Review
Cell Biology
Jun Wu, Xin Guo, Yi Wen, Shangqing Huang, Xiaohui Yuan, Lijun Tang, Hongyu Sun
Summary: m6A modification is widely present in circRNAs, playing key biological functions. By regulating circRNAs, m6A modification plays important roles in immunity and various diseases.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Pharmacology & Pharmacy
Xiaohan Mei, Shi-You Chen
Summary: In eukaryotes, circular RNAs (circRNAs) are produced through back-splicing of precursor mRNAs (pre-mRNAs), resulting in a covalently closed-loop structure. Due to their unconventional circular form, circRNAs exhibit higher stability compared to linear RNAs and play unique roles in cellular regulation. They are widely expressed in eukaryotes and show tissue- and disease-specific expression patterns, including in the cardiovascular system. Further research is needed to understand the characteristics, biogenesis, and functions of circRNAs, as well as their emerging roles in cardiovascular diseases.
PHARMACOLOGY & THERAPEUTICS
(2022)
Review
Cell Biology
Qi Huang, Juan Yang, Robby Miguel Wen-Jing Goh, Mingliang You, Lingzhi Wang, Zhaowu Ma
Summary: Circular RNAs (circRNAs) are a special class of RNA that are widely present in various organisms and are more stable and conserved than linear RNAs. They play important roles in the pathophysiological changes of human diseases, including cancer, particularly in relation to hypoxia-induced regulation. This review highlights the emerging evidence of the interplay between circRNAs and hypoxia, and discusses their impact on cancer progression, therapeutic resistance, angiogenesis, and energy metabolism. Furthermore, the potential application of circRNAs in the early detection, prognosis, and treatment of various diseases is emphasized.
Review
Biochemistry & Molecular Biology
Charlotte Delrue, Reinhart Speeckaert, Matthijs Oyaert, Tessa Kerre, Sylvie Rottey, Renaat Coopman, Wouter Huvenne, Sander De Bruyne, Marijn M. Speeckaert
Summary: Due to their complexity and diverse manifestations, hematological diseases present significant challenges in healthcare diagnosis. Infrared spectroscopy, known for its noninvasive, rapid, and cost-effective nature, has emerged as a promising adjunct for hematological diagnostics. This review explores the transformative role of IR spectroscopy and its applications in detecting and diagnosing various blood-related ailments, providing a balanced view of its potential and limitations.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Oncology
Baile Shen, Keke Sun
Summary: Exosomal circRNAs play crucial roles in the pathogenesis of cancer, especially in tumor metastasis. However, their functions and regulatory mechanisms in the progression of digestive system tumors require further investigation.
Review
Genetics & Heredity
Maedeh Bagheri Moghaddam, Majid Maleki, Maziar Oveisee, Mahrokh Bagheri Moghaddam, Maedeh Arabian, Mahshid Malakootian
Summary: Cardiomyopathies are a group of cardiac diseases that lead to heart failure and mortality. Circular RNAs, a novel type of noncoding RNAs with unique structure, have been found to play significant roles in cardiomyopathies and have potential clinical applications.
Review
Biochemistry & Molecular Biology
Xiaozhu Tang, Hongyan Ren, Mengjie Guo, Jinjun Qian, Ye Yang, Chunyan Gu
Summary: circRNAs are a class of interesting and conserved single-stranded RNA molecules that play important roles in various biological processes, especially in microRNA sponges, gene splicing and transcription regulation, RNA-binding protein sponges, and protein/peptide translation. They are involved in various human diseases, particularly cancers, and may serve as better predictive biomarkers and therapeutic targets for cancer treatment.
COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL
(2021)
Article
Multidisciplinary Sciences
Mahsa RezaSoltani, Flora Forouzesh, Zahra Salehi, Mohammad-Reza Zabihi, Leili Rejali, Ehsan Nazemalhosseini-Mojarad
Summary: LncPVT1 and CircPVT1, isoforms of the PVT1 gene, are significantly overexpressed in colon adenoma polyps compared to normal-adjacent tissues. In silico analysis suggests their involvement in colon cancer development through the CircPVT1/miR-484, miR-24-3p, miR-423-5p/PLAGL2 axis.
SCIENTIFIC REPORTS
(2023)
Review
Neurosciences
Feng Xiao, Zhi He, Siqi Wang, Jiamei Li, Xiaolan Fan, Taiming Yan, Mingyao Yang, Deying Yang
Summary: This article summarizes the pathological features of neurodegenerative diseases and the regulatory mechanisms of circRNAs in various types of neurodegenerative diseases. It is found that circRNAs mainly influence the pathological process of neurodegenerative diseases by affecting the abnormal deposition of proteins through multiple mechanisms such as acting as microRNA sponges, binding to proteins, and regulating transcription.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Review
Neurosciences
Xiaohan Yu, Haoyu Liu, Ning Chang, Weijia Fu, Zhiwen Guo, Yue Wang
Summary: Circular RNAs (circRNAs), previously considered as byproducts without biological functions, have been found to play important roles in cognitive function and cognitive-related diseases such as autism, depression, and Alzheimer's diseases. Recent advances in high-throughput sequencing and bioinformatics have led to the identification of thousands of circRNAs and their differential biological functions, particularly in the brain and synapses. This review summarizes the progress in understanding the role of circRNAs in cognitive function and their involvement in cognitive-related diseases.
FRONTIERS IN NEUROSCIENCE
(2023)
Review
Biochemistry & Molecular Biology
Rhanoica Oliveira Guerra, Jose Rodrigues do Carmo Neto, Tarcisio de Albuquerque Martins, Thais Soares Farnesi De-Assuncao, Virmondes Rodrigues Junior, Carlo Jose Freire de Oliveira, Anielle Christine Almeida Silva, Marcos Vinicius da Silva
Summary: Leishmaniasis, a parasitic disease caused by Leishmania protozoa, is responsible for thousands of deaths annually. Conventional treatments have limitations, prompting the search for new therapeutic strategies. Metallic nanoparticles have shown promise as they can be easily prepared, have a broad spectrum of action and low toxicity. This review explores the progress and gaps in knowledge regarding metallic nanoparticles as new tools in leishmaniasis treatment.
CURRENT MEDICINAL CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Wenliang Zhang, Yang Liu, Zhuochao Min, Guodong Liang, Jing Mo, Zhen Ju, Binghui Zeng, Wen Guan, Yan Zhang, Jianliang Chen, Qianshen Zhang, Hanguang Li, Chunxia Zeng, Yanjie Wei, Godfrey Chi-Fung Chan
Summary: The study introduces circMine as a tool to assist researchers in investigating circRNA transcriptome data. CircMine provides a large amount of data and online analytical functions to assess the clinical and biological significance of circRNA, and additional tools to systematically discover circRNA-miRNA interactions and circRNA translatability.
NUCLEIC ACIDS RESEARCH
(2022)
Review
Medicine, Research & Experimental
Mansour Almouh, Ehsan Razmara, Amirreza Bitaraf, Mohammad H. Ghazimoradi, Zuhair Mohammad Hassan, Sadegh Babashah
Summary: This study explores the role of circRNAs in regulating cell signaling pathways, particularly in tumorigenesis, providing important insights for identifying cancer therapeutic targets.
Review
Biochemistry & Molecular Biology
Sumeng Wang, Ke Zhang, Shanyue Tan, Junyi Xin, Qianyu Yuan, Huanhuan Xu, Xian Xu, Qi Liang, David C. Christiani, Meilin Wang, Lingxiang Liu, Mulong Du
Summary: Cancer is a major cause of death worldwide, prompting research into novel biomarkers for diagnosis. Circulating circRNAs, stably present in body fluids, exhibit distinct expression patterns that can be used to monitor cancer development and progression.
Article
Mathematical & Computational Biology
Katarzyna Nowis, Paulina Jackowiak, Marek Figlerowicz, Anna Philips
Summary: circRNAs are abundant and tissue-specifically regulated in plants, with the Arabidopsis thaliana circular RNA database integrating and standardizing data for circRNAs in the well-characterized model plant. This resource allows comparative analyses of A. thaliana circRNAs across organs, variants, and studies.
DATABASE-THE JOURNAL OF BIOLOGICAL DATABASES AND CURATION
(2021)
