Roles of cancer-associated fibroblasts (CAFs) in anti- PD-1/PD-L1 immunotherapy for solid cancers

RNA-mediated immunotherapy regulating tumor immune microenvironment: next wave of cancer therapeutics

(2022) Poonam R. Pandey et al.   Molecular Cancer

Identification of Functional Heterogeneity of Carcinoma-Associated Fibroblasts with Distinct IL6-Mediated Therapy Resistance in Pancreatic Cancer

(2022) Kathleen M. McAndrews et al.   Cancer Discovery

The complex role of tumor-infiltrating macrophages

(2022) Anthos Christofides et al.   NATURE IMMUNOLOGY

Adaptive immune resistance at the tumour site: mechanisms and therapeutic opportunities

(2022) Tae Kon Kim et al.   NATURE REVIEWS DRUG DISCOVERY

Multiomic analysis reveals conservation of cancer-associated fibroblast phenotypes across species and tissue of origin

(2022) Deshka S. Foster et al.   CANCER CELL

Pan-cancer single-cell analysis reveals the heterogeneity and plasticity of cancer-associated fibroblasts in the tumor microenvironment

(2022) Han Luo et al.   Nature Communications

Exosomal LncRNA LINC00659 transferred from cancer-associated fibroblasts promotes colorectal cancer cell progression via miR-342-3p/ANXA2 axis

(2021) Lin Zhou et al.   Journal of Translational Medicine

Implication of cancer associated fibroblast subtypes on cancer pathogenesis, prognosis, and immunotherapy resistance

(2021) Phillip M Galbo et al.   CLINICAL CANCER RESEARCH

Targeting cancer-associated fibroblast-secreted WNT2 restores dendritic cell-mediated antitumour immunity

(2021) Tuxiong Huang et al.   GUT

Cancer‐associated fibroblast‐mediated cellular crosstalk supports hepatocellular carcinoma progression

(2021) Mengjia Song et al.   HEPATOLOGY

PD-L1 as a biomarker of response to immune-checkpoint inhibitors

(2021) Deborah Blythe Doroshow et al.   Nature Reviews Clinical Oncology

Distinct Stromal and Immune Features Collectively Contribute to Long-Term Survival in Pancreatic Cancer

(2021) Hassan Sadozai et al.   Frontiers in Immunology

Laminin γ2–mediating T cell exclusion attenuates response to anti–PD-1 therapy

(2021) Lei Li et al.   Science Advances

Direct and Indirect Modulation of T Cells by VEGF-A Counteracted by Anti-Angiogenic Treatment

(2021) Morgane Bourhis et al.   Frontiers in Immunology

Exosomal circEIF3K from cancer-associated fibroblast promotes colorectal cancer (CRC) progression via miR-214/PD-L1 axis

(2021) Kaihua Yang et al.   BMC CANCER

CAFs shape myeloid‐derived suppressor cells to promote stemness of intrahepatic cholangiocarcinoma via 5‐lipoxygenase

(2021) Yuli Lin et al.   HEPATOLOGY

Clinical and therapeutic relevance of cancer-associated fibroblasts

(2021) Yang Chen et al.   Nature Reviews Clinical Oncology

Mechanisms of regulatory T cell infiltration in tumors: implications for innovative immune precision therapies

(2021) Shohei Koyama et al.   Journal for ImmunoTherapy of Cancer

Carcinoma-associated fibroblasts derived exosomes modulate breast cancer cell stemness through exonic circHIF1A by miR-580-5p in hypoxic stress

(2021) Yanxia Zhan et al.   Cell Death Discovery

Crosstalk between cancer-associated fibroblasts and immune cells in the tumor microenvironment: new findings and future perspectives

(2021) Xiaoqi Mao et al.   Molecular Cancer

Cancer-associated fibroblasts-derived exosomes promote lung cancer progression by OIP5-AS1/ miR-142-5p/ PD-L1 axis

(2021) Yun Jiang et al.   MOLECULAR IMMUNOLOGY

Next frontier in tumor immunotherapy: macrophage-mediated immune evasion

(2021) Yingqi Qiu et al.   Biomarker Research

SNHG3 Functions as miRNA Sponge to Promote Breast Cancer Cells Growth Through the Metabolic Reprogramming

(2020) Yan Li et al.   APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY

Blockade of DC-SIGN+ tumor-associated macrophages reactivates anti-tumor immunity and improves immunotherapy in muscle-invasive bladder cancer

(2020) Baoying Hu et al.   CANCER RESEARCH

Distinct fibroblast functional states drive clinical outcomes in ovarian cancer and are regulated by TCF21

(2020) Ali Hussain et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Metastasis-initiating cells induce and exploit a fibroblast niche to fuel malignant colonization of the lungs

(2020) Maren Pein et al.   Nature Communications

Single-cell analysis reveals fibroblast clusters linked to immunotherapy resistance in cancer

(2020) Yann Kieffer et al.   Cancer Discovery

The history and advances in cancer immunotherapy: understanding the characteristics of tumor-infiltrating immune cells and their therapeutic implications

(2020) Yuanyuan Zhang et al.   Cellular & Molecular Immunology

cDC1 prime and are licensed by CD4+ T cells to induce anti-tumour immunity

(2020) Stephen T. Ferris et al.   NATURE

Heat shock protein-90 inhibition alters activation of pancreatic stellate cells and enhances the efficacy of PD-1 blockade in pancreatic cancer.

(2020) Yuchen Zhang et al.   MOLECULAR CANCER THERAPEUTICS

Cancer-Associated Fibroblasts-Derived Exosomes Suppress Immune Cell Function in Breast Cancer via the miR-92/PD-L1 Pathway

(2020) Dongwei Dou et al.   Frontiers in Immunology

Nintedanib promotes antitumour immunity and shows antitumour activity in combination with PD-1 blockade in mice: potential role of cancer-associated fibroblasts

(2020) Ryoji Kato et al.   BRITISH JOURNAL OF CANCER

TGFβ-blockade uncovers stromal plasticity in tumors by revealing the existence of a subset of interferon-licensed fibroblasts

(2020) Angelo L. Grauel et al.   Nature Communications

Tumor microenvironment as a therapeutic target in cancer

(2020) Yi Xiao et al.   PHARMACOLOGY & THERAPEUTICS

Cancer-associated fibroblasts enhance tumor-associated macrophages enrichment and suppress NK cells function in colorectal cancer

(2019) Rongsheng Zhang et al.   Cell Death & Disease

Hypoxic cancer–associated fibroblasts increase NCBP2-AS2/HIAR to promote endothelial sprouting through enhanced VEGF signaling

(2019) Fernanda G. Kugeratski et al.   Science Signaling

Cancer-associated fibroblasts in gastrointestinal cancer

(2019) Hiroki Kobayashi et al.   Nature Reviews Gastroenterology & Hepatology

The extracellular matrix in tumor progression and metastasis

(2019) Johannes A. Eble et al.   CLINICAL & EXPERIMENTAL METASTASIS

The Intersection between Tumor Angiogenesis and Immune Suppression

(2019) Osama E. Rahma et al.   CLINICAL CANCER RESEARCH

Loss of exosomal miR-3188 in cancer-associated fibroblasts contributes to HNC progression

(2019) Xiaoning Wang et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

CAFs secreted exosomes promote metastasis and chemotherapy resistance by enhancing cell stemness and epithelial-mesenchymal transition in colorectal cancer

(2019) J. L. Hu et al.   Molecular Cancer

Adaptive plasticity of IL-10+ and IL-35+ Treg cells cooperatively promotes tumor T cell exhaustion

(2019) Deepali V. Sawant et al.   NATURE IMMUNOLOGY

Treg Cells Promote the SREBP1-Dependent Metabolic Fitness of Tumor-Promoting Macrophages via Repression of CD8+ T Cell-Derived Interferon-γ

(2019) Chang Liu et al.   IMMUNITY

Meflin-positive cancer-associated fibroblasts inhibit pancreatic carcinogenesis

(2019) Yasuyuki Mizutani et al.   CANCER RESEARCH

Integrin-Mediated TGFβ Activation Modulates the Tumour Microenvironment

(2019) Brown et al.   Cancers

Cancer-associated fibroblast-derived WNT2 increases tumor angiogenesis in colon cancer

(2019) Daniela Unterleuthner et al.   ANGIOGENESIS

Differences in Tumor Microenvironment Dictate T Helper Lineage Polarization and Response to Immune Checkpoint Therapy

(2019) Shiping Jiao et al.   CELL

Single-cell RNA sequencing reveals stromal evolution into LRRC15+ myofibroblasts as a determinant of patient response to cancer immunotherapy

(2019) Claudia X Dominguez et al.   Cancer Discovery

Harnessing Natural Killer Cell Antitumor Immunity: From the Bench to Bedside

(2019) Karrune V. Woan et al.   Cancer Immunology Research

microRNA-181d-5p-containing exosomes derived from cancer-associated fibroblasts promote epithelial-mesenchymal transition by regulating CDX2/HOXA5 in breast cancer

(2019) Hongbin Wang et al.   Molecular Therapy-Nucleic Acids

Fibroblast Heterogeneity and Immunosuppressive Environment in Human Breast Cancer

(2018) Ana Costa et al.   CANCER CELL

Inhibition of Rspo-Lgr4 facilitates checkpoint blockade therapy by switching macrophage polarization

(2018) Binghe Tan et al.   CANCER RESEARCH

LXR/ApoE Activation Restricts Innate Immune Suppression in Cancer

(2018) Masoud F. Tavazoie et al.   CELL

A peek into cancer-associated fibroblasts: origins, functions and translational impact

(2018) Valerie S. LeBleu et al.   Disease Models & Mechanisms

TGF-β and the Tissue Microenvironment: Relevance in Fibrosis and Cancer

(2018) Laia Caja et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

EVIR: chimeric receptors that enhance dendritic cell cross-dressing with tumor antigens

(2018) Mario Leonardo Squadrito et al.   NATURE METHODS

Cancer-associated fibroblasts induce PDL1+ neutrophils through the IL6-STAT3 pathway that foster immune suppression in hepatocellular carcinoma

(2018) Yusheng Cheng et al.   Cell Death & Disease

Bifunctional immune checkpoint-targeted antibody-ligand traps that simultaneously disable TGFβ enhance the efficacy of cancer immunotherapy

(2018) Rajani Ravi et al.   Nature Communications

Unveiling a CD70-positive subset of cancer-associated fibroblasts marked by pro-migratory activity and thriving regulatory T cell accumulation

(2018) Julie Jacobs et al.   OncoImmunology

Tumor matrix remodeling and novel immunotherapies: the promise of matrix-derived immune biomarkers

(2018) Muhammad Umair Mushtaq et al.   Journal for ImmunoTherapy of Cancer

Inhibition of Microsomal Prostaglandin E Synthase-1 in Cancer-Associated Fibroblasts Suppresses Neuroblastoma Tumor Growth

(2018) Anna Kock et al.   EBioMedicine

Exosomal PD-L1 contributes to immunosuppression and is associated with anti-PD-1 response

(2018) Gang Chen et al.   NATURE

TGFβ attenuates tumour response to PD-L1 blockade by contributing to exclusion of T cells

(2018) Sanjeev Mariathasan et al.   NATURE

WNT Signaling in Cancer Immunosurveillance

(2018) Lorenzo Galluzzi et al.   TRENDS IN CELL BIOLOGY

Cancer-associated fibroblasts contribute to oral cancer cells proliferation and metastasis via exosome-mediated paracrine miR-34a-5p

(2018) Yao-yin Li et al.   EBioMedicine

Cancer immunoediting and resistance to T cell-based immunotherapy

(2018) Jake S. O’Donnell et al.   Nature Reviews Clinical Oncology

Turning foes to friends: targeting cancer-associated fibroblasts

(2018) Xueman Chen et al.   NATURE REVIEWS DRUG DISCOVERY

TGF-β-associated extracellular matrix genes link cancer-associated fibroblasts to immune evasion and immunotherapy failure

(2018) Ankur Chakravarthy et al.   Nature Communications

Tumor-associated macrophages: from basic research to clinical application

(2017) Li Yang et al.   Journal of Hematology & Oncology

Extracellular matrix and the myeloid-in-myeloma compartment: balancing tolerogenic and immunogenic inflammation in the myeloma niche

(2017) Fotis Asimakopoulos et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Nivolumab in metastatic urothelial carcinoma after platinum therapy (CheckMate 275): a multicentre, single-arm, phase 2 trial

(2017) Padmanee Sharma et al.   LANCET ONCOLOGY

Rescue of exhausted CD8 T cells by PD-1–targeted therapies is CD28-dependent

(2017) Alice O. Kamphorst et al.   SCIENCE

Interleukin-35 Limits Anti-Tumor Immunity

(2016) Meghan E. Turnis et al.   IMMUNITY

Cancer-Associated Fibroblasts Regulate Tumor-Initiating Cell Plasticity in Hepatocellular Carcinoma through c-Met/FRA1/HEY1 Signaling

(2016) Eunice Yuen Ting Lau et al.   Cell Reports

Hepatic carcinoma-associated fibroblasts induce IDO-producing regulatory dendritic cells through IL-6-mediated STAT3 activation

(2016) J-t Cheng et al.   Oncogenesis

Depletion of Carcinoma-Associated Fibroblasts and Fibrosis Induces Immunosuppression and Accelerates Pancreas Cancer with Reduced Survival

(2015) Berna C. Özdemir et al.   CANCER CELL

Host stromal versican is essential for cancer-associated fibroblast function to inhibit cancer growth

(2015) Kanda Fanhchaksai et al.   INTERNATIONAL JOURNAL OF CANCER

Stromal gene expression defines poor-prognosis subtypes in colorectal cancer

(2015) Alexandre Calon et al.   NATURE GENETICS

Combined Nivolumab and Ipilimumab or Monotherapy in Untreated Melanoma

(2015) James Larkin et al.   NEW ENGLAND JOURNAL OF MEDICINE

CSF1/CSF1R Blockade Reprograms Tumor-Infiltrating Macrophages and Improves Response to T-cell Checkpoint Immunotherapy in Pancreatic Cancer Models

(2014) Y. Zhu et al.   CANCER RESEARCH

A FAK-Cas-Rac-Lamellipodin Signaling Module Transduces Extracellular Matrix Stiffness into Mechanosensitive Cell Cycling

(2014) Y. H. Bae et al.   Science Signaling

Regulation of the anti-tumour immune response by cancer-associated fibroblasts

(2014) James Harper et al.   SEMINARS IN CANCER BIOLOGY

The IL-6–STAT3 axis mediates a reciprocal crosstalk between cancer-derived mesenchymal stem cells and neutrophils to synergistically prompt gastric cancer progression

(2014) Q Zhu et al.   Cell Death & Disease

Tumor-Stroma Interaction: Revealing Fibroblast-Secreted Exosomes as Potent Regulators of Wnt-Planar Cell Polarity Signaling in Cancer Metastasis

(2013) V. Luga et al.   CANCER RESEARCH

Forkhead box P3 regulatory T cells coexisting with cancer associated fibroblasts are correlated with a poor outcome in lung adenocarcinoma

(2013) Tomonari Kinoshita et al.   CANCER SCIENCE

The role of chemokines in acute and chronic hepatitis C infection

(2013) Stephen Fahey et al.   Cellular & Molecular Immunology

Functional Heterogeneity of Cancer-Associated Fibroblasts from Human Colon Tumors Shows Specific Prognostic Gene Expression Signature

(2013) M. Herrera et al.   CLINICAL CANCER RESEARCH

Innate and adaptive immune cells in the tumor microenvironment

(2013) Thomas F Gajewski et al.   NATURE IMMUNOLOGY

Lung Collagens Perpetuate Pulmonary Fibrosis via CD204 and M2 Macrophage Activation

(2013) Mirjam Stahl et al.   PLoS One

Tumor-associated neutrophils: friend or foe?

(2012) Z. G. Fridlender et al.   CARCINOGENESIS

Melanoma exosomes educate bone marrow progenitor cells toward a pro-metastatic phenotype through MET

(2012) Héctor Peinado et al.   NATURE MEDICINE

In situ force mapping of mammary gland transformation

(2011) Jose I. Lopez et al.   Integrative Biology

Cancer-Associated Fibroblasts Are Activated in Incipient Neoplasia to Orchestrate Tumor-Promoting Inflammation in an NF-κB-Dependent Manner

(2010) Neta Erez et al.   CANCER CELL

Hyaluronan Deficiency in Tumor Stroma Impairs Macrophage Trafficking and Tumor Neovascularization

(2010) N. Kobayashi et al.   CANCER RESEARCH

Polarization of Tumor-Associated Neutrophil Phenotype by TGF-β: “N1” versus “N2” TAN

(2009) Zvi G. Fridlender et al.   CANCER CELL

Identification of an active site of EMMPRIN for the augmentation of matrix metalloproteinase-1 and -3 expression in a co-culture of human uterine cervical carcinoma cells and fibroblasts

(2009) Takashi Sato et al.   GYNECOLOGIC ONCOLOGY

Tumour-derived prostaglandin E2and transforming growth factor-β synergize to inhibit plasmacytoid dendritic cell-derived interferon-α

(2009) Isabelle Bekeredjian-Ding et al.   IMMUNOLOGY

Cutting Edge: Tumor-Specific CD8+ T Cells Infiltrating Prostatic Tumors Are Induced to Become Suppressor Cells

(2009) K. A. Shafer-Weaver et al.   JOURNAL OF IMMUNOLOGY

TGFβ in Cancer

(2008) Joan Massagué   CELL