The Josephin domain (JD) containing proteins are predicted to bind to the same interactors: Implications for spinocerebellar ataxia type 3 (SCA3) studies using Drosophila melanogaster mutants

A perspective on Drosophila genetics and its insight into human neurodegenerative disease

(2022) Nancy M. Bonini   Frontiers in Molecular Biosciences

Neurodegenerative phosphoprotein signaling landscape in models of SCA3

(2021) Anna S. Sowa et al.   Molecular Brain

Highly accurate protein structure prediction with AlphaFold

(2021) John Jumper et al.   NATURE

Highly accurate protein structure prediction for the human proteome

(2021) Kathryn Tunyasuvunakool et al.   NATURE

Between Interactions and Aggregates: The PolyQ Balance

(2021) Pablo Mier et al.   Genome Biology and Evolution

A Novel SCA3 Knock-in Mouse Model Mimics the Human SCA3 Disease Phenotype Including Neuropathological, Behavioral, and Transcriptional Abnormalities Especially in Oligodendrocytes

(2021) Eva Haas et al.   MOLECULAR NEUROBIOLOGY

The Gene Ontology resource: enriching a GOld mine

(2020) et al.   NUCLEIC ACIDS RESEARCH

EvoPPI 1.0: a Web Platform for Within- and Between-Species Multiple Interactome Comparisons and Application to Nine PolyQ Proteins Determining Neurodegenerative Diseases

(2019) Noé Vázquez et al.   Interdisciplinary Sciences-Computational Life Sciences

Altered Levels of Proteins and Phosphoproteins, in the Absence of Early Causative Transcriptional Changes, Shape the Molecular Pathogenesis in the Brain of Young Presymptomatic Ki91 SCA3/MJD Mouse

(2019) Kalina Wiatr et al.   MOLECULAR NEUROBIOLOGY

ATXN1 N-terminal region explains the binding differences of wild-type and expanded forms

(2019) Sara Rocha et al.   BMC Medical Genomics

Ensembl 2020

(2019) Andrew D Yates et al.   NUCLEIC ACIDS RESEARCH

Pathogenesis of SCA3 and implications for other polyglutamine diseases

(2019) Hayley S. McLoughlin et al.   NEUROBIOLOGY OF DISEASE

Machado-Joseph disease / Spinocerebellar ataxia type 3:lessons from disease pathogenesis and clues into therapy

(2018) Carlos Matos et al.   JOURNAL OF NEUROCHEMISTRY

Polyglutamine expansion diseases: More than simple repeats

(2018) Alexandra Silva et al.   JOURNAL OF STRUCTURAL BIOLOGY

Transcriptional profiling and biomarker identification reveal tissue specific effects of expanded ataxin-3 in a spinocerebellar ataxia type 3 mouse model

(2018) Lodewijk J. A. Toonen et al.   Molecular Neurodegeneration

Mass spectrometry analyses of normal and polyglutamine expanded ataxin-3 reveal novel interaction partners involved in mitochondrial function

(2018) Line V. Kristensen et al.   NEUROCHEMISTRY INTERNATIONAL

Cysteine Metabolism in Neuronal Redox Homeostasis

(2018) Bindu D. Paul et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Large Scale Analyses and Visualization of Adaptive Amino Acid Changes Projects

(2018) Noé Vázquez et al.   Interdisciplinary Sciences-Computational Life Sciences

Physiological and pathophysiological characteristics of ataxin-3 isoforms

(2018) Daniel Weishäupl et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

PANTHER version 14: more genomes, a new PANTHER GO-slim and improvements in enrichment analysis tools

(2018) Huaiyu Mi et al.   NUCLEIC ACIDS RESEARCH

Bioinformatics Protocols for Quickly Obtaining Large-Scale Data Sets for Phylogenetic Inferences

(2018) Hugo López-Fernández et al.   Interdisciplinary Sciences-Computational Life Sciences

The Evolution and Functional Diversification of the Deubiquitinating Enzyme Superfamily

(2017) Caitlyn Vlasschaert et al.   Genome Biology and Evolution

FlyAtlas 2: a new version of the Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

(2017) David P Leader et al.   NUCLEIC ACIDS RESEARCH

Ataxin-3 promotes genome integrity by stabilizing Chk1

(2017) Yingfeng Tu et al.   NUCLEIC ACIDS RESEARCH

The HADDOCK2.2 Web Server: User-Friendly Integrative Modeling of Biomolecular Complexes

(2016) G.C.P. van Zundert et al.   JOURNAL OF MOLECULAR BIOLOGY

Neurodegenerative diseases

(2016) Marie-Thérèse Heemels   NATURE

Genome evolution in the allotetraploid frog Xenopus laevis

(2016) Adam M. Session et al.   NATURE

Mitochondrial dynamics and quality control in Huntington's disease

(2016) Pedro Guedes-Dias et al.   NEUROBIOLOGY OF DISEASE

Promoter Variation and Expression Levels of Inflammatory Genes IL1A, IL1B, IL6 and TNF in Blood of Spinocerebellar Ataxia Type 3 (SCA3) Patients

(2016) Mafalda Raposo et al.   NEUROMOLECULAR MEDICINE

Studying polyglutamine diseases in Drosophila

(2015) Zhen Xu et al.   EXPERIMENTAL NEUROLOGY

The I-TASSER Suite: protein structure and function prediction

(2015) Jianyi Yang et al.   NATURE METHODS

I-TASSER server: new development for protein structure and function predictions

(2015) Jianyi Yang et al.   NUCLEIC ACIDS RESEARCH

UBA1: At the Crossroads of Ubiquitin Homeostasis and Neurodegeneration

(2015) Ewout J.N. Groen et al.   TRENDS IN MOLECULAR MEDICINE

Quantitative Interaction Proteomics of Neurodegenerative Disease Proteins

(2015) Fabian Hosp et al.   Cell Reports

Inactivation of PNKP by Mutant ATXN3 Triggers Apoptosis by Activating the DNA Damage-Response Pathway in SCA3

(2015) Rui Gao et al.   PLoS Genetics

The Role of the Mammalian DNA End-processing Enzyme Polynucleotide Kinase 3’-Phosphatase in Spinocerebellar Ataxia Type 3 Pathogenesis

(2015) Arpita Chatterjee et al.   PLoS Genetics

Interactions of ataxin-3 with its molecular partners in the protein machinery that sorts protein aggregates to the aggresome

(2014) Marcella Bonanomi et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Whole-genome duplication in teleost fishes and its evolutionary consequences

(2014) Stella M. K. Glasauer et al.   MOLECULAR GENETICS AND GENOMICS

Investigation of the Josephin Domain Protein-Protein Interaction by Molecular Dynamics

(2014) Marco A. Deriu et al.   PLoS One

Ubiquitin ligase ITCH recruitment suppresses the aggregation and cellular toxicity of cytoplasmic misfolded proteins

(2014) Deepak Chhangani et al.   Scientific Reports

Aggregation of polyglutamine-expanded ataxin-3 sequesters its specific interacting partners into inclusions: Implication in a loss-of-function pathology

(2014) Hui Yang et al.   Scientific Reports

Aggregation of polyQ-extended proteins is promoted by interaction with their natural coiled-coil partners

(2013) Spyros Petrakis et al.   BIOESSAYS

JosD1, a Membrane-targeted Deubiquitinating Enzyme, Is Activated by Ubiquitination and Regulates Membrane Dynamics, Cell Motility, and Endocytosis

(2013) Takahiro Seki et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

SUMO-1 Modification on K166 of PolyQ-Expanded aTaxin-3 Strengthens Its Stability and Increases Its Cytotoxicity

(2013) Ya-Fang Zhou et al.   PLoS One

Impact of whole-genome duplication on vertebrate development and evolution

(2013) Masanori Kasahara   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

A functional deficiency of TERA/VCP/p97 contributes to impaired DNA repair in multiple polyglutamine diseases

(2013) Kyota Fujita et al.   Nature Communications

Brain pathology of spinocerebellar ataxias

(2012) Kay Seidel et al.   ACTA NEUROPATHOLOGICA

An anatomically comprehensive atlas of the adult human brain transcriptome

(2012) Michael J. Hawrylycz et al.   NATURE

Development and application of a DNA microarray-based yeast two-hybrid system

(2012) Bernhard Suter et al.   NUCLEIC ACIDS RESEARCH

Evolution and function of CAG/polyglutamine repeats in protein–protein interaction networks

(2012) Martin H. Schaefer et al.   NUCLEIC ACIDS RESEARCH

Large-Scale Screen for Modifiers of Ataxin-3-Derived Polyglutamine-Induced Toxicity in Drosophila

(2012) Hannes Voßfeldt et al.   PLoS One

Compromised mitochondrial complex II in models of Machado–Joseph disease

(2011) Mário N. Laço et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

An integrative approach to ortholog prediction for disease-focused and other functional studies

(2011) Yanhui Hu et al.   BMC BIOINFORMATICS

FOXO4-dependent upregulation of superoxide dismutase-2 in response to oxidative stress is impaired in spinocerebellar ataxia type 3

(2011) Julieta Araujo et al.   HUMAN MOLECULAR GENETICS

Ataxin-3 Deubiquitination Is Coupled to Parkin Ubiquitination via E2 Ubiquitin-conjugating Enzyme

(2011) Thomas M. Durcan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Fast, scalable generation of high-quality protein multiple sequence alignments using Clustal Omega

(2011) F. Sievers et al.   Molecular Systems Biology

CPORT: A Consensus Interface Predictor and Its Performance in Prediction-Driven Docking with HADDOCK

(2011) Sjoerd J. de Vries et al.   PLoS One

Co-Chaperone HSJ1a Dually Regulates the Proteasomal Degradation of Ataxin-3

(2011) Xue-Chao Gao et al.   PLoS One

Episodic radiations in the fly tree of life

(2011) B. M. Wiegmann et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Toward understanding Machado–Joseph disease

(2011) Maria do Carmo Costa et al.   PROGRESS IN NEUROBIOLOGY

A Genomewide RNA Interference Screen for Modifiers of Aggregates Formation by Mutant Huntingtin in Drosophila

(2010) S. Zhang et al.   GENETICS

Silencing ataxin-3 mitigates degeneration in a rat model of Machado–Joseph disease: no role for wild-type ataxin-3?

(2010) Sandro Alves et al.   HUMAN MOLECULAR GENETICS

The Machado–Joseph disease-associated mutant form of ataxin-3 regulates parkin ubiquitination and stability

(2010) Thomas M. Durcan et al.   HUMAN MOLECULAR GENETICS

Crystal Structure of a Josephin-Ubiquitin Complex

(2010) Stephen D. Weeks et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A mitochondrial ubiquitin ligase MITOL controls cell toxicity of polyglutamine-expanded protein

(2010) Ayumu Sugiura et al.   MITOCHONDRION

I-TASSER: a unified platform for automated protein structure and function prediction

(2010) Ambrish Roy et al.   Nature Protocols

TranslatorX: multiple alignment of nucleotide sequences guided by amino acid translations

(2010) Federico Abascal et al.   NUCLEIC ACIDS RESEARCH

FastTree 2 – Approximately Maximum-Likelihood Trees for Large Alignments

(2010) Morgan N. Price et al.   PLoS One

Defining the Human Deubiquitinating Enzyme Interaction Landscape

(2009) Mathew E. Sowa et al.   CELL

The (CAG)n tract of Machado–Joseph Disease gene (ATXN3): a comparison between DNA and mRNA in patients and controls

(2009) Conceição Bettencourt et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Gp78, an ER associated E3, promotes SOD1 and ataxin-3 degradation

(2009) Zheng Ying et al.   HUMAN MOLECULAR GENETICS

CK2-dependent phosphorylation determines cellular localization and stability of ataxin-3

(2009) Thorsten Mueller et al.   HUMAN MOLECULAR GENETICS

Proteomic and biochemical analyses unveil tight interaction of ataxin-3 with tubulin

(2009) Serena Mazzucchelli et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

FastTree: Computing Large Minimum Evolution Trees with Profiles instead of a Distance Matrix

(2009) M. N. Price et al.   MOLECULAR BIOLOGY AND EVOLUTION

The evolutionary significance of ancient genome duplications

(2009) Yves Van de Peer et al.   NATURE REVIEWS GENETICS

Increased transcript diversity: novel splicing variants of Machado–Joseph Disease gene (ATXN3)

(2009) Conceição Bettencourt et al.   NEUROGENETICS

The Deubiquitinating Enzyme Ataxin-3, a Polyglutamine Disease Protein, Edits Lys63Linkages in Mixed Linkage Ubiquitin Chains

(2008) Brett J. Winborn et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Polyglutamine-expanded ataxin-3 causes cerebellar dysfunction of SCA3 transgenic mice by inducing transcriptional dysregulation

(2008) An-Hsun Chou et al.   NEUROBIOLOGY OF DISEASE