Phosphodiesterases in neurodegenerative disorders

Evidence for Global Reduction in Brain Cyclic Adenosine Monophosphate Signaling in Depression

(2012) James M. O'Donnell et al.   BIOLOGICAL PSYCHIATRY

Downregulation of Brain Phosphodiesterase Type IV Measured with 11C-(R)-Rolipram Positron Emission Tomography in Major Depressive Disorder

(2012) Masahiro Fujita et al.   BIOLOGICAL PSYCHIATRY

The neuropathological basis of clinical progression in multiple sclerosis

(2011) Richard Reynolds et al.   ACTA NEUROPATHOLOGICA

Nitric oxide activates PI3-K and MAPK signalling pathways in human and rat vascular smooth muscle cells: Influence of insulin resistance and oxidative stress

(2011) Gabriella Doronzo et al.   ATHEROSCLEROSIS

Cyclic AMP response element-binding protein (CREB) phosphorylation: A mechanistic marker in the development of memory enhancing Alzheimer's disease therapeutics

(2011) R. Scott Bitner   BIOCHEMICAL PHARMACOLOGY

Neuropathological correlates of late-life depression in older people

(2011) Christos Tsopelas et al.   BRITISH JOURNAL OF PSYCHIATRY

CREB in adult neurogenesis - master and partner in the development of adult-born neurons?

(2011) Katharina Merz et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Increased PKA signaling disrupts recognition memory and spatial memory: role in Huntington's disease

(2011) Albert Giralt et al.   HUMAN MOLECULAR GENETICS

Cyclic AMP-dependent Protein Kinase Regulates the Alternative Splicing of Tau Exon 10

(2011) Jianhua Shi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mammalian Cyclic Nucleotide Phosphodiesterases: Molecular Mechanisms and Physiological Functions

(2011) Sharron H. Francis et al.   PHYSIOLOGICAL REVIEWS

The role of CREB signaling in Alzheimer’s disease and other cognitive disorders

(2011) Carlos A. Saura et al.   REVIEWS IN THE NEUROSCIENCES

Autosomal-Dominant Striatal Degeneration Is Caused by a Mutation in the Phosphodiesterase 8B Gene

(2010) Silke Appenzeller et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Involvement of phosphodiesterases in autoimmune diseases

(2010) Keren Mizrachi et al.   JOURNAL OF NEUROIMMUNOLOGY

Advanced Research on Dopamine Signaling to Develop Drugs for the Treatment of Mental Disorders: Biochemical and Behavioral Profiles of Phosphodiesterase Inhibition in Dopaminergic Neurotransmission

(2010) Akinori Nishi et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Cyclic GMP and Nitric Oxide Synthase in Aging and Alzheimer's Disease

(2010) Katarzyna Urszula Domek-Łopacińska et al.   MOLECULAR NEUROBIOLOGY

Quantitative comparison of phosphodiesterase mRNA distribution in human brain and peripheral tissues

(2010) Viktor Lakics et al.   NEUROPHARMACOLOGY

Cilostazol attenuates ischemic brain injury and enhances neurogenesis in the subventricular zone of adult mice after transient focal cerebral ischemia

(2010) Y. Tanaka et al.   NEUROSCIENCE

Inhibition of cAMP Response Element-Binding Protein Reduces Neuronal Excitability and Plasticity, and Triggers Neurodegeneration

(2009) Dragana Jancic et al.   CEREBRAL CORTEX

Antidepressants increase neural progenitor cells in the human hippocampus

(2009) Maura Boldrini et al.   NEUROPSYCHOPHARMACOLOGY

Tau phosphorylation: the therapeutic challenge for neurodegenerative disease

(2009) Diane P. Hanger et al.   TRENDS IN MOLECULAR MEDICINE

Magnetic Resonance Imaging Investigation of Axonal Remodeling and Angiogenesis after Embolic Stroke in Sildenafil-Treated Rats

(2008) Guangliang Ding et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM