p53 dry gene powder enhances anti-cancer effects of chemotherapy against malignant pleural mesothelioma

Transfected plasmid DNA is incorporated into the nucleus via nuclear envelope reformation at telophase

(2022) Tokuko Haraguchi et al.   Communications Biology

p53 at the crossroad of DNA replication and ribosome biogenesis stress pathways

(2022) Mikael S. Lindström et al.   CELL DEATH AND DIFFERENTIATION

Effects of inhalable gene transfection as a novel gene therapy for non-small cell lung cancer and malignant pleural mesothelioma

(2022) Misa Ichikawa et al.   Scientific Reports

Metastasis-associated gene 1 (MTA1) enhances cisplatin resistance of malignant pleural mesothelioma by ATR-Chk1-mediated DNA repair

(2021) Caihua Xu et al.   Annals of Translational Medicine

Cancer Cachexia: Its Mechanism and Clinical Significance

(2021) Hiroki Nishikawa et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

An MDM2 inhibitor achieves synergistic cytotoxic effects with adenoviruses lacking E1B55kDa gene on mesothelioma with the wild-type p53 through augmenting NFI expression

(2021) Thao Thi Thanh Nguyen et al.   Cell Death & Disease

Expert consensus on the clinical application of recombinant adenovirus human p53 for head and neck cancers

(2021) Yi Li et al.   International Journal of Oral Science

Applications of Recombinant Adenovirus-p53 Gene Therapy for Cancers in the Clinic in China

(2020) Yu Xia et al.   CURRENT GENE THERAPY

Cytogenomic characterization of three murine malignant mesothelioma tumor cell lines

(2020) Eva Wahlbuhl et al.   Molecular Cytogenetics

Proteotoxic Stress and Cell Death in Cancer Cells

(2020) Claudio Brancolini et al.   Cancers

Current Clinical Applications of In Vivo Gene Therapy with AAVs

(2020) Jerry R. Mendell et al.   MOLECULAR THERAPY

Establishment of an Evaluation Method for Gene Silencing by Serial Pulmonary Administration of siRNA and pDNA Powders: Naked siRNA Inhalation Powder Suppresses Luciferase Gene Expression in the Lung

(2019) Takaaki Ito et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Recombinant Adeno-Associated Virus Gene Therapy in Light of Luxturna (and Zolgensma and Glybera): Where Are We, and How Did We Get Here?

(2019) Allison M. Keeler et al.   Annual Review of Virology

Naked pDNA/hyaluronic acid powder shows excellent long-term storage stability and gene expression in murine lungs

(2019) Takaaki Ito et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

The First Approved Gene Therapy Product for Cancer Ad-p53 (Gendicine): 12 Years in the Clinic

(2018) Wei-Wei Zhang et al.   HUMAN GENE THERAPY

Naked pDNA inhalation powder composed of hyaluronic acid exhibits high gene expression in the lungs

(2018) Takaaki Ito et al.   MOLECULAR PHARMACEUTICS

DNA repair pathways and cisplatin resistance: an intimate relationship

(2018) CR Rocha et al.   Clinics

Cisplatin nephrotoxicity: a review of the literature

(2017) Sandhya Manohar et al.   JOURNAL OF NEPHROLOGY

Drug Permeation Characterization of Inhaled Dry Powder Formulations in Air-Liquid Interfaced Cell Layer Using an Improved, Simple Apparatus for Dispersion

(2015) Ayumu Asai et al.   PHARMACEUTICAL RESEARCH

Whole-Exome Sequencing Reveals Frequent Genetic Alterations in BAP1, NF2, CDKN2A, and CUL1 in Malignant Pleural Mesothelioma

(2014) G. Guo et al.   CANCER RESEARCH

Engineering adeno-associated viruses for clinical gene therapy

(2014) Melissa A. Kotterman et al.   NATURE REVIEWS GENETICS

Consecutive Targetable Smart Nanoprobe for Molecular Recognition of Cytoplasmic microRNA in Metastatic Breast Cancer

(2012) Eunjung Kim et al.   ACS Nano

Upregulated p53 expression activates apoptotic pathways in wild-type p53-bearing mesothelioma and enhances cytotoxicity of cisplatin and pemetrexed

(2012) Q Li et al.   CANCER GENE THERAPY

Hyaluronic acid–paclitaxel: effects of intraperitoneal administration against CD44(+) human ovarian cancer xenografts

(2010) Ilaria De Stefano et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Optimized pulmonary gene transfection in mice by spray–freeze dried powder inhalation

(2010) Kohta Mohri et al.   JOURNAL OF CONTROLLED RELEASE

Paclitaxel-Hyaluronic Acid for Intravesical Therapy of Bacillus Calmette-Guérin Refractory Carcinoma In Situ of the Bladder: Results of a Phase I Study

(2010) P.F. Bassi et al.   JOURNAL OF UROLOGY

Dual imaging of pulmonary delivery and gene expression of dry powder inhalant by fluorescence and bioluminescence

(2008) Tomoyuki Mizuno et al.   JOURNAL OF CONTROLLED RELEASE