Causal effects on complex traits are similar for common variants across segments of different continental ancestries within admixed individuals

Inferring population structure in biobank-scale genomic data

(2022) Alec M. Chiu et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Genetic interactions drive heterogeneity in causal variant effect sizes for gene expression and complex traits

(2022) Roshni A. Patel et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Global and local ancestry modulate APOE association with Alzheimer’s neuropathology and cognitive outcomes in an admixed sample

(2022) Michel Satya Naslavsky et al.   MOLECULAR PSYCHIATRY

Tractor uses local ancestry to enable the inclusion of admixed individuals in GWAS and to boost power

(2021) Elizabeth G. Atkinson et al.   NATURE GENETICS

Population-specific causal disease effect sizes in functionally important regions impacted by selection

(2021) Huwenbo Shi et al.   Nature Communications

On powerful GWAS in admixed populations

(2021) Kangcheng Hou et al.   NATURE GENETICS

A cross-population atlas of genetic associations for 220 human phenotypes

(2021) Saori Sakaue et al.   NATURE GENETICS

Estimation of regional polygenicity from GWAS provides insights into the genetic architecture of complex traits

(2021) Ruth Johnson et al.   PLoS Computational Biology

The GWAS Diversity Monitor tracks diversity by disease in real time

(2020) Melinda C. Mills et al.   NATURE GENETICS

Localizing Components of Shared Transethnic Genetic Architecture of Complex Traits from GWAS Summary Data

(2020) Huwenbo Shi et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Ancestry-specific associations identified in genome-wide combined-phenotype study of red blood cell traits emphasize benefits of diversity in genomics

(2020) Chani J. Hodonsky et al.   BMC GENOMICS

Minimal phenotyping yields genome-wide association signals of low specificity for major depression

(2020) Na Cai et al.   NATURE GENETICS

Ancestry deconvolution and partial polygenic score can improve susceptibility predictions in recently admixed individuals

(2020) Davide Marnetto et al.   Nature Communications

A simple new approach to variable selection in regression, with application to genetic fine mapping

(2020) Gao Wang et al.   JOURNAL OF THE ROYAL STATISTICAL SOCIETY SERIES B-STATISTICAL METHODOLOGY

Theoretical and empirical quantification of the accuracy of polygenic scores in ancestry divergent populations

(2020) Ying Wang et al.   Nature Communications

Polygenic Scores for Height in Admixed Populations

(2020) Bárbara D. Bitarello et al.   G3-Genes Genomes Genetics

Comparing local ancestry inference models in populations of two- and three-way admixture

(2020) Ryan Schubert et al.   PeerJ

Quantification of frequency-dependent genetic architectures in 25 UK Biobank traits reveals action of negative selection

(2019) Armin P. Schoech et al.   Nature Communications

Clinical use of current polygenic risk scores may exacerbate health disparities

(2019) Alicia R. Martin et al.   NATURE GENETICS

The Missing Diversity in Human Genetic Studies

(2019) Giorgio Sirugo et al.   CELL

Genetic analyses of diverse populations improves discovery for complex traits

(2019) Genevieve L. Wojcik et al.   NATURE

Reconciling S-LDSC and LDAK functional enrichment estimates

(2019) Steven Gazal et al.   NATURE GENETICS

Accurate estimation of SNP-heritability from biobank-scale data irrespective of genetic architecture

(2019) Kangcheng Hou et al.   NATURE GENETICS

Genomics of disease risk in globally diverse populations

(2019) Deepti Gurdasani et al.   NATURE REVIEWS GENETICS

Signatures of negative selection in the genetic architecture of human complex traits

(2018) Jian Zeng et al.   NATURE GENETICS

Common schizophrenia alleles are enriched in mutation-intolerant genes and in regions under strong background selection

(2018) Antonio F. Pardiñas et al.   NATURE GENETICS

Estimation of complex effect-size distributions using summary-level statistics from genome-wide association studies across 32 complex traits

(2018) Yan Zhang et al.   NATURE GENETICS

Estimating cross-population genetic correlations of causal effect sizes

(2018) Kevin J. Galinsky et al.   GENETIC EPIDEMIOLOGY

The UK Biobank resource with deep phenotyping and genomic data

(2018) Clare Bycroft et al.   NATURE

SumHer better estimates the SNP heritability of complex traits from summary statistics

(2018) Doug Speed et al.   NATURE GENETICS

Ancestral origin of ApoE ε4 Alzheimer disease risk in Puerto Rican and African American populations

(2018) Farid Rajabli et al.   PLoS Genetics

Linkage disequilibrium–dependent architecture of human complex traits shows action of negative selection

(2017) Steven Gazal et al.   NATURE GENETICS

Transethnic Genetic-Correlation Estimates from Summary Statistics

(2016) Brielin C. Brown et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Multi-ethnic genome-wide association study identifies novel locus for type 2 diabetes susceptibility

(2016) James P Cook et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Reference-based phasing using the Haplotype Reference Consortium panel

(2016) Po-Ru Loh et al.   NATURE GENETICS

A global reference for human genetic variation

(2015) Richard A. Gibbs et al.   NATURE

Contrasting genetic architectures of schizophrenia and other complex diseases using fast variance-components analysis

(2015) Po-Ru Loh et al.   NATURE GENETICS

An atlas of genetic correlations across human diseases and traits

(2015) Brendan Bulik-Sullivan et al.   NATURE GENETICS

Second-generation PLINK: rising to the challenge of larger and richer datasets

(2015) Christopher C Chang et al.   GigaScience

The Role of Local Ancestry Adjustment in Association Studies Using Admixed Populations

(2014) Jianqi Zhang et al.   GENETIC EPIDEMIOLOGY

Gene-Based Sequencing Identifies Lipid-Influencing Variants with Ethnicity-Specific Effects in African Americans

(2014) Amy R. Bentley et al.   PLoS Genetics

Confounding and Heterogeneity in Genetic Association Studies with Admixed Populations

(2013) Jinghua Liu et al.   AMERICAN JOURNAL OF EPIDEMIOLOGY

RFMix: A Discriminative Modeling Approach for Rapid and Robust Local-Ancestry Inference

(2013) Brian K. Maples et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Analysis of Latino populations from GALA and MEC studies reveals genomic loci with biased local ancestry estimation

(2013) Bogdan Pasaniuc et al.   BIOINFORMATICS

High Trans-ethnic Replicability of GWAS Results Implies Common Causal Variants

(2013) Urko M. Marigorta et al.   PLoS Genetics

Improved Heritability Estimation from Genome-wide SNPs

(2012) Doug Speed et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Genome-wide Association and Population Genetic Analysis of C-Reactive Protein in African American and Hispanic American Women

(2012) Alex P. Reiner et al.   AMERICAN JOURNAL OF HUMAN GENETICS

New approaches to disease mapping in admixed populations

(2011) Michael F. Seldin et al.   NATURE REVIEWS GENETICS

Enhanced Statistical Tests for GWAS in Admixed Populations: Assessment using African Americans from CARe and a Breast Cancer Consortium

(2011) Bogdan Pasaniuc et al.   PLoS Genetics

GCTA: A Tool for Genome-wide Complex Trait Analysis

(2010) Jian Yang et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Robust relationship inference in genome-wide association studies

(2010) Ani Manichaikul et al.   BIOINFORMATICS

Integrating common and rare genetic variation in diverse human populations

(2010)   NATURE

Common SNPs explain a large proportion of the heritability for human height

(2010) Jian Yang et al.   NATURE GENETICS

Reduced Neutrophil Count in People of African Descent Is Due To a Regulatory Variant in the Duffy Antigen Receptor for Chemokines Gene

(2009) David Reich et al.   PLoS Genetics