Display of recombinant proteins at the surface of lactic acid bacteria: strategies and applications

Lactobacillus plantarum vaccine vector expressing hemagglutinin provides protection against H9N2 challenge infection

(2016) Shao-Hua Shi et al.   VIRUS RESEARCH

Effects of orally applied Fes p1-displaying L. plantarum WCFS1 on Fes p1 induced allergy in mice

(2015) Rajna Minic et al.   JOURNAL OF BIOTECHNOLOGY

Expanding the biotechnology potential of lactobacilli through comparative genomics of 213 strains and associated genera

(2015) Zhihong Sun et al.   Nature Communications

Chromosomal Insertions in the Lactobacillus caseiuppGene That Are Useful for Vaccine Expression

(2014) Bai-fen Song et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Engineered Pentafunctional Minicellulosome for Simultaneous Saccharification and Ethanol Fermentation in Saccharomyces cerevisiae

(2014) Youyun Liang et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Exploiting the peptidoglycan-binding motif, LysM, for medical and industrial applications

(2014) Ganesh Ram R. Visweswaran et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Towards lactic acid bacteria-based biorefineries

(2014) Roberto Mazzoli et al.   BIOTECHNOLOGY ADVANCES

A combined cell-consortium approach for lignocellulose degradation by specialized Lactobacillus plantarum cells

(2014) Sarah Moraïs et al.   Biotechnology for Biofuels

Precision genome engineering in lactic acid bacteria

(2014) Jan Peter van Pijkeren et al.   Microbial Cell Factories

Heterologous Protein Secretion in Lactobacilli with Modified pSIP Vectors

(2014) Ingrid Lea Karlskås et al.   PLoS One

Oral vaccination against HPV E7 for treatment of cervical intraepithelial neoplasia grade 3 (CIN3) elicits E7-specific mucosal immunity in the cervix of CIN3 patients

(2014) Kei Kawana et al.   VACCINE

Molecular basis for bacterial peptidoglycan recognition by LysM domains

(2014) Stéphane Mesnage et al.   Nature Communications

Genetically Engineered Immunomodulatory Streptococcus thermophilus Strains Producing Antioxidant Enzymes Exhibit Enhanced Anti-Inflammatory Activities

(2013) Silvina del Carmen et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Establishment of a Simple Lactobacillus plantarum Cell Consortium for Cellulase-Xylanase Synergistic Interactions

(2013) Sarah Moraïs et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Immobilization of nisin producer Lactococcus lactis strains to chitin with surface-displayed chitin-binding domain

(2013) Ömer Şimşek et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Lactobacillus surface layer proteins: structure, function and applications

(2013) Ulla Hynönen et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Anti-obesity effects of gut microbiota are associated with lactic acid bacteria

(2013) Yueh-Ting Tsai et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Phase 1b, multicenter, single blinded, placebo-controlled, sequential dose escalation study to assess the safety and tolerability of topically applied AG013 in subjects with locally advanced head and neck cancer receiving induction chemotherapy

(2013) Sewanti Atul Limaye et al.   CANCER

New generation of oral mucosal vaccines targeting dendritic cells

(2013) Jennifer L Owen et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Engineering lactococci and lactobacilli for human health

(2013) Luis G. Bermúdez-Humarán et al.   CURRENT OPINION IN MICROBIOLOGY

A novel peptide carrier for efficient targeting of antigens and nucleic acids to dendritic cells

(2013) Mouldy Sioud et al.   FASEB JOURNAL

Development of a Stress-Inducible Controlled Expression (SICE) system in Lactococcus lactis for the production and delivery of therapeutic molecules at mucosal surfaces

(2013) Bouasria Benbouziane et al.   JOURNAL OF BIOTECHNOLOGY

Engineering BmpA as a carrier for surface display of IgG-binding domain on Lactococcus lactis

(2013) P. Zadravec et al.   PROTEIN ENGINEERING DESIGN & SELECTION

Surface Display of N-Terminally Anchored Invasin by Lactobacillus plantarum Activates NF-κB in Monocytes

(2012) Lasse Fredriksen et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Protection against human papillomavirus type 16-induced tumors in mice using non-genetically modified lactic acid bacteria displaying E7 antigen at its surface

(2012) Pedro Ribelles et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

In vitro and in vivo characterization of DNA delivery using recombinant Lactococcus lactis expressing a mutated form of L. monocytogenes Internalin A

(2012) Marcela de Azevedo et al.   BMC MICROBIOLOGY

Effects of synthetic cohesin-containing scaffold protein architecture on binding dockerin-enzyme fusions on the surface of Lactococcus lactis

(2012) Andrew S Wieczorek et al.   Microbial Cell Factories

Immunization against Leishmania major Infection Using LACK- and IL-12-Expressing Lactococcus lactis Induces Delay in Footpad Swelling

(2012) Felix Hugentobler et al.   PLoS One

Production of Fibronectin Binding Protein A at the Surface of Lactococcus lactis Increases Plasmid Transfer In Vitro and In Vivo

(2012) Daniela Pontes et al.   PLoS One

Self-surface assembly of cellulosomes with two miniscaffoldins on Saccharomyces cerevisiae for cellulosic ethanol production

(2012) L.-H. Fan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Avian reovirus sigma C enhances the mucosal and systemic immune responses elicited by antigen-conjugated lactic acid bacteria

(2012) Kuan-Hsun Lin et al.   VACCINE

Oral administration of HPV-16 L2 displayed on Lactobacillus casei induces systematic and mucosal cross-neutralizing effects in Balb/c mice

(2012) Sun-Woo Yoon et al.   VACCINE

Oral immunization using live Lactococcus lactis co-expressing LACK and IL-12 protects BALB/c mice against Leishmania major infection

(2012) Felix Hugentobler et al.   VACCINE

Mucosal Vaccination and Therapy with Genetically Modified Lactic Acid Bacteria

(2012) Jerry Wells   Annual Review of Food Science and Technology

Dissimilar Properties of Two Recombinant Lactobacillus acidophilus Strains Displaying Salmonella FliC with Different Anchoring Motifs

(2011) Akinobu Kajikawa et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

In situ gastrointestinal protection against anthrax edema toxin by single-chain antibody fragment producing lactobacilli

(2011) Kasper Andersen et al.   BMC BIOTECHNOLOGY

Directed evolution and targeted mutagenesis to murinize listeria monocytogenes internalin A for enhanced infectivity in the murine oral infection model

(2011) Ian R Monk et al.   BMC MICROBIOLOGY

Evaluation of Oral Immunization with Recombinant Avian Influenza Virus HA1 Displayed on the Lactococcus lactis Surface and Combined with the Mucosal Adjuvant Cholera Toxin Subunit B

(2011) Han Lei et al.   Clinical and Vaccine Immunology

Anti-inflammatory capacity of selected lactobacilli in experimental colitis is driven by NOD2-mediated recognition of a specific peptidoglycan-derived muropeptide

(2011) E. M. Fernandez et al.   GUT

A Food-Grade System for Inducible Gene Expression inLactobacillus plantarumUsing an Alanine Racemase-Encoding Selection Marker

(2011) Tien-Thanh Nguyen et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Oral immunization with live Lactococcus lactis expressing rotavirus VP8* subunit induces specific immune response in mice

(2011) Belkis Marelli et al.   JOURNAL OF VIROLOGICAL METHODS

Novel surface display system for heterogonous proteins on Lactobacillus plantarum

(2011) W. Xu et al.   LETTERS IN APPLIED MICROBIOLOGY

Heterologous protein display on the cell surface of lactic acid bacteria mediated by the s-layer protein

(2011) Shumin Hu et al.   Microbial Cell Factories

Lactococci and lactobacilli as mucosal delivery vectors for therapeutic proteins and DNA vaccines

(2011) Luis G Bermúdez-Humarán et al.   Microbial Cell Factories

Recombinant lactic acid bacteria as mucosal biotherapeutic agents

(2011) Catherine Daniel et al.   TRENDS IN BIOTECHNOLOGY

Identification of Candidate Carrier Proteins for Surface Display onLactococcus lactisby Theoretical and Experimental Analyses of the Surface Proteome

(2010) Aleš Berlec et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Cell Wall Anchoring of the 37-Kilodalton Oncofetal Antigen by Lactobacillus plantarum for Mucosal Cancer Vaccine Delivery

(2010) L. Fredriksen et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Characterization of a Novel LysM Domain from Lactobacillus fermentum Bacteriophage Endolysin and Its Use as an Anchor To Display Heterologous Proteins on the Surfaces of Lactic Acid Bacteria

(2010) S. Hu et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Functionality of Sortase A in Lactococcus lactis

(2010) Y. Dieye et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Engineered Lactic Acid Bacterium Lactococcus lactis Capable of Binding Antibodies and Tumor Necrosis Factor Alpha

(2010) M. Ravnikar et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Improvement of human interferon alpha secretion by Lactococcus lactis

(2010) Qiuxiang Zhang et al.   BIOTECHNOLOGY LETTERS

Targeted expression of anthrax protective antigen byLactobacillus gasserias an anthrax vaccine

(2010) Mansour Mohamadzadeh et al.   Future Microbiology

Immobilization of Lactococcus lactis to cellulosic material by cellulose-binding domain of Cellvibrio japonicus

(2010) K. Kylä-Nikkilä et al.   JOURNAL OF APPLIED MICROBIOLOGY

Engineering the cell surface display of cohesins for assembly of cellulosome-inspired enzyme complexes on Lactococcus lactis

(2010) Andrew S Wieczorek et al.   Microbial Cell Factories

Probiotics and the gut microbiota in intestinal health and disease

(2010) Mélanie G. Gareau et al.   Nature Reviews Gastroenterology & Hepatology

AG013, a mouth rinse formulation of Lactococcus lactis secreting human Trefoil Factor 1, provides a safe and efficacious therapeutic tool for treating oral mucositis

(2010) Silvia Caluwaerts et al.   ORAL ONCOLOGY

Oral immunization with a Lactobacillus casei vaccine expressing human papillomavirus (HPV) type 16 E7 is an effective strategy to induce mucosal cytotoxic lymphocytes against HPV16 E7

(2010) Katsuyuki Adachi et al.   VACCINE

Lactococcus lactis Expressing either Staphylococcus aureus Fibronectin-Binding Protein A or Listeria monocytogenes Internalin A Can Efficiently Internalize and Deliver DNA in Human Epithelial Cells

(2009) S. Innocentin et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Genome-wide analysis of signal peptide functionality in Lactobacillus plantarum WCFS1

(2009) Geir Mathiesen et al.   BMC GENOMICS

Use of Lactobacilli and their Pheromone-Based Regulatory Mechanism in Gene Expression and Drug Delivery

(2009) D. Diep et al.   CURRENT PHARMACEUTICAL BIOTECHNOLOGY

Orally administered L. lactis secreting an anti-TNF Nanobody demonstrate efficacy in chronic colitis

(2009) K Vandenbroucke et al.   Mucosal Immunology

Dendritic cell targeting of Bacillus anthracis protective antigen expressed by Lactobacillus acidophilus protects mice from lethal challenge

(2009) M. Mohamadzadeh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Secretion and subcellular localizations of bacterial proteins: a semantic awareness issue

(2009) Mickaël Desvaux et al.   TRENDS IN MICROBIOLOGY

From cellulosomes to cellulosomics

(2008) Edward A. Bayer et al.   CHEMICAL RECORD

In vivo transfer of plasmid from food-grade transiting lactococci to murine epithelial cells

(2008) J-M Chatel et al.   GENE THERAPY

Heterologous protein secretion byLactobacillus plantarumusing homologous signal peptides

(2008) G. Mathiesen et al.   JOURNAL OF APPLIED MICROBIOLOGY

Genes and Molecules of Lactobacilli Supporting Probiotic Action

(2008) S. Lebeer et al.   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

LysM, a widely distributed protein motif for binding to (peptido)glycans

(2008) Girbe Buist et al.   MOLECULAR MICROBIOLOGY

Mucosal delivery of therapeutic and prophylactic molecules using lactic acid bacteria

(2008) Jerry M. Wells et al.   NATURE REVIEWS MICROBIOLOGY