Review
Immunology
Lucas Leite Cunha, Victor Alexandre dos Santos Valsecchi, Laura Sterian Ward
Summary: The immune response is remodeled with aging, which is called immunosenescence. Some scientists believe immunosenescence is an adaptation of the immune system to the aging environment, while others think aging leads to chronic inflammation. Studying immunosenescence can bring practical innovations to medicine and the health system.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Oncology
Leisheng Zhang, Yuan Meng, Xiaoming Feng, Zhongchao Han
Summary: This article mainly focuses on the latest updates, opportunities, and challenges of CAR-NK cell-based tactics in cancer immunotherapy. CAR-NK cells have the potential to improve efficacy and control adverse effects, while also meeting the demand for large-scale manufacture.
BIOMARKER RESEARCH
(2022)
Review
Cell Biology
Ludi Yang, Xiang Gu, Jie Yu, Shengfang Ge, Xianqun Fan
Summary: Oncolytic viruses, either natural or genetically engineered, can replicate in tumor cells and inhibit tumor growth, making them an effective anticancer strategy. Their multifunctional characteristics suggest promising application prospects in cancer therapeutics.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Chemistry, Multidisciplinary
Shijie Duan, Shuhang Wang, Lei Qiao, Xinbo Yu, Nan Wang, Liting Chen, Xinyuan Zhang, Xu Zhao, Hongyu Liu, Tianye Wang, Ying Wu, Ning Li, Funan Liu
Summary: With advancements in cancer biology and molecular virology, oncolytic virus-driven therapies have emerged as a promising alternative to traditional cancer treatments. However, current clinical trials have shown limited efficacy when using a single oncolytic virus. Integrated approaches combining immunotherapy, chemotherapy, or radiotherapy with oncolytic virus therapy have shown considerable effectiveness. Challenges in oncolytic virus therapy include restricted delivery and poor targeting. Further optimization of delivery methods is needed before oncolytic viruses can become a viable tumor treatment option.
Review
Medicine, Research & Experimental
Tingting Zhang, Adila Aipire, Yijie Li, Changying Guo, Jinyao Li
Summary: This review summarizes the mechanisms of cross-presentation (XPT) and its application in tumor immunotherapy. Dendritic cells enhance their antigen presentation capacity through receptor-mediated internalization of exogenous antigens, endosome escape, engagement of other XPT-related proteins, and the use of adjuvants, thereby improving the outcomes of DC-based therapy.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Editorial Material
Oncology
Francisco Hermida-Prado, Rinath Jeselsohn
Summary: ESR1 ligand-binding mutations, the most common genetic mechanism of acquired resistance to endocrine treatment, lead to constitutive ligand-independent activity, emerging under the selective pressure of aromatase inhibitors. New models of these mutations have been generated using CRISPR technology, shedding light on their functional consequences.
Review
Oncology
Emily F. Davis-Marcisak, Atul Deshpande, Genevieve L. Stein-O'Brien, Won J. Ho, Daniel Laheru, Elizabeth M. Jaffee, Elana J. Fertig, Luciane T. Kagohara
Summary: Single-cell technologies are powerful tools for cancer research, providing insights into tumor heterogeneity and cell state transitions affecting therapeutic response. Analyzing clinical samples is promising for precision medicine but requires coordination among multi-disciplinary teams for data accuracy and interpretation.
Article
Health Care Sciences & Services
Changwon Wang, Chungkeun Lee, Hangsik Shin
Summary: As a new therapeutic technique based on digital technology, the commercialization and clinical application of digital therapeutics (DTx) are increasing. However, the lack of consensus on a definition, insufficiencies in research and development, clinical trials, standardization of regulatory frameworks, and technological maturity have made the use of DTx as a general medical component ambiguous. This study investigates definitions, clinical trials, commercial products, and regulatory status related to DTx and suggests the necessity and considerations for international agreements on the definition and characteristics of DTx, focusing on commercialization characteristics.
NPJ DIGITAL MEDICINE
(2023)
Article
Oncology
Shalu Sharma Kharkwal, Christopher T. Johndrow, Natacha Veerapen, Himanshu Kharkwal, Noemi A. Saavedra-Avila, Leandro J. Carreno, Samantha Rothberg, Jinghang Zhang, Scott J. Garforth, Peter J. Jervis, Lianjun Zhang, Alena Donda, Amareeta K. Besra, Liam R. Cox, Steven C. Almo, Alan Howell, Elizabeth E. Evans, Maurice Zauderer, Gurdyal S. Besra, Steven A. Porcelli
Summary: A novel bispecific T-cell engager (BiTE) was developed to activate iNKT cells for antitumor immunity, enhancing multiple effector functions and promoting tumor-specific CD8(+) cytolytic T-cell responses. Simultaneous checkpoint blockade with anti-CTLA-4 antibodies further enhanced the antitumor effects, providing a potential approach for combination immunotherapy. Multiple injections of covalently stabilized iNKT cell-specific BiTEs led to effective and nontoxic cancer immunotherapy regimens without inducing anergy or exhaustion in responding iNKT cells.
Review
Biochemistry & Molecular Biology
Yutao Li, Amit Sharma, Jarek Maciaczyk, Ingo G. H. Schmidt-Wolf
Summary: Glioblastoma multiforme (GBM) is a devastating disease with poor prognosis and challenging treatment. Conventional therapies have limited success, prompting the exploration of immunotherapeutic approaches such as adjuvant NKT immunotherapy. This article discusses the current strategies of NKT therapy for GBM and their potential for improving clinical outcomes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Chemistry, Physical
Chanyuan Jin, Sanjun Fang, Zechao Zhuang, Yongsheng Zhou
Summary: Single-atom nanozymes (SANs) are emerging catalytic nanomaterials with enzyme-like activities, which hold great promise in medical applications. This article presents the recent developments of SANs in anti-infective treatment, cancer diagnosis and therapy, biosensing, and antioxidative therapy.
Article
Hematology
Sangeetha Venugopal, Justin Watts
Summary: The discovery of IDH1 mutations in AML and the success of molecularly targeted therapies led to the development of IDH1mut inhibitors. Olutasidenib, a novel IDH1mut inhibitor, showed promising results in treating patients with R/R IDH1mut AML, including durable remission rates and transfusion independence. This review examines the development and positioning of olutasidenib in the treatment of IDH1mut AML.
Review
Chemistry, Physical
Chanyuan Jin, Sanjun Fan, Zechao Zhuang, Yongsheng Zhou
Summary: Single-atom nanozymes (SANs), a new type of catalytic nanomaterials with enzyme-mimetic activities, have gained extensive research attention in the fields of chemistry, energy conversion, and environmental purification. Recent studies have demonstrated the great potential of SANs in biological applications, including anti-infective treatment, cancer diagnosis and therapy, biosensing, and antioxidative therapy.
Review
Medicine, Research & Experimental
Miao Wang, Jie Rao, Meng Wang, Xiaosong Li, Kaili Liu, Mark F. Naylor, Robert E. Nordquist, Wei R. Chen, Feifan Zhou
Summary: The combination of targeted therapy and immunotherapy is considered an ideal strategy for treating metastatic cancer, with phototherapy emerging as a promising targeted therapy that can initiate antitumor immune responses through induced immunogenic tumor cell death. The use of phototherapy in conjunction with immunoadjuvant therapy has shown to induce a systemic antitumor immune response, controlling residual tumor cells at the treatment site and distant metastases.
Article
Engineering, Biomedical
Hatice B. Bingol, Johan C. M. E. Bender, Joost A. Opsteen, Sander C. G. Leeuwenburgh
Summary: Biodegradable bone adhesives are highly sought-after biomaterials that can replace traditional metallic devices for bone fixation. However, these biomaterials must meet numerous requirements, and commercially available bone-adhesive biomaterials that fulfill all of these requirements are currently not available. This comprehensive review provides an extensive overview of the development of bone adhesives from a translational perspective, highlighting the definition, classification, and chemistry of various types of bone adhesives. The review also focuses on materials capable of gluing two pieces of bone together within a time frame of minutes to days and critically reflects on commonly employed adhesion tests and the current state-of-the-art in their preclinical and clinical applicability.
MATERIALS TODAY BIO
(2023)
Article
Biochemistry & Molecular Biology
Eva Sahakian, John J. Powers, Jie Chen, Susan L. Deng, Fengdong Cheng, Allison Distler, David M. Woods, Jennifer Rock-Klotz, Andressa L. Sodre, Je-In Youn, Karrune V. Woan, Alejandro Villagra, Dmitry Gabrilovich, Eduardo M. Sotomayor, Javier Pinilla-Ibarz
MOLECULAR IMMUNOLOGY
(2015)
Article
Oncology
K. V. Woan, M. Lienlaf, P. Perez-Villaroel, C. Lee, F. Cheng, T. Knox, D. M. Woods, K. Barrios, J. Powers, E. Sahakian, H. W. Wang, J. Canales, D. Marante, K. S. M. Smalley, J. Bergman, E. Seto, A. Kozikowski, J. Pinilla-Ibarz, A. Sarnaik, E. Celis, J. Weber, E. M. Sotomayor, A. Villagra
MOLECULAR ONCOLOGY
(2015)
Article
Oncology
Fengdong Cheng, Hongwei Wang, Pedro Horna, Zi Wang, Bijal Shah, Eva Sahakian, Karrune V. Woan, Alejandro Villagra, Javier Pinilla-Ibarz, Said Sebti, Mitchell Smith, Jianguo Tao, Eduardo M. Sotomayor
Article
Oncology
Krithika N. Kodumudi, Karrune Woan, Danielle L. Gilvary, Eva Sahakian, Sheng Wei, Julie Y. Djeu
CLINICAL CANCER RESEARCH
(2010)
Review
Cell Biology
Karrune V. Woan, Eva Sahakian, Eduardo M. Sotomayor, Edward Seto, Alejandro Villagra
IMMUNOLOGY AND CELL BIOLOGY
(2012)
Article
Immunology
Hongwei Wang, Fengdong Cheng, Karrune Woan, Eva Sahakian, Oscar Merino, Jennifer Rock-Klotz, Ildefonso Vicente-Suarez, Javier Pinilla-Ibarz, Kenneth L. Wright, Edward Seto, Kapil Bhalla, Alejandro Villagra, Eduardo M. Sotomayor
JOURNAL OF IMMUNOLOGY
(2011)
Article
Immunology
Fengdong Cheng, Maritza Lienlaf, Hong-Wei Wang, Patricio Perez-Villarroel, Calvin Lee, Karrune Woan, Jennifer Rock-Klotz, Eva Sahakian, David Woods, Javier Pinilla-Ibarz, Jay Kalin, Jianguo Tao, Wayne Hancock, Alan Kozikowski, Edward Seto, Alejandro Villagra, Eduardo M. Sotomayor
JOURNAL OF IMMUNOLOGY
(2014)
Article
Chemistry, Medicinal
Joel A. Bergman, Karrune Woan, Patricio Perez-Villarroel, Alejandro Villagra, Eduardo M. Sotomayor, Alan P. Kozikowski
JOURNAL OF MEDICINAL CHEMISTRY
(2012)
Article
Oncology
David M. Woods, Karrune Woan, Fengdong Cheng, Hongwei Wang, Patricio Perez-Villarroel, Calvin Lee, Maritza Lienlaf, Peter Atadja, Edward Seto, Jeffrey Weber, Eduardo M. Sotomayor, Alejandro Villagra
Article
Biochemistry & Molecular Biology
Fengdong Cheng, Maritza Lienlaf, Patricio Perez-Villarroel, Hong-Wei Wang, Calvin Lee, Karrune Woan, David Woods, Tessa Knox, Joel Bergman, Javier Pinilla-Ibarz, Alan Kozikowski, Edward Seto, Eduardo M. Sotomayor, Alejandro Villagra
MOLECULAR IMMUNOLOGY
(2014)
Article
Hematology
David M. Woods, Karrune V. Woan, Fengdong Cheng, Andressa L. Sodre, Dapeng Wang, Yongxia Wu, Zi Wang, Jie Chen, John Powers, Javier Pinilla-Ibarz, Yu Yu, Ya Zhang, Xuefeng Wu, Xiaoyan Zheng, Jeffrey Weber, Wayne W. Hancock, Edward Seto, Alejandro Villagra, Xue-Zhong Yu, Eduardo M. Sotomayor
Review
Biotechnology & Applied Microbiology
Karrune Woan, Vijay Reddy
EXPERT OPINION ON BIOLOGICAL THERAPY
(2007)