The Allostery Model of TCR Regulation

A Cholesterol-Based Allostery Model of T Cell Receptor Phosphorylation

(2016) Mahima Swamy et al.   IMMUNITY

Inhibition of T cell receptor signaling by cholesterol sulfate, a naturally occurring derivative of membrane cholesterol

(2016) Feng Wang et al.   NATURE IMMUNOLOGY

Functional role of T-cell receptor nanoclusters in signal initiation and antigen discrimination

(2016) Sophie V. Pageon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mechanisms of localized activation of the T cell antigen receptor inside clusters

(2015) Yair Neve-Oz et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

A Mechanical Switch Couples T Cell Receptor Triggering to the Cytoplasmic Juxtamembrane Regions of CD3ζζ

(2015) Mark S. Lee et al.   IMMUNITY

Accumulation of Dynamic Catch Bonds between TCR and Agonist Peptide-MHC Triggers T Cell Signaling

(2014) Baoyu Liu et al.   CELL

A Role for CD8 in the Developmental Tuning of Antigen Recognition and CD3 Conformational Change

(2014) D. Gil et al.   JOURNAL OF IMMUNOLOGY

Conformational changes in the T cell receptor differentially determine T cell subset development in mice

(2014) R. Blanco et al.   Science Signaling

The CD3 Conformational Change in the γδ T Cell Receptor Is Not Triggered by Antigens but Can Be Enforced to Enhance Tumor Killing

(2014) Elaine P. Dopfer et al.   Cell Reports

From feedback inhibition to allostery: the enduring example of aspartate transcarbamoylase

(2013) John Gerhart   FEBS Journal

50 years of allosteric interactions: the twists and turns of the models

(2013) Jean-Pierre Changeux   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Organization of the resting TCR in nanoscale oligomers

(2012) Wolfgang W. A. Schamel et al.   IMMUNOLOGICAL REVIEWS

Cholesterol and Sphingomyelin Drive Ligand-independent T-cell Antigen Receptor Nanoclustering

(2012) Eszter Molnár et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Propagation of Allosteric States in Large Multiprotein Complexes

(2012) Dennis Bray   JOURNAL OF MOLECULAR BIOLOGY

Ca2+ regulates T-cell receptor activation by modulating the charge property of lipids

(2012) Xiaoshan Shi et al.   NATURE

TCR Nanoclusters as the Framework for Transmission of Conformational Changes and Cooperativity

(2012) Raquel Blanco et al.   Frontiers in Immunology

TCR Signaling Emerges from the Sum of Many Parts

(2012) Michael S. Kuhns et al.   Frontiers in Immunology

Functional Nanoscale Organization of Signaling Molecules Downstream of the T Cell Antigen Receptor

(2011) Eilon Sherman et al.   IMMUNITY

Increased Sensitivity of Antigen-Experienced T Cells through the Enrichment of Oligomeric T Cell Receptor Complexes

(2011) Rashmi Kumar et al.   IMMUNITY

The T Cell Receptor Triggering Apparatus Is Composed of Monovalent or Monomeric Proteins

(2011) John R. James et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Basal and Antigen-Induced Exposure of the Proline-Rich Sequence in CD3 

(2011) J. de la Cruz et al.   JOURNAL OF IMMUNOLOGY

Hemoglobin and Cooperativity: Experiments and Theories

(2010) Andrea Bellelli   CURRENT PROTEIN & PEPTIDE SCIENCE

Dependence of T Cell Antigen Recognition on T Cell Receptor-Peptide MHC Confinement Time

(2010) Milos Aleksic et al.   IMMUNITY

Structural characterization of the TCR complex by electron microscopy

(2010) Ignacio Arechaga et al.   INTERNATIONAL IMMUNOLOGY

The right team at the right time to go for a home run: tyrosine kinase activation by the TCR

(2010) Arthur Weiss   NATURE IMMUNOLOGY

Organization of proximal signal initiation at the TCR:CD3 complex

(2009) Clifford S. Guy et al.   IMMUNOLOGICAL REVIEWS

TCR and Lat are expressed on separate protein islands on T cell membranes and concatenate during activation

(2009) Björn F Lillemeier et al.   NATURE IMMUNOLOGY

Cooperativity Between T Cell Receptor Complexes Revealed by Conformational Mutants of CD3 

(2009) N. Martinez-Martin et al.   Science Signaling

Regulation of T Cell Receptor Activation by Dynamic Membrane Binding of the CD3ɛ Cytoplasmic Tyrosine-Based Motif

(2008) Chenqi Xu et al.   CELL

The proline-rich sequence of CD3ε controls T cell antigen receptor expression on and signaling potency in preselection CD4+CD8+ thymocytes

(2008) Michaël Mingueneau et al.   NATURE IMMUNOLOGY

T Cell Receptor Engagement Triggers Its CD3ε and CD3ζ Subunits to Adopt a Compact, Locked Conformation

(2008) Ruth M. Risueño et al.   PLoS One

A permissive geometry model for TCR–CD3 activation

(2008) Susana Minguet et al.   TRENDS IN BIOCHEMICAL SCIENCES