Targeting cholesterol metabolism in Cancer: From molecular mechanisms to therapeutic implications
出版年份 2023 全文链接
标题
Targeting cholesterol metabolism in Cancer: From molecular mechanisms to therapeutic implications
作者
关键词
-
出版物
BIOCHEMICAL PHARMACOLOGY
Volume -, Issue -, Pages 115907
出版商
Elsevier BV
发表日期
2023-11-05
DOI
10.1016/j.bcp.2023.115907
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- EGFR/SRC/ERK-stabilized YTHDF2 promotes cholesterol dysregulation and invasive growth of glioblastoma
- (2021) Runping Fang et al. Nature Communications
- Lipid signalling enforces functional specialization of Treg cells in tumours
- (2021) Seon Ah Lim et al. NATURE
- In vivo PCSK9 gene editing using an all-in-one self-cleavage AAV-CRISPR system
- (2021) Qian Li et al. Molecular Therapy-Methods & Clinical Development
- Cholesterol activates the Wnt/PCP-YAP signaling in SOAT1-targeted treatment of colon cancer
- (2021) Huanji Xu et al. Cell Death Discovery
- LDLR inhibition promotes hepatocellular carcinoma proliferation and metastasis by elevating intracellular cholesterol synthesis through the MEK/ERK signaling pathway
- (2021) Ziye Chen et al. Molecular Metabolism
- Role of Cholesterol and Lipid Rafts in Cancer Signaling: A Promising Therapeutic Opportunity?
- (2021) Rosa Vona et al. Frontiers in Cell and Developmental Biology
- Treatment with HIV-Protease Inhibitor Nelfinavir Identifies Membrane Lipid Composition and Fluidity as a Therapeutic Target in Advanced Multiple Myeloma
- (2021) Lenka Besse et al. CANCER RESEARCH
- Influence of cholesterol on cancer progression and therapy
- (2021) Shyamananda Singh Mayengbam et al. Translational Oncology
- Structural basis for sterol sensing by Scap and Insig
- (2021) Renhong Yan et al. Cell Reports
- Correction to: Potentiating CD8+ T cell antitumor activity by inhibiting PCSK9 to promote LDLR-mediated TCR recycling and signaling
- (2021) Juanjuan Yuan et al. Protein & Cell
- CRISPR screens identify cholesterol biosynthesis as a therapeutic target on stemness and drug resistance of colon cancer
- (2021) Shanshan Gao et al. ONCOGENE
- High Serum Levels of Cholesterol Increase Anti-tumor Functions of Nature Killer Cells and Reduce Growth of Liver Tumors in Mice
- (2020) Wen-Hao Qin et al. GASTROENTEROLOGY
- Assessment of acyl-CoA cholesterol acyltransferase (ACAT-1) role in ovarian cancer progression—An in vitro study
- (2020) Vijayalakshmi N. Ayyagari et al. PLoS One
- Impaired lipid biosynthesis hinders anti-tumor efficacy of intratumoral iNKT cells
- (2020) Sicheng Fu et al. Nature Communications
- Targeted deletion of PD-1 in myeloid cells induces antitumor immunity
- (2020) Laura Strauss et al. Science Immunology
- Metabolic reprogramming and cancer progression
- (2020) Brandon Faubert et al. SCIENCE
- Epigenome environment interactions accelerate epigenomic aging and unlock metabolically restricted epigenetic reprogramming in adulthood
- (2020) Lindsey S. Treviño et al. Nature Communications
- CRISPR-Cas12a delivery by DNA-mediated bioresponsive editing for cholesterol regulation
- (2020) Wujin Sun et al. Science Advances
- Pseurotin A as a novel suppressor of hormone dependent breast cancer progression and recurrence by inhibiting PCSK9 secretion and interaction with LDL receptor
- (2020) Khaldoun S. Abdelwahed et al. PHARMACOLOGICAL RESEARCH
- Impact of Cholesterol Metabolism in Immune Cell Function and Atherosclerosis
- (2020) María Aguilar-Ballester et al. Nutrients
- Staphylococcal Enterotoxin C2 Mutant–Directed Fatty Acid and Mitochondrial Energy Metabolic Programs Regulate CD8+ T Cell Activation
- (2020) Xuanhe Fu et al. JOURNAL OF IMMUNOLOGY
- A multi-omic analysis of birthweight in newborn cord blood reveals new underlying mechanisms related to cholesterol metabolism
- (2020) Rossella Alfano et al. METABOLISM-CLINICAL AND EXPERIMENTAL
- Isocitrate dehydrogenase 1 mutation enhances 24(S)-hydroxycholesterol production and alters cholesterol homeostasis in glioma
- (2020) Risheng Yang et al. ONCOGENE
- MITOCHONDRIAL CHOLESTEROL AND CANCER
- (2020) Carmen Garcia-Ruiz et al. SEMINARS IN CANCER BIOLOGY
- Targeting SREBP-2-Regulated Mevalonate Metabolism for Cancer Therapy
- (2020) Linyuan Xue et al. Frontiers in Oncology
- Cholesterol metabolism: At the cross road between cancer cells and immune environment
- (2020) Joanna Kopecka et al. INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
- The ABCs of Sterol Transport
- (2020) Ashlee M. Plummer et al. Annual Review of Physiology
- LDL, HDL and endocrine-related cancer: From pathogenic mechanisms to therapies
- (2020) Giovanna Revilla et al. SEMINARS IN CANCER BIOLOGY
- A chemical biology screen identifies a vulnerability of neuroendocrine cancer cells to SQLE inhibition
- (2019) Christopher E. Mahoney et al. Nature Communications
- Total cholesterol and all-cause mortality by sex and age: a prospective cohort study among 12.8 million adults
- (2019) Sang-Wook Yi et al. Scientific Reports
- Navigating metabolic pathways to enhance antitumour immunity and immunotherapy
- (2019) Xiaoyun Li et al. Nature Reviews Clinical Oncology
- Squalene accumulation in cholesterol auxotrophic lymphomas prevents oxidative cell death
- (2019) Javier Garcia-Bermudez et al. NATURE
- ZEB2 and LMO2 drive immature T-cell lymphoblastic leukemia via distinct oncogenic mechanisms
- (2019) Steven Goossens et al. HAEMATOLOGICA
- Activation of liver X receptor up-regulates the expression of the NKG2D ligands MICA and MICB in multiple myeloma through different molecular mechanisms
- (2019) Maria Teresa Bilotta et al. FASEB JOURNAL
- Cyclosporin A inhibits differentiation and activation of monocytic cells induced by 27-hydroxycholesterol
- (2019) Yonghae Son et al. INTERNATIONAL IMMUNOPHARMACOLOGY
- SREBP1 promotes the invasion of colorectal cancer accompanied upregulation of MMP7 expression and NF-κB pathway activation
- (2019) Yuyan Gao et al. BMC CANCER
- Tumor Cholesterol Up, T Cells Down
- (2019) Elodie Picarda et al. Cell Metabolism
- Increased Cholesterol Biosynthesis Is a Key Characteristic of Breast Cancer Stem Cells Influencing Patient Outcome
- (2019) Sidse Ehmsen et al. Cell Reports
- HDL and LDL: Potential New Players in Breast Cancer Development
- (2019) Lídia Cedó et al. Journal of Clinical Medicine
- Targeting the metabolic response to statin-mediated oxidative stress produces a synergistic anti-tumor response
- (2019) Grace H McGregor et al. CANCER RESEARCH
- SREBP-1 inhibitor Betulin enhances the antitumor effect of Sorafenib on hepatocellular carcinoma via restricting cellular glycolytic activity
- (2019) Fan Yin et al. Cell Death & Disease
- Artesunate inhibits the mevalonate pathway and promotes glioma cell senescence
- (2019) Shupei Wei et al. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
- Oxysterols and sterols: from lipidomics to food sciences
- (2019) M T Rodriguez-Estrada et al. JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY
- Even Cancer Cells Watch Their Cholesterol!
- (2019) Romain Riscal et al. MOLECULAR CELL
- RORγ is a targetable master regulator of cholesterol biosynthesis in a cancer subtype
- (2019) Demin Cai et al. Nature Communications
- Potentiation of Kras peptide cancer vaccine by avasimibe, a cholesterol modulator
- (2019) Jing Pan et al. EBioMedicine
- Retrospective on Cholesterol Homeostasis: The Central Role of Scap
- (2018) Michael S. Brown et al. Annual Review of Biochemistry
- Squalene epoxidase as a promising metabolic target in cancer treatment
- (2018) Gabriella Cirmena et al. CANCER LETTERS
- Cholesterol inhibits hepatocellular carcinoma invasion and metastasis by promoting CD44 localization in lipid rafts
- (2018) Zhishi Yang et al. CANCER LETTERS
- Lysosomal acid lipase promotes cholesterol ester metabolism and drives clear cell renal cell carcinoma progression
- (2018) Jun Wang et al. CELL PROLIFERATION
- Phospholipid Remodeling and Cholesterol Availability Regulate Intestinal Stemness and Tumorigenesis
- (2018) Bo Wang et al. Cell Stem Cell
- Statin Therapy and Association with Ovarian Cancer risk in the New England Case Control (NEC) Study
- (2018) Babatunde Akinwunmi et al. INTERNATIONAL JOURNAL OF CANCER
- Less cholesterol means better tumor killing for cytotoxic T9 cells
- (2018) Brad Griesenauer et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Cholesterol negatively regulates IL-9–producing CD8+T cell differentiation and antitumor activity
- (2018) Xingzhe Ma et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Cholesterol esterification inhibition and gemcitabine synergistically suppress pancreatic ductal adenocarcinoma proliferation
- (2018) Junjie Li et al. PLoS One
- Squalene epoxidase drives NAFLD-induced hepatocellular carcinoma and is a pharmaceutical target
- (2018) Dabin Liu et al. Science Translational Medicine
- Metabolic Control of CD8 + T Cell Fate Decisions and Antitumor Immunity
- (2018) Lianjun Zhang et al. TRENDS IN MOLECULAR MEDICINE
- In Vivo Double Targeting of C26 Colon Carcinoma Cells and Microenvironmental Protumor Processes Using Liposomal Simvastatin
- (2018) Lavinia Luput et al. Journal of Cancer
- Low-Density Lipoprotein Uptake Inhibits the Activation and Antitumor Functions of Human Vγ9Vδ2 T Cells
- (2018) Neidy V. Rodrigues et al. Cancer Immunology Research
- Enhanced chemo-immunotherapy against melanoma by inhibition of cholesterol esterification in CD8+ T cells
- (2018) Man Li et al. Nanomedicine-Nanotechnology Biology and Medicine
- Myeloid apolipoprotein E controls dendritic cell antigen presentation and T cell activation
- (2018) Fabrizia Bonacina et al. Nature Communications
- Fatostatin induces pro- and anti-apoptotic lipid accumulation in breast cancer
- (2018) Viktor Brovkovych et al. Oncogenesis
- p53 Represses the Mevalonate Pathway to Mediate Tumor Suppression
- (2018) Sung-Hwan Moon et al. CELL
- IL-33 drives the antitumor effects of dendritic cells via the induction of Tc9 cells
- (2018) Ning Liu et al. Cellular & Molecular Immunology
- CtBP promotes metastasis of breast cancer through repressing cholesterol and activating TGF-β signaling
- (2018) Zhiqiang Zhao et al. ONCOGENE
- Enzymatic Inactivation of Oxysterols in Breast Tumor Cells Constraints Metastasis Formation by Reprogramming the Metastatic Lung Microenvironment
- (2018) Marta A. Moresco et al. Frontiers in Immunology
- 27-Hydroxycholesterol induces invasion and migration of breast cancer cells by increasing MMP9 and generating EMT through activation of STAT-3
- (2017) Zhaoxia Shen et al. ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
- Loss-of-function screens of druggable targetome against cancer stem–like cells
- (2017) Mee Song et al. FASEB JOURNAL
- Arginine 123 of apolipoprotein A-I is essential for lecithin:cholesterol acyltransferase activity
- (2017) Irina N. Gorshkova et al. JOURNAL OF LIPID RESEARCH
- ACTC1 as an invasion and prognosis marker in glioma
- (2017) Shunya Ohtaki et al. JOURNAL OF NEUROSURGERY
- Macrophages: Key orchestrators of a tumor microenvironment defined by therapeutic resistance
- (2017) Kristen B. Long et al. MOLECULAR IMMUNOLOGY
- Elevated tumor LDLR expression accelerates LDL cholesterol-mediated breast cancer growth in mouse models of hyperlipidemia
- (2017) E J Gallagher et al. ONCOGENE
- The cholesterol metabolite 27 hydroxycholesterol facilitates breast cancer metastasis through its actions on immune cells
- (2017) Amy E. Baek et al. Nature Communications
- Extracellular Acidic pH Activates the Sterol Regulatory Element-Binding Protein 2 to Promote Tumor Progression
- (2017) Ayano Kondo et al. Cell Reports
- Pancreatic Adenocarcinoma Therapeutic Targets Revealed by Tumor-Stroma Cross-Talk Analyses in Patient-Derived Xenografts
- (2017) Rémy Nicolle et al. Cell Reports
- Tissue Tregs
- (2016) Marisella Panduro et al. Annual Review of Immunology
- Touché! STARD3 and STARD3NL tether the ER to endosomes
- (2016) Léa P. Wilhelm et al. BIOCHEMICAL SOCIETY TRANSACTIONS
- LXR agonist treatment of blastic plasmacytoid dendritic cell neoplasm restores cholesterol efflux and triggers apoptosis
- (2016) A. Ceroi et al. BLOOD
- Role of hesperetin in LDL-receptor expression in hepatoma HepG2 cells
- (2016) Nora A. Bawazeer et al. BMC Complementary and Alternative Medicine
- The Emerging Hallmarks of Cancer Metabolism
- (2016) Natalya N. Pavlova et al. Cell Metabolism
- Inhibition of SOAT1 Suppresses Glioblastoma Growth via Blocking SREBP-1-Mediated Lipogenesis
- (2016) F. Geng et al. CLINICAL CANCER RESEARCH
- Targeting regulatory T cells in tumors
- (2016) Chang Liu et al. FEBS Journal
- A Cholesterol-Based Allostery Model of T Cell Receptor Phosphorylation
- (2016) Mahima Swamy et al. IMMUNITY
- The Allostery Model of TCR Regulation
- (2016) Wolfgang W. A. Schamel et al. JOURNAL OF IMMUNOLOGY
- Potentiating the antitumour response of CD8+ T cells by modulating cholesterol metabolism
- (2016) Wei Yang et al. NATURE
- Abrogating cholesterol esterification suppresses growth and metastasis of pancreatic cancer
- (2016) J Li et al. ONCOGENE
- Statins Attenuate Helicobacter pylori CagA Translocation and Reduce Incidence of Gastric Cancer: In Vitro and Population-Based Case-Control Studies
- (2016) Chun-Jung Lin et al. PLoS One
- The ROS-mediated activation of STAT-3/VEGF signaling is involved in the 27-hydroxycholesterol-induced angiogenesis in human breast cancer cells
- (2016) Dongmei Zhu et al. TOXICOLOGY LETTERS
- CD24 promoted cancer cell angiogenesis via Hsp90-mediated STAT3/VEGF signaling pathway in colorectal cancer
- (2016) Xinying Wang et al. Oncotarget
- Squalene epoxidase is a bona fide oncogene by amplification with clinical relevance in breast cancer
- (2016) David N. Brown et al. Scientific Reports
- Upregulation of the mevalonate pathway by cholesterol depletion abolishes tolerance to N-bisphosphonate induced Vγ9Vδ2 T cell cytotoxicity in PC-3 prostate cancer cells
- (2015) S. Arkko et al. CANCER LETTERS
- Uncoupling Nuclear Receptor LXR and Cholesterol Metabolism in Cancer
- (2015) Fabiola Bovenga et al. Cell Metabolism
- The cholesterol metabolite 27-hydroxycholesterol regulates p53 activity and increases cell proliferation via MDM2 in breast cancer cells
- (2015) Shaneabbas Raza et al. MOLECULAR AND CELLULAR BIOCHEMISTRY
- In vivo genome editing using Staphylococcus aureus Cas9
- (2015) F. Ann Ran et al. NATURE
- Mast Cells, Mastocytosis, and Related Disorders
- (2015) NEW ENGLAND JOURNAL OF MEDICINE
- SREBP maintains lipid biosynthesis and viability of cancer cells under lipid- and oxygen-deprived conditions and defines a gene signature associated with poor survival in glioblastoma multiforme
- (2015) C A Lewis et al. ONCOGENE
- Targeting SREBPs for treatment of the metabolic syndrome
- (2015) Selma M. Soyal et al. TRENDS IN PHARMACOLOGICAL SCIENCES
- The cholesterol transporter ABCG1 links cholesterol homeostasis and tumour immunity
- (2015) Duygu Sag et al. Nature Communications
- Highly Selective Anti-Cancer Activity of Cholesterol-Interacting Agents Methyl-β-Cyclodextrin and Ostreolysin A/Pleurotolysin B Protein Complex on Urothelial Cancer Cells
- (2015) Nataša Resnik et al. PLoS One
- Squalene Synthase Induces Tumor Necrosis Factor Receptor 1 Enrichment in Lipid Rafts to Promote Lung Cancer Metastasis
- (2014) Yi-Fang Yang et al. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
- Itraconazole suppresses the growth of glioblastoma through induction of autophagy
- (2014) Rui Liu et al. Autophagy
- Induction of cholesterol biosynthesis by archazolid B in T24 bladder cancer cells
- (2014) R. Hamm et al. BIOCHEMICAL PHARMACOLOGY
- Lovastatin inhibits human B lymphoma cell proliferation by reducing intracellular ROS and TRPC6 expression
- (2014) Xiang Song et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
- Cholesteryl Ester Accumulation Induced by PTEN Loss and PI3K/AKT Activation Underlies Human Prostate Cancer Aggressiveness
- (2014) Shuhua Yue et al. Cell Metabolism
- Oxidized Lipids Block Antigen Cross-Presentation by Dendritic Cells in Cancer
- (2014) W. Cao et al. JOURNAL OF IMMUNOLOGY
- LDL-cholesterol signaling induces breast cancer proliferation and invasion
- (2014) Catarina Rodrigues dos Santos et al. Lipids in Health and Disease
- Fatostatin Displays High Antitumor Activity in Prostate Cancer by Blocking SREBP-Regulated Metabolic Pathways and Androgen Receptor Signaling
- (2014) X. Li et al. MOLECULAR CANCER THERAPEUTICS
- Tumor-specific IL-9–producing CD8+Tc9 cells are superior effector than type-I cytotoxic Tc1 cells for adoptive immunotherapy of cancers
- (2014) Yong Lu et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Oxysterols induce transition of monocytic cells to phenotypically mature dendritic cell-like cells
- (2013) Yonghae Son et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- The Cardioprotective Protein Apolipoprotein A1 Promotes Potent Anti-tumorigenic Effects
- (2013) Maryam Zamanian-Daryoush et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- mTORC1 couples immune signals and metabolic programming to establish Treg-cell function
- (2013) Hu Zeng et al. NATURE
- Sterol regulatory element–binding proteins are essential for the metabolic programming of effector T cells and adaptive immunity
- (2013) Yoko Kidani et al. NATURE IMMUNOLOGY
- Zoledronic Acid Restores Doxorubicin Chemosensitivity and Immunogenic Cell Death in Multidrug-Resistant Human Cancer Cells
- (2013) Chiara Riganti et al. PLoS One
- Neutralizing Tumor-Promoting Chronic Inflammation: A Magic Bullet?
- (2013) L. M. Coussens et al. SCIENCE
- 27-Hydroxycholesterol Links Hypercholesterolemia and Breast Cancer Pathophysiology
- (2013) E. R. Nelson et al. SCIENCE
- Lipid Raft Association Restricts CD44-Ezrin Interaction and Promotion of Breast Cancer Cell Migration
- (2012) Simona Donatello et al. AMERICAN JOURNAL OF PATHOLOGY
- Lipid Droplets and Cellular Lipid Metabolism
- (2012) Tobias C. Walther et al. Annual Review of Biochemistry
- A key regulator of cholesterol homoeostasis, SREBP-2, can be targeted in prostate cancer cells with natural products
- (2012) James R. Krycer et al. BIOCHEMICAL JOURNAL
- Atorvastatin delays progression of pancreatic lesions to carcinoma by regulating PI3/AKT signaling in p48Cre/+ LSL-KrasG12D/+ mice
- (2012) Altaf Mohammed et al. INTERNATIONAL JOURNAL OF CANCER
- Regulatory T cells in melanoma: the final hurdle towards effective immunotherapy?
- (2012) Joannes FM Jacobs et al. LANCET ONCOLOGY
- Curcumin inhibits cholesterol uptake in Caco-2 cells by down-regulation of NPC1L1 expression
- (2012) Dan Feng et al. Lipids in Health and Disease
- Anticancer Activity of the Cholesterol Exporter ABCA1 Gene
- (2012) Bradley Smith et al. Cell Reports
- Migration of MDA-MB-231 breast cancer cells depends on the availability of exogenous lipids and cholesterol esterification
- (2011) Caryl J. Antalis et al. CLINICAL & EXPERIMENTAL METASTASIS
- Involvement of Chk1–Cdc25A-cyclin A/CDk2 pathway in simvastatin induced S-phase cell cycle arrest and apoptosis in multiple myeloma cells
- (2011) Yong-Sheng Tu et al. EUROPEAN JOURNAL OF PHARMACOLOGY
- The mammalian START domain protein family in lipid transport in health and disease
- (2011) Barbara J Clark JOURNAL OF ENDOCRINOLOGY
- An LXR Agonist Promotes Glioblastoma Cell Death through Inhibition of an EGFR/AKT/SREBP-1/LDLR-Dependent Pathway
- (2011) D. Guo et al. Cancer Discovery
- IL-2 Costimulation Enables Statin-Mediated Activation of Human NK Cells, Preferentially through a Mechanism Involving CD56+ Dendritic Cells
- (2010) G. Gruenbacher et al. CANCER RESEARCH
- The Functional Roles of Lipid Rafts in T Cell Activation, Immune Diseases and HIV Infection and Prevention
- (2010) Cheng Luo et al. Cellular & Molecular Immunology
- Synergic effect of Eicosapentaenoic acid and Lovastatin on gene expression of HMGCoA reductase and LDL receptor in cultured HepG2 cells
- (2010) Maria Notarnicola et al. Lipids in Health and Disease
- Ezetimibe reverses the inhibitory effects of dietary cholesterol on mammary tumorigenesis in rats
- (2009) Erin McNamara et al. INTERNATIONAL JOURNAL OF CANCER
- Tumor-mediated liver X receptor-α activation inhibits CC chemokine receptor-7 expression on dendritic cells and dampens antitumor responses
- (2009) Eduardo J Villablanca et al. NATURE MEDICINE
- LXR Regulates Cholesterol Uptake Through Idol-Dependent Ubiquitination of the LDL Receptor
- (2009) Noam Zelcer et al. SCIENCE
- Mitochondrial Cholesterol Contributes to Chemotherapy Resistance in Hepatocellular Carcinoma
- (2008) J. Montero et al. CANCER RESEARCH
- A Cholesterol Toggle Switch
- (2008) Randolph Y. Hampton Cell Metabolism
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExploreFind the ideal target journal for your manuscript
Explore over 38,000 international journals covering a vast array of academic fields.
Search