Article
Neurosciences
Mahmoud S. Abdallah, Esraa M. Mosalam, Ahmed Hassan, Ahmed N. Ramadan, Hend Omara-Reda, Abdel-Aziz A. Zidan, Waad A. Samman, Eman El-Berri
Summary: This study aimed to investigate the effectiveness and safety of pentoxifylline as an adjuvant to risperidone in mitigating the negative symptoms in patients with chronic schizophrenia. The results showed that pentoxifylline adjunctive therapy had a significant effect in reducing PANSS-negative subscale scores, PANSS general psychopathology subscale scores, and PANSS total scores. Furthermore, it also led to an increase in cAMP serum level and a decrease in TNF-alpha and IL-6 serum levels.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Review
Chemistry, Medicinal
Harsh S. Amin, Palak K. Parikh, Manjunath D. Ghate
Summary: PDE10A is highly expressed in the brain, regulating cyclic nucleotide signaling. PDE10A inhibitors are expected to be a new approach for treating schizophrenia and other neurodegenerative disorders, with pharmaceutical companies conducting research and development in this area.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Chemistry, Medicinal
Mohammad Banazadeh, Mitra Mehrabani, Nabi Banazadeh, Fatemeh Dabaghzadeh, Farzad Shahabi
Summary: The study showed that black myrobalan significantly improved cognitive impairments, negative symptoms, and excitement/activity symptoms in chronic schizophrenic patients, suggesting a positive impact on symptom improvement in these patients.
PHYTOTHERAPY RESEARCH
(2022)
Article
Psychology, Clinical
Hui Shen, Li Zhang, Yuhuan Li, Denise Zheng, Lizhao Du, Feikang Xu, Chuchen Xu, Yan Liu, Jie Shen, Zezhi Li, Donghong Cui
Summary: This study investigated the efficacy of a mindfulness-based intervention (MBI) on negative and cognitive symptoms in schizophrenia patients with residual negative symptoms. The results showed that MBI alleviated negative symptoms, improved cognitive performance, and emotional state in these patients.
PSYCHOLOGICAL MEDICINE
(2023)
Review
Neurosciences
Qiongqiong Wu, Xiaoyi Wang, Ying Wang, Yu-Jun Long, Jing-Ping Zhao, Ren-Rong Wu
Summary: This review focuses on the causal mechanisms and treatment options for the negative symptoms and cognitive dysfunction in schizophrenia, providing insights into potential therapeutic strategies for the future.
NEUROSCIENCE BULLETIN
(2021)
Article
Psychiatry
Laura E. Grover, Rebecca Jones, Nicholas J. Bass, Andrew McQuillin
Summary: Negative symptoms are associated with a reduced risk of suicidality, while positive symptoms are associated with an increased risk of suicidality. Depressive symptoms may confound or mediate these associations.
SCHIZOPHRENIA RESEARCH
(2022)
Article
Clinical Neurology
Andreas Meyer-Lindenberg, Jacob Nielsen, Pedro Such, Ole Michael Lemming, Janos Zambori, Raimund Buller, Christoph von der Goltz
Summary: Lu AF11167 showed no significant efficacy in reducing persistent negative symptoms in stable, non-acute patients with schizophrenia, regardless of the dosage used. The study also found no significant improvements in overall symptomology, negative symptoms, positive symptoms, or functioning compared to the placebo group.
EUROPEAN NEUROPSYCHOPHARMACOLOGY
(2022)
Editorial Material
Psychiatry
Rafael Penades, Til Wykes
Summary: Cognitive remediation is recommended for treating cognitive and functional impairments in patients with schizophrenia. Recent research suggests that it could also help reduce negative symptoms, but more studies focusing on individuals with primary negative symptoms are needed. Furthermore, the role of moderators and mediators and the use of more specific assessments should be investigated. Despite these challenges, cognitive remediation shows promise as a treatment option for primary negative symptoms.
BRITISH JOURNAL OF PSYCHIATRY
(2023)
Review
Medicine, General & Internal
Max B. Butler, Sundar K. Vellaiyappan, Faheem Bhatti, Fazal-E-Momin Syed, Amir Rafati Fard, Jye Quan Teh, Ben Grodzinski, Melika Akhbari, Sylva Adeeko, Rory Dilworth, Aniqah Bhatti, Unaiza Waheed, Sophie Robinson, Temidayo Osunronbi, Benn Walker, Luke Ottewell, Gayathri Suresh, Isla Kuhn, Benjamin M. Davies, Mark R. N. Kotter, Oliver D. Mowforth
Summary: This systematic review evaluated the impact of phosphodiesterase (PDE) inhibitors on neurobehavioral outcomes in preclinical models of traumatic and non-traumatic spinal cord injury (SCI). The majority of included studies showed that administration of PDE inhibitors was associated with statistically significant improvements in neurobehavioral outcomes. However, inconsistent evidence and high risk of bias were observed.
FRONTIERS IN MEDICINE
(2023)
Article
Integrative & Complementary Medicine
Zhengping Pu, Hui Wen, Hongxia Jiang, Qingmei Hou, Hui Yan
Summary: This study aims to investigate the efficacy of berberine in treating negative symptoms and cognitive deficits in adult patients with chronic schizophrenia. Results showed that patients receiving berberine demonstrated a decrease in total scores on clinical scales and showed a serum level reduction of inflammatory markers compared to the control group. Thus, berberine has shown potential as an anti-inflammatory agent that can mitigate the negative symptoms and cognitive deficits in patients with schizophrenia.
Article
Neurosciences
Eleanor S. Smith, Trevor J. Crawford
Summary: This study investigates the mechanisms related to predictive saccades in patients with psychosis and finds no differences between schizophrenia and bipolar disorder. It supports a dimensional hypothesis and reveals significant hypometria and lower gain in individuals with more negative symptoms, regardless of diagnosis.
Article
Neurosciences
Xiaowei Tan, Donel Martin, Jimmy Lee, Phern Chern Tor
Summary: This study examined the efficacy of electroconvulsive therapy (ECT) on negative symptoms in schizophrenia. The results showed that ECT was associated with improvements in negative symptoms, as well as overall function and cognition. Additionally, several clinical factors were identified as potential predictors of negative symptom improvement.
Article
Oncology
Elizabeth R. Tucker, Irene Jimenez, Lindi Chen, Angela Bellini, Chiara Gorrini, Elizabeth Calton, Qiong Gao, Harvey Che, Evon Poon, Yann Jamin, Barbara Martins Da Costa, Karen Barker, Sumana Shrestha, J. Ciaran Hutchinson, Simran Dhariwal, Angharad Goodman, Elaine Del Nery, Pierre Gestraud, Jaydutt Bhalshankar, Yasmine Iddir, Elnaz Saberi-Ansari, Alexandra Saint-Charles, Birgit Geoerger, Maria Eugenia Marques Da Costa, Cecile Pierre-Eugene, Isabelle Janoueix-Lerosey, Didier Decaudin, Fariba Nemati, Angel M. Carcaboso, Didier Surdez, Olivier Delattre, Sally L. George, Louis Chesler, Deborah A. Tweddle, Gudrun Schleiermacher
Summary: ALK-activating mutations are present in approximately 10% of neuroblastomas and ALK amplifications in a further 1%-2% of cases. Lorlatinib, a third-generation ALK inhibitor, is being considered as a treatment for children with ALK-aberrant neuroblastoma. Resistance to single-agent treatment has been reported, and combination therapies with chemotherapy or MDM2 inhibitor are being explored to improve treatment efficacy.
CLINICAL CANCER RESEARCH
(2023)
Article
Medicine, Research & Experimental
Ming Tatt Lee, Akihiro Mouri, Hisayoshi Kubota, Hsin-Jung Lee, Man-Hsin Chang, Chen-Yi Wu, Daniel E. Knutson, Marko Mihovilovic, James Cook, Werner Sieghart, Toshitaka Nabeshima, Lih-Chu Chiou
Summary: GABAA receptors containing alpha 6 subunits are implicated in schizophrenia. Selective positive allosteric modulators of alpha 6GABA(A)Rs can rescue various symptoms related to schizophrenia in animal models, including disrupted prepulse inhibition, hyperlocomotion, social withdrawal, and cognitive impairment.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Psychiatry
Na Wen, Lei Chen, Xuemeng Miao, Min Zhang, Yaoyao Zhang, Jie Liu, Yao Xu, Siyu Tong, Wei Tang, Mengpu Wang, Jiahong Liu, Siyao Zhou, Xinyu Fang, Ke Zhao
Summary: The study found that high-frequency rTMS stimulation over the left DLPFC as a supplement to antipsychotics may have potential benefits in improving clinical symptoms and cognitive functions in patients with chronic schizophrenia. The active rTMS group was more effective in ameliorating negative symptoms and memory functions, and a negative correlation was found between PANSS negative symptoms scores and RBANS language scores.
FRONTIERS IN PSYCHIATRY
(2021)
Article
Biochemistry & Molecular Biology
Liang Ma, Stephen A. Semick, Qiang Chen, Chao Li, Ran Tao, Amanda J. Price, Joo Heon Shin, Yankai Jia, Nicholas J. Brandon, Alan J. Cross, Thomas M. Hyde, Joel E. Kleinman, Andrew E. Jaffe, Daniel R. Weinberger, Richard E. Straub
MOLECULAR PSYCHIATRY
(2020)
Article
Chemistry, Medicinal
Jon Read, Lain T. Collie, Michelle Nguyen-McCarty, Christopher Lucaj, James Robinson, Leslie Conway, Jayanta Mukherjee, Eileen McCall, Gerard Donohoe, Elizabeth Flavell, Karolina Peciak, Juli Warwicker, Carly Dix, Bernard G. Van den Hoven, Andrew Madin, Dean G. Brown, Stephen Moss, Stephen J. Haggarty, Nicholas J. Brandon, Roland W. Burli
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2019)
Article
Biochemistry & Molecular Biology
Katy Pilarzyk, Jennifer Klett, Edsel A. Pena, Latarsha Porcher, Abigail J. Smith, Michy P. Kelly
Review
Biotechnology & Applied Microbiology
George S. Baillie, Gonzalo S. Tejeda, Michy P. Kelly
NATURE REVIEWS DRUG DISCOVERY
(2019)
Article
Cell Biology
Reagan Farmer, Steven D. Burbano, Neema S. Patel, Angelo Sarmiento, Abigail J. Smith, Michy P. Kelly
CELLULAR SIGNALLING
(2020)
Review
Chemistry, Medicinal
Heike J. Wobst, Korrie L. Mack, Dean G. Brown, Nicholas J. Brandon, James Shorter
MEDICINAL RESEARCH REVIEWS
(2020)
Article
Multidisciplinary Sciences
Gonzalo S. Tejeda, Ellanor L. Whiteley, Tarek Z. Deeb, Roland W. Burli, Stephen J. Moss, Eamonn Sheridan, Nicholas J. Brandon, George S. Baillie
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2020)
Article
Multidisciplinary Sciences
Emily E. Burke, Joshua G. Chenoweth, Joo Heon Shin, Leonardo Collado-Torres, Suel-Kee Kim, Nicola Micali, Yanhong Wang, Carlo Colantuoni, Richard E. Straub, Daniel J. Hoeppner, Huei-Ying Chen, Alana Sellers, Kamel Shibbani, Gregory R. Hamersky, Marcelo Diaz Bustamante, BaDoi N. Phan, William S. Ulrich, Cristian Valencia, Amritha Jaishankar, Amanda J. Price, Anandita Rajpurohit, Stephen A. Semick, Roland W. Burli, James C. Barrow, Daniel J. Hiler, Stephanie C. Page, Keri Martinowich, Thomas M. Hyde, Joel E. Kleinman, Karen F. Berman, Jose A. Apud, Alan J. Cross, Nicholas J. Brandon, Daniel R. Weinberger, Brady J. Maher, Ronald D. G. McKay, Andrew E. Jaffe
NATURE COMMUNICATIONS
(2020)
Article
Psychiatry
Filippo Erli, Alish B. Palmos, Pooja Raval, Jayanta Mukherjee, Katherine J. Sellers, Nicholas J. F. Gatford, Stephen J. Moss, Nicholas J. Brandon, Peter Penzes, Deepak P. Srivastava
TRANSLATIONAL PSYCHIATRY
(2020)
Article
Cell Biology
Nicola Micali, Suel-Kee Kim, Marcelo Diaz-Bustamante, Genevieve Stein-O'Brien, Seungmae Seo, Joo-Heon Shin, Brian G. Rash, Shaojie Ma, Yanhong Wang, Nicolas A. Olivares, Jon Arellano, Kristen R. Maynard, Elana J. Fertig, Alan J. Cross, Roland W. Burli, Nicholas J. Brandon, Daniel R. Weinberger, Joshua G. Chenoweth, Daniel J. Hoeppner, Nenad Sestan, Pasko Rakic, Carlo Colantuoni, Ronald D. McKay
Article
Neurosciences
Wenchen Zhao, Jianjia Fan, Iva Kulic, Cheryl Koh, Amanda Clark, Johan Meuller, Ola Engkvist, Samantha Barichievy, Carina Raynoschek, Ryan Hicks, Marcello Maresca, Qi Wang, Dean G. Brown, Alvin Lok, Cameron Parro, Jerome Robert, Hsien-Ya Chou, Andrea M. Zuhl, Michael W. Wood, Nicholas J. Brandon, Cheryl L. Wellington
Article
Biochemistry & Molecular Biology
Alicyia Walczyk-Mooradally, Jennifer Holborn, Karamjeet Singh, Marshall Tyler, Debasis Patnaik, Hendrik Wesseling, Nicholas J. Brandon, Judith Steen, Steffen P. Graether, Stephen J. Haggarty, Jasmin Lalonde
Summary: Arc is a protein crucial for cognitive function and memory formation, able to self-assemble into virus-like capsids for mRNA transportation. The study shows that TNIK kinase can modify Arc at Serine 67 and Threonine 278, influencing its subcellular distribution and self-assembly. Understanding the interaction between Arc and TNIK in neuronal cells could offer new insights into psychiatric disorders.
JOURNAL OF NEUROCHEMISTRY
(2021)
Article
Immunology
Latarsha Porcher, Sophie Bruckmeier, Steven D. Burbano, Julie E. Finnell, Nicole Gorny, Jennifer Klett, Susan K. Wood, Michy P. Kelly
Summary: Despite the wide acceptance of neuroinflammation contributing to age-related cognitive decline, studies on cytokine protein expression in young versus old brains are limited. Age-related increases in cytokines are more pronounced in the hippocampus, especially in females, with a shift in glycosylated forms of IL-10 and IL-1 beta in this brain region. Age-related increases in IL-6 expression are also seen in extra-hippocampal regions but are more discreet.
JOURNAL OF NEUROINFLAMMATION
(2021)
Article
Biochemistry & Molecular Biology
Abigail J. Smith, Reagan Farmer, Katy Pilarzyk, Latarsha Porcher, Michy P. Kelly
Summary: Despite the known benefits of friendships, the neurobiological mechanisms driving mutual social preferences are not well understood. Through controlled experiments with mice, it was discovered that Pde11a homophily can dictate mutual social preferences and the regulatory mechanisms involved were identified.
MOLECULAR PSYCHIATRY
(2021)
Article
Cell Biology
Katy Pilarzyk, Latarsha Porcher, William R. Capell, Steven D. Burbano, Jeff Davis, Janet L. Fisher, Nicole Gorny, Siena Petrolle, Michy P. Kelly
Summary: In both humans and mice, aging and traumatic brain injury-associated dementia increase the expression of the cAMP/cGMP-degrading enzyme PDE11A in the hippocampus, leading to decreased signaling and increased vulnerability of associative memories to age-related cognitive decline. PDE11A4 protein accumulates abnormally in the aged hippocampus, causing impairments in cognitive function. Preventing age-related increases in PDE11 expression protects against age-related cognitive decline in mice.