Nuclear lamina erosion-induced resurrection of endogenous retroviruses underlies neuronal aging

Resurrection of endogenous retroviruses during aging reinforces senescence

(2023) Xiaoqian Liu et al.   CELL

SESN1 is a FOXO3 effector that counteracts human skeletal muscle ageing

(2023) Ying Jing et al.   CELL PROLIFERATION

Biomarkers of aging

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Decoding Aging Hallmarks at the Single-Cell Level

(2023) Shuai Ma et al.   Annual Review of Biomedical Data Science

Lineage Landscape: a comprehensive database that records lineage commitment across species

(2022) Haoteng Yan et al.   NUCLEIC ACIDS RESEARCH

The landscape of aging

(2022) Yusheng Cai et al.   Science China-Life Sciences

Spatially resolved gene regulatory and disease-related vulnerability map of the adult Macaque cortex

(2022) Ying Lei et al.   Nature Communications

A single-nucleus transcriptomic atlas of primate testicular aging reveals exhaustion of the spermatogonial stem cell reservoir and loss of Sertoli cell homeostasis

(2022) Daoyuan Huang et al.   Protein & Cell

Single-nucleus profiling unveils a geroprotective role of the FOXO3 in primate skeletal muscle aging

(2022) Ying Jing et al.   Protein & Cell

SIRT3 consolidates heterochromatin and counteracts senescence

(2021) Zhiqing Diao et al.   NUCLEIC ACIDS RESEARCH

Cellular Senescence in Brain Aging

(2021) Ewa Sikora et al.   Frontiers in Aging Neuroscience

Single-nucleus transcriptomic landscape of primate hippocampal aging

(2021) Hui Zhang et al.   Protein & Cell

Caloric Restriction Reprograms the Single-Cell Transcriptional Landscape of Rattus Norvegicus Aging

(2020) Shuai Ma et al.   CELL

Single-Cell Transcriptomic Atlas of Primate Ovarian Aging

(2020) Si Wang et al.   CELL

Decoding the development of the human hippocampus

(2020) Suijuan Zhong et al.   NATURE

The ageing epigenome and its rejuvenation

(2020) Weiqi Zhang et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Single-nucleus transcriptomics of the prefrontal cortex in major depressive disorder implicates oligodendrocyte precursor cells and excitatory neurons

(2020) Corina Nagy et al.   NATURE NEUROSCIENCE

ZKSCAN3 counteracts cellular senescence by stabilizing heterochromatin

(2020) Huifang Hu et al.   NUCLEIC ACIDS RESEARCH

A single-cell transcriptomic landscape of primate arterial aging

(2020) Weiqi Zhang et al.   Nature Communications

Quantitative proteomic landscape of metaplastic breast carcinoma pathological subtypes and their relationship to triple-negative tumors

(2020) Sabra I. Djomehri et al.   Nature Communications

Stabilization of heterochromatin by CLOCK promotes stem cell rejuvenation and cartilage regeneration

(2020) Chuqian Liang et al.   CELL RESEARCH

Author Correction: Lipid-droplet-accumulating microglia represent a dysfunctional and proinflammatory state in the aging brain

(2020) Julia Marschallinger et al.   NATURE NEUROSCIENCE

Generation of a Hutchinson–Gilford progeria syndrome monkey model by base editing

(2020) Fang Wang et al.   Protein & Cell

SIRT7 antagonizes human stem cell aging as a heterochromatin stabilizer

(2020) Shijia Bi et al.   Protein & Cell

A Single-cell Transcriptomic Atlas of Primate Pancreatic Islet Aging

(2020) Jingyi Li et al.   National Science Review

Single-cell transcriptomic atlas of primate cardiopulmonary aging

(2020) Shuai Ma et al.   CELL RESEARCH

Heterochromatin: an epigenetic point of view in aging

(2020) Jong-Hyuk Lee et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

Innovations present in the primate interneuron repertoire

(2020) Fenna M. Krienen et al.   NATURE

Divergence of rodent and primate medial frontal cortex functional connectivity

(2020) David J. Schaeffer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Deciphering primate retinal aging at single-cell resolution

(2020) Si Wang et al.   Protein & Cell

Single cell RNA sequencing of human microglia uncovers a subset associated with Alzheimer’s disease

(2020) Marta Olah et al.   Nature Communications

A cynomolgus monkey with naturally occurring Parkinson's disease

(2020) Hao Li et al.   National Science Review

Author Correction: Regulation of transposable elements by DNA modifications

(2019) Özgen Deniz et al.   NATURE REVIEWS GENETICS

L1 drives IFN in senescent cells and promotes age-associated inflammation

(2019) Marco De Cecco et al.   NATURE

LINE1 Derepression in Aged Wild-Type and SIRT6-Deficient Mice Drives Inflammation

(2019) Matthew Simon et al.   Cell Metabolism

Human pluripotent stem cell–derived models and drug screening in CNS precision medicine

(2019) M. Catarina Silva et al.   Annals of the New York Academy of Sciences

DoubletFinder: Doublet Detection in Single-Cell RNA Sequencing Data Using Artificial Nearest Neighbors

(2019) Christopher S. McGinnis et al.   Cell Systems

Matrix metalloproteinase signals following neurotrauma are right on cue

(2019) Alpa Trivedi et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Large-scale proteomic analysis of human brain identifies proteins associated with cognitive trajectory in advanced age

(2019) Aliza P. Wingo et al.   Nature Communications

Metascape provides a biologist-oriented resource for the analysis of systems-level datasets

(2019) Yingyao Zhou et al.   Nature Communications

Single-cell transcriptomic profiling of the aging mouse brain

(2019) Methodios Ximerakis et al.   NATURE NEUROSCIENCE

Ageing as a risk factor for neurodegenerative disease

(2019) Yujun Hou et al.   Nature Reviews Neurology

Integrated Proteogenomic Characterization of HBV-Related Hepatocellular Carcinoma

(2019) Qiang Gao et al.   CELL

Age-related hyperinsulinemia leads to insulin resistance in neurons and cell-cycle-induced senescence

(2019) Hei-Man Chow et al.   NATURE NEUROSCIENCE

Undulating changes in human plasma proteome profiles across the lifespan

(2019) Benoit Lehallier et al.   NATURE MEDICINE

Cerebral cortical folding, parcellation, and connectivity in humans, nonhuman primates, and mice

(2019) David C. Van Essen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

OUP accepted manuscript

(2018)   BIOINFORMATICS

A Single-Cell Transcriptome Atlas of the Aging Drosophila Brain

(2018) Kristofer Davie et al.   CELL

Human Hippocampal Neurogenesis Persists throughout Aging

(2018) Maura Boldrini et al.   Cell Stem Cell

A single-cell RNA-seq survey of the developmental landscape of the human prefrontal cortex

(2018) Suijuan Zhong et al.   NATURE

Integrating single-cell transcriptomic data across different conditions, technologies, and species

(2018) Andrew Butler et al.   NATURE BIOTECHNOLOGY

A molecular network of the aging human brain provides insights into the pathology and cognitive decline of Alzheimer’s disease

(2018) Sara Mostafavi et al.   NATURE NEUROSCIENCE

Epigenetic Regulation in Neurodegenerative Diseases

(2018) Amit Berson et al.   TRENDS IN NEUROSCIENCES

Differential stem cell aging kinetics in Hutchinson-Gilford progeria syndrome and Werner syndrome

(2018) Zeming Wu et al.   Protein & Cell

Aging in a Dish: iPSC-Derived and Directly Induced Neurons for Studying Brain Aging and Age-Related Neurodegenerative Diseases

(2018) Jerome Mertens et al.   Annual Review of Genetics

SIRT6 deficiency results in developmental retardation in cynomolgus monkeys

(2018) Weiqi Zhang et al.   NATURE

Clearance of senescent glial cells prevents tau-dependent pathology and cognitive decline

(2018) Tyler J. Bussian et al.   NATURE

δ-Secretase-cleaved Tau stimulates Aβ production via upregulating STAT1-BACE1 signaling in Alzheimer’s disease

(2018) Zhentao Zhang et al.   MOLECULAR PSYCHIATRY

CNS penetration of ART in HIV-infected children

(2017) Malon Van den Hof et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

The gelatinases, MMP-2 and MMP-9, as fine tuners of neuroinflammatory processes

(2017) M.-J. Hannocks et al.   MATRIX BIOLOGY

Integrative single-cell analysis of transcriptional and epigenetic states in the human adult brain

(2017) Blue B Lake et al.   NATURE BIOTECHNOLOGY

Shared molecular and cellular mechanisms of premature ageing and ageing-associated diseases

(2017) Nard Kubben et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Inhibition of human endogenous retrovirus-K by antiretroviral drugs

(2017) Richa Tyagi et al.   Retrovirology

Aging and neurodegeneration are associated with increased mutations in single human neurons

(2017) Michael A. Lodato et al.   SCIENCE

CRISPR/Cas9-mediated targeted gene correction in amyotrophic lateral sclerosis patient iPSCs

(2017) Lixia Wang et al.   Protein & Cell

Epigenetic Mechanisms of Longevity and Aging

(2016) Payel Sen et al.   CELL

Ageing, neurodegeneration and brain rejuvenation

(2016) Tony Wyss-Coray   NATURE

p16Ink4a-induced senescence of pancreatic beta cells enhances insulin secretion

(2016) Aharon Helman et al.   NATURE MEDICINE

Using single nuclei for RNA-seq to capture the transcriptome of postmortem neurons

(2016) Suguna Rani Krishnaswami et al.   Nature Protocols

deepTools2: a next generation web server for deep-sequencing data analysis

(2016) Fidel Ramírez et al.   NUCLEIC ACIDS RESEARCH

Chronic administration of resveratrol prevents morphological changes in prefrontal cortex and hippocampus of aged rats

(2016) Elizabeth Monserrat Hernández-Hernández et al.   SYNAPSE

Opposite monosynaptic scaling of BLP–vCA1 inputs governs hopefulness- and helplessness-modulated spatial learning and memory

(2016) Ying Yang et al.   Nature Communications

HISAT: a fast spliced aligner with low memory requirements

(2015) Daehwan Kim et al.   NATURE METHODS

A Werner syndrome stem cell model unveils heterochromatin alterations as a driver of human aging

(2015) W. Zhang et al.   SCIENCE

Human endogenous retrovirus-K contributes to motor neuron disease

(2015) Wenxue Li et al.   Science Translational Medicine

Genome-Derived Cytosolic DNA Mediates Type I Interferon-Dependent Rejection of B Cell Lymphoma Cells

(2015) Yu J. Shen et al.   Cell Reports

DNA Damage and Its Links to Neurodegeneration

(2014) Ram Madabhushi et al.   NEURON

Increased L1 Retrotransposition in the Neuronal Genome in Schizophrenia

(2014) Miki Bundo et al.   NEURON

Tumor-targeted in vivo gene silencing via systemic delivery of cRGD-conjugated siRNA

(2014) Xiaoxia Liu et al.   NUCLEIC ACIDS RESEARCH

SIRT6 represses LINE1 retrotransposons by ribosylating KAP1 but this repression fails with stress and age

(2014) Michael Van Meter et al.   Nature Communications

A Chaperome Subnetwork Safeguards Proteostasis in Aging and Neurodegenerative Disease

(2014) Marc Brehme et al.   Cell Reports

featureCounts: an efficient general purpose program for assigning sequence reads to genomic features

(2013) Y. Liao et al.   BIOINFORMATICS

Human iPSC-Based Modeling of Late-Onset Disease via Progerin-Induced Aging

(2013) Justine D. Miller et al.   Cell Stem Cell

Modeling Alzheimer’s Disease with iPSCs Reveals Stress Phenotypes Associated with Intracellular Aβ and Differential Drug Responsiveness

(2013) Takayuki Kondo et al.   Cell Stem Cell

Cellular senescence and the senescent secretory phenotype: therapeutic opportunities

(2013) Tamara Tchkonia et al.   JOURNAL OF CLINICAL INVESTIGATION

The Role of Transposable Elements in Health and Diseases of the Central Nervous System

(2013) M. T. Reilly et al.   JOURNAL OF NEUROSCIENCE

Galectin-1 Deactivates Classically Activated Microglia and Protects from Inflammation-Induced Neurodegeneration

(2012) Sarah C. Starossom et al.   IMMUNITY

Induced pluripotent stem cells as tools for disease modelling and drug discovery in Alzheimer’s disease

(2012) Lezanne Ooi et al.   JOURNAL OF NEURAL TRANSMISSION

Progressive degeneration of human neural stem cells caused by pathogenic LRRK2

(2012) Guang-Hui Liu et al.   NATURE

NIH Image to ImageJ: 25 years of image analysis

(2012) Caroline A Schneider et al.   NATURE METHODS

 -Amyloid burden in healthy aging: Regional distribution and cognitive consequences

(2012) K. M. Rodrigue et al.   NEUROLOGY

Evaluation of Cynomolgus Macaque (Macaca fascicularis) Endogenous Retrovirus Expression Following Simian Immunodeficiency Virus Infection

(2012) Angie K. Marsh et al.   PLoS One

The role of nuclear lamin B1 in cell proliferation and senescence

(2011) T. Shimi et al.   GENES & DEVELOPMENT

Recapitulation of premature ageing with iPSCs from Hutchinson–Gilford progeria syndrome

(2011) Guang-Hui Liu et al.   NATURE

Identification of active loci of a human endogenous retrovirus in neurons of patients with amyotrophic lateral sclerosis

(2010) Renée Douville et al.   ANNALS OF NEUROLOGY

The Senescence-Associated Secretory Phenotype: The Dark Side of Tumor Suppression

(2010) Jean-Philippe Coppé et al.   Annual Review of Pathology-Mechanisms of Disease

Chromatin immunoprecipitation (ChIP) of plant transcription factors followed by sequencing (ChIP-SEQ) or hybridization to whole genome arrays (ChIP-CHIP)

(2010) Kerstin Kaufmann et al.   Nature Protocols

Human stem cells and drug screening: opportunities and challenges

(2010) Allison D. Ebert et al.   NATURE REVIEWS DRUG DISCOVERY

Expression ofp16INK4ain peripheral blood T-cells is a biomarker of human aging

(2009) Yan Liu et al.   AGING CELL

BSMAP: whole genome bisulfite sequence MAPping program

(2009) Yuanxin Xi et al.   BMC BIOINFORMATICS

Protocols to detect senescence-associated beta-galactosidase (SA-βgal) activity, a biomarker of senescent cells in culture and in vivo

(2009) Florence Debacq-Chainiaux et al.   Nature Protocols

Aging by epigenetics—A consequence of chromatin damage?

(2008) John M. Sedivy et al.   EXPERIMENTAL CELL RESEARCH