Enhancing myelin renewal reverses cognitive dysfunction in a murine model of Alzheimer’s disease

Human and mouse single-nucleus transcriptomics reveal TREM2-dependent and TREM2-independent cellular responses in Alzheimer’s disease

(2020) Yingyue Zhou et al.   NATURE MEDICINE

Preservation of a remote fear memory requires new myelin formation

(2020) Simon Pan et al.   NATURE NEUROSCIENCE

Myelin degeneration and diminished myelin renewal contribute to age-related deficits in memory

(2020) Fei Wang et al.   NATURE NEUROSCIENCE

Amyloidosis is associated with thicker myelin and increased oligodendrogenesis in the adult mouse brain

(2020) Solène Ferreira et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Remyelination in multiple sclerosis: from basic science to clinical translation

(2020) Catherine Lubetzki et al.   LANCET NEUROLOGY

Young blood plasma reduces Alzheimer’s disease-like brain pathologies and ameliorates cognitive impairment in 3×Tg-AD mice

(2020) Ying Zhao et al.   Alzheimers Research & Therapy

Myelin plasticity: sculpting circuits in learning and memory

(2020) Wendy Xin et al.   NATURE REVIEWS NEUROSCIENCE

Beyond the neuron–cellular interactions early in Alzheimer disease pathogenesis

(2019) Christopher M. Henstridge et al.   NATURE REVIEWS NEUROSCIENCE

A method for combining multiple-units readout of optogenetic control with natural stimulation-evoked eyeblink conditioning in freely-moving mice

(2019) Jie Zhang et al.   Scientific Reports

The role of astroglia in Alzheimer's disease: pathophysiology and clinical implications

(2019) Amaia M Arranz et al.   LANCET NEUROLOGY

Single-cell transcriptomic analysis of Alzheimer’s disease

(2019) Hansruedi Mathys et al.   NATURE

Senolytic therapy alleviates Aβ-associated oligodendrocyte progenitor cell senescence and cognitive deficits in an Alzheimer’s disease model

(2019) Peisu Zhang et al.   NATURE NEUROSCIENCE

Application of T1-/T2-Weighted Ratio Mapping to Elucidate Intracortical Demyelination Process in the Alzheimer’s Disease Continuum

(2019) Xiao Luo et al.   Frontiers in Neuroscience

Alzheimer Disease: An Update on Pathobiology and Treatment Strategies

(2019) Justin M. Long et al.   CELL

A single-cell atlas of entorhinal cortex from individuals with Alzheimer’s disease reveals cell-type-specific gene expression regulation

(2019) Alexandra Grubman et al.   NATURE NEUROSCIENCE

Disruption of Oligodendrogenesis Impairs Memory Consolidation in Adult Mice

(2019) Patrick E. Steadman et al.   NEURON

Early Hippocampal Sharp-Wave Ripple Deficits Predict Later Learning and Memory Impairments in an Alzheimer’s Disease Mouse Model

(2019) Emily A. Jones et al.   Cell Reports

SIRT3 Haploinsufficiency Aggravates Loss of GABAergic Interneurons and Neuronal Network Hyperexcitability in an Alzheimer's Disease Model

(2019) Aiwu Cheng et al.   JOURNAL OF NEUROSCIENCE

LINGO-1 antibody ameliorates myelin impairment and spatial memory deficits in the early stage of 5XFAD mice

(2018) Di Wu et al.   CNS Neuroscience & Therapeutics

Myelin remodeling through experience-dependent oligodendrogenesis in the adult somatosensory cortex

(2018) Ethan G. Hughes et al.   NATURE NEUROSCIENCE

Lifelong cortical myelin plasticity and age-related degeneration in the live mammalian brain

(2018) Robert A. Hill et al.   NATURE NEUROSCIENCE

A Visual-Cue-Dependent Memory Circuit for Place Navigation

(2018) Han Qin et al.   NEURON

Enhancing Oligodendrocyte Myelination Rescues Synaptic Loss and Improves Functional Recovery after Chronic Hypoxia

(2018) Fei Wang et al.   NEURON

The metalloprotease ADAMTS4 generates N-truncated Aβ4–x species and marks oligodendrocytes as a source of amyloidogenic peptides in Alzheimer’s disease

(2018) Susanne Walter et al.   ACTA NEUROPATHOLOGICA

Demyelination precedes axonal loss in the transneuronal spread of human neurodegenerative disease

(2018) Yuyi You et al.   BRAIN

The hippocampal sharp wave–ripple in memory retrieval for immediate use and consolidation

(2018) Hannah R. Joo et al.   NATURE REVIEWS NEUROSCIENCE

Remyelination: A Potential Therapeutic Strategy for Alzheimer’s Disease?

(2017) Junjun Sun et al.   JOURNAL OF ALZHEIMERS DISEASE

Clemastine fumarate as a remyelinating therapy for multiple sclerosis (ReBUILD): a randomised, controlled, double-blind, crossover trial

(2017) Ari J Green et al.   LANCET

Learning-enhanced coupling between ripple oscillations in association cortices and hippocampus

(2017) Dion Khodagholy et al.   SCIENCE

Axonal and myelinic pathology in 5xFAD Alzheimer’s mouse spinal cord

(2017) Tak-Ho Chu et al.   PLoS One

The Cellular Phase of Alzheimer’s Disease

(2016) Bart De Strooper et al.   CELL

The superficial white matter in Alzheimer's disease

(2016) Owen R Phillips et al.   HUMAN BRAIN MAPPING

Alzheimer's disease

(2016) Philip Scheltens et al.   LANCET

Accelerated remyelination during inflammatory demyelination prevents axonal loss and improves functional recovery

(2016) Feng Mei et al.   eLife

Hippocampal sharp wave-ripple: A cognitive biomarker for episodic memory and planning

(2015) György Buzsáki   HIPPOCAMPUS

Neuroinflammation in Alzheimer's disease

(2015) Michael T Heneka et al.   LANCET NEUROLOGY

Altered hippocampal information coding and network synchrony in APP-PS1 mice

(2015) Sebastien Cayzac et al.   NEUROBIOLOGY OF AGING

Glia Disease and Repair—Remyelination

(2015) Robin J.M. Franklin et al.   Cold Spring Harbor Perspectives in Biology

Motor skill learning requires active central myelination

(2014) I. A. McKenzie et al.   SCIENCE

Degeneration and impaired regeneration of gray matter oligodendrocytes in amyotrophic lateral sclerosis

(2013) Shin H Kang et al.   NATURE NEUROSCIENCE

Oligodendrocyte progenitors balance growth with self-repulsion to achieve homeostasis in the adult brain

(2013) Ethan G Hughes et al.   NATURE NEUROSCIENCE

Oligodendrocyte Dynamics in the Healthy Adult CNS: Evidence for Myelin Remodeling

(2013) Kaylene M. Young et al.   NEURON

White matter tract integrity metrics reflect the vulnerability of late-myelinating tracts in Alzheimer's disease

(2013) Andreana Benitez et al.   NeuroImage-Clinical

White matter atrophy in Alzheimer's disease variants

(2012) Raffaella Migliaccio et al.   Alzheimers & Dementia

Cerebral white matter disease is associated with Alzheimer pathology in a prospective cohort

(2012) Abhay Moghekar et al.   Alzheimers & Dementia

Dynamic changes in myelin aberrations and oligodendrocyte generation in chronic amyloidosis in mice and men

(2012) Gwendolyn Behrendt et al.   GLIA

Oligodendroglia metabolically support axons and contribute to neurodegeneration

(2012) Youngjin Lee et al.   NATURE

Glycolytic oligodendrocytes maintain myelin and long-term axonal integrity

(2012) Ursula Fünfschilling et al.   NATURE

Neuropathologically defined subtypes of Alzheimer's disease with distinct clinical characteristics: a retrospective study

(2011) Melissa E Murray et al.   LANCET NEUROLOGY

The SK2-long isoform directs synaptic localization and function of SK2-containing channels

(2011) Duane Allen et al.   NATURE NEUROSCIENCE

Focal demyelination in Alzheimer’s disease and transgenic mouse models

(2010) Stanislaw Mitew et al.   ACTA NEUROPATHOLOGICA

Early Oligodendrocyte/Myelin Pathology in Alzheimer's Disease Mice Constitutes a Novel Therapeutic Target

(2010) Maya K. Desai et al.   AMERICAN JOURNAL OF PATHOLOGY

Oligodendrocytes are a Novel Source of Amyloid Peptide Generation

(2009) Stephen D. Skaper et al.   NEUROCHEMICAL RESEARCH

Triple-transgenic Alzheimer's disease mice exhibit region-specific abnormalities in brain myelination patterns prior to appearance of amyloid and tau pathology

(2008) Maya K. Desai et al.   GLIA

Remyelination in the CNS: from biology to therapy

(2008) Robin J. M. Franklin et al.   NATURE REVIEWS NEUROSCIENCE

Decreased white matter integrity in late-myelinating fiber pathways in Alzheimer's disease supports retrogenesis

(2008) N.H. Stricker et al.   NEUROIMAGE