PPARɑ Ligand Caudatin Improves Cognitive Functions and Mitigates Alzheimer’s Disease Defects By Inducing Autophagy in Mice Models

Delivery of Apoplastic Extracellular Vesicles Encapsulating Green-Synthesized Silver Nanoparticles to Treat Citrus Canker

(2023) Isha Gaurav et al.   Nanomaterials

Enhancing autophagy maturation with CCZ1-MON1A complex alleviates neuropathology and memory defects in Alzheimer disease models

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Corynoxine B derivative CB6 prevents Parkinsonian toxicity in mice by inducing PIK3C3 complex-dependent autophagy

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Celastrol, a TFEB (transcription factor EB) agonist, is a promising drug candidate for Alzheimer disease

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Theranostic F-SLOH mitigates Alzheimer's disease pathology involving TFEB and ameliorates cognitive functions in Alzheimer's disease models

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Real-Time Detection and Visualization of Amyloid-β Aggregates Induced by Hydrogen Peroxide in Cell and Mouse Models of Alzheimer’s Disease

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Lithium Enhances Hippocampal Glucose Metabolism in an In Vitro Mice Model of Alzheimer’s Disease

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Bromo-protopine, a novel protopine derivative, alleviates tau pathology by activating chaperone-mediated autophagy for Alzheimer’s disease therapy

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Lithium Provides Broad Therapeutic Benefits in an Alzheimer’s Disease Mouse Model

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Electroacupuncture ameliorates beta-amyloid pathology and cognitive impairment in Alzheimer disease via a novel mechanism involving activation of TFEB (transcription factor EB)

(2021) Xiaoyan Zheng et al.   Autophagy

Factors Affecting Extracellular Vesicles Based Drug Delivery Systems

(2021) Isha Gaurav et al.   MOLECULES

Cerebrospinal Fluid Biomarkers of Alzheimer’s Disease: Current Evidence and Future Perspectives

(2021) Donovan A. McGrowder et al.   Brain Sciences

Acetylated tau inhibits chaperone-mediated autophagy and promotes tau pathology propagation in mice

(2021) Benjamin Caballero et al.   Nature Communications

TFEB, a master regulator of autophagy and biogenesis, unexpectedly promotes apoptosis in response to the cyclopentenone prostaglandin 15d-PGJ2

(2021) Chuan-bin Yang et al.   ACTA PHARMACOLOGICA SINICA

Autophagy in Alzheimer’s Disease Pathogenesis: Therapeutic Potential and Future Perspectives

(2021) Zhigang Zhang et al.   AGEING RESEARCH REVIEWS

Lysosomal TPCN (two pore segment channel) inhibition ameliorates beta-amyloid pathology and mitigates memory impairment in Alzheimer disease

(2021) Benjamin Chun-Kit Tong et al.   Autophagy

The informed road map to prevention of Alzheimer Disease: A call to arms

(2021) Eric McDade et al.   Molecular Neurodegeneration

Autophagy deficiency modulates microglial lipid homeostasis and aggravates tau pathology and spreading

(2021) Yin Xu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

PPAR-α Agonist GW7647 Protects Against Oxidative Stress and Iron Deposit via GPx4 in a Transgenic Mouse Model of Alzheimer’s Diseases

(2021) Xiao-Xia Qu et al.   ACS Chemical Neuroscience

Presenilin/γ-Secretase Activity Is Located in Acidic Compartments of Live Neurons

(2021) Masato Maesako et al.   JOURNAL OF NEUROSCIENCE

The probabilistic model of Alzheimer disease: the amyloid hypothesis revised

(2021) Giovanni B. Frisoni et al.   NATURE REVIEWS NEUROSCIENCE

Protopine promotes the proteasomal degradation of pathological tau in Alzheimer's disease models via HDAC6 inhibition

(2021) Sravan Gopalkrishnashetty Sreenivasmurthy et al.   PHYTOMEDICINE

Qingyangshen mitigates amyloid-β and Tau aggregate defects involving PPARα-TFEB activation in transgenic mice of Alzheimer's disease

(2021) Ashok Iyaswamy et al.   PHYTOMEDICINE

Activation of PPARα enhances astroglial uptake and degradation of β-amyloid

(2021) Sumita Raha et al.   Science Signaling

Pharmacological enhancement of TFEB-mediated autophagy alleviated neuronal death in oxidative stress-induced Parkinson’s disease models

(2020) Xu-Xu Zhuang et al.   Cell Death & Disease

5-lipoxygenase pathway and its downstream cysteinyl leukotrienes as potential therapeutic targets for Alzheimer’s disease

(2020) Fang Chen et al.   BRAIN BEHAVIOR AND IMMUNITY

Synergy between amyloid-β and tau in Alzheimer’s disease

(2020) Marc Aurel Busche et al.   NATURE NEUROSCIENCE

Prolonged tau clearance and stress vulnerability rescue by pharmacological activation of autophagy in tauopathy neurons

(2020) M. Catarina Silva et al.   Nature Communications

Mechanisms of Pathogenic Tau and Aβ Protein Spreading in Alzheimer’s Disease

(2020) Paolo d‘Errico et al.   Frontiers in Aging Neuroscience

Traditional Chinese medicine compounds regulate autophagy for treating neurodegenerative disease: A mechanism review

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Amyloid-β oligomer targeted theranostic probes for in vivo NIR imaging and inhibition of self-aggregation and amyloid-β induced ROS generation

(2020) Xueli Wang et al.   TALANTA

Mitophagy inhibits amyloid-β and tau pathology and reverses cognitive deficits in models of Alzheimer’s disease

(2019) Evandro F. Fang et al.   NATURE NEUROSCIENCE

Activation of PPARA-mediated autophagy reduces Alzheimer disease-like pathology and cognitive decline in a murine model

(2019) Rongcan Luo et al.   Autophagy

Lithium as a Treatment for Alzheimer’s Disease: The Systems Pharmacology Perspective

(2019) Harald Hampel et al.   JOURNAL OF ALZHEIMERS DISEASE

Role of TREM2 in Alzheimer's disease and its consequences on β-amyloid, Tau and neurofibrillary tangles

(2019) Anurag Kumar Singh et al.   Current Alzheimer Research

NeuroDefend, a novel Chinese medicine, attenuates amyloid-β and tau pathology in experimental Alzheimer's disease models

(2019) Ashok Iyaswamy et al.   JOURNAL OF FOOD AND DRUG ANALYSIS

A small molecule transcription factor EB activator ameliorates beta‐amyloid precursor protein and Tau pathology in Alzheimer's disease models

(2019) Ju‐Xian Song et al.   AGING CELL

PPARα serves as a new receptor of aspirin for neuroprotection

(2019) Dhruv Patel et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Lithium chloride (LiCl) induced autophagy and downregulated expression of transforming growth factor β-induced protein (TGFBI) in granular corneal dystrophy

(2018) Danyao Nie et al.   EXPERIMENTAL EYE RESEARCH

Aspirin induces Lysosomal biogenesis and attenuates Amyloid plaque pathology in a mouse model of Alzheimer's disease via PPARα

(2018) Sujyoti Chandra et al.   JOURNAL OF NEUROSCIENCE

Aspirin binds to PPARα to stimulate hippocampal plasticity and protect memory

(2018) Dhruv Patel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Promoting the clearance of neurotoxic proteins in neurodegenerative disorders of ageing

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Trehalose induces autophagy via lysosomal-mediated TFEB activation in models of motoneuron degeneration

(2018) Paola Rusmini et al.   Autophagy

Cinnamic acid activates PPARα to stimulate Lysosomal biogenesis and lower Amyloid plaque pathology in an Alzheimer's disease mouse model

(2018) Sujyoti Chandra et al.   NEUROBIOLOGY OF DISEASE

C 21 steroidal glycosides from Cynanchum auriculatum and their neuroprotective effects against H 2 O 2 -induced damage in PC12 cells

(2017) Xicheng Qian et al.   PHYTOCHEMISTRY

Caudatin targets TNFAIP1/NF-κB and cytochrome c/caspase signaling to suppress tumor progression in human uterine cancer

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Amyloid β oligomers in Alzheimer’s disease pathogenesis, treatment, and diagnosis

(2015) Kirsten L. Viola et al.   ACTA NEUROPATHOLOGICA

PPARα Signaling in the Hippocampus: Crosstalk Between Fat and Memory

(2015) Avik Roy et al.   Journal of Neuroimmune Pharmacology

Pharmacokinetics and Tissue Distribution Study of Caudatin in Normal and Diethylnitrosamine-Induced Hepatocellular Carcinoma Model Rats

(2015) Yunru Peng et al.   MOLECULES

Determination of Caudatin in Rat Plasma by UPLC-MS/MS: Application to a Preclinical Pharmacokinetic Study

(2015) Qiqi Zhu et al.   PHARMACOLOGY

LigPlot+: Multiple Ligand–Protein Interaction Diagrams for Drug Discovery

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TFEB Links Autophagy to Lysosomal Biogenesis

(2011) C. Settembre et al.   SCIENCE

Identification of new qingyangshengenin and caudatin glycosides from the roots of Cynanchum otophyllum

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Adaptability and selectivity of human peroxisome proliferator-activated receptor (PPAR) pan agonists revealed from crystal structures

(2009) Takuji Oyama et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY