Ancestry-specific associations identified in genome-wide combined-phenotype study of red blood cell traits emphasize benefits of diversity in genomics

Clinical use of current polygenic risk scores may exacerbate health disparities

(2019) Alicia R. Martin et al.   NATURE GENETICS

Genetic analyses of diverse populations improves discovery for complex traits

(2019) Genevieve L. Wojcik et al.   NATURE

Towards clinical utility of polygenic risk scores

(2019) Samuel A Lambert et al.   HUMAN MOLECULAR GENETICS

Genome-wide Association Studies in Ancestrally Diverse Populations: Opportunities, Methods, Pitfalls, and Recommendations

(2019) Roseann E. Peterson et al.   CELL

Contributions of common genetic variants to risk of schizophrenia among individuals of African and Latino ancestry

(2019) Tim B. Bigdeli et al.   MOLECULAR PSYCHIATRY

Genetic analysis of quantitative traits in the Japanese population links cell types to complex human diseases

(2018) Masahiro Kanai et al.   NATURE GENETICS

Identification of nine novel loci related to hematological traits in a Japanese population

(2018) Yoshiki Yasukochi et al.   PHYSIOLOGICAL GENOMICS

Exploring the phenotypic consequences of tissue specific gene expression variation inferred from GWAS summary statistics

(2018) Alvaro N. Barbeira et al.   Nature Communications

Will Big Data Close the Missing Heritability Gap?

(2017) Hwasoon Kim et al.   GENETICS

The ubiquity of pleiotropy in human disease

(2017) Kevin Chesmore et al.   HUMAN GENETICS

Anemia is a mortality prognostic factor in patients initially hospitalized for acute heart failure

(2017) Margherita Migone de Amicis et al.   Internal and Emergency Medicine

Genome-wide association study of red blood cell traits in Hispanics/Latinos: The Hispanic Community Health Study/Study of Latinos

(2017) Chani J. Hodonsky et al.   PLoS Genetics

Will Big Data Close the Missing Heritability Gap?

(2017) Hwasoon Kim et al.   GENETICS

Admixture mapping in two Mexican samples identifies significant associations of locus ancestry with triglyceride levels in the BUD13/ZNF259/APOA5 region and fine mapping points to rs964184 as the main driver of the association signal

(2017) Esteban J. Parra et al.   PLoS One

Exome Genotyping Identifies Pleiotropic Variants Associated with Red Blood Cell Traits

(2016) Nathalie Chami et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Genome-wide Association Study of Platelet Count Identifies Ancestry-Specific Loci in Hispanic/Latino Americans

(2016) Ursula M. Schick et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Improved methods for multi-trait fine mapping of pleiotropic risk loci

(2016) Gleb Kichaev et al.   BIOINFORMATICS

The Allelic Landscape of Human Blood Cell Trait Variation and Links to Common Complex Disease

(2016) William J. Astle et al.   CELL

Laboratory diagnosis of anemia: are the old and new red cell parameters useful in classification and treatment, how?

(2016) M. Buttarello   International Journal of Laboratory Hematology

Lineage-specific BCL11A knockdown circumvents toxicities and reverses sickle phenotype

(2016) Christian Brendel et al.   JOURNAL OF CLINICAL INVESTIGATION

Discovery and refinement of genetic loci associated with cardiometabolic risk using dense imputation maps

(2016) Valentina Iotchkova et al.   NATURE GENETICS

Detection and interpretation of shared genetic influences on 42 human traits

(2016) Joseph K Pickrell et al.   NATURE GENETICS

The new NHGRI-EBI Catalog of published genome-wide association studies (GWAS Catalog)

(2016) Jacqueline MacArthur et al.   NUCLEIC ACIDS RESEARCH

Hemoglobin Concentration and Risk of Incident Stroke in Community-Living Adults

(2016) Bhupesh Panwar et al.   STROKE

On Robust Association Testing for Quantitative Traits and Rare Variants

(2016) Peng Wei et al.   G3-Genes Genomes Genetics

Multivariate Analysis of Anthropometric Traits Using Summary Statistics of Genome-Wide Association Studies from GIANT Consortium

(2016) Haeil Park et al.   PLoS One

Strategies for Enriching Variant Coverage in Candidate Disease Loci on a Multiethnic Genotyping Array

(2016) Stephanie A. Bien et al.   PLoS One

The Predictive Role of Red Cell Distribution Width in Mortality among Chronic Kidney Disease Patients

(2016) Yao-Peng Hsieh et al.   PLoS One

An Adaptive Association Test for Multiple Phenotypes with GWAS Summary Statistics

(2015) Junghi Kim et al.   GENETIC EPIDEMIOLOGY

A global reference for human genetic variation

(2015) Richard A. Gibbs et al.   NATURE

The Genotype-Tissue Expression (GTEx) pilot analysis: Multitissue gene regulation in humans

(2015) et al.   SCIENCE

Genetic Association Analysis under Complex Survey Sampling: The Hispanic Community Health Study/Study of Latinos

(2014) Dan-Yu Lin et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Induction of adult levels of  -globin in human erythroid cells that intrinsically express embryonic or fetal globin by transduction with KLF1 and BCL11A-XL

(2014) K. Trakarnsanga et al.   HAEMATOLOGICA

Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility

(2014) Anubha Mahajan et al.   NATURE GENETICS

Heritability and genomics of gene expression in peripheral blood

(2014) Fred A Wright et al.   NATURE GENETICS

Red cell distribution width predicts short- and long-term outcomes of acute congestive heart failure more effectively than hemoglobin

(2014) YUXIANG DAI et al.   Experimental and Therapeutic Medicine

Trans-ethnic genome-wide association studies: advantages and challenges of mapping in diverse populations

(2014) Yun R Li et al.   Genome Medicine

Genome-wide association analysis of red blood cell traits in African Americans: the COGENT Network

(2013) Zhao Chen et al.   HUMAN MOLECULAR GENETICS

Pleiotropy in complex traits: challenges and strategies

(2013) Nadia Solovieff et al.   NATURE REVIEWS GENETICS

Genome Wide Association Analysis of a Founder Population Identified TAF3 as a Gene for MCHC in Humans

(2013) Giorgio Pistis et al.   PLoS One

Erythropoiesis: Development and Differentiation

(2013) E. Dzierzak et al.   Cold Spring Harbor Perspectives in Medicine

Genetic Variants That Confer Resistance to Malaria Are Associated with Red Blood Cell Traits in African-Americans: An Electronic Medical Record-based Genome-Wide Association Study

(2013) Keyue Ding et al.   G3-Genes Genomes Genetics

A high-performance computing toolset for relatedness and principal component analysis of SNP data

(2012) X. Zheng et al.   BIOINFORMATICS

GWAS of blood cell traits identifies novel associated loci and epistatic interactions in Caucasian and African-American children

(2012) Jin Li et al.   HUMAN MOLECULAR GENETICS

Common genetic factors for hematological traits in Humans

(2012) Yukinori Okada et al.   JOURNAL OF HUMAN GENETICS

Seventy-five genetic loci influencing the human red blood cell

(2012) Pim van der Harst et al.   NATURE

The Next PAGE in Understanding Complex Traits: Design for the Analysis of Population Architecture Using Genetics and Epidemiology (PAGE) Study

(2011) Tara C. Matise et al.   AMERICAN JOURNAL OF EPIDEMIOLOGY

Genomics for the world

(2011) Carlos D. Bustamante et al.   NATURE

Cerebral Oxygen Transport Failure?: Decreasing Hemoglobin and Hematocrit Levels After Ischemic Stroke Predict Poor Outcome and Mortality

(2011) Lars Kellert et al.   STROKE

METAL: fast and efficient meta-analysis of genomewide association scans

(2010) C. J. Willer et al.   BIOINFORMATICS

Genetic association analysis highlights new loci that modulate hematological trait variation in Caucasians and African Americans

(2010) Ken Sin Lo et al.   HUMAN GENETICS

Genome-wide association study of hematological and biochemical traits in a Japanese population

(2010) Yoichiro Kamatani et al.   NATURE GENETICS

Sequence Variants in Three Loci Influence Monocyte Counts and Erythrocyte Volume

(2009) Manuel A.R. Ferreira et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Genome-wide association study identifies variants in TMPRSS6 associated with hemoglobin levels

(2009) John C Chambers et al.   NATURE GENETICS

Multiple loci influence erythrocyte phenotypes in the CHARGE Consortium

(2009) Santhi K Ganesh et al.   NATURE GENETICS

A genome-wide meta-analysis identifies 22 loci associated with eight hematological parameters in the HaemGen consortium

(2009) Nicole Soranzo et al.   NATURE GENETICS

Variability and heritability of hemoglobin concentration: an opportunity to improve understanding of anemia in older adults

(2008) K. V. Patel   HAEMATOLOGICA