MRX protects fork integrity at protein–DNA barriers, and its absence causes checkpoint activation dependent on chromatin context

Topoisomerase I poisoning results in PARP-mediated replication fork reversal

(2012) Arnab Ray Chaudhuri et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Regulation of ribosomal RNA gene copy number and its role in modulating genome integrity and evolutionary adaptability in yeast

(2011) Takehiko Kobayashi   CELLULAR AND MOLECULAR LIFE SCIENCES

Interplay between oncogene-induced DNA damage response and heterochromatin in senescence and cancer

(2011) Raffaella Di Micco et al.   NATURE CELL BIOLOGY

The Rad50 coiled-coil domain is indispensable for Mre11 complex functions

(2011) Marcel Hohl et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

DNA ligase 4 stabilizes the ribosomal DNA array upon fork collapse at the replication fork barrier

(2010) Olivier Fritsch et al.   DNA REPAIR

Ku prevents Exo1 and Sgs1-dependent resection of DNA ends in the absence of a functional MRX complex or Sae2

(2010) Eleni P Mimitou et al.   EMBO JOURNAL

Saccharomyces cerevisiae Mre11/Rad50/Xrs2 and Ku proteins regulate association of Exo1 and Dna2 with DNA breaks

(2010) Eun Yong Shim et al.   EMBO JOURNAL

Homologous Recombination Restarts Blocked Replication Forks at the Expense of Genome Rearrangements by Template Exchange

(2010) Sarah Lambert et al.   MOLECULAR CELL

Mechanism of the ATP-dependent DNA end-resection machinery from Saccharomyces cerevisiae

(2010) Hengyao Niu et al.   NATURE

DNA end resection by Dna2–Sgs1–RPA and its stimulation by Top3–Rmi1 and Mre11–Rad50–Xrs2

(2010) Petr Cejka et al.   NATURE

53BP1-dependent robust localized KAP-1 phosphorylation is essential for heterochromatic DNA double-strand break repair

(2010) Angela T. Noon et al.   NATURE CELL BIOLOGY

Replicon Dynamics, Dormant Origin Firing, and Terminal Fork Integrity after Double-Strand Break Formation

(2009) Ylli Doksani et al.   CELL

The MRX complex stabilizes the replisome independently of the S phase checkpoint during replication stress

(2009) Mireille Tittel-Elmer et al.   EMBO JOURNAL

Nearby inverted repeats fuse to generate acentric and dicentric palindromic chromosomes by a replication template exchange mechanism

(2009) K. Mizuno et al.   GENES & DEVELOPMENT

A Flp-nick system to study repair of a single protein-bound nick in vivo

(2009) Ida Nielsen et al.   NATURE METHODS

Replication fork reversal and the maintenance of genome stability

(2009) J. Atkinson et al.   NUCLEIC ACIDS RESEARCH

Sgs1 Helicase and Two Nucleases Dna2 and Exo1 Resect DNA Double-Strand Break Ends

(2008) Zhu Zhu et al.   CELL

ATM Signaling Facilitates Repair of DNA Double-Strand Breaks Associated with Heterochromatin

(2008) Aaron A. Goodarzi et al.   MOLECULAR CELL

Differential Regulation of the Cellular Response to DNA Double-Strand Breaks in G1

(2008) Jacqueline H. Barlow et al.   MOLECULAR CELL

Sae2, Exo1 and Sgs1 collaborate in DNA double-strand break processing

(2008) Eleni P. Mimitou et al.   NATURE