Genetic interactions drive heterogeneity in causal variant effect sizes for gene expression and complex traits

Genetics of 35 blood and urine biomarkers in the UK Biobank

(2021) Nasa Sinnott-Armstrong et al.   NATURE GENETICS

Large-scale cis- and trans-eQTL analyses identify thousands of genetic loci and polygenic scores that regulate blood gene expression

(2021) Urmo Võsa et al.   NATURE GENETICS

Variable prediction accuracy of polygenic scores within an ancestry group

(2020) Hakhamanesh Mostafavi et al.   eLife

Genotyping Array Design and Data Quality Control in the Million Veteran Program

(2020) Haley Hunter-Zinck et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Clinical Genetics Lacks Standard Definitions and Protocols for the Collection and Use of Diversity Measures

(2020) Alice B. Popejoy et al.   AMERICAN JOURNAL OF HUMAN GENETICS

A community-maintained standard library of population genetic models

(2020) Jeffrey R Adrion et al.   eLife

Polygenic Scores for Height in Admixed Populations

(2020) Bárbara D. Bitarello et al.   G3-Genes Genomes Genetics

Clinical use of current polygenic risk scores may exacerbate health disparities

(2019) Alicia R. Martin et al.   NATURE GENETICS

Why structure matters

(2019) Nick Barton et al.   eLife

Polygenic adaptation on height is overestimated due to uncorrected stratification in genome-wide association studies

(2019) Mashaal Sohail et al.   eLife

Reduced signal for polygenic adaptation of height in UK Biobank

(2019) Jeremy J Berg et al.   eLife

Genetic analyses of diverse populations improves discovery for complex traits

(2019) Genevieve L. Wojcik et al.   NATURE

Harmonizing Genetic Ancestry and Self-identified Race/Ethnicity in Genome-wide Association Studies

(2019) Huaying Fang et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Genome-wide Association Studies in Ancestrally Diverse Populations: Opportunities, Methods, Pitfalls, and Recommendations

(2019) Roseann E. Peterson et al.   CELL

Estimating cross-population genetic correlations of causal effect sizes

(2018) Kevin J. Galinsky et al.   GENETIC EPIDEMIOLOGY

Genetic effects on gene expression across human tissues

(2017) François Aguet et al.   NATURE

Transethnic Genetic-Correlation Estimates from Summary Statistics

(2016) Brielin C. Brown et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Genetic Ancestry and Natural Selection Drive Population Differences in Immune Responses to Pathogens

(2016) Yohann Nédélec et al.   CELL

Multiple novel gene-by-environment interactions modify the effect of FTO variants on body mass index

(2016) Alexander I. Young et al.   Nature Communications

Efficient Coalescent Simulation and Genealogical Analysis for Large Sample Sizes

(2016) Jerome Kelleher et al.   PLoS Computational Biology

The Great Migration and African-American Genomic Diversity

(2016) Soheil Baharian et al.   PLoS Genetics

A global reference for human genetic variation

(2015) Richard A. Gibbs et al.   NATURE

The contribution of rare variation to prostate cancer heritability

(2015) Nicholas Mancuso et al.   NATURE GENETICS

Class II HLA interactions modulate genetic risk for multiple sclerosis

(2015) Loukas Moutsianas et al.   NATURE GENETICS

Additive Genetic Variation in Schizophrenia Risk Is Shared by Populations of African and European Descent

(2013) Teresa R. de Candia et al.   AMERICAN JOURNAL OF HUMAN GENETICS

RFMix: A Discriminative Modeling Approach for Rapid and Robust Local-Ancestry Inference

(2013) Brian K. Maples et al.   AMERICAN JOURNAL OF HUMAN GENETICS

RNA-SeQC: RNA-seq metrics for quality control and process optimization

(2012) David S. DeLuca et al.   BIOINFORMATICS

Analysis of 6,515 exomes reveals the recent origin of most human protein-coding variants

(2012) Wenqing Fu et al.   NATURE

Evolution and Functional Impact of Rare Coding Variation from Deep Sequencing of Human Exomes

(2012) J. A. Tennessen et al.   SCIENCE

Interaction between ERAP1 and HLA-B27 in ankylosing spondylitis implicates peptide handling in the mechanism for HLA-B27 in disease susceptibility

(2011) David M Evans et al.   NATURE GENETICS

Physical Activity Attenuates the Influence of FTO Variants on Obesity Risk: A Meta-Analysis of 218,166 Adults and 19,268 Children

(2011) Tuomas O. Kilpeläinen et al.   PLOS MEDICINE

Robust relationship inference in genome-wide association studies

(2010) Ani Manichaikul et al.   BIOINFORMATICS

Fast model-based estimation of ancestry in unrelated individuals

(2009) D. H. Alexander et al.   GENOME RESEARCH

Prediction and Interaction in Complex Disease Genetics: Experience in Type 1 Diabetes

(2009) David G. Clayton   PLoS Genetics

A Flexible and Accurate Genotype Imputation Method for the Next Generation of Genome-Wide Association Studies

(2009) Bryan N. Howie et al.   PLoS Genetics

Correlation between Genetic and Geographic Structure in Europe

(2008) Oscar Lao et al.   CURRENT BIOLOGY

Genes mirror geography within Europe

(2008) John Novembre et al.   NATURE

Effects of cis and trans Genetic Ancestry on Gene Expression in African Americans

(2008) Alkes L. Price et al.   PLoS Genetics