Age-related hyperinsulinemia leads to insulin resistance in neurons and cell-cycle-induced senescence

ATM is activated by ATP depletion and modulates mitochondrial function through NRF1

(2019) Hei-Man Chow et al.   JOURNAL OF CELL BIOLOGY

Elevated levels of Secreted-Frizzled-Related-Protein 1 contribute to Alzheimer’s disease pathogenesis

(2019) Pilar Esteve et al.   NATURE NEUROSCIENCE

Cellular Senescence in Postmitotic Cells: Beyond Growth Arrest

(2018) Przemyslaw Sapieha et al.   TRENDS IN CELL BIOLOGY

Tau protein aggregation is associated with cellular senescence in the brain

(2018) Nicolas Musi et al.   AGING CELL

Insulin Resistance and Future Cognitive Performance and Cognitive Decline in Elderly Patients with Cardiovascular Disease

(2017) Miri Lutski et al.   JOURNAL OF ALZHEIMERS DISEASE

The ClusPro web server for protein–protein docking

(2017) Dima Kozakov et al.   Nature Protocols

HDOCK: a web server for protein–protein and protein–DNA/RNA docking based on a hybrid strategy

(2017) Yumeng Yan et al.   NUCLEIC ACIDS RESEARCH

Reduced Circulating Insulin Enhances Insulin Sensitivity in Old Mice and Extends Lifespan

(2017) Nicole M. Templeman et al.   Cell Reports

Insulin Detemir Is Transported From Blood to Cerebrospinal Fluid and Has Prolonged Central Anorectic Action Relative to NPH Insulin

(2015) Denovan P. Begg et al.   DIABETES

Cellular Senescence in Type 2 Diabetes: A Therapeutic Opportunity

(2015) Allyson K. Palmer et al.   DIABETES

Neuronal LRP1 Regulates Glucose Metabolism and Insulin Signaling in the Brain

(2015) C.-C. Liu et al.   JOURNAL OF NEUROSCIENCE

Impaired insulin action in the human brain: causes and metabolic consequences

(2015) Martin Heni et al.   Nature Reviews Endocrinology

Use of the Open Field Maze to Measure Locomotor and Anxiety-like Behavior in Mice

(2015) Michael L. Seibenhener et al.   Jove-Journal of Visualized Experiments

Reduced Adolescent-Age Spatial Learning Ability Associated with Elevated Juvenile-Age Superoxide Levels in Complex I Mouse Mutants

(2015) Johannes Mayer et al.   PLoS One

Role of the SIK2–p35–PJA2 complex in pancreatic β-cell functional compensation

(2014) Jun-Ichi Sakamaki et al.   NATURE CELL BIOLOGY

CDK5 activator protein p25 preferentially binds and activates GSK3β

(2014) Hei-Man Chow et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Intracerebroventricular Viral Injection of the Neonatal Mouse Brain for Persistent and Widespread Neuronal Transduction

(2014) Ji-Yoen Kim et al.   Jove-Journal of Visualized Experiments

Liraglutide ameliorates glycometabolism and insulin resistance through the upregulation of GLUT4 in diabetic KKAy mice

(2013) LI-NA CHEN et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Reduced basal and novelty-induced levels of activity-regulated cytoskeleton associated protein (Arc) and c-Fos mRNA in the cerebral cortex and hippocampus of APPswe/PS1ΔE9 transgenic mice

(2013) Ditte Z. Christensen et al.   NEUROCHEMISTRY INTERNATIONAL

High and low activity rats: Elevated intrinsic physical activity drives resistance to diet-induced obesity in non-bred rats

(2013) Claudio E. Perez-Leighton et al.   Obesity

Metformin Impairs Glucose Consumption and Survival in Calu-1 Cells by Direct Inhibition of Hexokinase-II

(2013) Barbara Salani et al.   Scientific Reports

Aging, Cellular Senescence, and Cancer

(2012) Judith Campisi   Annual Review of Physiology

Nuclear accumulation of HDAC4 in ATM deficiency promotes neurodegeneration in ataxia telangiectasia

(2012) Jiali Li et al.   NATURE MEDICINE

Effects of Insulin on Brain Glucose Metabolism in Impaired Glucose Tolerance

(2011) J. Hirvonen et al.   DIABETES

Hyperinsulinemia Induces Insulin Resistance in Dorsal Root Ganglion Neurons

(2011) Bhumsoo Kim et al.   ENDOCRINOLOGY

Cyclin-dependent Kinase-5 Is a Key Molecule in Tumor Necrosis Factor-α-induced Insulin Resistance

(2011) Atsushi Nohara et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Mouse Forced Swim Test

(2011) Adem Can et al.   Jove-Journal of Visualized Experiments

Wnt signaling and senescence: A tug of war in early neoplasia?

(2010) Peter D. Adams et al.   CANCER BIOLOGY & THERAPY

A Prospective Analysis of Elevated Fasting Glucose Levels and Cognitive Function in Older People: Results From PROSPER and the Rotterdam Study

(2010) S. M. Euser et al.   DIABETES

Incretin-based therapies for type 2 diabetes mellitus

(2009) Julie A. Lovshin et al.   Nature Reviews Endocrinology

Receptors for the incretin glucagon-like peptide-1 are expressed on neurons in the central nervous system

(2009) Alison Hamilton et al.   NEUROREPORT

The atypical kinase Cdk5 is activated by insulin, regulates the association between GLUT4 and E-Syt1, and modulates glucose transport in 3T3-L1 adipocytes

(2009) V. Lalioti et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Insulin Resistance and Hyperinsulinemia: Is hyperinsulinemia the cart or the horse?

(2008) M. H. Shanik et al.   DIABETES CARE

Gain and fidelity of transmission patterns at cortical excitatory unitary synapses improve spike encoding

(2008) J.-H. Wang et al.   JOURNAL OF CELL SCIENCE

A Technique for Serial Collection of Cerebrospinal Fluid from the Cisterna Magna in Mouse

(2008) Li Liu et al.   Jove-Journal of Visualized Experiments