Apolipoprotein E and Alzheimer’s disease: the influence of apolipoprotein E on amyloid-β and other amyloidogenic proteins

Neuropathological and genetic correlates of survival and dementia onset in synucleinopathies: a retrospective analysis

(2017) David J Irwin et al.   LANCET NEUROLOGY

Direct Transcriptional Effects of Apolipoprotein E

(2016) V. Theendakara et al.   JOURNAL OF NEUROSCIENCE

TREM2 Haplodeficiency in Mice and Humans Impairs the Microglia Barrier Function Leading to Decreased Amyloid Compaction and Severe Axonal Dystrophy

(2016) Peng Yuan et al.   NEURON

TREM2 Binds to Apolipoproteins, Including APOE and CLU/APOJ, and Thereby Facilitates Uptake of Amyloid-Beta by Microglia

(2016) Felix L. Yeh et al.   NEURON

Effects of different isoforms of apoE on aggregation of the α‐synuclein protein implicated in Parkinson’s disease

(2016) Fatemeh Nouri Emamzadeh et al.   NEUROSCIENCE LETTERS

Neuronal heparan sulfates promote amyloid pathology by modulating brain amyloid-β clearance and aggregation in Alzheimer’s disease

(2016) Chia-Chen Liu et al.   Science Translational Medicine

Soluble Amyloid-beta Aggregates from Human Alzheimer’s Disease Brains

(2016) Thomas J. Esparza et al.   Scientific Reports

TREM2 Lipid Sensing Sustains the Microglial Response in an Alzheimer’s Disease Model

(2015) Yaming Wang et al.   CELL

Different mechanisms of apolipoprotein E isoform–dependent modulation of prostaglandin E2 production and triggering receptor expressed on myeloid cells 2 (TREM2) expression after innate immune activation of microglia

(2015) Xianwu Li et al.   FASEB JOURNAL

Apolipoprotein E Is a Ligand for Triggering Receptor Expressed on Myeloid Cells 2 (TREM2)

(2015) Yuka Atagi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Triggering Receptor Expressed on Myeloid Cells 2 Binds Apolipoprotein E

(2015) Charles C. Bailey et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Accelerated pericyte degeneration and blood–brain barrier breakdown in apolipoprotein E4 carriers with Alzheimer’s disease

(2015) Matthew R Halliday et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Qualitative changes in human γ-secretase underlie familial Alzheimer’s disease

(2015) Maria Szaruga et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Lack of Widespread BBB Disruption in Alzheimer’s Disease Models: Focus on Therapeutic Antibodies

(2015) Nga Bien-Ly et al.   NEURON

Murine versus human apolipoprotein E4: differential facilitation of and co-localization in cerebral amyloid angiopathy and amyloid plaques in APP transgenic mouse models

(2015) Fan Liao et al.   Acta Neuropathologica Communications

The Binding of Apolipoprotein E to Oligomers and Fibrils of Amyloid-β Alters the Kinetics of Amyloid Aggregation

(2014) Kanchan Garai et al.   BIOCHEMISTRY

Human Apolipoprotein E ε4 Expression Impairs Cerebral Vascularization and Blood—Brain Barrier Function in Mice

(2014) Wael Alata et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Soluble Aβ Oligomers Are Rapidly Sequestered from Brain ISF In Vivo and Bind GM1 Ganglioside on Cellular Membranes

(2014) Soyon Hong et al.   NEURON

Lack of association between APOE gene polymorphisms and amyotrophic lateral sclerosis: A comprehensive meta-analysis

(2014) Flora Govone et al.   Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration

Effects of the Absence of Apolipoprotein E on Lipoproteins, Neurocognitive Function, and Retinal Function

(2014) Angel C. Y. Mak et al.   JAMA Neurology

Apolipoprotein Ε e4 Frequency Is Increased among Chinese Patients with Frontotemporal Dementia and Alzheimer's Disease

(2013) Yong Ji et al.   DEMENTIA AND GERIATRIC COGNITIVE DISORDERS

Non-toxic amyloid beta formed in the presence of glypican-1 or its deaminatively generated heparan sulfate degradation products

(2013) Fang Cheng et al.   GLYCOBIOLOGY

APOE-ε2 and APOE-ε4 Correlate With Increased Amyloid Accumulation in Cerebral Vasculature

(2013) Peter T. Nelson et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

In vivo measurement of apolipoprotein E from the brain interstitial fluid using microdialysis

(2013) Jason D Ulrich et al.   Molecular Neurodegeneration

Parkinson's disease dementia: convergence of α-synuclein, tau and amyloid-β pathologies

(2013) David J. Irwin et al.   NATURE REVIEWS NEUROSCIENCE

ApoE influences amyloid-  (A ) clearance despite minimal apoE/A  association in physiological conditions

(2013) P. B. Verghese et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Neuropathologic substrates of Parkinson disease dementia

(2012) David J. Irwin et al.   ANNALS OF NEUROLOGY

Pathologic Accumulation of α-Synuclein and Aβ in Parkinson Disease Patients With Dementia

(2012) Paul T. Kotzbauer et al.   ARCHIVES OF NEUROLOGY

Low-density Lipoprotein Receptor Represents an Apolipoprotein E-independent Pathway of Aβ Uptake and Degradation by Astrocytes

(2012) Jacob M. Basak et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Reducing Human Apolipoprotein E Levels Attenuates Age-Dependent A  Accumulation in Mutant Human Amyloid Precursor Protein Transgenic Mice

(2012) N. Bien-Ly et al.   JOURNAL OF NEUROSCIENCE

Apolipoprotein E controls cerebrovascular integrity via cyclophilin A

(2012) Robert D. Bell et al.   NATURE

The toxic Aβ oligomer and Alzheimer's disease: an emperor in need of clothes

(2012) Iryna Benilova et al.   NATURE NEUROSCIENCE

The many faces of α-synuclein: from structure and toxicity to therapeutic target

(2012) Hilal A. Lashuel et al.   NATURE REVIEWS NEUROSCIENCE

Variant of TREM2 Associated with the Risk of Alzheimer's Disease

(2012) Thorlakur Jonsson et al.   NEW ENGLAND JOURNAL OF MEDICINE

TREM2 Variants in Alzheimer's Disease

(2012) Rita Guerreiro et al.   NEW ENGLAND JOURNAL OF MEDICINE

Low-density lipoprotein receptor overexpression enhances the rate of brain-to-blood A  clearance in a mouse model of  -amyloidosis

(2012) J. M. Castellano et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Development of Positron Emission Tomography β-Amyloid Plaque Imaging Agents

(2012) Chester A. Mathis et al.   SEMINARS IN NUCLEAR MEDICINE

Comprehensive Research Synopsis and Systematic Meta-Analyses in Parkinson's Disease Genetics: The PDGene Database

(2012) Christina M. Lill et al.   PLoS Genetics

APOE ϵ4 Increases Risk for Dementia in Pure Synucleinopathies

(2012) Debby Tsuang et al.   JAMA Neurology

APOE ε4 allele is associated with an increased risk of bulbar-onset amyotrophic lateral sclerosis in men

(2011) J. Praline et al.   EUROPEAN JOURNAL OF NEUROLOGY

Alzheimer's dementia begins as a disease of small blood vessels, damaged by oxidative-induced inflammation and dysregulated amyloid metabolism: implications for early detection and therapy

(2011) Vincent T. Marchesi   FASEB JOURNAL

Apolipoprotein E Promotes β-Amyloid Trafficking and Degradation by Modulating Microglial Cholesterol Levels

(2011) C. Y. Daniel Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Are amyloid-degrading enzymes viable therapeutic targets in Alzheimer’s disease?

(2011) Natalia N. Nalivaeva et al.   JOURNAL OF NEUROCHEMISTRY

Haploinsufficiency of Human APOE Reduces Amyloid Deposition in a Mouse Model of Amyloid-  Amyloidosis

(2011) J. Kim et al.   JOURNAL OF NEUROSCIENCE

Human apoE Isoforms Differentially Regulate Brain Amyloid-  Peptide Clearance

(2011) J. M. Castellano et al.   Science Translational Medicine

Autosomal-dominant Alzheimer's disease: a review and proposal for the prevention of Alzheimer's disease

(2011) Randall J Bateman et al.   Alzheimers Research & Therapy

Vascular risk factor detection and control may prevent Alzheimer's disease

(2010) Jack C. de la Torre   AGEING RESEARCH REVIEWS

CSF amyloid   1-42 predicts cognitive decline in Parkinson disease

(2010) A. Siderowf et al.   NEUROLOGY

Amyloid load in nondemented brains correlates with APOE e4

(2010) Richard J. Caselli et al.   NEUROSCIENCE LETTERS

Parkinson Disease With Dementia

(2009) Marwan N. Sabbagh et al.   ALZHEIMER DISEASE & ASSOCIATED DISORDERS

APOEpredicts amyloid-beta but not tau Alzheimer pathology in cognitively normal aging

(2009) John C. Morris et al.   ANNALS OF NEUROLOGY

Receptor-associated Protein Interacts with Amyloid-β Peptide and Promotes Its Cellular Uptake

(2009) Takahisa Kanekiyo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Chronic Traumatic Encephalopathy in Athletes: Progressive Tauopathy After Repetitive Head Injury

(2009) Ann C. McKee et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Human APOE Isoform-Dependent Effects on Brain  -Amyloid Levels in PDAPP Transgenic Mice

(2009) K. R. Bales et al.   JOURNAL OF NEUROSCIENCE

Microglia Mediate the Clearance of Soluble A  through Fluid Phase Macropinocytosis

(2009) S. Mandrekar et al.   JOURNAL OF NEUROSCIENCE

Apolipoprotein E and its receptors in Alzheimer's disease: pathways, pathogenesis and therapy

(2009) Guojun Bu   NATURE REVIEWS NEUROSCIENCE

Overexpression of Low-Density Lipoprotein Receptor in the Brain Markedly Inhibits Amyloid Deposition and Increases Extracellular Aβ Clearance

(2009) Jungsu Kim et al.   NEURON

The Role of Apolipoprotein E in Alzheimer's Disease

(2009) Jungsu Kim et al.   NEURON

Fibrillar amyloid-  burden in cognitively normal people at 3 levels of genetic risk for Alzheimer's disease

(2009) E. M. Reiman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Amyloid seeds formed by cellular uptake, concentration, and aggregation of the amyloid-beta peptide

(2009) X. Hu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Apolipoprotein E ε4 is associated with disease-specific effects on brain atrophy in Alzheimer's disease and frontotemporal dementia

(2009) Federica Agosta et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Interaction with Amyloid β Peptide Compromises the Lipid Binding Function of Apolipoprotein E†

(2008) Shiori Tamamizu-Kato et al.   BIOCHEMISTRY

Binding and uptake of Aβ1-42 by primary human astrocytesin vitro

(2008) Henrietta M. Nielsen et al.   GLIA

Amyloid β-Protein Assembly and Alzheimer Disease

(2008) Robin Roychaudhuri et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Overexpression of ABCA1 reduces amyloid deposition in the PDAPP mouse model of Alzheimer disease

(2008) Suzanne E. Wahrle et al.   JOURNAL OF CLINICAL INVESTIGATION

apoE isoform–specific disruption of amyloid β peptide clearance from mouse brain

(2008) Rashid Deane et al.   JOURNAL OF CLINICAL INVESTIGATION

A molecular pathway of neurodegeneration linking α-synuclein to ApoE and Aβ peptides

(2008) Gilbert Gallardo et al.   NATURE NEUROSCIENCE

ApoE Promotes the Proteolytic Degradation of Aβ

(2008) Qingguang Jiang et al.   NEURON