期刊
REPRODUCTIVE TOXICOLOGY
卷 43, 期 -, 页码 56-66出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.reprotox.2013.11.001
关键词
Bisphenol A; Prostate; Inflammation; Indole-3-carbinol; Chemoprevention; Reproductive toxicology
资金
- FAPESP [2010/17262-0, 2011/01954-2, 2010/14110-4]
- CNPq [471646/2011-3]
- Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP) [11/01954-2] Funding Source: FAPESP
Bisphenol A (BPA) is a chemical that has been investigated for it potential to cause prostate diseases. In this study, pregnant Sprague-Dawley rats were treated with 25 or 250 mu g/kg BPA from gestational day (GD) 10 to GD21 with or without concurrent indole-3-carbinol (I3C) feeding. I3C is a phytochemical, and it affords chemoprotection against many types of neoplasia. Male F1 rats from different litters were euthanized on post-natal day (PND) 21 and PND180. BPA-treated groups showed a significant increase in histopathological lesions, but I3C feeding reversed many of these changes, mainly at PND180. Maternal I3C feeding increased prostate epithelial apoptosis in the BPA-treated groups and across age groups. Furthermore, I3C induced partial normalization of the prostate histoarchitecture. The results pointed to a protective effect of maternal I3C feeding during pregnancy in the BPA-exposed male offspring, thereby indicating reduction in the harmful effects of gestational BPA imprinting on the prostate. (C) 2013 Elsevier Inc. All rights reserved.
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