Stabilization of heterochromatin by CLOCK promotes stem cell rejuvenation and cartilage regeneration

The ageing epigenome and its rejuvenation

(2020) Weiqi Zhang et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

αKLOTHO and sTGFβR2 treatment counteract the osteoarthritic phenotype developed in a rat model

(2020) Paloma Martinez-Redondo et al.   Protein & Cell

ZKSCAN3 counteracts cellular senescence by stabilizing heterochromatin

(2020) Huifang Hu et al.   NUCLEIC ACIDS RESEARCH

SIRT7 antagonizes human stem cell aging as a heterochromatin stabilizer

(2020) Shijia Bi et al.   Protein & Cell

FOXO3-Engineered Human ESC-Derived Vascular Cells Promote Vascular Protection and Regeneration

(2019) Pengze Yan et al.   Cell Stem Cell

Telomere-dependent and telomere-independent roles of RAP1 in regulating human stem cell homeostasis

(2019) Xing Zhang et al.   Protein & Cell

Maintenance of Nucleolar Homeostasis by CBX4 Alleviates Senescence and Osteoarthritis

(2019) Xiaoqing Ren et al.   Cell Reports

CLOCK gene polymorphisms and quality of aging in a cohort of nonagenarians – The MUGELLO Study

(2019) Giuditta Pagliai et al.   Scientific Reports

Improved identification of DNA double strand breaks: γ-H2AX-epitope visualization by confocal microscopy and 3D reconstructed images

(2019) Nico Ruprecht et al.   RADIATION AND ENVIRONMENTAL BIOPHYSICS

L1 drives IFN in senescent cells and promotes age-associated inflammation

(2019) Marco De Cecco et al.   NATURE

LINE1 Derepression in Aged Wild-Type and SIRT6-Deficient Mice Drives Inflammation

(2019) Matthew Simon et al.   Cell Metabolism

Up-regulation of FOXD1 by YAP alleviates senescence and osteoarthritis

(2019) Lina Fu et al.   PLOS BIOLOGY

Molecular mechanisms and physiological importance of circadian rhythms

(2019) Alina Patke et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

BMAL1 associates with chromosome ends to control rhythms in TERRA and telomeric heterochromatin

(2019) Jinhee Park et al.   PLoS One

Genome-wide DNA methylation analysis reveals that mouse chemical iPSCs have closer epigenetic features to mESCs than OSKM-integrated iPSCs

(2018) Wangfang Ping et al.   Cell Death & Disease

Differential stem cell aging kinetics in Hutchinson-Gilford progeria syndrome and Werner syndrome

(2018) Zeming Wu et al.   Protein & Cell

ATF6 safeguards organelle homeostasis and cellular aging in human mesenchymal stem cells

(2018) Si Wang et al.   Cell Discovery

Simultaneous assessment of cognitive function, circadian rhythm, and spontaneous activity in aging mice

(2018) Sreemathi Logan et al.   GeroScience

Heterochromatin: Guardian of the Genome

(2018) Aniek Janssen et al.   Annual Review of Cell and Developmental Biology

The Circadian Protein Period2 Suppresses mTORC1 Activity via Recruiting Tsc1 to mTORC1 Complex

(2018) Rong Wu et al.   Cell Metabolism

Multiple circadian transcriptional elements cooperatively regulate cell-autonomous transcriptional oscillation ofPeriod3, a mammalian clock gene

(2017) Ritsuko Matsumura et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Colonic organoids derived from human induced pluripotent stem cells for modeling colorectal cancer and drug testing

(2017) Miguel Crespo et al.   NATURE MEDICINE

Mechanisms and functions of nuclear envelope remodelling

(2017) Rosemarie Ungricht et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Mesenchymal Stem Cell-Based Cartilage Regeneration Approach and Cell Senescence: Can We Manipulate Cell Aging and Function?

(2017) Marta A. Szychlinska et al.   TISSUE ENGINEERING PART B-REVIEWS

Circadian Clocks and Metabolism: Implications for Microbiome and Aging

(2017) Georgios K. Paschos et al.   TRENDS IN GENETICS

SMURF2 regulates bone homeostasis by disrupting SMAD3 interaction with vitamin D receptor in osteoblasts

(2017) Zhan Xu et al.   Nature Communications

CLOCK gene variation is associated with incidence of type-2 diabetes and cardiovascular diseases in type-2 diabetic subjects: dietary modulation in the PREDIMED randomized trial

(2016) Dolores Corella et al.   Cardiovascular Diabetology

Repression of the Antioxidant NRF2 Pathway in Premature Aging

(2016) Nard Kubben et al.   CELL

SIRT6 safeguards human mesenchymal stem cells from oxidative stress by coactivating NRF2

(2016) Huize Pan et al.   CELL RESEARCH

TFEB regulates PER3 expression via glucose-dependent effects on CLOCK/BMAL1

(2016) Wenwen Luo et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Mesenchymal stem cells in regenerative medicine: Focus on articular cartilage and intervertebral disc regeneration

(2016) Stephen M. Richardson et al.   METHODS

Histone H3K9 methylation is dispensable for Caenorhabditis elegans development but suppresses RNA:DNA hybrid-associated repeat instability

(2016) Peter Zeller et al.   NATURE GENETICS

Mechanisms linking circadian clocks, sleep, and neurodegeneration

(2016) Erik S. Musiek et al.   SCIENCE

Role of circadian gene Clock during differentiation of mouse pluripotent stem cells

(2016) Chao Lu et al.   Protein & Cell

Deficiency of circadian protein CLOCK reduces lifespan and increases age-related cataract development in mice

(2016) Yuliya V. Dubrovsky et al.   Aging-US

Transposable elements become active and mobile in the genomes of aging mammalian somatic tissues

(2016) Marco De Cecco et al.   Aging-US

The chondrocyte clock gene Bmal1 controls cartilage homeostasis and integrity

(2015) Michal Dudek et al.   JOURNAL OF CLINICAL INVESTIGATION

StringTie enables improved reconstruction of a transcriptome from RNA-seq reads

(2015) Mihaela Pertea et al.   NATURE BIOTECHNOLOGY

HISAT: a fast spliced aligner with low memory requirements

(2015) Daehwan Kim et al.   NATURE METHODS

Effects of aging on circadian patterns of gene expression in the human prefrontal cortex

(2015) Cho-Yi Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Werner syndrome stem cell model unveils heterochromatin alterations as a driver of human aging

(2015) W. Zhang et al.   SCIENCE

PTEN deficiency reprogrammes human neural stem cells towards a glioblastoma stem cell-like phenotype

(2015) Shunlei Duan et al.   Nature Communications

Ageing and osteoarthritis: a circadian rhythm connection

(2014) Nicole Gossan et al.   BIOGERONTOLOGY

HTSeq--a Python framework to work with high-throughput sequencing data

(2014) S. Anders et al.   BIOINFORMATICS

Isolation, expansion and characterisation of mesenchymal stem cells from human bone marrow, adipose tissue, umbilical cord blood and matrix: a comparative study

(2014) R. Secunda et al.   CYTOTECHNOLOGY

Resident mesenchymal progenitors of articular cartilage

(2014) Maria Elena Candela et al.   MATRIX BIOLOGY

Suv39h-Dependent H3K9me3 Marks Intact Retrotransposons and Silences LINE Elements in Mouse Embryonic Stem Cells

(2014) Aydan Bulut-Karslioglu et al.   MOLECULAR CELL

Improved vectors and genome-wide libraries for CRISPR screening

(2014) Neville E Sanjana et al.   NATURE METHODS

Temporal orchestration of repressive chromatin modifiers by circadian clock Period complexes

(2014) Hao A Duong et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

SIRT6 represses LINE1 retrotransposons by ribosylating KAP1 but this repression fails with stress and age

(2014) Michael Van Meter et al.   Nature Communications

Genomes of replicatively senescent cells undergo global epigenetic changes leading to gene silencing and activation of transposable elements

(2013) Marco De Cecco et al.   AGING CELL

Polymorphism of CLOCK Gene rs 4580704 C>G Is Associated with Susceptibility of Alzheimer’s Disease in a Chinese Population

(2013) Hai-feng Chen et al.   ARCHIVES OF MEDICAL RESEARCH

The Circadian Clock in Murine Chondrocytes Regulates Genes Controlling Key Aspects of Cartilage Homeostasis

(2013) Nicole Gossan et al.   ARTHRITIS AND RHEUMATISM

The Hallmarks of Aging

(2013) Carlos López-Otín et al.   CELL

Transposition of native chromatin for fast and sensitive epigenomic profiling of open chromatin, DNA-binding proteins and nucleosome position

(2013) Jason D Buenrostro et al.   NATURE METHODS

RNA-Guided Human Genome Engineering via Cas9

(2013) P. Mali et al.   SCIENCE

Intermolecular recognition revealed by the complex structure of human CLOCK-BMAL1 basic helix-loop-helix domains with E-box DNA

(2012) Zixi Wang et al.   CELL RESEARCH

Fast gapped-read alignment with Bowtie 2

(2012) Ben Langmead et al.   NATURE METHODS

Age-Related Decline in Circadian Output

(2011) T. J. Nakamura et al.   JOURNAL OF NEUROSCIENCE

Recapitulation of premature ageing with iPSCs from Hutchinson–Gilford progeria syndrome

(2011) Guang-Hui Liu et al.   NATURE

The circadian molecular clock creates epidermal stem cell heterogeneity

(2011) Peggy Janich et al.   NATURE

JTK_CYCLE: An Efficient Nonparametric Algorithm for Detecting Rhythmic Components in Genome-Scale Data Sets

(2010) Michael E. Hughes et al.   JOURNAL OF BIOLOGICAL RHYTHMS

Simple Combinations of Lineage-Determining Transcription Factors Prime cis-Regulatory Elements Required for Macrophage and B Cell Identities

(2010) Sven Heinz et al.   MOLECULAR CELL

Epigenetic silencing of engineered L1 retrotransposition events in human embryonic carcinoma cells

(2010) Jose L. Garcia-Perez et al.   NATURE

KAP1 controls endogenous retroviruses in embryonic stem cells

(2010) Helen M. Rowe et al.   NATURE

Clocks not winding down: unravelling circadian networks

(2010) Eric E. Zhang et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Identification and Clonal Characterisation of a Progenitor Cell Sub-Population in Normal Human Articular Cartilage

(2010) Rebecca Williams et al.   PLoS One

CLOCK genetic variation and metabolic syndrome risk: modulation by monounsaturated fatty acids

(2009) Marta Garaulet et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

A clustering approach for identification of enriched domains from histone modification ChIP-Seq data

(2009) Chongzhi Zang et al.   BIOINFORMATICS

The Sequence Alignment/Map format and SAMtools

(2009) H. Li et al.   BIOINFORMATICS

A small molecule that directs differentiation of human ESCs into the pancreatic lineage

(2009) Shuibing Chen et al.   Nature Chemical Biology

ToppGene Suite for gene list enrichment analysis and candidate gene prioritization

(2009) J. Chen et al.   NUCLEIC ACIDS RESEARCH