Translating phage therapy into the clinic: Recent accomplishments but continuing challenges

Phage therapy: From biological mechanisms to future directions

(2023) Steffanie A. Strathdee et al.   CELL

Ecology and Evolutionary Biology of Hindering Phage Therapy: The Phage Tolerance vs. Phage Resistance of Bacterial Biofilms

(2023) Stephen T. Abedon   Antibiotics-Basel

As Superbugs Flourish, Bacteriophage Therapy Recaptures Researchers’ Interest

(2023) Eli Cahan   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Bacteriophage Adsorption: Likelihood of Virion Encounter with Bacteria and Other Factors Affecting Rates

(2023) Stephen Tobias Abedon   Antibiotics-Basel

The unregulated potential of phages

(2023) The Lancet Microbe   Lancet Microbe

Considerations for the Use of Phage Therapy in Clinical Practice

(2022) Gina A. Suh et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Global burden of bacterial antimicrobial resistance in 2019: a systematic analysis

(2022) Christopher JL Murray et al.   LANCET

Host and pathogen response to bacteriophage engineered against Mycobacterium abscessus lung infection

(2022) Jerry A. Nick et al.   CELL

Safety and efficacy of phage therapy in difficult-to-treat infections: a systematic review

(2022) Saartje Uyttebroek et al.   LANCET INFECTIOUS DISEASES

A Thorough Synthesis of Phage Therapy Unit Activity in Poland—Its History, Milestones and International Recognition

(2022) Maciej Żaczek et al.   Viruses-Basel

Aminoglycoside Antibiotics Inhibit Phage Infection by Blocking an Early Step of the Infection Cycle

(2022) Larissa Kever et al.   mBio

Bacteriophage treatment of disseminated cutaneous Mycobacterium chelonae infection

(2022) Jessica S. Little et al.   Nature Communications

An overview of the current state of phage therapy for the treatment of biofilm-related infections

(2022) Diana P Pires et al.   Current Opinion in Virology

Mitigation of evolved bacterial resistance to phage therapy

(2022) Clara Torres-Barceló et al.   Current Opinion in Virology

Antibiotic Exposure Leads to Reduced Phage Susceptibility in Vancomycin Intermediate Staphylococcus aureus (VISA)

(2022) Shawna McCallin et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Targeted suppression of human IBD-associated gut microbiota commensals by phage consortia for treatment of intestinal inflammation

(2022) Sara Federici et al.   CELL

Phage Therapy of Mycobacterium Infections: Compassionate-use of Phages in Twenty Patients with Drug-Resistant Mycobacterial Disease

(2022) Rebekah M. Dedrick et al.   CLINICAL INFECTIOUS DISEASES

Reassessment of Historical Clinical Trials Supports the Effectiveness of Phage Therapy

(2022) Luigi Marongiu et al.   CLINICAL MICROBIOLOGY REVIEWS

Phage Cocktails with Daptomycin and Ampicillin Eradicates Biofilm-Embedded Multidrug-Resistant Enterococcus faecium with Preserved Phage Susceptibility

(2022) Ashlan Kunz Coyne et al.   Antibiotics-Basel

The Safety and Efficacy of Phage Therapy: A Systematic Review of Clinical and Safety Trials

(2022) Helen J. Stacey et al.   Antibiotics-Basel

Standardised treatment and monitoring protocol to assess safety and tolerability of bacteriophage therapy for adult and paediatric patients (STAMP study): protocol for an open-label, single-arm trial

(2022) Ameneh Khatami et al.   BMJ Open

Bacteriophage-resistant Acinetobacter baumannii are resensitized to antimicrobials

(2021) Fernando Gordillo Altamirano et al.   Nature Microbiology

Risks and benefits of reducing the number of drugs to treat HIV-1 infection

(2021) Julen Cadiñanos et al.   Expert Opinion On Drug Safety

Improving the Inhibitory Effect of Phages against Pseudomonas aeruginosa Isolated from a Burn Patient Using a Combination of Phages and Antibiotics

(2021) Bahareh Lashtoo Aghaee et al.   Viruses-Basel

Pre-optimized phage therapy on secondary Acinetobacter baumannii infection in four critical COVID-19 patients

(2021) Nannan Wu et al.   Emerging Microbes & Infections

Engineered Bacteriophage Therapeutics: Rationale, Challenges and Future

(2021) Małgorzata Łobocka et al.   BIODRUGS

Targeting biofilms using phages and their enzymes

(2021) Joana Azeredo et al.   CURRENT OPINION IN BIOTECHNOLOGY

A Roadmap for Genome-Based Phage Taxonomy

(2021) Dann Turner et al.   Viruses-Basel

Phage Therapy for Antibiotic-Resistant Bacterial Infections

(2021) Graham F. Hatfull et al.   Annual Review of Medicine

Aminoglycosides Antagonize Bacteriophage Proliferation, Attenuating Phage Suppression of Bacterial Growth, Biofilm Formation, and Antibiotic Resistance

(2021) Pengxiao Zuo et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

A commentary on the development of engineered phage as therapeutics

(2021) Anne M.L. Barnard et al.   DRUG DISCOVERY TODAY

Bacterial lysis, autophagy and innate immune responses during adjunctive phage therapy in a child

(2021) Ameneh Khatami et al.   EMBO Molecular Medicine

The Safety and Toxicity of Phage Therapy: A Review of Animal and Clinical Studies

(2021) Dan Liu et al.   Viruses-Basel

Phage Therapy Experience at the Eliava Phage Therapy Center: Three Cases of Bacterial Persistence

(2021) Elisabed Zaldastanishvili et al.   Viruses-Basel

Bacteriophage Therapy for Difficult-to-Treat Infections: The Implementation of a Multidisciplinary Phage Task Force (The PHAGEFORCE Study Protocol)

(2021) Jolien Onsea et al.   Viruses-Basel

Black box of phage–bacterium interactions: exploring alternative phage infection strategies

(2021) Sari Mäntynen et al.   Open Biology

Pharmacokinetics and Pharmacodynamics of a Novel Virulent Klebsiella Phage Kp_Pokalde_002 in a Mouse Model

(2021) Gunaraj Dhungana et al.   Frontiers in Cellular and Infection Microbiology

Evolution of Bacterial Cross-Resistance to Lytic Phages and Albicidin Antibiotic

(2021) Kaitlyn E. Kortright et al.   Frontiers in Microbiology

Case Report: Chronic Bacterial Prostatitis Treated With Phage Therapy After Multiple Failed Antibiotic Treatments

(2021) Apurva Virmani Johri et al.   Frontiers in Pharmacology

The Many Applications of Engineered Bacteriophages—An Overview

(2021) Bryan Gibb et al.   Pharmaceuticals

Rapid evolutionary turnover of mobile genetic elements drives bacterial resistance to phages

(2021) Fatima Aysha Hussain et al.   SCIENCE

Targeting bacterial outer-membrane remodelling to impact antimicrobial drug resistance

(2021) Natalia C. Rosas et al.   TRENDS IN MICROBIOLOGY

Staphylococcal phages and pathogenicity islands drive plasmid evolution

(2021) Suzanne Humphrey et al.   Nature Communications

European regulatory aspects of phage therapy: magistral phage preparations

(2021) Gilbert Verbeken et al.   Current Opinion in Virology

Shopping for phages? Unpacking design rules for therapeutic phage cocktails

(2021) Cédric Lood et al.   Current Opinion in Virology

Treating Bacterial Infections with Bacteriophage-Based Enzybiotics: In Vitro, In Vivo and Clinical Application

(2021) Katarzyna M. Danis-Wlodarczyk et al.   Antibiotics-Basel

Phage Therapy in the 21st Century: Is There Modern, Clinical Evidence of Phage-Mediated Efficacy?

(2021) Stephen Abedon et al.   Pharmaceuticals

Friends or Foes? Rapid Determination of Dissimilar Colistin and Ciprofloxacin Antagonism of Pseudomonas aeruginosa Phages

(2021) Katarzyna M. Danis-Wlodarczyk et al.   Pharmaceuticals

Phage Cocktail Development for Bacteriophage Therapy: Toward Improving Spectrum of Activity Breadth and Depth

(2021) Stephen T. Abedon et al.   Pharmaceuticals

Myoviridae phage PDX kills enteroaggregative Escherichia coli without human microbiome dysbiosis

(2020) Leah C. S. Cepko et al.   JOURNAL OF MEDICAL MICROBIOLOGY

The Future of Phage: Ethical Challenges of Using Phage Therapy to Treat Bacterial Infections

(2020) Jonathan Anomaly   Public Health Ethics

Safety of bacteriophage therapy in severe Staphylococcus aureus infection

(2020) Aleksandra Petrovic Fabijan et al.   Nature Microbiology

Bacteriophage-Antibiotic Combination Strategy: An Alternative against Methicillin-resistant Phenotypes of Staphylococcus aureus

(2020) Razieh Kebriaei et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Current challenges and future opportunities of phage therapy

(2020) Diana P Pires et al.   FEMS MICROBIOLOGY REVIEWS

The forgotten tale of Brazilian phage therapy

(2020) Gabriel Magno de Freitas Almeida et al.   LANCET INFECTIOUS DISEASES

Pleiotropy complicates a trade-off between phage resistance and antibiotic resistance

(2020) Alita R. Burmeister et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Phage Therapy for Limb-threatening Prosthetic Knee Klebsiella pneumoniae Infection: Case Report and In Vitro Characterization of Anti-biofilm Activity

(2020) Edison J Cano et al.   CLINICAL INFECTIOUS DISEASES

High-throughput discovery of phage receptors using transposon insertion sequencing of bacteria

(2020) Kaitlyn E. Kortright et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Phage Therapy in the Year 2035

(2020) Jean-Paul Pirnay   Frontiers in Microbiology

Bacteriophage Therapy for Critical Infections Related to Cardiothoracic Surgery

(2020) Evgenii Rubalskii et al.   Antibiotics-Basel

Phage Therapy in the Resistance Era: Where Do We Stand and Where Are We Going?

(2020) Tiffany Luong et al.   CLINICAL THERAPEUTICS

Intravesical bacteriophages for treating urinary tract infections in patients undergoing transurethral resection of the prostate: a randomised, placebo-controlled, double-blind clinical trial

(2020) Lorenz Leitner et al.   LANCET INFECTIOUS DISEASES

Phage Therapy in the Postantibiotic Era

(2019) Fernando L. Gordillo Altamirano et al.   CLINICAL MICROBIOLOGY REVIEWS

PHAGE Study: Effects of Supplemental Bacteriophage Intake on Inflammation and Gut Microbiota in Healthy Adults

(2019) Hallie Febvre et al.   Nutrients

Protection of Phage Applications in Crop Production: A Patent Landscape

(2019) Dominique Holtappels et al.   Viruses-Basel

Processing Phage Therapy Requests in a Brussels Military Hospital: Lessons Identified

(2019) Sarah Djebara et al.   Viruses-Basel

Directed in Vitro Evolution of Therapeutic Bacteriophages: The Appelmans Protocol

(2019) Ben Burrowes et al.   Viruses-Basel

Phage therapy: What factors shape phage pharmacokinetics and bioavailability? Systematic and critical review

(2019) Krystyna Dąbrowska   MEDICINAL RESEARCH REVIEWS

The genera of bacteriophages and their receptors are the major determinants of host range

(2019) Yilmaz Emre Gencay et al.   ENVIRONMENTAL MICROBIOLOGY

Successful treatment of antibiotic resistant poly-microbial bone infection with bacteriophages and antibiotics combination

(2019) Ran Nir-Paz et al.   CLINICAL INFECTIOUS DISEASES

Phage Therapy: A Renewed Approach to Combat Antibiotic-Resistant Bacteria

(2019) Kaitlyn E. Kortright et al.   Cell Host & Microbe

Phage therapy’s latest makeover

(2019) Charles Schmidt   NATURE BIOTECHNOLOGY

Engineered bacteriophages for treatment of a patient with a disseminated drug-resistant Mycobacterium abscessus

(2019) Rebekah M. Dedrick et al.   NATURE MEDICINE

Current State of Compassionate Phage Therapy

(2019) McCallin et al.   Viruses-Basel

Phage Therapy Regulation: From Night to Dawn

(2019) Alan Fauconnier   Viruses-Basel

Early clinical experience of bacteriophage therapy in 3 lung transplant recipients

(2019) Saima Aslam et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Dynamic Modulation of the Gut Microbiota and Metabolome by Bacteriophages in a Mouse Model

(2019) Bryan B. Hsu et al.   Cell Host & Microbe

Adjunctive bacteriophage therapy for prosthetic valve endocarditis due to Staphylococcus aureus

(2019) Timothy Gilbey et al.   MEDICAL JOURNAL OF AUSTRALIA

Evolution of Superinfection Immunity in Cluster A Mycobacteriophages

(2019) Travis N. Mavrich et al.   mBio

Safety and Tolerability of Bacteriophage Therapy for Chronic Rhinosinusitis Due to Staphylococcus aureus

(2019) Mian Li Ooi et al.   JAMA Otolaryngology-Head & Neck Surgery

Bacteriophage Therapy of Ventilator-associated Pneumonia and Empyema caused by Pseudomonas aeruginosa

(2019) Susan Maddocks et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Polyclonal Staphylococcus aureus Bacteremia

(2019) Aleksandra Petrovic Fabijan et al.   ANNALS OF INTERNAL MEDICINE

Eradication of a multi-drug resistant, carbapenemase-producing Klebsiella pneumoniae isolate following oral and intra-rectal therapy with a custom-made, lytic bacteriophage preparation

(2019) Mario Corbellino et al.   CLINICAL INFECTIOUS DISEASES

Genetic transduction by phages and chromosomal islands: The new and noncanonical

(2019) Yin Ning Chiang et al.   PLoS Pathogens

A Dutch Case Report of Successful Treatment of Chronic Relapsing Urinary Tract Infection with Bacteriophages in a Renal Transplant Patient

(2019) Saskia Kuipers et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Engineering Phage Host-Range and Suppressing Bacterial Resistance through Phage Tail Fiber Mutagenesis

(2019) Kevin Yehl et al.   CELL

Pharmacologically Aware Phage Therapy: Pharmacodynamic and Pharmacokinetic Obstacles to Phage Antibacterial Action in Animal and Human Bodies

(2019) Krystyna Dąbrowska et al.   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

Evolutionary entanglement of mobile genetic elements and host defence systems: guns for hire

(2019) Eugene V. Koonin et al.   NATURE REVIEWS GENETICS

Pharmacological limitations of phage therapy

(2019) Anders S. Nilsson   UPSALA JOURNAL OF MEDICAL SCIENCES

Bacteriophage Therapeutics: A Primer for Clinicians on Phage‐Antibiotic Combinations

(2019) Taylor Morrisette et al.   PHARMACOTHERAPY

Use of phage therapy to treat long-standing, persistent, or chronic bacterial infections

(2018) Stephen T. Abedon   ADVANCED DRUG DELIVERY REVIEWS

Contribution of the Immune Response to Phage Therapy

(2018) Oleg Krut et al.   JOURNAL OF IMMUNOLOGY

Phage therapy against Achromobacter xylosoxidan s lung infection in a patient with cystic fibrosis: a case report

(2018) N. Hoyle et al.   RESEARCH IN MICROBIOLOGY

Viruses of archaea: Structural, functional, environmental and evolutionary genomics

(2018) Mart Krupovic et al.   VIRUS RESEARCH

The Magistral Phage

(2018) Jean-Paul Pirnay et al.   Viruses-Basel

Expert Opinion on Three Phage Therapy Related Topics: Bacterial Phage Resistance, Phage Training and Prophages in Bacterial Production Strains

(2018) Christine Rohde et al.   Viruses-Basel

OUP accepted manuscript

(2018)   JOURNAL OF THE HISTORY OF MEDICINE AND ALLIED SCIENCES

Bacteriophage Therapy: Clinical Trials and Regulatory Hurdles

(2018) Lucy L. Furfaro et al.   Frontiers in Cellular and Infection Microbiology

Lysogeny in nature: mechanisms, impact and ecology of temperate phages

(2017) Cristina Howard-Varona et al.   ISME Journal

A brief history of antibiotics and select advances in their synthesis

(2017) Kyriacos C Nicolaou et al.   JOURNAL OF ANTIBIOTICS

Ménage à trois in the human gut: interactions between host, bacteria and phages

(2017) Mohammadali Khan Mirzaei et al.   NATURE REVIEWS MICROBIOLOGY

A growing microcolony can survive and support persistent propagation of virulent phages

(2017) Rasmus Skytte Eriksen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An inclusive Research Education Community (iREC): Impact of the SEA-PHAGES program on research outcomes and student learning

(2017) David I. Hanauer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Bacteriophages for treating urinary tract infections in patients undergoing transurethral resection of the prostate: a randomized, placebo-controlled, double-blind clinical trial

(2017) Lorenz Leitner et al.   BMC Urology

In silico Evolution of Lysis-Lysogeny Strategies Reproduces Observed Lysogeny Propensities in Temperate Bacteriophages

(2017) Vaibhhav Sinha et al.   Frontiers in Microbiology

Synergy and Order Effects of Antibiotics and Phages in Killing Pseudomonas aeruginosa Biofilms

(2017) Waqas Nasir Chaudhry et al.   PLoS One

Bacteriophages to reduce gut carriage of antibiotic resistant uropathogens with low impact on microbiota composition

(2016) Matthieu Galtier et al.   ENVIRONMENTAL MICROBIOLOGY

Evolutionary Rationale for Phages as Complements of Antibiotics

(2016) Clara Torres-Barceló et al.   TRENDS IN MICROBIOLOGY

Antibody Production in Response to Staphylococcal MS-1 Phage Cocktail in Patients Undergoing Phage Therapy

(2016) Maciej Żaczek et al.   Frontiers in Microbiology

Bacteriophage T4 Infection of Stationary Phase E. coli: Life after Log from a Phage Perspective

(2016) Daniel Bryan et al.   Frontiers in Microbiology

Bacteriophage treatment of intransigent diabetic toe ulcers: a case series

(2016) R. Fish et al.   Journal of Wound Care

Phage selection restores antibiotic sensitivity in MDR Pseudomonas aeruginosa

(2016) Benjamin K. Chan et al.   Scientific Reports

Re-establishing a place for phage therapy in western medicine

(2015) Elizabeth Martin Kutter et al.   Future Microbiology

Mammalian Host-Versus-Phage immune response determines phage fate in vivo

(2015) Katarzyna Hodyra-Stefaniak et al.   Scientific Reports

Virulence reduction in bacteriophage resistant bacteria

(2015) Marcela León et al.   Frontiers in Microbiology

Inhibition of Biofilm Formation by T7 Bacteriophages Producing Quorum-Quenching Enzymes

(2014) Ruoting Pei et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Immunogenicity Studies of Proteins Forming the T4 Phage Head Surface

(2014) K. D browska et al.   JOURNAL OF VIROLOGY

Efficient engineering of a bacteriophage genome using the type I-E CRISPR-Cas system

(2014) Ruth Kiro et al.   RNA Biology

Phage Neutralization by Sera of Patients Receiving Phage Therapy

(2014) Marzanna Łusiak-Szelachowska et al.   VIRAL IMMUNOLOGY

Are archaeons incapable of being parasites or have we simply failed to notice?

(2013) Stephen T. Abedon   BIOESSAYS

Beyond phage therapy: virotherapy of protozoal diseases

(2013) Eric C Keen   Future Microbiology

Genetic modifications to temperate Enterococcus faecalis phage  Ef11 that abolish the establishment of lysogeny and sensitivity to repressor, and increase host range and productivity of lytic infection

(2013) H. Zhang et al.   MICROBIOLOGY-SGM

Bacteriophage adhering to mucus provide a non-host-derived immunity

(2013) J. J. Barr et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Fleas and smaller fleas: virotherapy for parasite infections

(2013) Paul Hyman et al.   TRENDS IN MICROBIOLOGY

Safety analysis of a Russian phage cocktail: From MetaGenomic analysis to oral application in healthy human subjects

(2013) Shawna McCallin et al.   VIROLOGY

Archaeal Viruses, Not Archaeal Phages: An Archaeological Dig

(2013) Stephen T. Abedon et al.   ARCHAEA-AN INTERNATIONAL MICROBIOLOGICAL JOURNAL

Bacteriophage virion-associated peptidoglycan hydrolases: potential new enzybiotics

(2012) Lorena Rodríguez-Rubio et al.   CRITICAL REVIEWS IN MICROBIOLOGY

Heterogeneity of selection and the evolution of resistance

(2012)   TRENDS IN ECOLOGY & EVOLUTION

The proportional lack of archaeal pathogens: Do viruses/phages hold the key?

(2011) Erin E. Gill et al.   BIOESSAYS

Combination therapies for combating antimicrobial resistance

(2011) Michael A Fischbach   CURRENT OPINION IN MICROBIOLOGY

Antibacterial efficacy of lytic Pseudomonas bacteriophage in normal and neutropenic mice models

(2011) Birendra R. Tiwari et al.   JOURNAL OF MICROBIOLOGY

General Principles of Antimicrobial Therapy

(2011) Surbhi Leekha et al.   MAYO CLINIC PROCEEDINGS

Designing Phage Therapeutics

(2010) Lawrence Goodridge   CURRENT PHARMACEUTICAL BIOTECHNOLOGY

Phage Therapy Pharmacology

(2010) Stephen Abedon et al.   CURRENT PHARMACEUTICAL BIOTECHNOLOGY

Phage Therapy in Clinical Practice: Treatment of Human Infections

(2010) Elizabeth Kutter et al.   CURRENT PHARMACEUTICAL BIOTECHNOLOGY

Isolation and characterization of Klebsiella pneumoniae specific bacteriophages from sewage samples

(2010) S. Kumari et al.   FOLIA MICROBIOLOGICA

A controlled clinical trial of a therapeutic bacteriophage preparation in chronic otitis due to antibiotic-resistantPseudomonas aeruginosa; a preliminary report of efficacy

(2009) A. Wright et al.   CLINICAL OTOLARYNGOLOGY

Site-specific recombination of T2 phage using IP008 long tail fiber genes provides a targeted method for expanding host range while retaining lytic activity

(2009) Faezeh Mahichi et al.   FEMS MICROBIOLOGY LETTERS

Plasmid Transfer via Transduction from Streptococcus thermophilus to Lactococcus lactis

(2008) A. Ammann et al.   JOURNAL OF BACTERIOLOGY

Phage therapy experience at the Eliava Institute

(2008) M. Kutateladze et al.   MEDECINE ET MALADIES INFECTIEUSES

BRED: A Simple and Powerful Tool for Constructing Mutant and Recombinant Bacteriophage Genomes

(2008) Laura J. Marinelli et al.   PLoS One