Myelin dysfunction drives amyloid-β deposition in models of Alzheimer’s disease

Amyloid Beta Pathology Exacerbates Weight Loss and Brain Cytokine Responses following Low-Dose Lipopolysaccharide in Aged Female Tg2576 Mice

(2022) Rachel C. Knopp et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

White matter integrity in mice requires continuous myelin synthesis at the inner tongue

(2022) Martin Meschkat et al.   Nature Communications

A shared disease-associated oligodendrocyte signature among multiple CNS pathologies

(2022) Mor Kenigsbuch et al.   NATURE NEUROSCIENCE

Simplify enrichment: A bioconductor package for clustering and visualizing functional enrichment results

(2022) Zuguang Gu et al.   GENOMICS PROTEOMICS & BIOINFORMATICS

White matter aging drives microglial diversity

(2021) Shima Safaiyan et al.   NEURON

Integrated analysis of multimodal single-cell data

(2021) Yuhan Hao et al.   CELL

Enhancing myelin renewal reverses cognitive dysfunction in a murine model of Alzheimer’s disease

(2021) Jing-Fei Chen et al.   NEURON

Diagnosis of Alzheimer's disease and related dementia among people with multiple sclerosis: Large cohort study, USA

(2021) Elham Mahmoudi et al.   Multiple Sclerosis and Related Disorders

Human and mouse single-nucleus transcriptomics reveal TREM2-dependent and TREM2-independent cellular responses in Alzheimer’s disease

(2020) Yingyue Zhou et al.   NATURE MEDICINE

Spatial Transcriptomics and In Situ Sequencing to Study Alzheimer’s Disease

(2020) Wei-Ting Chen et al.   CELL

Microglia facilitate repair of demyelinated lesions via post-squalene sterol synthesis

(2020) Stefan A. Berghoff et al.   NATURE NEUROSCIENCE

Structural myelin defects are associated with low axonal ATP levels but rapid recovery from energy deprivation in a mouse model of spastic paraplegia

(2020) Andrea Trevisiol et al.   PLOS BIOLOGY

Oligodendroglial glycolytic stress triggers inflammasome activation and neuropathology in Alzheimer’s disease

(2020) Xinwen Zhang et al.   Science Advances

Single-cell transcriptomic analysis of Alzheimer’s disease

(2019) Hansruedi Mathys et al.   NATURE

WebGestalt 2019: gene set analysis toolkit with revamped UIs and APIs

(2019) Yuxing Liao et al.   NUCLEIC ACIDS RESEARCH

Comprehensive Integration of Single-Cell Data

(2019) Tim Stuart et al.   CELL

The MS4A gene cluster is a key modulator of soluble TREM2 and Alzheimer’s disease risk

(2019) Yuetiva Deming et al.   Science Translational Medicine

White matter diffusion alterations precede symptom onset in autosomal dominant Alzheimer’s disease

(2018) Miguel Ángel Araque Caballero et al.   BRAIN

Innate immune memory in the brain shapes neurological disease hallmarks

(2018) Ann-Christin Wendeln et al.   NATURE

Single-Cell RNA Sequencing of Microglia throughout the Mouse Lifespan and in the Injured Brain Reveals Complex Cell-State Changes

(2018) Timothy R. Hammond et al.   IMMUNITY

Loss of TREM2 function increases amyloid seeding but reduces plaque-associated ApoE

(2018) Samira Parhizkar et al.   NATURE NEUROSCIENCE

Coexistence of Multiple Sclerosis and Alzheimer's disease: A review

(2018) Pauline Luczynski et al.   Multiple Sclerosis and Related Disorders

Genetic dissection of oligodendroglial and neuronal Plp1 function in a novel mouse model of spastic paraplegia type 2

(2017) Katja A. Lüders et al.   GLIA

Impaired JIP3-dependent axonal lysosome transport promotes amyloid plaque pathology

(2017) Swetha Gowrishankar et al.   JOURNAL OF CELL BIOLOGY

Microglia ablation alleviates myelin-associated catatonic signs in mice

(2017) Hana Janova et al.   JOURNAL OF CLINICAL INVESTIGATION

Apolipoprotein E and Alzheimer’s disease: the influence of apolipoprotein E on amyloid-β and other amyloidogenic proteins

(2017) Tien-Phat V. Huynh et al.   JOURNAL OF LIPID RESEARCH

An improved ATAC-seq protocol reduces background and enables interrogation of frozen tissues

(2017) M Ryan Corces et al.   NATURE METHODS

N-truncated Aβ4–x peptides in sporadic Alzheimer’s disease cases and transgenic Alzheimer mouse models

(2017) Oliver Wirths et al.   Alzheimers Research & Therapy

Antagonistic Functions of MBP and CNP Establish Cytosolic Channels in CNS Myelin

(2017) Nicolas Snaidero et al.   Cell Reports

Association of Amyloid Pathology With Myelin Alteration in Preclinical Alzheimer Disease

(2017) Douglas C. Dean et al.   JAMA Neurology

Presynaptic dystrophic neurites surrounding amyloid plaques are sites of microtubule disruption, BACE1 elevation, and increased Aβ generation in Alzheimer’s disease

(2016) Katherine R. Sadleir et al.   ACTA NEUROPATHOLOGICA

Generation and analysis of an improved Foxg1-IRES-Cre driver mouse line

(2016) Daichi Kawaguchi et al.   DEVELOPMENTAL BIOLOGY

Age-related myelin degradation burdens the clearance function of microglia during aging

(2016) Shima Safaiyan et al.   NATURE NEUROSCIENCE

TREM2 Haplodeficiency in Mice and Humans Impairs the Microglia Barrier Function Leading to Decreased Amyloid Compaction and Severe Axonal Dystrophy

(2016) Peng Yuan et al.   NEURON

Oligodendroglial NMDA Receptors Regulate Glucose Import and Axonal Energy Metabolism

(2016) Aiman S. Saab et al.   NEURON

Three-Dimensional Study of Alzheimer’s Disease Hallmarks Using the iDISCO Clearing Method

(2016) Thomas Liebmann et al.   Cell Reports

Axonal amyloid precursor protein and its fragments undergo somatodendritic endocytosis and processing

(2015) Emily D. Niederst et al.   MOLECULAR BIOLOGY OF THE CELL

Massive accumulation of luminal protease-deficient axonal lysosomes at Alzheimer’s disease amyloid plaques

(2015) Swetha Gowrishankar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dynamics of Oligodendrocyte Generation and Myelination in the Human Brain

(2014) Maggie S.Y. Yeung et al.   CELL

Single App knock-in mouse models of Alzheimer's disease

(2014) Takashi Saito et al.   NATURE NEUROSCIENCE

featureCounts: an efficient general purpose program for assigning sequence reads to genomic features

(2013) Y. Liao et al.   BIOINFORMATICS

Identification of Long-Lived Proteins Reveals Exceptional Stability of Essential Cellular Structures

(2013) Brandon H. Toyama et al.   CELL

STAR: ultrafast universal RNA-seq aligner

(2012) Alexander Dobin et al.   BIOINFORMATICS

Dynamic changes in myelin aberrations and oligodendrocyte generation in chronic amyloidosis in mice and men

(2012) Gwendolyn Behrendt et al.   GLIA

Calsyntenin-1 mediates axonal transport of the amyloid precursor protein and regulates A  production

(2012) A. Vagnoni et al.   HUMAN MOLECULAR GENETICS

Oligodendroglia metabolically support axons and contribute to neurodegeneration

(2012) Youngjin Lee et al.   NATURE

Glycolytic oligodendrocytes maintain myelin and long-term axonal integrity

(2012) Ursula Fünfschilling et al.   NATURE

Fiji: an open-source platform for biological-image analysis

(2012) Johannes Schindelin et al.   NATURE METHODS

NCBI GEO: archive for functional genomics data sets—update

(2012) Tanya Barrett et al.   NUCLEIC ACIDS RESEARCH

Focal demyelination in Alzheimer’s disease and transgenic mouse models

(2010) Stanislaw Mitew et al.   ACTA NEUROPATHOLOGICA

Age changes in myelinated nerve fibers of the cingulate bundle and corpus callosum in the rhesus monkey

(2010) Michael P. Bowley et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Early ultrastructural defects of axons and axon-glia junctions in mice lacking expression ofCnp1

(2009) Julia M. Edgar et al.   GLIA