Epitope editing enables targeted immunotherapy of acute myeloid leukaemia

Improving adenine and dual base editors through introduction of TadA-8e and Rad51DBD

(2023) Niannian Xue et al.   Nature Communications

Longitudinal single-cell profiling of chemotherapy response in acute myeloid leukemia

(2023) Matteo Maria Naldini et al.   Nature Communications

Choice of template delivery mitigates the genotoxic risk and adverse impact of editing in human hematopoietic stem cells

(2022) Samuele Ferrari et al.   Cell Stem Cell

Modeling, optimization, and comparable efficacy of T cell and hematopoietic stem cell gene editing for treating hyper‐IgM syndrome

(2021) Valentina Vavassori et al.   EMBO Molecular Medicine

Anti-CD117 immunotherapy to eliminate hematopoietic and leukemia stem cells

(2021) Norman F. Russkamp et al.   EXPERIMENTAL HEMATOLOGY

Acute myeloid leukemia: current progress and future directions

(2021) Hagop Kantarjian et al.   Blood Cancer Journal

Chromothripsis as an on-target consequence of CRISPR–Cas9 genome editing

(2021) Mitchell L. Leibowitz et al.   NATURE GENETICS

Structure-guided engineering of adenine base editor with minimized RNA off-targeting activity

(2021) Jianan Li et al.   Nature Communications

Immunotherapy in Acute Myeloid Leukemia: Where We Stand

(2021) Alessandro Isidori et al.   Frontiers in Oncology

Catalytically Enhanced Cas9 Through Directed Protein Evolution

(2021) Travis H. Hand et al.   CRISPR Journal

BAR-Seq clonal tracking of gene-edited cells

(2021) Samuele Ferrari et al.   Nature Protocols

Demethylating therapy increases anti-CD123 CAR T cell cytotoxicity against acute myeloid leukemia

(2021) Nadia El Khawanky et al.   Nature Communications

Investigating RNA editing in deep transcriptome datasets with REDItools and REDIportal

(2020) Claudio Lo Giudice et al.   Nature Protocols

Anti-human CD117 CAR T-cells efficiently eliminate healthy and malignant CD117-expressing hematopoietic cells

(2020) Renier Myburgh et al.   LEUKEMIA

Efficient gene editing of human long-term hematopoietic stem cells validated by clonal tracking

(2020) Samuele Ferrari et al.   NATURE BIOTECHNOLOGY

Overexpression of CD200 and CD123 is a major influential factor in the clinical course of pediatric acute myeloid leukemia

(2020) Eman Z. Kandeel et al.   EXPERIMENTAL AND MOLECULAR PATHOLOGY

Precise Gene Editing Preserves Hematopoietic Stem Cell Function following Transient p53-Mediated DNA Damage Response

(2019) Giulia Schiroli et al.   Cell Stem Cell

Gene-edited stem cells enable CD33-directed immune therapy for myeloid malignancies

(2019) Florence Borot et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Chimeric Antigen Receptor (CAR) T Cell Therapy in Acute Myeloid Leukemia (AML)

(2019) Susanne Hofmann et al.   Journal of Clinical Medicine

Genetic Inactivation of CD33 in Hematopoietic Stem Cells to Enable CAR T Cell Immunotherapy for Acute Myeloid Leukemia

(2018) Miriam Y. Kim et al.   CELL

Precision therapy for acute myeloid leukemia

(2018) Xue Yang et al.   Journal of Hematology & Oncology

CAR T-cells targeting FLT3 have potent activity against FLT3−ITD+ AML and act synergistically with the FLT3-inhibitor crenolanib

(2018) Hardikkumar Jetani et al.   LEUKEMIA

Coexpression profile of leukemic stem cell markers for combinatorial targeted therapy in AML

(2018) S. Haubner et al.   LEUKEMIA

CRISPR/Cas9 genome editing in human hematopoietic stem cells

(2018) Rasmus O Bak et al.   Nature Protocols

A Flow Cytometry‐Based Assay for High‐Throughput Detection and Quantification of Neutrophil Extracellular Traps in Mixed Cell Populations

(2018) Olga Zharkova et al.   CYTOMETRY PART A

CD123 expression levels in 846 acute leukemia patients based on standardized immunophenotyping

(2018) Anne E. Bras et al.   CYTOMETRY PART B-CLINICAL CYTOMETRY

Engineering resistance to CD33-targeted immunotherapy in normal hematopoiesis by CRISPR/Cas9-deletion of CD33 exon 2

(2018) Olivier Humbert et al.   LEUKEMIA

Orthogonal Cas9–Cas9 chimeras provide a versatile platform for genome editing

(2018) Mehmet Fatih Bolukbasi et al.   Nature Communications

Targeting FLT3 by chimeric antigen receptor T cells for the treatment of acute myeloid leukemia

(2017) L Chen et al.   LEUKEMIA

multiplierz v2.0: A Python-based ecosystem for shared access and analysis of native mass spectrometry data

(2017) William M. Alexander et al.   PROTEOMICS

Megakaryocyte Differentiation and Platelet Formation from Human Cord Blood-derived CD34+ Cells

(2017) Jose Perdomo et al.   Jove-Journal of Visualized Experiments

In Vivo Tracking of Human Hematopoiesis Reveals Patterns of Clonal Dynamics during Early and Steady-State Reconstitution Phases

(2016) Luca Biasco et al.   Cell Stem Cell

CD19 CAR immune pressure induces B-precursor acute lymphoblastic leukaemia lineage switch exposing inherent leukaemic plasticity

(2016) Elad Jacoby et al.   Nature Communications

Catch me if you can: Leukemia Escape after CD19-Directed T Cell Immunotherapies

(2016) Marco Ruella et al.   Computational and Structural Biotechnology Journal

CD33-specific chimeric antigen receptor T cells exhibit potent preclinical activity against human acute myeloid leukemia

(2015) S S Kenderian et al.   LEUKEMIA

Convergence of Acquired Mutations and Alternative Splicing of CD19 Enables Resistance to CART-19 Immunotherapy

(2015) E. Sotillo et al.   Cancer Discovery

High Expression of c-kit mRNA Predicts Unfavorable Outcome in Adult Patients with t(8;21) Acute Myeloid Leukemia

(2015) Xiaoning Gao et al.   PLoS One

Preclinical targeting of human acute myeloid leukemia and myeloablation using chimeric antigen receptor-modified T cells

(2014) S. Gill et al.   BLOOD

Targeted genome editing in human repopulating haematopoietic stem cells

(2014) Pietro Genovese et al.   NATURE

GUIDE-seq enables genome-wide profiling of off-target cleavage by CRISPR-Cas nucleases

(2014) Shengdar Q Tsai et al.   NATURE BIOTECHNOLOGY

Dual Mechanism of Interleukin-3 Receptor Blockade by an Anti-Cancer Antibody

(2014) Sophie E. Broughton et al.   Cell Reports

Chimeric Antigen Receptor–Modified T Cells for Acute Lymphoid Leukemia

(2013) Stephan A. Grupp et al.   NEW ENGLAND JOURNAL OF MEDICINE

Structural basis for KIT receptor tyrosine kinase inhibition by antibodies targeting the D4 membrane-proximal region

(2013) A. V. Reshetnyak et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

CD19-Targeted T Cells Rapidly Induce Molecular Remissions in Adults with Chemotherapy-Refractory Acute Lymphoblastic Leukemia

(2013) R. J. Brentjens et al.   Science Translational Medicine

STAR: ultrafast universal RNA-seq aligner

(2012) Alexander Dobin et al.   BIOINFORMATICS

IL-7 and IL-15 instruct the generation of human memory stem T cells from naive precursors

(2012) N. Cieri et al.   BLOOD

Generation, selection and preclinical characterization of an Fc-optimized FLT3 antibody for the treatment of myeloid leukemia

(2012) M Hofmann et al.   LEUKEMIA

Stem Cell Factor Receptor/c-Kit: From Basic Science to Clinical Implications

(2012) Johan Lennartsson et al.   PHYSIOLOGICAL REVIEWS

A transgene-encoded cell surface polypeptide for selection, in vivo tracking, and ablation of engineered cells

(2011) X. Wang et al.   BLOOD

Online Nanoflow Multidimensional Fractionation for High Efficiency Phosphopeptide Analysis

(2011) Scott B. Ficarro et al.   MOLECULAR & CELLULAR PROTEOMICS

Gamma-1-Syntrophin Mediates Trafficking of Gamma-Enolase towards the Plasma Membrane and Enhances Its Neurotrophic Activity

(2011) Anja Hafner et al.   NEUROSIGNALS

A recombinant trispecific single-chain Fv derivative directed against CD123 and CD33 mediates effective elimination of acute myeloid leukaemia cells by dual targeting

(2010) Markus Kügler et al.   BRITISH JOURNAL OF HAEMATOLOGY

Improved Electrospray Ionization Efficiency Compensates for Diminished Chromatographic Resolution and Enables Proteomics Analysis of Tyrosine Signaling in Embryonic Stem Cells

(2009) Scott B. Ficarro et al.   ANALYTICAL CHEMISTRY

Loss of Mismatched HLA in Leukemia after Stem-Cell Transplantation

(2009) Luca Vago et al.   NEW ENGLAND JOURNAL OF MEDICINE