Article
Pharmacology & Pharmacy
Bishal Raj Adhikari, Shyamal C. Das
Summary: This study investigated the aerosol performance of spray-dried powders based on Soluplus polymer for pulmonary drug delivery. The potential use of leucine to improve aerosolization was also explored. The results showed that Soluplus powder without leucine exhibited good performance for pulmonary drug delivery, and the addition of 20% leucine further enhanced aerosolization of the particles.
Article
Pharmacology & Pharmacy
Khaled AboulFotouh, Haiyue Xu, Chaeho Moon, Robert O. Williams, Zhengrong Cui
Summary: The study demonstrated that thin-film freeze-drying technology can produce AS01(B) liposomal adjuvant and vaccines in freezing-insensitive, inhalable dry powder form without compromising particle size and immunogenicity.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2022)
Article
Pharmacology & Pharmacy
Malihe Karimi, Hossein Kamali, Marzieh Mohammadi, Mohsen Tafaghodi
Summary: Therapeutic proteins and peptides have gained attention for chronic diseases, and pulmonary drug administration is a promising alternative with acceptable bioavailability and stability. Stabilizing proteins through drying techniques is critical, and various methods have been used to prepare inhalable powders.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2022)
Article
Pharmacology & Pharmacy
Jason C. K. Lo, Harry W. Pan, Jenny K. W. Lam
Summary: The study evaluated the conditions and formulation of inhalable dry powders containing biological medicines produced by spray-freeze-drying (SFD), with atomization gas flow rate identified as a significant factor influencing the powder formulations and protein aggregation. High atomization gas flow rate induced aggregation, highlighting the need for further optimization.
Article
Instruments & Instrumentation
Ashish Sarode, Priyal Patel, Natalia Vargas-Montoya, Ayed Allawzi, Alisa Zhilin-Roth, Saswata Karmakar, Lianne Boeglin, Hongfeng Deng, Shrirang Karve, Frank DeRosa
Summary: Pulmonary delivery of mRNA via inhalation is a promising approach for RNA-based therapy for lung diseases. In this study, a successful mRNA-lipid nanoparticle (LNP) dry powder product (DPP) was developed. Formulation optimization of mRNA LNPs in DPP form resulted in efficient and functional delivery of mRNA for treatment of lung diseases.
DRUG DELIVERY AND TRANSLATIONAL RESEARCH
(2023)
Article
Pharmacology & Pharmacy
Sara Bahrainian, Maryam Sadat Mirmoeini, Zahra Gilani, Kambiz Gilani
Summary: The study found that the concomitant use of leucine and dipalmitoylphosphatidylcholine can improve the aerosolization performance of levodopa, leading to the production of a three-component formulation with significantly higher performance than two-component formulations.
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2021)
Article
Engineering, Chemical
Lorena Pasero, Francesca Susa, Riccardo Chiavarino, Tania Limongi, Adamo Sulpizi, Tomaso Guidi, Roberto Pisano
Summary: Spray freeze-drying is a viable alternative to traditional spray drying for producing therapeutic dry microparticles, particularly suitable for pulmonary drug delivery. This study used ultrasonic spray freeze-drying to generate dry microparticles composed of mannitol or a combination of mannitol and salbutamol sulphate. The particle size, morphology, surface area, porosity, and crystallinity were influenced by solid concentration and feed flow rate. The aerodynamic properties for drug deposition were found to depend on solid concentration and feed flow rate.
Article
Pharmacology & Pharmacy
Han Cong Seow, Qiuying Liao, Andy T. Y. Lau, Susan W. S. Leung, Shuofeng Yuan, Jenny K. W. Lam
Summary: This study aimed to develop a dual targeting powder formulation that can simultaneously target the nasal cavity and the lung through a single administration route. Spray freeze drying and spray drying techniques were used to prepare tamibarotene powder formulations, and the powder mixing ratio could be adjusted to modulate the aerosol deposition in the nasal and pulmonary regions. The formulated powder exhibited spherical structures, amorphous characteristics, and improved dissolution profile.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2022)
Article
Chemistry, Multidisciplinary
Rick Heida, Renate Akkerman, Paulo H. Jacob Silva, Anke J. Lakerveld, Daniel Ortiz, Chiara Bigogno, Matteo Gasbarri, Puck B. van Kasteren, Francesco Stellacci, Henderik W. Frijlink, Anke L. W. Huckriede, Wouter L. J. Hinrichs
Summary: Respiratory viruses, including RSV, pose a significant global health burden. Entry inhibitors, such as CD-MUS, have shown promise as antiviral drugs that can prevent infection in the respiratory tract. In this study, CD-MUS was shown to be well tolerated when administered to mice's respiratory tract and retained its activity against RSV after spray drying. This research sets the foundation for future in vivo studies on the efficacy of CD-MUS in animal models of RSV infection.
JOURNAL OF CONTROLLED RELEASE
(2023)
Review
Pharmacology & Pharmacy
Takaaki Ito
Summary: Biopharmaceuticals are highly-targeted and flexible drugs, but their high molecular weight and low stability make injection the most common delivery route. Inhalation drug delivery could provide an alternative, especially for lung diseases. However, biopharmaceutical inhalers need to ensure the integrity of the drugs during the manufacturing and administration process. A novel dry powder inhaler (DPI) preparation method using spray-freeze-drying was presented, which maintained the inhalation characteristics and integrity of plasmid DNA (pDNA) for 12 months. This method has the potential to expand the clinical application of DPIs.
YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN
(2023)
Article
Pharmacology & Pharmacy
Myla Manser, Xueya Feng, Zhou Xing, Emily D. Cranston, Michael R. Thompson
Summary: This study analyzed the effects of cryoprotective agents on a spray dried, inhalable vaccine vector with high viral loading. The results showed that powders containing glycerol had the highest viral log loss, while powders containing trehalose had lower viral log loss and higher thermal stability.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2022)
Article
Food Science & Technology
Sandra Maria Oses, Leire Cantero, Miranda Crespo, Guillermo Puertas, Lara Gonzalez-Ceballos, Saul Vallejos, Miguel Angel Fernandez-Muino, Maria Teresa Sancho
Summary: This study evaluated the effects of three dehydration methods and three carrier agents on the preparation of ling-heather honey powder. Results showed that using maltodextrin as the carrier agent, vacuum drying and freeze drying yielded the best honey powder.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2021)
Article
Engineering, Chemical
Aijun Di, Shengyu Zhang, Xuan Liu, Zhenbo Tong, Siping Sun, Zengchao Tang, Xiao Dong Chen, Winston Duo Wu
Summary: This study developed microparticles with improved solubility and antioxidant activity using resveratrol as a model drug. Chitosan played a key role in adjusting drug release behavior and enhancing mucoadhesion properties.
Article
Food Science & Technology
Sandra Maria Oses, Leire Cantero, Guillermo Puertas, Miguel Angel Fernandez-Muino, Maria Teresa Sancho
Summary: Honey powder is widely used in food, cosmetic and pharmaceutical industries. This study evaluated the effects of different drying methods and carriers on the quality of honey powder and found that the drying procedures and carriers had minimal impact on the parameters and properties of honey powder.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2022)
Article
Engineering, Chemical
Annika Rautenberg, Alf Lamprecht
Summary: In this study, spray-freeze-dried (SFD) particles were analyzed for their flowability, mechanical stability, product properties, and physicochemical properties of the spraying solution. The results showed that SFD is a suitable method to produce freeze-dried flowable products that maintain their mechanical stability. Manipulating the nozzle diameter and solid content of the solution allows for control over particle size and the production of free-flowable powder.
Article
Pharmacology & Pharmacy
Takehiro Noda, Tomoyuki Okuda, Ryota Mizuno, Tetsuya Ozeki, Hirokazu Okamoto
BIOLOGICAL & PHARMACEUTICAL BULLETIN
(2018)
Article
Chemistry, Multidisciplinary
Tomoyuki Okuda, Masaki Morishita, Kimiyasu Mizutani, Ayumi Shibayama, Maki Okazaki, Hirokazu Okamoto
JOURNAL OF CONTROLLED RELEASE
(2018)
Article
Chemistry, Medicinal
Daiki Hira, Tomoyuki Okuda, Ayano Mizutani, Nao Tomida, Hirokazu Okamoto
JOURNAL OF PHARMACEUTICAL SCIENCES
(2018)
Article
Chemistry, Medicinal
Takaaki Ito, Tomoyuki Okuda, Ryo Takayama, Hirokazu Okamoto
JOURNAL OF PHARMACEUTICAL SCIENCES
(2019)
Article
Pharmacology & Pharmacy
Tomoyuki Okuda, Yoko Toyoda, Takashi Murakami, Hirokazu Okamoto
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2019)
Article
Pharmacology & Pharmacy
Daiki Hira, Tomoyuki Okuda, Ayano Mizutani, Nao Tomida, Megumi Mizuno, Satoshi Ueshima, Mikio Kakumoto, Tomonobu Okano, Hirokazu Okamoto
Article
Pharmacology & Pharmacy
Takaaki Ito, Maino Fukuhara, Tomoyuki Okuda, Hirokazu Okamoto
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2020)
Review
Chemistry, Medicinal
Tomoyuki Okuda, Hirokazu Okamoto
CHEMICAL & PHARMACEUTICAL BULLETIN
(2020)
Article
Pharmacology & Pharmacy
Kana Suenaga, Daiki Hira, Eri Ishido, Hiroyoshi Koide, Satoshi Ueshima, Tomoyuki Okuda, Masafumi Yamaguchi, Shin-ya Morita, Hirokazu Okamoto, Tomonobu Okano, Yasutaka Nakano, Tomohiro Terada, Mikio Kakumoto
Summary: The study revealed that 33.3% of participants held the inhaler at an incorrect angle during the drug-loading step. In vitro experiments showed that holding the inhaler at an incorrect angle significantly decreased OE (an index of the loaded dose) by 73.3%, while St2 (an index of the deagglomerating efficiency) remained stable regardless of the holding angle. OE x St2, indicating the bronchial and pulmonary drug delivery amount, decreased by 76.9%. Holding the inhaler at an incorrect angle reduces the loaded dose, leading to decreased pulmonary delivery.
BIOLOGICAL & PHARMACEUTICAL BULLETIN
(2021)
Article
Multidisciplinary Sciences
Misa Ichikawa, Naomi Muramatsu, Wataru Matsunaga, Takahiro Ishikawa, Tomoyuki Okuda, Hirokazu Okamoto, Akinobu Gotoh
Summary: This study developed an orally inhalable gene therapy drug for the treatment of lung cancer. The drug effectively decreased cell proliferation and directly impacted the lungs. It provides a novel gene therapy option that patients can self-administer.
SCIENTIFIC REPORTS
(2022)