The molecular basis of nutrient sensing and signalling by mTORC1 in metabolism regulation and disease
出版年份 2023 全文链接
标题
The molecular basis of nutrient sensing and signalling by mTORC1 in metabolism regulation and disease
作者
关键词
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出版物
NATURE REVIEWS MOLECULAR CELL BIOLOGY
Volume -, Issue -, Pages -
出版商
Springer Science and Business Media LLC
发表日期
2023-08-23
DOI
10.1038/s41580-023-00641-8
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注意:仅列出部分参考文献,下载原文获取全部文献信息。- Familial multiple discoid fibromas is linked to a locus on chromosome 5 including the FNIP1 gene
- (2023) Irma van de Beek et al. JOURNAL OF HUMAN GENETICS
- Structure of the lysosomal mTORC1–TFEB–Rag–Ragulator megacomplex
- (2023) Zhicheng Cui et al. NATURE
- EGOC inhibits TOROID polymerization by structurally activating TORC1
- (2023) Manoël Prouteau et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Genome-wide CRISPR screens identify ILF3 as a mediator of mTORC1-dependent amino acid sensing
- (2023) Guokai Yan et al. NATURE CELL BIOLOGY
- Induction of lysosomal and mitochondrial biogenesis by AMPK phosphorylation of FNIP1
- (2023) Nazma Malik et al. SCIENCE
- AMPK-dependent phosphorylation of the GATOR2 component WDR24 suppresses glucose-mediated mTORC1 activation
- (2023) Xiaoming Dai et al. Nature Metabolism
- Structural advances in sterol-sensing domain-containing proteins
- (2022) Xuelan Wu et al. TRENDS IN BIOCHEMICAL SCIENCES
- Cryo-EM structures of the human GATOR1-Rag-Ragulator complex reveal a spatial-constraint regulated GAP mechanism
- (2022) Shawn B. Egri et al. MOLECULAR CELL
- Inhibition of nonalcoholic fatty liver disease in mice by selective inhibition of mTORC1
- (2022) Bridget S. Gosis et al. SCIENCE
- Non-canonical mTORC1 signaling at the lysosome
- (2022) Gennaro Napolitano et al. TRENDS IN CELL BIOLOGY
- Folliculin promotes substrate-selective mTORC1 activity by activating RagC to recruit TFE3
- (2022) Kristina Li et al. PLOS BIOLOGY
- Sestrin mediates detection of and adaptation to low-leucine diets in Drosophila
- (2022) Xin Gu et al. NATURE
- Structure of the nutrient-sensing hub GATOR2
- (2022) Max L. Valenstein et al. NATURE
- Zonated leucine sensing by Sestrin-mTORC1 in the liver controls the response to dietary leucine
- (2022) Andrew L. Cangelosi et al. SCIENCE
- Molecular mechanism of S -adenosylmethionine sensing by SAMTOR in mTORC1 signaling
- (2022) Xin Tang et al. Science Advances
- Long‐term treatment of cancer‐prone germline PTEN mutant mice with low‐dose rapamycin extends lifespan and delays tumour development
- (2022) Priyanka Tibarewal et al. JOURNAL OF PATHOLOGY
- Brain-restricted mTOR inhibition with binary pharmacology
- (2022) Ziyang Zhang et al. NATURE
- Cryo-EM structure of the SEA complex
- (2022) Lucas Tafur et al. NATURE
- A Rag GTPase dimer code defines the regulation of mTORC1 by amino acids
- (2022) Peter Gollwitzer et al. NATURE CELL BIOLOGY
- Brain-enriched RagB isoforms regulate the dynamics of mTORC1 activity through GATOR1 inhibition
- (2022) Gianluca Figlia et al. NATURE CELL BIOLOGY
- The mechanisms and roles of selective autophagy in mammals
- (2022) Jose Norberto S. Vargas et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Lysosomal GPCR-like protein LYCHOS signals cholesterol sufficiency to mTORC1
- (2022) Hijai R. Shin et al. SCIENCE
- Structural basis for FLCN RagC GAP activation in MiT-TFE substrate-selective mTORC1 regulation
- (2022) Rachel M. Jansen et al. Science Advances
- Ring domains are essential for GATOR2-dependent mTORC1 activation
- (2022) Cong Jiang et al. MOLECULAR CELL
- Structural insights into TSC complex assembly and GAP activity on Rheb
- (2021) Huirong Yang et al. Nature Communications
- TSC1 binding to lysosomal PIPs is required for TSC complex translocation and mTORC1 regulation
- (2021) Katharina Fitzian et al. MOLECULAR CELL
- The dynamic mechanism of 4E-BP1 recognition and phosphorylation by mTORC1
- (2021) Raphael Böhm et al. MOLECULAR CELL
- SAR1B senses leucine levels to regulate mTORC1 signalling
- (2021) Jie Chen et al. NATURE
- TSC2 regulates lysosome biogenesis via a non-canonical RAGC and TFEB-dependent mechanism
- (2021) Nicola Alesi et al. Nature Communications
- Structural basis for membrane recruitment of ATG16L1 by WIPI2 in autophagy
- (2021) Lisa M Strong et al. eLife
- mTOR at the nexus of nutrition, growth, ageing and disease
- (2020) Grace Y. Liu et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- mTOR in Lung Neoplasms
- (2020) Ildiko Krencz et al. PATHOLOGY & ONCOLOGY RESEARCH
- Global analysis of LARP1 translation targets reveals tunable and dynamic features of 5′ TOP motifs
- (2020) Lucas Philippe et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Inter-domain dynamics drive cholesterol transport by NPC1 and NPC1L1 proteins
- (2020) Piyali Saha et al. eLife
- Structural Basis of Low-pH-Dependent Lysosomal Cholesterol Egress by NPC1 and NPC2
- (2020) Hongwu Qian et al. CELL
- The Lysosome at the Intersection of Cellular Growth and Destruction
- (2020) Hijai R. Shin et al. DEVELOPMENTAL CELL
- A substrate-specific mTORC1 pathway underlies Birt–Hogg–Dubé syndrome
- (2020) Gennaro Napolitano et al. NATURE
- Structure of the TSC2 GAP Domain: Mechanistic Insight into Catalysis and Pathogenic Mutations
- (2020) Patrick Hansmann et al. STRUCTURE
- Structural Insights into TOR Signaling
- (2020) Lucas Tafur et al. Genes
- Structural mechanism for amino acid-dependent Rag GTPase nucleotide state switching by SLC38A9
- (2020) Simon A. Fromm et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Aldolase is a sensor for both low and high glucose, linking to AMPK and mTORC1
- (2020) Mengqi Li et al. CELL RESEARCH
- Cholesterol access in cellular membranes controls Hedgehog signaling
- (2020) Arun Radhakrishnan et al. Nature Chemical Biology
- A Conformational Change in the N Terminus of SLC38A9 Signals mTORC1 Activation
- (2020) Hsiang-Ting Lei et al. STRUCTURE
- Arg78 of Nprl2 catalyzes GATOR1-stimulated GTP hydrolysis by the Rag GTPases
- (2019) Kuang Shen et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Sestrin modulator NV-5138 produces rapid antidepressant effects via direct mTORC1 activation
- (2019) Taro Kato et al. JOURNAL OF CLINICAL INVESTIGATION
- Covalent targeting of the vacuolar H+-ATPase activates autophagy via mTORC1 inhibition
- (2019) Clive Yik-Sham Chung et al. Nature Chemical Biology
- A novel rapamycin analog is highly selective for mTORC1 in vivo
- (2019) Katherine H. Schreiber et al. Nature Communications
- ER–lysosome contacts enable cholesterol sensing by mTORC1 and drive aberrant growth signalling in Niemann–Pick type C
- (2019) Chun-Yan Lim et al. NATURE CELL BIOLOGY
- Cryo-EM Structure of the Human FLCN-FNIP2-Rag-Ragulator Complex
- (2019) Kuang Shen et al. CELL
- Structural Insight into Eukaryotic Sterol Transport through Niemann-Pick Type C Proteins
- (2019) Mikael B.L. Winkler et al. CELL
- GATOR opathies: The role of amino acid regulatory gene mutations in epilepsy and cortical malformations
- (2019) Philip H. Iffland et al. EPILEPSIA
- Lysosomes as dynamic regulators of cell and organismal homeostasis
- (2019) Andrea Ballabio et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Architecture of human Rag GTPase heterodimers and their complex with mTORC1
- (2019) Madhanagopal Anandapadamanaban et al. SCIENCE
- Structural basis for the docking of mTORC1 on the lysosomal surface
- (2019) Kacper B. Rogala et al. SCIENCE
- Structural mechanism of a Rag GTPase activation checkpoint by the lysosomal folliculin complex
- (2019) Rosalie E. Lawrence et al. SCIENCE
- TFEB drives PGC-1α expression in adipocytes to protect against diet-induced metabolic dysfunction
- (2019) Trent D. Evans et al. Science Signaling
- Retrospective on Cholesterol Homeostasis: The Central Role of Scap
- (2018) Michael S. Brown et al. Annual Review of Biochemistry
- The complex relationship between TFEB transcription factor phosphorylation and subcellular localization
- (2018) Rosa Puertollano et al. EMBO JOURNAL
- Architecture of the human GATOR1 and GATOR1–Rag GTPases complexes
- (2018) Kuang Shen et al. NATURE
- Crystal structure of arginine-bound lysosomal transporter SLC38A9 in the cytosol-open state
- (2018) Hsiang-Ting Lei et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- A mouse model of DEPDC5 -related epilepsy: Neuronal loss of Depdc5 causes dysplastic and ectopic neurons, increased mTOR signaling, and seizure susceptibility
- (2018) Christopher J. Yuskaitis et al. NEUROBIOLOGY OF DISEASE
- Crystal structure of arginine-bound lysosomal transporter SLC38A9 in the cytosol-open state
- (2018) Hsiang-Ting Lei et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- DEPDC5 deficiency contributes to resistance to leucine starvation via p62 accumulation in hepatocellular carcinoma
- (2018) Yuki Mizuno et al. Scientific Reports
- Architecture of the human mTORC2 core complex
- (2018) Edward Stuttfeld et al. eLife
- The landscape of epilepsy-related GATOR1 variants
- (2018) Sara Baldassari et al. GENETICS IN MEDICINE
- A nutrient-induced affinity switch controls mTORC1 activation by its Rag GTPase–Ragulator lysosomal scaffold
- (2018) Rosalie E. Lawrence et al. NATURE CELL BIOLOGY
- Ragulator and SLC38A9 activate the Rag GTPases through noncanonical GEF mechanisms
- (2018) Kuang Shen et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Here, there, and everywhere: The importance of ER membrane contact sites
- (2018) Haoxi Wu et al. SCIENCE
- Lipid sensing by mTOR complexes viade novosynthesis of phosphatidic acid
- (2017) Deepak Menon et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Intersubunit Crosstalk in the Rag GTPase Heterodimer Enables mTORC1 to Respond Rapidly to Amino Acid Availability
- (2017) Kuang Shen et al. MOLECULAR CELL
- Hybrid Structure of the RagA/C-Ragulator mTORC1 Activation Complex
- (2017) Ming-Yuan Su et al. MOLECULAR CELL
- TORC1 organized in inhibited domains (TOROIDs) regulate TORC1 activity
- (2017) Manoël Prouteau et al. NATURE
- SZT2 dictates GATOR control of mTORC1 signalling
- (2017) Min Peng et al. NATURE
- Mechanisms of mTORC1 activation by RHEB and inhibition by PRAS40
- (2017) Haijuan Yang et al. NATURE
- Whole-genome landscape of pancreatic neuroendocrine tumours
- (2017) Aldo Scarpa et al. NATURE
- KICSTOR recruits GATOR1 to the lysosome and is necessary for nutrients to regulate mTORC1
- (2017) Rachel L. Wolfson et al. NATURE
- Crystal structure of the human lysosomal mTORC1 scaffold complex and its impact on signaling
- (2017) Mariana E. G. de Araujo et al. SCIENCE
- SAMTOR is anS-adenosylmethionine sensor for the mTORC1 pathway
- (2017) Xin Gu et al. SCIENCE
- Transcriptional activation of RagD GTPase controls mTORC1 and promotes cancer growth
- (2017) Chiara Di Malta et al. SCIENCE
- Lysosomal cholesterol activates mTORC1 via an SLC38A9–Niemann-Pick C1 signaling complex
- (2017) Brian M. Castellano et al. SCIENCE
- Emerging Roles for the Lysosome in Lipid Metabolism
- (2017) Ashley M. Thelen et al. TRENDS IN CELL BIOLOGY
- Feedback Inhibition of the Rag GTPase GAP Complex Lst4-Lst7 Safeguards TORC1 from Hyperactivation by Amino Acid Signals
- (2017) Marie-Pierre Péli-Gulli et al. Cell Reports
- Purine Nucleotide Availability Regulates mTORC1 Activity through the Rheb GTPase
- (2017) Natasha Emmanuel et al. Cell Reports
- The mTORC1 Signaling Network Senses Changes in Cellular Purine Nucleotide Levels
- (2017) Gerta Hoxhaj et al. Cell Reports
- Substrate specificity of TOR complex 2 is determined by a ubiquitin-fold domain of the Sin1 subunit
- (2017) Hisashi Tatebe et al. eLife
- Continuous transport of a small fraction of plasma membrane cholesterol to endoplasmic reticulum regulates total cellular cholesterol
- (2017) Rodney Elwood Infante et al. eLife
- The ULK1 complex mediates MTORC1 signaling to the autophagy initiation machinery via binding and phosphorylating ATG14
- (2016) Ji-Man Park et al. Autophagy
- Endosome-ER Contacts Control Actin Nucleation and Retromer Function through VAP-Dependent Regulation of PI4P
- (2016) Rui Dong et al. CELL
- Structural Insights into the Niemann-Pick C1 (NPC1)-Mediated Cholesterol Transfer and Ebola Infection
- (2016) Xin Gong et al. CELL
- The CASTOR Proteins Are Arginine Sensors for the mTORC1 Pathway
- (2016) Lynne Chantranupong et al. CELL
- PI3K–mTOR Pathway Inhibition Exhibits Efficacy Against High-grade Glioma in Clinically Relevant Mouse Models
- (2016) Fan Lin et al. CLINICAL CANCER RESEARCH
- Overcoming mTOR resistance mutations with a new-generation mTOR inhibitor
- (2016) Vanessa S. Rodrik-Outmezguine et al. NATURE
- Mechanism of arginine sensing by CASTOR1 upstream of mTORC1
- (2016) Robert A. Saxton et al. NATURE
- Depdc5 knockout rat: A novel model of mTORopathy
- (2016) Elise Marsan et al. NEUROBIOLOGY OF DISEASE
- Lysosomal recruitment of TSC2 is a universal response to cellular stress
- (2016) Constantinos Demetriades et al. Nature Communications
- Tor forms a dimer through an N-terminal helical solenoid with a complex topology
- (2016) Domagoj Baretić et al. Nature Communications
- Tuberous sclerosis complex
- (2016) Elizabeth P. Henske et al. Nature Reviews Disease Primers
- Novel homozygous mutation inKPTNgene causing a familial intellectual disability-macrocephaly syndrome
- (2015) Sander Pajusalu et al. AMERICAN JOURNAL OF MEDICAL GENETICS PART A
- Familial cortical dysplasia caused by mutation in the mammalian target of rapamycin regulatorNPRL3
- (2015) Joe C. Sim et al. ANNALS OF NEUROLOGY
- Mutations in the mammalian target of rapamycin pathway regulatorsNPRL2andNPRL3cause focal epilepsy
- (2015) Michael G. Ricos et al. ANNALS OF NEUROLOGY
- Nutrient-Sensing Mechanisms across Evolution
- (2015) Lynne Chantranupong et al. CELL
- A Century of Cholesterol and Coronaries: From Plaques to Genes to Statins
- (2015) Joseph L. Goldstein et al. CELL
- GCN2 sustains mTORC1 suppression upon amino acid deprivation by inducing Sestrin2
- (2015) Jiangbin Ye et al. GENES & DEVELOPMENT
- Amino Acid-Dependent mTORC1 Regulation by the Lysosomal Membrane Protein SLC38A9
- (2015) Jennifer Jung et al. MOLECULAR AND CELLULAR BIOLOGY
- Molecular Basis of the Rapamycin Insensitivity of Target Of Rapamycin Complex 2
- (2015) Christl Gaubitz et al. MOLECULAR CELL
- SLC38A9 is a component of the lysosomal amino acid sensing machinery that controls mTORC1
- (2015) Manuele Rebsamen et al. NATURE
- Recurrent mTORC1-activating RRAGC mutations in follicular lymphoma
- (2015) Jessica Okosun et al. NATURE GENETICS
- Architecture of human mTOR complex 1
- (2015) C. H. S. Aylett et al. SCIENCE
- Structural basis for leucine sensing by the Sestrin2-mTORC1 pathway
- (2015) R. A. Saxton et al. SCIENCE
- Lysosomal amino acid transporter SLC38A9 signals arginine sufficiency to mTORC1
- (2015) S. Wang et al. SCIENCE
- Sestrin2 is a leucine sensor for the mTORC1 pathway
- (2015) R. L. Wolfson et al. SCIENCE
- Differential regulation of mTORC1 by leucine and glutamine
- (2015) J. L. Jewell et al. SCIENCE
- Co-occurring Genomic Alterations Define Major Subsets of KRAS-Mutant Lung Adenocarcinoma with Distinct Biology, Immune Profiles, and Therapeutic Vulnerabilities
- (2015) F. Skoulidis et al. Cancer Discovery
- Amino Acids Stimulate TORC1 through Lst4-Lst7, a GTPase-Activating Protein Complex for the Rag Family GTPase Gtr2
- (2015) Marie-Pierre Péli-Gulli et al. Cell Reports
- Spatial Control of the TSC Complex Integrates Insulin and Nutrient Regulation of mTORC1 at the Lysosome
- (2014) Suchithra Menon et al. CELL
- BRAF V600E Cooperates with PI3K Signaling, Independent of AKT, to Regulate Melanoma Cell Proliferation
- (2014) Jillian M. Silva et al. MOLECULAR CANCER RESEARCH
- WIPI2 Links LC3 Conjugation with PI3P, Autophagosome Formation, and Pathogen Clearance by Recruiting Atg12–5-16L1
- (2014) Hannah C. Dooley et al. MOLECULAR CELL
- Molecular genetics and cellular features of TFE3 and TFEB fusion kidney cancers
- (2014) Eric C. Kauffman et al. Nature Reviews Urology
- The Nutrient-Responsive Transcription Factor TFE3 Promotes Autophagy, Lysosomal Biogenesis, and Clearance of Cellular Debris
- (2014) J. A. Martina et al. Science Signaling
- A Four-Step Cycle Driven by PI(4)P Hydrolysis Directs Sterol/PI(4)P Exchange by the ER-Golgi Tether OSBP
- (2013) Bruno Mesmin et al. CELL
- SEACing the GAP that nEGOCiates TORC1 activation
- (2013) Nicolas Panchaud et al. CELL CYCLE
- Rag GTPases mediate amino acid–dependent recruitment of TFEB and MITF to lysosomes
- (2013) Jose A. Martina et al. JOURNAL OF CELL BIOLOGY
- The Folliculin Tumor Suppressor Is a GAP for the RagC/D GTPases That Signal Amino Acid Levels to mTORC1
- (2013) Zhi-Yang Tsun et al. MOLECULAR CELL
- mTOR kinase structure, mechanism and regulation
- (2013) Haijuan Yang et al. NATURE
- TFEB controls cellular lipid metabolism through a starvation-induced autoregulatory loop
- (2013) Carmine Settembre et al. NATURE CELL BIOLOGY
- MXL-3 and HLH-30 transcriptionally link lipolysis and autophagy to nutrient availability
- (2013) Eyleen J. O’Rourke et al. NATURE CELL BIOLOGY
- mTORC1 Phosphorylation Sites Encode Their Sensitivity to Starvation and Rapamycin
- (2013) S. A. Kang et al. SCIENCE
- A Tumor Suppressor Complex with GAP Activity for the Rag GTPases That Signal Amino Acid Sufficiency to mTORC1
- (2013) L. Bar-Peled et al. SCIENCE
- Amino Acid Deprivation Inhibits TORC1 Through a GTPase-Activating Protein Complex for the Rag Family GTPase Gtr1
- (2013) N. Panchaud et al. Science Signaling
- Acquisition of epithelial–mesenchymal transition and cancer stem cell phenotypes is associated with activation of the PI3K/Akt/mTOR pathway in prostate cancer radioresistance
- (2013) L Chang et al. Cell Death & Disease
- MTORC1 functions as a transcriptional regulator of autophagy by preventing nuclear transport of TFEB
- (2012) Jose A. Martina et al. Autophagy
- Ragulator Is a GEF for the Rag GTPases that Signal Amino Acid Levels to mTORC1
- (2012) Liron Bar-Peled et al. CELL
- Leucyl-tRNA Synthetase Is an Intracellular Leucine Sensor for the mTORC1-Signaling Pathway
- (2012) Jung Min Han et al. CELL
- Hepatic mTORC2 Activates Glycolysis and Lipogenesis through Akt, Glucokinase, and SREBP1c
- (2012) Asami Hagiwara et al. Cell Metabolism
- A lysosome-to-nucleus signalling mechanism senses and regulates the lysosome via mTOR and TFEB
- (2012) Carmine Settembre et al. EMBO JOURNAL
- Identification of Akt-independent Regulation of Hepatic Lipogenesis by Mammalian Target of Rapamycin (mTOR) Complex 2
- (2012) Minsheng Yuan et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Leucyl-tRNA Synthetase Controls TORC1 via the EGO Complex
- (2012) Grégory Bonfils et al. MOLECULAR CELL
- Regulation of mTORC1 by the Rag GTPases is necessary for neonatal autophagy and survival
- (2012) Alejo Efeyan et al. NATURE
- A unifying model for mTORC1-mediated regulation of mRNA translation
- (2012) Carson C. Thoreen et al. NATURE
- The translational landscape of mTOR signalling steers cancer initiation and metastasis
- (2012) Andrew C. Hsieh et al. NATURE
- Transcriptional integration of metabolism by the nuclear sterol-activated receptors LXR and FXR
- (2012) Anna C. Calkin et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Intratumor Heterogeneity and Branched Evolution Revealed by Multiregion Sequencing
- (2012) Marco Gerlinger et al. NEW ENGLAND JOURNAL OF MEDICINE
- Rapamycin-Induced Insulin Resistance Is Mediated by mTORC2 Loss and Uncoupled from Longevity
- (2012) D. W. Lamming et al. SCIENCE
- The Transcription Factor TFEB Links mTORC1 Signaling to Transcriptional Control of Lysosome Homeostasis
- (2012) A. Roczniak-Ferguson et al. Science Signaling
- Ego3 Functions as a Homodimer to Mediate the Interaction between Gtr1-Gtr2 and Ego1 in the EGO Complex to Activate TORC1
- (2012) Tianlong Zhang et al. STRUCTURE
- Crystal structure of the Gtr1p-Gtr2p complex reveals new insights into the amino acid-induced TORC1 activation
- (2011) R. Gong et al. GENES & DEVELOPMENT
- Characterization of the CLEAR network reveals an integrated control of cellular clearance pathways
- (2011) Michela Palmieri et al. HUMAN MOLECULAR GENETICS
- A Conserved Coatomer-related Complex Containing Sec13 and Seh1 Dynamically Associates With the Vacuole inSaccharomyces cerevisiae
- (2011) Svetlana Dokudovskaya et al. MOLECULAR & CELLULAR PROTEOMICS
- Structure of mammalian AMPK and its regulation by ADP
- (2011) Bing Xiao et al. NATURE
- mTORC1 Senses Lysosomal Amino Acids Through an Inside-Out Mechanism That Requires the Vacuolar H+-ATPase
- (2011) R. Zoncu et al. SCIENCE
- TFEB Links Autophagy to Lysosomal Biogenesis
- (2011) C. Settembre et al. SCIENCE
- Ragulator-Rag Complex Targets mTORC1 to the Lysosomal Surface and Is Necessary for Its Activation by Amino Acids
- (2010) Yasemin Sancak et al. CELL
- Activation of a Metabolic Gene Regulatory Network Downstream of mTOR Complex 1
- (2010) Katrin Düvel et al. MOLECULAR CELL
- Inactivation of the FLCN Tumor Suppressor Gene Induces TFE3 Transcriptional Activity by Increasing Its Nuclear Localization
- (2010) Seung-Beom Hong et al. PLoS One
- DEPTOR Is an mTOR Inhibitor Frequently Overexpressed in Multiple Myeloma Cells and Required for Their Survival
- (2009) Timothy R. Peterson et al. CELL
- The novel lipid raft adaptor p18 controls endosome dynamics by anchoring the MEK–ERK pathway to late endosomes
- (2009) Shigeyki Nada et al. EMBO JOURNAL
- ULK1·ATG13·FIP200 Complex Mediates mTOR Signaling and Is Essential for Autophagy
- (2009) Ian G. Ganley et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Glycolytic Flux Signals to mTOR through Glyceraldehyde-3-Phosphate Dehydrogenase-Mediated Regulation of Rheb
- (2009) M. N. Lee et al. MOLECULAR AND CELLULAR BIOLOGY
- Tor Directly Controls the Atg1 Kinase Complex To Regulate Autophagy
- (2009) Y. Kamada et al. MOLECULAR AND CELLULAR BIOLOGY
- Nutrient-dependent mTORC1 Association with the ULK1–Atg13–FIP200 Complex Required for Autophagy
- (2009) Nao Hosokawa et al. MOLECULAR BIOLOGY OF THE CELL
- The Vam6 GEF Controls TORC1 by Activating the EGO Complex
- (2009) Matteo Binda et al. MOLECULAR CELL
- BrafV600E cooperates with Pten loss to induce metastatic melanoma
- (2009) David Dankort et al. NATURE GENETICS
- Homozygous loss of BHD causes early embryonic lethality and kidney tumor development with activation of mTORC1 and mTORC2
- (2009) Y. Hasumi et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- A Gene Network Regulating Lysosomal Biogenesis and Function
- (2009) Marco Sardiello et al. SCIENCE
- HowSaccharomycesResponds to Nutrients
- (2008) Shadia Zaman et al. Annual Review of Genetics
- p53 Target Genes Sestrin1 and Sestrin2 Connect Genotoxic Stress and mTOR Signaling
- (2008) Andrei V. Budanov et al. CELL
- Hypoxia regulates TSC1/2 mTOR signaling and tumor suppression through REDD1-mediated 14 3 3 shuttling
- (2008) M. P. DeYoung et al. GENES & DEVELOPMENT
- AMPK Phosphorylation of Raptor Mediates a Metabolic Checkpoint
- (2008) Dana M. Gwinn et al. MOLECULAR CELL
- Regulation of TORC1 by Rag GTPases in nutrient response
- (2008) Eunjung Kim et al. NATURE CELL BIOLOGY
- The Rag GTPases Bind Raptor and Mediate Amino Acid Signaling to mTORC1
- (2008) Y. Sancak et al. SCIENCE
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