Review of Cell and Developmental Biology

ebv-circRPMS1 promotes the progression of EBV-associated gastric carcinoma via Sam68-dependent activation of METTL3

(2022) Jing-yue Zhang et al.   CANCER LETTERS

Circular RNA vaccines against SARS-CoV-2 and emerging variants

(2022) Liang Qu et al.   CELL

Lipid nanoparticle-encapsulated mRNA antibody provides long-term protection against SARS-CoV-2 in mice and hamsters

(2022) Yong-Qiang Deng et al.   CELL RESEARCH

Roles and clinical application of exosomal circRNAs in the diagnosis and treatment of malignant tumors

(2022) Dong Ye et al.   Journal of Translational Medicine

Marek’s Disease Virus Virulence Genes Encode Circular RNAs

(2022) Alexis S. Chasseur et al.   JOURNAL OF VIROLOGY

Author Correction: Engineering circular RNA for enhanced protein production

(2022) Robert Chen et al.   NATURE BIOTECHNOLOGY

Pervasive translation of circular RNAs driven by short IRES-like elements

(2022) Xiaojuan Fan et al.   Nature Communications

Viral Circular RNAs and Their Possible Roles in Virus-Host Interaction

(2022) Xing Zhang et al.   Frontiers in Immunology

The landscape of mRNA nanomedicine

(2022) Xiangang Huang et al.   NATURE MEDICINE

Critical involvement of circular RNAs in virus-associated cancers

(2022) Arghavan Zebardast et al.   Genes and Diseases

A Highly Conserved Circular RNA circRasGEF1B Enhances Antiviral Immunity by Regulating miR-21-3p/MITA Pathway in Lower Vertebrates

(2021) Qing Chu et al.   JOURNAL OF VIROLOGY

The RNA-binding protein SFPQ preserves long-intron splicing and regulates circRNA biogenesis in mammals

(2021) Lotte Victoria Winther Stagsted et al.   eLife

Engineering highly efficient backsplicing and translation of synthetic circRNAs

(2021) Rita M. Meganck et al.   Molecular Therapy-Nucleic Acids

Circular RNA circPIKfyve acts as a sponge of miR-21-3p to enhance antiviral immunity through regulating MAVS in teleost fish

(2021) Hui Su et al.   JOURNAL OF VIROLOGY

Circular RNA-encoded oncogenic E-cadherin variant promotes glioblastoma tumorigenicity through activation of EGFR–STAT3 signalling

(2021) Xinya Gao et al.   NATURE CELL BIOLOGY

Characterization of ALTO-encoding circular RNAs expressed by Merkel cell polyomavirus and trichodysplasia spinulosa polyomavirus

(2021) Rong Yang et al.   PLoS Pathogens

From A to m6A: The Emerging Viral Epitranscriptome

(2021) Belinda Baquero-Perez et al.   Viruses-Basel

Hepatocellular carcinoma progression mediated by hepatitis B virus-encoded circRNA HBV_circ_1 through interaction with CDK1

(2021) Min Zhu et al.   Molecular Therapy-Nucleic Acids

Characterizing viral circRNAs and their application in identifying circRNAs in viruses

(2021) Mengting Niu et al.   BRIEFINGS IN BIOINFORMATICS

Circular RNA circSamd4a Regulates Antiviral Immunity in Teleost Fish by Upregulating STING through Sponging miR-29a-3p

(2021) Hui Su et al.   JOURNAL OF IMMUNOLOGY

Inhibition of SARS-CoV-2 coronavirus proliferation by designer antisense-circRNAs

(2021) Christina Pfafenrot et al.   NUCLEIC ACIDS RESEARCH

A Previously Undiscovered Circular RNA, circTNFAIP3, and Its Role in Coronavirus Replication

(2021) Liuyang Du et al.   mBio

The Cellular and Viral circRNAome Induced by Respiratory Syncytial Virus Infection

(2021) Wenxia Yao et al.   mBio

Circular RNA: Biosynthesis in vitro

(2021) Xinjie Chen et al.   Frontiers in Bioengineering and Biotechnology

Kaposi’s Sarcoma-Associated Herpesvirus-Encoded circRNAs Are Expressed in Infected Tumor Tissues and Are Incorporated into Virions

(2020) Bizunesh Abere et al.   mBio

N6-methyladenosine modification enables viral RNA to escape recognition by RNA sensor RIG-I

(2020) Mijia Lu et al.   Nature Microbiology

The expanding regulatory mechanisms and cellular functions of circular RNAs

(2020) Ling-Ling Chen   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Recent Progress in Aptamer Discoveries and Modifications for Therapeutic Applications

(2020) Shuaijian Ni et al.   ACS Applied Materials & Interfaces

Epstein–Barr virus‐derived circular RNA LMP 2A induces stemness in EBV ‐associated gastric cancer

(2020) Li‐ping Gong et al.   EMBO REPORTS

Host-derived circular RNAs display proviral activities in Hepatitis C virus-infected cells

(2020) Tzu-Chun Chen et al.   PLoS Pathogens

Increased PIP3 activity blocks nanoparticle mRNA delivery

(2020) Kalina Paunovska et al.   Science Advances

Targeting Mitochondria-Located circRNA SCAR Alleviates NASH via Reducing mROS Output

(2020) Qiyi Zhao et al.   CELL

Circular RNAs in Immune Response and Viral Infection

(2020) Lichong Yan et al.   TRENDS IN BIOCHEMICAL SCIENCES

The role of circular RNAs in viral infection and related diseases

(2020) He Xie et al.   VIRUS RESEARCH

Identification and characterization of circRNAs encoded by MERS-CoV, SARS-CoV-1 and SARS-CoV-2

(2020) Zena Cai et al.   BRIEFINGS IN BIOINFORMATICS

Viruses join the circular RNA world

(2020) Ke‐En Tan et al.   FEBS Journal

Characterizing and circumventing sequence restrictions for synthesis of circular RNA in vitro

(2020) Jason W Rausch et al.   NUCLEIC ACIDS RESEARCH

Grass carp reovirus encoding circular RNAs with antiviral activity

(2020) Jun Pan et al.   AQUACULTURE

Identification of virus-encoded circular RNA

(2019) Jun-ting Huang et al.   VIROLOGY

Circular RNA GATAD2A promotes H1N1 replication through inhibiting autophagy

(2019) Yina Zhang et al.   VETERINARY MICROBIOLOGY

The current state and future directions of RNAi-based therapeutics

(2019) Ryan L. Setten et al.   NATURE REVIEWS DRUG DISCOVERY

RNA Circularization Diminishes Immunogenicity and Can Extend Translation Duration In Vivo

(2019) R. Alexander Wesselhoeft et al.   MOLECULAR CELL

A novel protein encoded by a circular RNA circPPP1R12A promotes tumor pathogenesis and metastasis of colon cancer via Hippo-YAP signaling

(2019) Xiao Zheng et al.   Molecular Cancer

Structure and Degradation of Circular RNAs Regulate PKR Activation in Innate Immunity

(2019) Chu-Xiao Liu et al.   CELL

Highly efficient expression of circular RNA aptamers in cells using autocatalytic transcripts

(2019) Jacob L. Litke et al.   NATURE BIOTECHNOLOGY

HBV-related hepatocarcinogenesis: the role of signalling pathways and innovative ex vivo research models

(2019) Joseph Torresi et al.   BMC CANCER

The Translational Landscape of the Human Heart

(2019) Sebastiaan van Heesch et al.   CELL

The biogenesis, biology and characterization of circular RNAs

(2019) Lasse S. Kristensen et al.   NATURE REVIEWS GENETICS

Interior circular RNA

(2019) Xiaoxin Liu et al.   RNA Biology

Mild Innate Immune Activation Overrides Efficient Nanoparticle‐Mediated RNA Delivery

(2019) Melissa P. Lokugamage et al.   ADVANCED MATERIALS

N6-Methyladenosine Modification Controls Circular RNA Immunity

(2019) Y. Grace Chen et al.   MOLECULAR CELL

Association of N6-methyladenosine with viruses and related diseases

(2019) Fang Wu et al.   Virology Journal

Electrochemical detection of circRNAs based on the combination of back-splice junction and duplex-specific nuclease

(2019) Jin Jiao et al.   SENSORS AND ACTUATORS B-CHEMICAL

Twist1 regulates Vimentin through Cul2 circular RNA to promote EMT in hepatocellular carcinoma

(2018) Jing Meng et al.   CANCER RESEARCH

Functional sequestration of microRNA-122 from Hepatitis C Virus by circular RNA sponges

(2018) Isabelle Jost et al.   RNA Biology

Engineering circular RNA for potent and stable translation in eukaryotic cells

(2018) R. Alexander Wesselhoeft et al.   Nature Communications

The Biogenesis, Functions, and Challenges of Circular RNAs

(2018) Xiang Li et al.   MOLECULAR CELL

Circular DNA tumor viruses make circular RNAs

(2018) Tuna Toptan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Epstein Barr virus circRNAome

(2018) Nathan Ungerleider et al.   PLoS Pathogens

Discovery of Kaposi’s sarcoma herpesvirus-encoded circular RNAs and a human antiviral circular RNA

(2018) Takanobu Tagawa et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Translation of CircRNAs

(2017) Nagarjuna Reddy Pamudurti et al.   MOLECULAR CELL

Circ-ZNF609 Is a Circular RNA that Can Be Translated and Functions in Myogenesis

(2017) Ivano Legnini et al.   MOLECULAR CELL

The Output of Protein-Coding Genes Shifts to Circular RNAs When the Pre-mRNA Processing Machinery Is Limiting

(2017) Dongming Liang et al.   MOLECULAR CELL

Sensing Self and Foreign Circular RNAs by Intron Identity

(2017) Y. Grace Chen et al.   MOLECULAR CELL

Coordinated circRNA Biogenesis and Function with NF90/NF110 in Viral Infection

(2017) Xiang Li et al.   MOLECULAR CELL

DHX9 suppresses RNA processing defects originating from the Alu invasion of the human genome

(2017) Tuğçe Aktaş et al.   NATURE

Non-coding RNA: More uses for genomic junk

(2017) Karen Adelman et al.   NATURE

RNA: Translated circular RNAs

(2017) Linda Koch   NATURE REVIEWS GENETICS

Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing

(2017) Teng Fei et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

FUS affects circular RNA expression in murine embryonic stem cell-derived motor neurons

(2017) Lorenzo Errichelli et al.   Nature Communications

Administration of nucleoside-modified mRNA encoding broadly neutralizing antibody protects humanized mice from HIV-1 challenge

(2017) Norbert Pardi et al.   Nature Communications

Genome-Wide Maps of m6A circRNAs Identify Widespread and Cell-Type-Specific Methylation Patterns that Are Distinct from mRNAs

(2017) Chan Zhou et al.   Cell Reports

The complexity of the translation ability of circRNAs

(2016) Javier T. Granados-Riveron et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Circular RNAs: a new frontier in the study of human diseases

(2016) Yonghua Chen et al.   JOURNAL OF MEDICAL GENETICS

Circular RNAs: Unexpected outputs of many protein-coding genes

(2016) Jeremy E. Wilusz   RNA Biology

The RNA Binding Protein Quaking Regulates Formation of circRNAs

(2015) Simon J. Conn et al.   CELL

One Small Step for Muscle: A New Micropeptide Regulates Performance

(2015) Joanne Tonkin et al.   Cell Metabolism

Combinatorial control ofDrosophilacircular RNA expression by intronic repeats, hnRNPs, and SR proteins

(2015) Marianne C. Kramer et al.   GENES & DEVELOPMENT

RNA circularization strategies in vivo and in vitro

(2015) Sonja Petkovic et al.   NUCLEIC ACIDS RESEARCH

Rolling Circle Translation of Circular RNA in Living Human Cells

(2015) Naoko Abe et al.   Scientific Reports

Analysis of Intron Sequences Reveals Hallmarks of Circular RNA Biogenesis in Animals

(2015) Andranik Ivanov et al.   Cell Reports

Identification and Characterization of Circular RNAs As a New Class of Putative Biomarkers in Human Blood

(2015) Sebastian Memczak et al.   PLoS One

Complementary Sequence-Mediated Exon Circularization

(2014) Xiao-Ou Zhang et al.   CELL

circRNA Biogenesis Competes with Pre-mRNA Splicing

(2014) Reut Ashwal-Fluss et al.   MOLECULAR CELL

Noninvasive in vivo monitoring of tissue-specific global gene expression in humans

(2014) W. Koh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Novel coding, translation, and gene expression of a replicating covalently closed circular RNA of 220 nt

(2014) Mounir Georges AbouHaidar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Efficient backsplicing produces translatable circular mRNAs

(2014) Yang Wang et al.   RNA

KSHV LANA—The Master Regulator of KSHV Latency

(2014) Timsy Uppal et al.   Viruses-Basel

Genome-wide Analysis of Drosophila Circular RNAs Reveals Their Structural and Sequence Properties and Age-Dependent Neural Accumulation

(2014) Jakub O. Westholm et al.   Cell Reports

Rolling Circle Amplification in a Prokaryotic Translation System Using Small Circular RNA

(2013) Naoko Abe et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

N6-methyladenosine-dependent regulation of messenger RNA stability

(2013) Xiao Wang et al.   NATURE

Natural RNA circles function as efficient microRNA sponges

(2013) Thomas B. Hansen et al.   NATURE

Circular RNAs are a large class of animal RNAs with regulatory potency

(2013) Sebastian Memczak et al.   NATURE

Circular RNAs are abundant, conserved, and associated with ALU repeats

(2012) W. R. Jeck et al.   RNA

RNA Interference: From Basic Research to Therapeutic Applications

(2009) Jens Kurreck   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

microRNA-122 stimulates translation of hepatitis C virus RNA

(2008) Jura Inga Henke et al.   EMBO JOURNAL

In vitro and in vivo production and purification of circular RNA aptamer

(2008) So Umekage et al.   JOURNAL OF BIOTECHNOLOGY

Tuning in to the signals: noncoding sequence conservation in vertebrate genomes

(2008) Greg Elgar et al.   TRENDS IN GENETICS