Regulatory processes that maintain or alter ribosomal DNA stability during the repair of programmed DNA double-strand breaks

Variability of Human rDNA

(2021) Evgeny Smirnov et al.   Cells

The S-phase Cyclin Clb5 Promotes rDNA Stability by Maintaining Replication Initiation Efficiency in rDNA

(2021) Goto Mayuko et al.   MOLECULAR AND CELLULAR BIOLOGY

The human ribosomal DNA array is composed of highly homogenized tandem clusters

(2021) Yutaro Hori et al.   GENOME RESEARCH

Approaching Protein Barriers: Emerging Mechanisms of Replication Pausing in Eukaryotes

(2021) Maksym Shyian et al.   Frontiers in Cell and Developmental Biology

V(D)J recombination, somatic hypermutation and class switch recombination of immunoglobulins: mechanism and regulation

(2020) Xiying Chi et al.   IMMUNOLOGY

Age-Dependent Ribosomal DNA Variations in Mice

(2020) Eriko Watada et al.   MOLECULAR AND CELLULAR BIOLOGY

The molecular basis and disease relevance of non-homologous DNA end joining

(2020) Bailin Zhao et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The nucleolus as a multiphase liquid condensate

(2020) Denis L. J. Lafontaine et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

RNA Polymerase I Activators Count and Adjust Ribosomal RNA Gene Copy Number

(2019) Tetsushi Iida et al.   MOLECULAR CELL

How do cells count multi-copy genes?: “Musical Chair” model for preserving the number of rDNA copies

(2019) Tetsushi Iida et al.   CURRENT GENETICS

Ribosomal RNA gene repeats associate with the nuclear pore complex for maintenance after DNA damage

(2019) Chihiro Horigome et al.   PLoS Genetics

Replication fork pausing at protein barriers on chromosomes

(2019) Kohji Hizume et al.   FEBS LETTERS

Phenotypic and Genotypic Consequences of CRISPR/Cas9 Editing of the Replication Origins in the rDNA of Saccharomyces cerevisiae

(2019) Joseph C. Sanchez et al.   GENETICS

DNA double-strand break repair-pathway choice in somatic mammalian cells

(2019) Ralph Scully et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Ribosomopathies: Old Concepts, New Controversies

(2019) Katherine I. Farley-Barnes et al.   TRENDS IN GENETICS

Defects in the NuA4 acetyltransferase complex increase stability of the ribosomal RNA gene and extend replicative lifespan

(2019) Tsuyoshi Wakatsuki et al.   GENES & GENETIC SYSTEMS

The CCR4-NOT Complex Maintains Stability and Transcription of rRNA Genes by Repressing Antisense Transcripts

(2019) Shun Hosoyamada et al.   MOLECULAR AND CELLULAR BIOLOGY

Fork pausing complex engages topoisomerases at the replisome

(2019) Maksym Shyian et al.   GENES & DEVELOPMENT

The yeast replicative aging model

(2018) Chong He et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

The Eukaryotic CMG Helicase at the Replication Fork: Emerging Architecture Reveals an Unexpected Mechanism

(2018) Huilin Li et al.   BIOESSAYS

Long reads: their purpose and place

(2018) Martin O Pollard et al.   HUMAN MOLECULAR GENETICS

Variant ribosomal RNA alleles are conserved and exhibit tissue-specific expression

(2018) Matthew M. Parks et al.   Science Advances

DNA polymerase ε-dependent modulation of the pausing property of the CMG helicase at the barrier

(2018) Kohji Hizume et al.   GENES & DEVELOPMENT

Eurokaryotic Ribosome Assembly

(2018) Jochen Baßler et al.   Annual Review of Biochemistry

Genomic Copy-Number Loss Is Rescued by Self-Limiting Production of DNA Circles

(2018) Andrés Mansisidor et al.   MOLECULAR CELL

The conservation landscape of the human ribosomal RNA gene repeats

(2018) Saumya Agrawal et al.   PLoS One

Role of the Mre11 Complex in Preserving Genome Integrity

(2018) Julyun Oh et al.   Genes

Ctf4 Prevents Genome Rearrangements by Suppressing DNA Double-Strand Break Formation and Its End Resection at Arrested Replication Forks

(2017) Mariko Sasaki et al.   MOLECULAR CELL

Non-homologous DNA end joining and alternative pathways to double-strand break repair

(2017) Howard H. Y. Chang et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

DNA replication stress restricts ribosomal DNA copy number

(2017) Devika Salim et al.   PLoS Genetics

More than 10% of yeast genes are related to genome stability and influence cellular senescence via rDNA maintenance

(2016) Kimiko Saka et al.   NUCLEIC ACIDS RESEARCH

Rad51-mediated replication fork reversal is a global response to genotoxic treatments in human cells

(2015) Ralph Zellweger et al.   JOURNAL OF CELL BIOLOGY

The Human RNA Polymerase I Transcription Terminator Complex Acts as a Replication Fork Barrier That Coordinates the Progress of Replication with rRNA Transcription Activity

(2015) Yufuko Akamatsu et al.   MOLECULAR AND CELLULAR BIOLOGY

Error-Free DNA Damage Tolerance and Sister Chromatid Proximity during DNA Replication Rely on the Polα/Primase/Ctf4 Complex

(2015) Marco Fumasoni et al.   MOLECULAR CELL

Concerted copy number variation balances ribosomal DNA dosage in human and mouse genomes

(2015) John G. Gibbons et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mechanisms and Regulation of Mitotic Recombination in Saccharomyces cerevisiae

(2014) L. S. Symington et al.   GENETICS

Mechanism and Regulation of Meiotic Recombination Initiation

(2014) Isabel Lam et al.   Cold Spring Harbor Perspectives in Biology

Cellular Senescence in Yeast Is Regulated by rDNA Noncoding Transcription

(2013) Kimiko Saka et al.   CURRENT BIOLOGY

MRX protects fork integrity at protein–DNA barriers, and its absence causes checkpoint activation dependent on chromatin context

(2013) Iben B. Bentsen et al.   NUCLEIC ACIDS RESEARCH

Break-Induced DNA Replication

(2013) R. P. Anand et al.   Cold Spring Harbor Perspectives in Biology

Rtt109 Prevents Hyper-Amplification of Ribosomal RNA Genes through Histone Modification in Budding Yeast

(2013) Satoru Ide et al.   PLoS Genetics

A Distinct Replication Fork Protection Pathway Connects Fanconi Anemia Tumor Suppressors to RAD51-BRCA1/2

(2012) Katharina Schlacher et al.   CANCER CELL

Double-Strand Break Repair-Independent Role for BRCA2 in Blocking Stalled Replication Fork Degradation by MRE11

(2011) Katharina Schlacher et al.   CELL

A Hierarchical Combination of Factors Shapes the Genome-wide Topography of Yeast Meiotic Recombination Initiation

(2011) Jing Pan et al.   CELL

Regulation of ribosomal RNA gene copy number and its role in modulating genome integrity and evolutionary adaptability in yeast

(2011) Takehiko Kobayashi   CELLULAR AND MOLECULAR LIFE SCIENCES

Restless 5S: The re-arrangement(s) and evolution of the nuclear ribosomal DNA in land plants

(2011) Susann Wicke et al.   MOLECULAR PHYLOGENETICS AND EVOLUTION

The MRE11 complex: starting from the ends

(2011) Travis H. Stracker et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Repeated reunions and splits feature the highly dynamic evolution of 5S and 35S ribosomal RNA genes (rDNA) in the Asteraceae family

(2010) Sònia Garcia et al.   BMC PLANT BIOLOGY

DNA ligase 4 stabilizes the ribosomal DNA array upon fork collapse at the replication fork barrier

(2010) Olivier Fritsch et al.   DNA REPAIR

Genome destabilization by homologous recombination in the germ line

(2010) Mariko Sasaki et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Abundance of Ribosomal RNA Gene Copies Maintains Genome Integrity

(2010) S. Ide et al.   SCIENCE

The Nucleolus

(2010) T. Pederson   Cold Spring Harbor Perspectives in Biology

Copy Number Variation in Human Health, Disease, and Evolution

(2009) Feng Zhang et al.   Annual Review of Genomics and Human Genetics

Loss of Bloom syndrome protein destabilizes human gene cluster architecture

(2009) Michael W. Killen et al.   HUMAN MOLECULAR GENETICS

Cdc14 inhibits transcription by RNA polymerase I during anaphase

(2009) Andrés Clemente-Blanco et al.   NATURE

A quantitative estimation of the global translational activity in logarithmically growing yeast cells

(2008) Tobias von der Haar   BMC Systems Biology