Article
Chemistry, Multidisciplinary
Clarinda Costa, Beatriz Nobre, Ana Sofia Matos, Ana Sofia Silva, Teresa Casimiro, Maria Luisa Corvo, Ana Aguiar-Ricardo
Summary: Liposomes are a promising drug delivery system for biopharmaceuticals, however, they can destabilize during storage. Converting liposomal suspension into solid form can overcome this issue, as shown in this study utilizing pharmaceutical and supercritical carbon dioxide technologies. The dry powder formulations demonstrated stability at specific relative humidities, showing potential for long-term storage.
JOURNAL OF CO2 UTILIZATION
(2021)
Article
Pharmacology & Pharmacy
Kahori Miyamoto, Yuko Ishibashi, Tomomi Akita, Chikamasa Yamashita
Summary: The study aimed to develop a formulation of hGhrelin derivative that can eliminate the need for injections and be clinically applied, utilizing a LDPI system. The optimized formulation showed good pharmacokinetic properties in monkeys and is expected to serve as a substitute for injections in clinical settings.
Article
Engineering, Environmental
Chaoping Fu, Ruili Wei, Peiyao Xu, Shiwei Luo, Chunyang Zhang, Ranjith Kumar Kankala, Shibin Wang, Xinqing Jiang, Xinhua Wei, Liming Zhang, Aizheng Chen, Ruimeng Yang
Summary: In recent years, the use of diselenide-bridged polymeric nanocomposites for drug delivery, especially in enhanced anticancer therapy, has gained significant attention. However, the high sensitivity of diselenide bonds to various stimuli limits the fabrication of such nanocomposites with high performance efficiency. This study successfully demonstrated the fabrication of ICG-loaded diselenide-containing polymeric nanoparticles using a supercritical fluid-assisted rapid synthesis approach for ROS/GSH-responsive drug delivery, showing high drug loading and encapsulation efficiency.
CHEMICAL ENGINEERING JOURNAL
(2021)
Article
Chemistry, Multidisciplinary
Kehong Lv, Lang Yao, Xinyu Fu, Xuan Gao, Hongli Wang, Yifei Zhou, Ruohao Zhang, Yu Lu, Jing Feng, Hongjie Zhang
Summary: Researchers developed a nanoplatform called UICCIP, which combines indocyanine green-equipped upconversion nanoparticles (UCNPs) with CeO2 modified with NH2-PEG1000-cRGDfK. This nanoplatform enhances the photodynamic therapy (PDT) effect of tumors by generating reactive oxygen species (ROS) through two pathways.
Review
Pharmacology & Pharmacy
Francesca Buttini, Eride Quarta, Chiara Allegrini, Federico Lavorini
Summary: Pulmonary drug delivery is focused on directing drugs to lung disease sites for maximum therapeutic benefit, with capsule-based dry powder inhalers (cDPIs) being a popular and convenient option for treating a variety of diseases. cDPI technology is relatively simple, cost-effective, and has a lower carbon footprint compared to other inhaler devices.
Article
Multidisciplinary Sciences
Jaison Darson, Radha Thirunellai Seshadri, Kajal Katariya, Mothilal Mohan, Manjunath Srinivas Kamath, Meher Abhinav Etyala, Gopalakrishnan Chandrasekaran
Summary: This study focuses on the design, development, and optimization of multifunctional Doxorubicin (Dox)-loaded Indocyanine Green (ICG) proniosomal gel-derived niosomes. Design of Experiments (2(3) factorial model) was used to study the effect of formulation variables on various responses. The optimized formulation variables were validated and the cytotoxic effect of the optimized formulation was demonstrated invitro.
SCIENTIFIC REPORTS
(2023)
Article
Biochemistry & Molecular Biology
Changkyu Lee, Sebyung Kang
Summary: The study introduced a novel method for conjugating targeting ligands to albumin NPs using the ST/SC ligation system, which showed high efficiency and rapidity, and demonstrated superior therapeutic effects in cells overexpressing HER2.
Article
Biophysics
Kun Yang, Yixin Dong, Xun Li, Fei Wang, Yu Zhang
Summary: The development of a biocompatible nanoplatform containing indocyanine green (ICG) and paclitaxel (PTX) significantly enhances the effectiveness of combined chemo/photothermal/photodynamic therapy against tumors. The nanoplatform effectively delivers both drugs to the target site, and under near-infrared (NIR) light irradiation, it enhances the photothermal effect and internalization of ICG, as well as the production of reactive oxygen species in cancer cells. This study demonstrates the potential application of the dual-targeting HAS1411 nanocarrier in cancer therapy.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2023)
Article
Chemistry, Multidisciplinary
Mingze Li, Yundong Zhang, Jinli Ma, Jianshi Du
Summary: The lymphatic system is a complex network that is not well understood, hindering research on its function, diagnosis of lymphatic diseases, and control of tumor metastasis. Novel imaging methods such as magnetic resonance imaging, positron emission computed tomography, single-photon emission computed tomography, contrast-enhanced ultrasonography, and near-infrared imaging can provide more accurate and detailed information about the lymphatic system. We successfully fabricated a new IR-780@BSA@Gd3+ nanocomposite that can be used for dual-modality imaging of the lymphatic system, which will facilitate the study of its mechanism and morphological structure.
Review
Pharmacology & Pharmacy
Alberto Baldelli, Mohammed A. Boraey, Hale Oguzlu, Aylin Cidem, Athenea Pascual Rodriguez, Hui Xin Ong, Feng Jiang, Mattia Bacca, Andrew Thamboo, Daniela Traini, Anubhav Pratap-Singh
Summary: This review presents the potential of nasal dry powders in delivering stable bioactive compounds and the manufacturing techniques using spray-drying for encapsulation. It also discusses the approved and experimental excipients used for powder manufacturing for specific target drugs, such as polymers, sugars, and amino acids.
DRUG DISCOVERY TODAY
(2022)
Article
Nanoscience & Nanotechnology
Wenfeng Lin, Chaoming Li, Naijin Xu, Masami Watanabe, Ruizhi Xue, Abai Xu, Motoo Araki, Ruifen Sun, Chunxiao Liu, Yasutomo Nasu, Peng Huang
Summary: This study successfully developed dual-functional nanoparticles (NPs) PLGA-ICG-R848 combining photothermal therapy (PTT) with immunotherapy, showing significant anti-tumor efficacy for PCa treatment.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2021)
Article
Chemistry, Analytical
Petra Party, Rita Ambrus
Summary: Pulmonary drug transport offers advantages such as large absorption surface areas and limited degradation in the gastrointestinal system. Dry powder formulations have gained popularity due to their stability and ease of administration. A long-term stability study was conducted on a nanosized dry powder inhaler formulation containing meloxicam. Various testing techniques were used to evaluate the characteristics and dissolution of the formulation. The results showed that the DPI formulation maintained its essential qualities after 6 and 12 months of storage, indicating its potential for further studies and development.
Review
Pharmacology & Pharmacy
Styliani Xiroudaki, Aurelie Schoubben, Stefano Giovagnoli, Dimitrios M. Rekkas
Summary: The term drug delivery systems has replaced previous terms like dosage forms to emphasize the importance of drug carriers, but may not always be fully justified in the case of delivery devices, which require a deep understanding of the complex formulation-device-patient interplay. Despite progress in particle engineering and device design, dry powder inhalers' clinical performance is limited by variable patients' breathing patterns, prompting the need for next-generation DPIs to adapt to individual respiratory capacity. The recent wave of digitalization in healthcare and industry may drive DPI technology towards personalized device-formulation-patient liaison, aligning novel technologies with a systems theory approach.
Article
Pharmacology & Pharmacy
Noemie Penoy, Kouka Luc Delma, Hermane Avohou Tonakpon, Bruno Grignard, Brigitte Evrard, Geraldine Piel
Summary: Budesonide and salbutamol-loaded liposomes were prepared using an innovative supercritical CO2 method, resulting in small-sized liposomes and high encapsulation efficiency. The physical stability of the formulation was improved by optimizing the drying method and lipid composition. After 15 weeks, the concentrations of budesonide and salbutamol in the formulation were close to those in existing pharmaceutical products. The formulation showed no significant impact on cell viability when tested on lung cells.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2022)
Article
Biochemical Research Methods
Zhongqiang Li, Zheng Li, Waleed Zaid, Michelle L. Osborn, Yanping Li, Shaomian Yao, Jian Xu
Summary: This study demonstrates the feasibility of using indocyanine green-assisted near-infrared fluorescence dental imaging, which can provide good imaging results for both erupted and unerupted teeth structures at different NIR wavelengths.
JOURNAL OF BIOMEDICAL OPTICS
(2022)
Letter
Pharmacology & Pharmacy
Chie Emoto, David Hahn, Joshua C. Euteneuer, Tomoyuki Mizuno, Alexander A. Vinks, Tsuyoshi Fukuda
CLINICAL PHARMACOLOGY & THERAPEUTICS
(2020)
Article
Pharmacology & Pharmacy
Matthijs W. van Hoogdalem, Chie Emoto, Tsuyoshi Fukuda, Tomoyuki Mizuno, Parinda A. Mehta, Alexander A. Vinks
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
(2020)
Review
Pharmacology & Pharmacy
Tomoyuki Mizuno, Min Dong, Zachary L. Taylor, Laura B. Ramsey, Alexander A. Vinks
Summary: Providing maximal therapeutic efficacy without toxicity is a universal goal of rational drug therapy. However, substantial between-patient variability in drug response often impedes such successful treatments and brings the necessity of tailoring drug dose to individual needs for more precise therapy. In many cases, the integration of patient characteristics, such as body size, genetic makeup, and environmental factors, is needed to find the optimal dose in clinical practice. The development and implementation of pharmacogenetics-guided and PK/PD model-informed decision support, including the use of electronic health records, have facilitated precision dosing and improved healthcare.
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
(2022)
Article
Pharmacology & Pharmacy
Zachary L. Taylor, Tomoyuki Mizuno, Nieko C. Punt, Balaji Baskaran, Adriana Navarro Sainz, William Shuman, Nicholas Felicelli, Alexander A. Vinks, Jesper Heldrup, Laura B. Ramsey
CLINICAL PHARMACOLOGY & THERAPEUTICS
(2020)
Article
Pharmacology & Pharmacy
Tomoyuki Mizuno, Brooks T. McPhail, Suyog Kamatkar, Scott Wexelblatt, Laura Ward, Uwe Christians, Henry T. Akinbi, Alexander A. Vinks
Summary: An integrated pharmacokinetic and pharmacodynamic model for buprenorphine treatment in newborns with neonatal opioid withdrawal syndrome was developed successfully, which could optimize the dosing regimen in the treatment of this condition.
CLINICAL PHARMACOKINETICS
(2021)
Review
Biochemistry & Molecular Biology
Matthijs W. van Hoogdalem, Brooks T. McPhail, David Hahn, Scott L. Wexelblatt, Henry T. Akinbi, Alexander A. Vinks, Tomoyuki Mizuno
Summary: Neonatal opioid withdrawal syndrome (NOWS) often occurs in infants born to mothers who used opioids during pregnancy. The pharmacological treatments for NOWS exhibit substantial variability in pharmacokinetics (PK) and pharmacodynamics (PD), with current treatments largely relying on empirical treatment of patient symptoms. Further research on the PK/PD relationship of medications used in the treatment of NOWS is needed.
EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY
(2021)
Article
Pharmacology & Pharmacy
Kohta Mohri, Emi Hayashi, Manato Nishino, Nao Matsushita, Sohei Tanishita, Makiya Nishikawa, Shinji Sakuma
Summary: In this study, Guanine-rich oligonucleotide (GRO) was developed as an effective anticancer agent with high selectivity and antiproliferative activity in cancer cells. By incorporating GRO29A into polypod-like structured DNA, the potency of the drug was increased, showing high cytotoxicity against nucleolin-positive cancer cells.
JOURNAL OF DRUG TARGETING
(2021)
Article
Biotechnology & Applied Microbiology
Andrew Tae-Jun Kwon, Kohta Mohri, Satoshi Takizawa, Takahiro Arakawa, Maiko Takahashi, Bogumil Kaczkowski, Masaaki Furuno, Harukazu Suzuki, Shunsuke Tagami, Hidefumi Mukai, Erik Arner
Summary: This study demonstrated the creation of multiple mutant variants of U87MG cells using gene editing techniques, showing that loss of p53 function led to major transcriptional differences in the cells. Transcriptome data was used to predict mutant clones with less divergent phenotypes, which served as the best candidates for drug delivery testing platforms. In vitro and in vivo experiments supported these predictions, ultimately leading to the successful selection of the best qualifying mutant clone.
JOURNAL OF BIOTECHNOLOGY
(2021)
Article
Gastroenterology & Hepatology
Ruben J. Colman, Ye Xiong, Tomoyuki Mizuno, Jeffrey S. Hyams, Joshua D. Noe, Brendan Boyle, Geert R. D'Haens, Johan van Limbergen, Kelly Chun, Jane Yang, Michael J. Rosen, Lee A. Denson, Alexander A. Vinks, Phillip Minar
Summary: This study evaluated the impact of ATI on infliximab clearance and loss of response, finding that even low levels of ATI can affect drug clearance. The data suggest that dose optimization for low-level ATI can improve infliximab clearance and prevent loss of response.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2022)
Article
Pharmacology & Pharmacy
Matthijs W. van Hoogdalem, Trevor N. Johnson, Brooks T. McPhail, Suyog Kamatkar, Scott L. Wexelblatt, Laura P. Ward, Uwe Christians, Henry T. Akinbi, Alexander A. Vinks, Tomoyuki Mizuno
Summary: Neonatal opioid withdrawal syndrome is a public health concern in the US, with sublingual buprenorphine emerging as a treatment. However, precision dosing is needed due to variability in newborns' pharmacokinetics. PBPK modeling shows biliary clearance, sublingual absorption, and CYP3A4 abundance drive buprenorphine PK variability.
CLINICAL PHARMACOLOGY & THERAPEUTICS
(2022)
Article
Pharmacology & Pharmacy
Shota Warashina, Maki Zouda, Kohta Mohri, Yasuhiro Wada, Kazuya Maeda, Yasuyoshi Watanabe, Hidefumi Mukai
Summary: A method of labeling small extracellular vesicles (sEVs) with Cu-64 was developed and applied to pharmacokinetics study. The labeled sEVs rapidly disappeared from the systemic blood circulation and mainly accumulated in the liver and spleen, suggesting the involvement of macrophages.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2022)
Article
Gastroenterology & Hepatology
Ruben J. Colman, Tomoyuki Mizuno, Keizo Fukushima, David B. Haslam, Jeffrey S. Hyams, Brendan Boyle, Joshua D. Noe, Geert R. D'Haens, Johan Van Limbergen, Kelly Chun, Jane Yang, Lee A. Denson, Nicholas J. Ollberding, Alexander A. Vinks, Phillip Minar
Summary: This study established a pediatric vedolizumab pharmacokinetic model to optimize dosing. By analyzing fecal microbiota, it was found that an early abundance of butyrate-producing bacteria was associated with patients' response to vedolizumab.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2023)
Article
Pharmacology & Pharmacy
Kohta Mohri, Kim Phuong Huynh Nhat, Maki Zouda, Shota Warashina, Yasuhiro Wada, Yasuyoshi Watanabe, Shunsuke Tagami, Hidefumi Mukai
Summary: In this study, we generated a PET probe based on MccJ25 analog with an RGD motif and investigated its utility for tumor imaging. The probe showed high accumulation in tumors with integrin alpha v beta 3 expression and low non-specific accumulation in other tissues. These results suggest that MccJ25 variants can be useful tools for cancer molecular imaging.
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2023)
Meeting Abstract
Pharmacology & Pharmacy
T. Mizuno, J. Nieves, A. Grahn, R. Alpaugh, M. R. Zibelman, A. A. Vinks
CLINICAL PHARMACOLOGY & THERAPEUTICS
(2019)
Meeting Abstract
Pharmacology & Pharmacy
T. Fukuda, D. Hahn, J. C. Euteneuer, T. Mizuno, A. A. Vinks, C. Emoto
CLINICAL PHARMACOLOGY & THERAPEUTICS
(2019)
Review
Chemistry, Multidisciplinary
Zhiyuan Shi, Yong Hu, Xin Li
Summary: Controlled drug delivery systems that can respond to mechanical force offer a unique solution for on-demand drug activation and release. Among various mechanical stimuli, ultrasound (US) has advantages in achieving spatiotemporally controlled drug release. Traditional US-triggered drug release relies on heat-induced phase transitions or chemical transformations, while the cutting-edge approach of Sonopharmacology leverages polymer mechanochemistry. The remaining challenges and potential future directions in this field are also discussed.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Lijie Zheng, Yuanzheng Chen, Xun Gu, Yingying Li, Hanqing Zhao, Wenjun Shao, Tao Ma, Chuanbin Wu, Qingqing Wang
Summary: In this study, a novel dosage form consisting of dissolving microneedles and an adhesive transdermal patch was developed for the treatment of rheumatoid arthritis. In vitro and in vivo experiments demonstrated that the combination of drugs delivered by this dosage form effectively reduced joint inflammation and damage.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Kyungjik Yang, Hwa Seung Han, Seung Hwan An, Kyung Hoon Park, Keonwook Nam, Shinha Hwang, Yuyeon Lee, Sung Yeon Cho, Taehyung Kim, Deokyeong Choe, Sang Won Kim, Wonkyu Yu, Hyunah Lee, Jiyong Park, Sangguan You, Dong- Gyu Jo, Ki Young Choi, Young Hoon Roh, Jae Hyung Park
Summary: This study developed CP-loaded CS microcapsules to enhance the oral bioavailability of CP through controlled gastrointestinal delivery. The optimized microcapsules exhibited desirable physicochemical properties, showed anti-photoaging effects via antioxidant activity, and achieved controlled release in the gastrointestinal tract. This research provides a simple and economical approach for enhancing the oral bioavailability of CP for customized bioactive compound administration.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Huiyang Li, Shuo Liu, Wenjin Dai, Bingmei Yao, Yong Zhou, Sujia Si, Hairong Yu, Riguang Zhao, Fang Jin, Liqun Jiang
Summary: Changes in bodily fluid pressures are crucial in diseases like high-altitude pulmonary edema (HAPE). Researchers have developed hydrostatic pressure-sensitive multivesicular liposomes (PSMVLs) that can release drugs in response to pressure changes, with potential applications in HAPE treatment. Animal experiments showed that this system provides better protection for lung tissues and respiratory function, reducing the occurrence of pulmonary edema.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Qian Hu, Hongbing Lan, Yinmei Tian, Xiaonan Li, Mengmeng Wang, Jiao Zhang, Yulin Yu, Wei Chen, Li Kong, Yuanyuan Guo, Zhiping Zhang
Summary: Coacervate droplets formed through liquid-liquid phase separation have potential as delivery vesicles for therapeutics. However, their lack of physiological stability and membranes are challenges. In this study, polylysine-polynucleotide complex coacervate droplets with favorable stability were formulated to concentrate molecules and nanoparticles. Phospholipid membranes were further coated on the droplets to create coacervate-based artificial protocells (ArtPC) with membrane-like structures. These biofunctional ArtPC effectively reduced blood uric acid levels and prevented renal injuries.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Xiaowei Wang, Hongwei Lu, Fang Luo, Dan Wang, Apeng Wang, Xuelei Wang, Wenkai Feng, Xiaobo Wang, Jiayi Su, Mingliang Liu, Guimin Xia
Summary: Four novel lipid-like GEM diesters were synthesized and encapsulated into liposomes to improve the antitumor efficacy of Gemcitabine. The liposomes loaded with dimyristoyl GEM (LipodmGEM) showed enhanced cellular uptake, improved inhibition of cell migration, and a greatly extended half-life compared to free Gemcitabine. LipodmGEM successfully enriched the drug in the tumor and exhibited excellent anticancer efficacy in vivo with negligible systemic toxicity.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Pengyu Li, Jieyi Pan, Yating Dong, Yingying Sun, Yalong Wang, Kang Liao, Yili Chen, Xin Deng, Shihui Yu, Haiyan Hu
Summary: Chronic pulmonary infection caused by Pseudomonas aeruginosa is a serious public health problem with high mortality rates. In this study, infection-microenvironment responsive nanoparticles were developed to eradicate biofilms and inhibit virulence. These nanoparticles showed promising results in treating chronic pulmonary infections.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Yajing Sun, Ze Lu, John A. Taylor, Jessie L. S. Au
Summary: A recent development in cancer chemotherapy is the use of cytotoxics to induce tumor-specific immune response through immunogenic cell death (ICD). This study describes a method that utilizes immunostaining and machine-learning to identify cells with ecto-CRT in intact 3-dimensional tissues. The method was successfully applied to study drug-induced ICD in human bladder cancer.
JOURNAL OF CONTROLLED RELEASE
(2024)
Review
Chemistry, Multidisciplinary
Rafat Ali, Shantanu Sen, Rohil Hameed, Aamir Nazir, Sandeep Verma
Summary: This review provides a focused overview of emerging strategies for delivering gasotransmitters in a controlled and sustained manner to reestablish neurophysiological homeostasis.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Jing Chen, Xinyi Zhang, Jinshen Zhang, Zhaoxia Wang, Guilan Zhu, Ming Geng, Jinmiao Zhu, Yajun Chen, Wei Wang, Youcui Xu
Summary: In this study, a multifunctional responsive hydrogel system was developed for synergistic reoxygenation and chemo/photothermal therapy. The hydrogel system showed both therapeutic effects against metastatic breast cancer and wound infection, making it a promising strategy for treating and preventing tumor recurrence and associated wound infection.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Baoshan Huang, Na Zhang, Xinying Qiu, Rui Zeng, Shuimiao Wang, Mengxia Hua, Qing Li, Kaihui Nan, Sen Lin
Summary: This study revealed that robust ROS can oxidize mitochondrial DNA (ox-mtDNA) and cause its release into the cytosol, resulting in the activation of NLRP3 inflammasome. By using the mitochondria-targeted antioxidant SkQ1 and a novel mitochondria-targeted nanoparticle (SkQ1 NP), it was found that mitochondrial ROS scavenging could in situ inhibit DED-induced mtDNA oxidation and suppress NLRP3-mediated inflammation.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Wenqi Liu, Cheng Hu, Linyu Long, Shuyi He, Wen Zhang, Zhicun Wang, Li Yang, Yunbing Wang
Summary: Myocardial infarction is the leading cause of cardiovascular mortality, and current treatment methods have limitations. This study developed a smart carrier that can release different therapeutic substances for different pathological processes, effectively improving cardiac function, promoting cardiac repair, and preventing ventricular remodeling.
JOURNAL OF CONTROLLED RELEASE
(2024)