期刊
BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS
卷 1859, 期 10, 页码 1245-1251出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.bbagrm.2016.07.009
关键词
Circular RNAs; MicroRNA sponges; IRES sequences; CircRNA-derived protein; Translation
资金
- Mexican Council of Sciences and Technology (CONACyT) [CB-168661]
- Mexican Federal Funds [HIM/2015/004-SSA 1175]
Circular RNAs (circRNAs) are a new class of long non-coding RNAs that play a potential role in gene expression regulation, acting as efficient microRNAs sponges. The latest surprise concerning circRNAs is that we now know that they can serve as transcriptional activators in human cells, indicating that circRNAs are involved in important regulatory tasks. Recently, new insight has been gained about the coding potential of circular viroid RNAs, as well as the presence of Internal Ribosomal Entry Sites (IRES) allowing the formation of peptides or proteins from circular RNA. Here, we discuss the current state of our knowledge regarding evidence supporting the hypothesis that circRNAs serve as protein-coding sequences in vitro and in vivo. Also, we remark on the difficulties of their identification and highlight some tools currently available for exploring the coding potential of circRNA. (C) 2016 Elsevier B.V. All rights reserved.
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