Transcriptional integration of metabolism by the nuclear sterol-activated receptors LXR and FXR

Liver X receptors regulate de novo lipogenesis in a tissue-specific manner in C57BL/6 female mice

(2011) Marion Korach-André et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

FGF15/19 Regulates Hepatic Glucose Metabolism by Inhibiting the CREB-PGC-1α Pathway

(2011) Matthew J. Potthoff et al.   Cell Metabolism

Farnesoid X Receptor Deficiency Improves Glucose Homeostasis in Mouse Models of Obesity

(2011) J. Prawitt et al.   DIABETES

The IDOL-UBE2D complex mediates sterol-dependent degradation of the LDL receptor

(2011) L. Zhang et al.   GENES & DEVELOPMENT

Lowering Bile Acid Pool Size with a Synthetic Farnesoid X Receptor (FXR) Agonist Induces Obesity and Diabetes through Reduced Energy Expenditure

(2011) Mitsuhiro Watanabe et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Aldo-keto reductase 1B7 is a target gene of FXR and regulates lipid and glucose homeostasis

(2011) Xuemei Ge et al.   JOURNAL OF LIPID RESEARCH

FERM-dependent E3 ligase recognition is a conserved mechanism for targeted degradation of lipoprotein receptors

(2011) A. C. Calkin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

ATP binding cassette transporter G1 (ABCG1) is an intracellular sterol transporter

(2011) E. J. Tarling et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

FGF19 as a Postprandial, Insulin-Independent Activator of Hepatic Protein and Glycogen Synthesis

(2011) S. Kir et al.   SCIENCE

Colesevelam improves insulin resistance in a diet-induced obesity (F-DIO) rat model by increasing the release of GLP-1

(2010) Quan Shang et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Tissue-Specific Liver X Receptor Activation Promotes Macrophage Reverse Cholesterol Transport In Vivo

(2010) Tomoyuki Yasuda et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Suggestive evidence of associations between liver X receptor β polymorphisms with type 2 diabetes mellitus and obesity in three cohort studies: HUNT2 (Norway), MONICA (France) and HELENA (Europe)

(2010) Karianne Solaas et al.   BMC Medical Genetics

Transgenic expression of cholesterol 7α-hydroxylase in the liver prevents high-fat diet-induced obesity and insulin resistance in mice

(2010) Tiangang Li et al.   HEPATOLOGY

The E3 Ubiquitin Ligase IDOL Induces the Degradation of the Low Density Lipoprotein Receptor Family Members VLDLR and ApoER2

(2010) Cynthia Hong et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Non-redundant roles for LXR  and LXR  in atherosclerosis susceptibility in low density lipoprotein receptor knockout mice

(2010) E. D. Bischoff et al.   JOURNAL OF LIPID RESEARCH

Constitutive activation of LXR in macrophages regulates metabolic and inflammatory gene expression: identification of ARL7 as a direct target

(2010) Cynthia Hong et al.   JOURNAL OF LIPID RESEARCH

Genetic variation within the NR1H2 gene encoding liver X receptor β associates with insulin secretion in subjects at increased risk for type 2 diabetes

(2010) Caroline Ketterer et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Activation of the Farnesoid X Receptor Provides Protection against Acetaminophen-Induced Hepatic Toxicity

(2010) Florence Ying Lee et al.   MOLECULAR ENDOCRINOLOGY

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(2010) Gie Ken-Dror et al.   MOLECULAR MEDICINE

Both liver-X receptor (LXR) isoforms control energy expenditure by regulating Brown Adipose Tissue activity

(2010) M. Korach-Andre et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Activation of Liver X Receptor Regulates Substrate Oxidation in White Adipocytes

(2009) Britta M. Stenson et al.   ENDOCRINOLOGY

Activation of the Liver X Receptor Stimulates Trans-intestinal Excretion of Plasma Cholesterol

(2009) Jelske N. van der Veen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Liver X Receptor Agonists Augment Human Islet Function through Activation of Anaplerotic Pathways and Glycerolipid/Free Fatty Acid Cycling

(2009) Takeshi Ogihara et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

c-Jun N-Terminal Kinase 1/2 Activation by Tumor Necrosis Factor-α Induces Insulin Resistance In Human Visceral But Not Subcutaneous Adipocytes: Reversal by Liver X Receptor Agonists

(2009) Sonia Fernández-Veledo et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Activation of farnesoid X receptor prevents atherosclerotic lesion formation in LDLR−/−and apoE−/−mice

(2009) Helen B. Hartman et al.   JOURNAL OF LIPID RESEARCH

FXR activation reverses insulin resistance and lipid abnormalities and protects against liver steatosis in Zucker (fa/fa) obese rats

(2009) Sabrina Cipriani et al.   JOURNAL OF LIPID RESEARCH

Discovery of XL335 (WAY-362450), a Highly Potent, Selective, and Orally Active Agonist of the Farnesoid X Receptor (FXR)

(2009) Brenton Flatt et al.   JOURNAL OF MEDICINAL CHEMISTRY

LXR Regulates Cholesterol Uptake Through Idol-Dependent Ubiquitination of the LDL Receptor

(2009) Noam Zelcer et al.   SCIENCE

Antiatherosclerotic effect of farnesoid X receptor

(2008) Andrea Mencarelli et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Colesevelam Hydrochloride Therapy in Patients With Type 2 Diabetes Mellitus Treated With Metformin

(2008) Harold E. Bays et al.   ARCHIVES OF INTERNAL MEDICINE

Effect of Macrophage Overexpression of Murine Liver X Receptor -α ( LXR -α) on Atherosclerosis in LDL-Receptor Deficient Mice

(2008) Daniel Teupser et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Coordination of inflammation and metabolism by PPAR and LXR nuclear receptors

(2008) Cynthia Hong et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

LXR agonist suppresses atherosclerotic lesion growth and promotes lesion regression in apoE*3Leiden mice: time course and mechanisms

(2008) Lars Verschuren et al.   JOURNAL OF LIPID RESEARCH