Article
Agriculture, Multidisciplinary
Hyun Kyung Kim, Yejee Park, Minhye Shin, Jun-Mo Kim, Gwang-woong Go
Summary: Betulinic acid reduces intracellular lipid accumulation and inhibits mTOR/S6K/S6 pathway activity by inhibiting insulin and IGF1 signaling pathways. These findings suggest that betulinic acid may be an effective natural nutraceutical for the treatment of metabolic syndromes.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2021)
Article
Chemistry, Medicinal
Miao Luo, Xiaoyan Ma, Weiling Jiang, Jun Zhang, Wukun Liu, Shuang Wei, Huiguo Liu
Summary: The upregulation of lipid metabolism is a common characteristic change in tumor cells. This study investigated the effects of phosphanegold(I) thiolate complexes on the regulation of lipid metabolism in lung cancer cells. The complexes inhibited lung cancer cell growth, impaired mitochondrial structure and function, reduced endogenous fatty acid and phospholipid synthesis, and induced apoptosis in lung cancer cells.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Article
Agriculture, Multidisciplinary
Lu Ma, Xuekai Tian, Fengxue Xi, Yulin He, Dong Li, Jingchun Sun, Tiantian Yuan, Ke Li, Lin Fan, Chunlei Zhang, Gongshe Yang, Taiyong Yu
Summary: A study found that the disruption of Tas1r1 gene in mice leads to changes in lipid metabolism, resulting in reduced fat accumulation, decreased lipid synthesis, and increased lipid catabolism. This suggests that umami receptors play an important role in regulating lipid metabolism.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Review
Biochemistry & Molecular Biology
Yongjun Kou, Feng Geng, Deliang Guo
Summary: This review summarizes the recent progress in understanding lipid metabolism regulation in GBM and discusses novel strategies to induce lipotoxicity in tumor cells by disrupting lipid storage. These findings provide new directions for treating GBM.
Article
Agriculture, Dairy & Animal Science
Gregory S. Archer, Eric B. Sobotik
Summary: With the increased interest in improving broiler performance and carcass yield, there has been a study conducted to evaluate the effects of phosphatidic acid (PA) supplementation on broiler growth performance and carcass yield. The results showed that PA supplementation for 42 days can increase live weights, improve feed conversion ratio (FCR), increase carcass yields, and increase breast fillet weight at processing.
Article
Biochemistry & Molecular Biology
Liang Huang, Qichao Liao, Tingli Pan, Yu Sun, Zhier Aluo, Lianggui Xiao, Jingsu Yu, Siqi Liu, Yang Xiao, Yufeng Yang, Yixing Li, Lei Zhou
Summary: This study highlights the importance of CIDEC in lipid metabolism, particularly in the small intestine. Knockout mice with a specific deletion of CIDEC in the small intestine showed improved lipid metabolism, including decreased body weight, body fat mass, and liver triglycerides. Mechanistic studies revealed that CIDEC interacts with 1-acylglycerol-3-phosphate-O-acyltransferase to promote phosphatidic acid synthesis and TG accumulation.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2022)
Article
Environmental Sciences
Youjin Wang, Yuqing Liang, Zansheng Yuan, Wanwen Mai, Yang Leng, Runze Zhang, Jiayan Chen, Caiyong Lai, Hongxia Chen, Xiaoping Wu, Chao Sheng, Qihao Zhang
Summary: Cadmium exposure increases LDs size and reduces cholesterol and progesterone levels in Leydig cells. The accumulation of PA regulated by the PLC beta 2-DAG-DGKε signal pathway is responsible for the formation of large LDs and insufficient steroid hormone synthesis.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Article
Cell Biology
Sophia Urbanczyk, Olivier R. Baris, Joerg Hofmann, R. Verena Taudte, Naig Guegen, Florian Golombek, Kathrin Castiglione, Xianyi Meng, Aline Bozec, Jana Thomas, Leonie Weckwerth, Dimitrios Mougiakakos, Sebastian R. Schulz, Wolfgang Schuh, Ursula Schloetzer-Schrehardt, Tobit D. Steinmetz, Susanne Brodesser, Rudolf J. Wiesner, Dirk Mielenz
Summary: The metabolism of activated B cells is regulated by mitochondrial DNA and oxidative phosphorylation (OxPhos), which plays a crucial role in promoting humoral immunity.
Article
Multidisciplinary Sciences
Dolma Michellod, Tanja Bien, Daniel Birgel, Marlene Violette, Manuel Kleiner, Sarah Fearn, Caroline Zeidler, Harald R. Gruber-Vodicka, Nicole Dubilier, Manuel Liebeke
Summary: Using various techniques, such as metabolite imaging and enzyme assays, we have discovered that gutless marine annelids synthesize the plant sterol sitosterol, which is commonly found in plants. This synthesis is facilitated by a noncanonical C-24 sterol methyltransferase, an enzyme that is essential for sitosterol synthesis in plants but not widely known in most animals. Our phylogenetic analyses also indicate that this enzyme is present in representatives of at least five animal phyla, suggesting that the synthesis of plant-like sterols is more common in animals than previously believed.
Article
Biochemistry & Molecular Biology
Eunus S. Ali, Anna Liponska, Brendan P. O'Hara, David R. Amici, Michael D. Torno, Peng Gao, John M. Asara, Mee-Ngan F. Yap, Marc L. Mendillo, Issam Ben-Sahra
Summary: The study reveals that mTORC1 regulates the utilization of environmental bicarbonate by controlling the expression of SLC4A7, which promotes nucleotide synthesis and cell growth.
Article
Chemistry, Multidisciplinary
Xueting Zhou, Qingqin Huang, Jiami Guo, Lei Dai, Yixin Lu
Summary: This study reports a simple and efficient method for the enantioselective synthesis of chiral α,α-diaryl ketones using chiral phosphoric acid catalysis, which also serves as an efficient method for the preparation of enantiomerically enriched deuterated α,α-diaryl ketones. This methodology is of great significance for the synthesis of bioactive molecules.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Multidisciplinary Sciences
Iqbal Mahmud, Guimei Tian, Jia Wang, Tarun E. Hutchinson, Brandon J. Kim, Nikee Awasthee, Seth Hale, Chengcheng Meng, Allison Moore, Liming Zhao, Jessica E. Lewis, Aaron Waddell, Shangtao Wu, Julia M. Steger, McKenzie L. Lydon, Aaron Chait, Lisa Y. Zhao, Haocheng Ding, Jian-Liang Li, Hamsa Thayele Purayil, Zhiguang Huo, Yehia Daaka, Timothy J. Garrett, Daiqing Liao
Summary: The authors find that DAXX promotes lipogenesis and tumorigenesis through interaction with SREBP1/2. Lipid production-related genes are highly upregulated in cancer cells, but the mechanisms controlling their expression are not well understood. DAXX acts as a regulator of oncogenic lipogenesis by interacting with SREBP1 and SREBP2.
NATURE COMMUNICATIONS
(2023)
Article
Biotechnology & Applied Microbiology
Jiu-Ying Sun, Jian-Qun Deng, Ran-Ran Du, Si-Yu Xin, Ya-Lin Cao, Zhen Lu, Xue-Ping Guo, Feng-Shan Wang, Ju-Zheng Sheng
Summary: In this study, a novel bacterial beta-1,4 N-acetylglucosaminyltransferase (EcGnT) derived from Escherichia coli was identified and characterized for the efficient synthesis of hyaluronic acid (HA) oligosaccharides. The EcGnT exhibited superior activity compared to the commonly used PmHAS in the initial steps of HA synthesis, making it a better option for de novo HA oligosaccharide production. A biocatalytic approach was developed using the disaccharide produced by EcGnT as a starting material, followed by stepwise synthesis of longer oligosaccharides using PmHAS, enabling size-controlled production of HA oligosaccharides.
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
(2023)
Article
Virology
Pu Yang, Yuncong Yuan, Yidan Sun, Bonan Lv, Hang Du, Zhou Zhou, Zhuang Yang, Xuemei Liu, Huimin Duan, Chao Shen
Summary: Research shows that HDAC1 promotes the replication of FMDV by upregulating RNA and protein levels, while activation of the AKT-mTOR signaling pathway also promotes replication. Suppression of CAD, a downstream transcription factor of the AKT-mTOR pathway, leads to downregulation of FMDV levels. The CAD ACTase domain interacts with the FMDV 2C protein and is involved in de novo pyrimidine synthesis.
JOURNAL OF VIROLOGY
(2023)
Article
Cell Biology
Jolanta Zelasko, Aleksander Czogalla
Summary: This study investigated the specific recognition of different physiologically important phosphatidic acid (PA) species by the mTOR FRB domain and found that the length and saturation of PA acyl chains influence the binding of mTOR FRB domain to the membrane. Moreover, cholesterol was found to modulate the recognition of PA-FRB. These findings provide insights into the molecular details of physiological effects and reveal novel mechanisms for fine-tuning signaling cascades dependent on PA.
Article
Medicine, Research & Experimental
Akrit Sodhi, Tao Ma, Deepak Menon, Monika Deshpande, Kathleen Jee, Aumreetam Dinabandhu, Jordan Vancel, Daoyuan Lu, Silvia Montaner
JOURNAL OF CLINICAL INVESTIGATION
(2019)
Article
Biochemistry & Molecular Biology
Maria A. Frias, Suman Mukhopadhyay, Elyssa Lehman, Aleksandra Walasek, Matthew Utter, Deepak Menon, David A. Foster
JOURNAL OF BIOLOGICAL CHEMISTRY
(2020)
Article
Dentistry, Oral Surgery & Medicine
Ghalia Bhadila, Xiaohong Wang, Wen Zhou, Deepak Menon, Mary Ann S. Melo, Silvia Montaner, Thomas W. Oates, Michael D. Weir, Jirun Sun, Hockin H. K. Xu
JOURNAL OF DENTISTRY
(2020)
Article
Cell Biology
Reeja S. Maskey, Fang Wang, Elyssa Lehman, Yiqun Wang, Natasha Emmanuel, Wenyan Zhong, Guixian Jin, Robert T. Abraham, Kim T. Arndt, Jeremy S. Myers, Anthony Mazurek
Summary: Palbociclib, a new drug used for the treatment of advanced estrogen receptor positive breast cancer, acts as a cytostatic agent by inhibiting CDK4/6 kinase. Research indicates that sustained mTORC1 activity may promote complete senescence in ER+ breast cancer cells during CDK4/6 inhibitor-induced cell cycle arrest.
Article
Engineering, Biomedical
Ghalia Bhadila, Deepak Menon, Xiaohong Wang, Taissa Vila, Mary Ann S. Melo, Silvia Montaner, Dwayne D. Arola, Michael D. Weir, Jirun Sun, Hockin H. K. Xu
Summary: The study demonstrated that the new bioactive composite material exhibited low cytotoxicity, antibacterial properties, and maintained long-term antibacterial activity after aging for 90 days.
JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION
(2021)
Article
Oncology
Sohag Chakraborty, Matthew B. Utter, Maria A. Frias, David A. Foster
Summary: This study reveals that mutations in the RB and CDKN2A genes in cancer cells lead to resistance to rapamycin, which can be reversed by restoring wild type RB or inhibiting E2F activity. This has important implications for precision medicine approaches to anti-cancer therapies.
Article
Medicine, Research & Experimental
Yu Qin, Aumreetam Dinabandhu, Xuan Cao, Jaron Castillo Sanchez, Kathleen Jee, Murilo Rodrigues, Chuanyu Guo, Jing Zhang, Jordan Vancel, Deepak Menon, Noore-Sabah Khan, Tao Ma, Stephany Y. Tzeng, Yassine Daoud, Jordan J. Green, Gregg L. Semenza, Silvia Montaner, Akrit Sodhi
Article
Multidisciplinary Sciences
Ahmet Hatipoglu, Deepak Menon, Talia Levy, Maria A. Frias, David A. Foster
Summary: Inhibition of glutamate oxaloacetate transaminase and ACLY in KRas-driven cancer cells leads to cell death, revealing a synthetic lethality specific to these cells.
Review
Endocrinology & Metabolism
Maria A. Frias, Ahmet Hatipoglu, David A. Foster
Summary: mTORC1, a key regulator of cellular physiology, is activated by the lipid metabolite phosphatidic acid (PA). PA binds to a conserved sequence in the alpha 4 helix of mTOR's FKBP12/rapamycin-binding (FRB) domain. This binding disrupts and shortens the C-terminal region of the alpha 4 helix, resulting in significant consequences for substrate binding and catalytic activity of mTORC1.
TRENDS IN ENDOCRINOLOGY AND METABOLISM
(2023)
Article
Cell Biology
Eman Hefni, Deepak Menon, Tao Ma, Emmanuel B. Asiedu, Ahmed Sultan, Timothy Meiller, Abraham Schneider, Akrit Sodhi, Silvia Montaner
Summary: This study investigated the molecular mechanisms of angiopoietin-like 4 (ANGPTL4) in the growth and dissemination of head and neck squamous cell carcinoma (HNSCC). It was found that ANGPTL4 was upregulated in premalignant cells and HNSCC cell lines, as well as tissue samples from patients with oral dysplasia and HNSCC. Furthermore, ANGPTL4 was found to promote tumor cell migration through its binding to neuropilin1 (NRP1) and subsequent phosphorylation of focal adhesion protein, paxillin (PXN), in a pathway dependent on ABL1 tyrosine kinase. Inhibition of ABL1 or NRP1 expression blocked this pathway and inhibited tumor cell migration.
CELLULAR SIGNALLING
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Sabha Ahmed, Ankit Arora, Karthik Kulanthaivelu, Jitender Saini, Deepak Menon, Dhritiman Chakrabarti
Summary: This study evaluated the accuracy of 3D-T1 turbo spin echo (T1S) sequences in detecting venous thrombosis and compared it with other conventional sequences. The results showed that T1S demonstrated similar accuracy to conventional sequences in overall detection of CVT, but showed superior accuracy in detecting cortical venous thrombosis.
EMERGENCY RADIOLOGY
(2023)
Meeting Abstract
Ophthalmology
Silvia Montaner Sodhi, Deepak Menon, Tao Ma, Monika Deshpande, Kathleen Jee, Aumreetam Dinabandhu, Jordan Vancel, Akrit Sodhi
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2020)