Article
Cell Biology
Xiuru Shi, Ke Wei, Yulun Wu, Lingyu Mao, Wenhao Pei, Haitao Zhu, Yingxiang Shi, Shiwen Zhang, Shuang Tao, Jing Wang, Siyan Pang, Huilan Mao, Wenrui Wang, Qingling Yang, Changjie Chen
Summary: This study elucidated the molecular mechanism of exosomal miR-372-5p promoting metastasis and stemness in colorectal cancer (CRC), which may provide new therapeutic targets for CRC metastasis and prognosis assessment.
CELLULAR SIGNALLING
(2023)
Article
Biochemistry & Molecular Biology
Jing Xu, Peng Chen, Chaoqun Yu, Qiangqiang Shi, Susu Wei, Yaxin Li, Hongzhao Qi, Qilong Cao, Chuanlong Guo, Xianggen Wu, Guohu Di
Summary: Hypoxia preconditioning of mesenchymal stromal cells (Hp-MSCs) enhances liver regeneration through secreted exosomes (Hp-Exo), which mediate M2 macrophage polarization by modulating the FOXO1/TLR4 signaling pathway.
Article
Chemistry, Medicinal
Huan Hu, Guangyu Mao, Jianghong Zheng, Feng Guo
Summary: In this study, it was found that plasma-derived exosomal hsa_circ_0020792 from keloid patients promotes the proliferation, migration, and fibrogenesis of normal skin fibroblasts through modulation of miR-193a-5p and activation of the TGF-I31/Smad2/3 signaling pathway.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2022)
Article
Gastroenterology & Hepatology
Wenwei Qian, Liangyu Huang, Yihan Xu, Wen Lu, Weiwei Wen, Zhen Guo, Weiming Zhu, Yi Li
Summary: In this study, it was found that exosomal miR-216a-5p released from hypoxia-preconditioned adipose-derived stem cells (ASCs) exhibited higher therapeutic efficacy than normal exosomes (NExos) in experimental colitis by promoting the M2 macrophage phenotype. This suggests that hypoxia preconditioning may be a promising approach to optimize the function of ASC-derived exosomes.
INFLAMMATORY BOWEL DISEASES
(2023)
Article
Oncology
Chao Chen, Chenbo Yang, Xiangyu Tian, Yinghao Liang, Shuaiyuan Wang, Xiaoqian Wang, Yuwei Shou, Hui Li, Qiankun Xiao, Jiao Shu, Miaomiao Sun, Kuisheng Chen
Summary: Esophageal squamous cell carcinoma (ESCC) is an aggressive gastrointestinal tumor with high early lymphatic metastatic potential. The impact of cancer-associated fibroblasts (CAFs) and its derived exosomes on lymphangiogenesis remains unclear.
Article
Oncology
Xinglei Qin, Min Lu, Gang Li, Yajun Zhou, Zhaoyang Liu
Summary: The study showed that downregulation of miR-34c in exosomes can enhance communication between cancer cells and fibroblasts, leading to the progression of cholangiocarcinoma.
CANCER CELL INTERNATIONAL
(2021)
Article
Oncology
Xihao Yao, Yingqing Mao, Di Wu, Yi Zhu, Jingjing Lu, Yan Huang, Yibing Guo, Zhiwei Wang, Shajun Zhu, Xiaohong Li, Yuhua Lu
Summary: Pancreatic cancer is a lethal malignancy with low survival rates, and exosomes derived from bone marrow mesenchymal stem cells contain crucial circRNAs for tumor progression. These exosomal circRNAs inhibit the stemness and progression of pancreatic cancer cells through the miR-338-5p/Wif1/Wnt8/β-catenin axis.
Article
Biotechnology & Applied Microbiology
Zekun Shen, Weiyi Wang, Jinxing Chen, Bingyi Chen, Yanan Tang, Jiaxuan Hou, Jiayan Li, Shuang Liu, Yifan Mei, Liwei Zhang, Shaoying Lu
Summary: This study uncovered the potential of sEVs derived from hypoxic HUVECs to enhance the therapeutic efficacy of ADSCs in CLI by improving their resistance to reactive oxygen species and angiogenic ability. The mechanism involves downregulation of PTEN via miR-486-5p targeting, leading to activation of the AKT/MTOR/HIF-1 alpha pathway and influencing ADSCs' survival and pro-angiogenesis ability.
JOURNAL OF NANOBIOTECHNOLOGY
(2022)
Article
Oncology
Gaosai Dai, Yupeng Yang, Shuhao Liu, Huantao Liu
Summary: Hypoxia in breast cancer cells and their derived exosomes could promote tumor growth and angiogenesis. SNHG1 could increase JAK2 level, thus promoting tumor angiogenesis and growth through regulating miR-216b-5p/JAK2 axis.
CANCER MANAGEMENT AND RESEARCH
(2022)
Article
Cell Biology
Yiqing Xu, Yulong Ge, Xuming Chen, Yingzi Zhang, Huanliang Chen, Dongli Liu, Yue Lu, Yong Liu, Wenzhi Tu
Summary: This study investigated the bystander effect of hypoxia on radiation-induced rectal injury. The results showed that secreted factors from hypoxic HIEC cells promoted apoptosis in normoxic HIEC cells. Further analysis revealed that miR-122-5p played a critical role in radiation-induced rectal injury. This study provides potential therapeutic targets for the treatment of radiation-induced rectal injury.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Pharmacology & Pharmacy
Qinghai Zhu, Yuting Tang, Tian Zhou, Li Yang, Gao Zhang, Ying Meng, Huixin Zhang, Jun Gao, Chenxing Wang, Yu-Xiong Su, Jinhai Ye
Summary: This study found that exosomes derived from pre-differentiated AB-BMSCs carrying specific miRNAs have a positive effect on bone regeneration. The 7-day pre-differentiation of exosomes effectively promoted BMSCs differentiation and activated the PI3K/Akt signaling pathway through differential expression of miRNAs. Gene modification of exosomes provides great potential as a bone regeneration strategy.
PHARMACOLOGICAL RESEARCH
(2023)
Article
Immunology
Reza Salehi, Meshach Asare-Werehene, Brandon A. Wyse, Atefeh Abedini, Bo Pan, Alex Gutsol, Sahar Jahangiri, Peter Szaraz, Kevin D. Burns, Barbara Vanderhyden, Julang Li, Dylan Burger, Clifford L. Librach, Benjamin K. Tsang
Summary: Polycystic ovarian syndrome (PCOS) is associated with increased levels of androgen and arrested follicle growth. Previous studies have shown that androgen-induced release of miR-379-5p from follicle granulosa cells promotes cell proliferation through PDK1 upregulation. Androgen also affects macrophage polarization and increases the inflammatory M1 phenotype in rat follicles. However, the role of small extracellular vesicles (exosomes) in mediating the effects of miRNAs on receiving cells is not well understood. This study aimed to investigate the regulatory role of exosomal miR-379 from granulosa cells on macrophage polarization and ovarian inflammation, and its impact on granulosa cell proliferation in a stage-specific manner.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Gastroenterology & Hepatology
Jifei Wang, Wangjie Jiang, Shuochen Liu, Kuangheng Shi, Yaodong Zhang, Yananlan Chen, Jijun Shan, Yuming Wang, Xiao Xu, Changxian Li, Xiangcheng Li
Summary: The study found that miR-182-5p can be taken up by exosomes secreted from cholangiocarcinoma, promoting vascular endothelial cell proliferation, migration, and angiogenesis. Additionally, miR-182-5p also activates the PI3K/AKT/mTOR signaling pathway, leading to drug resistance in cholangiocarcinoma.
LIVER INTERNATIONAL
(2023)
Article
Immunology
Qingzeng Qian, Qinghua Ma, Bin Wang, Qingqiang Qian, Changsong Zhao, Fumin Feng, Xiaona Dong
Summary: The study revealed that miR-129-5p promotes pulmonary fibrosis in rats by inhibiting the expression of STAT1 gene, which can be carried by M2 macrophages to inhibit the expression of STAT1 and suppress the development of pulmonary fibrosis.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Virology
Aunji Pradhan, Ashish Aneja, Sahana Ghosh, Himadri Devvanshi, C. Deepika, Risabh Sahu, Celil Ross, Pallavi Kshetrapal, Arindam Maitra, Saumitra Das
Summary: In this study, the role of exosomal miRNAs in dengue virus-induced disease progression was analyzed in an Indian cohort. After comprehensive analysis, miR-96-5p was found to be upregulated while miR-146a-5p was downregulated with the progression of disease to severe form. The expression levels of miR-96-5p and miR-146a-5p were strongly correlated with platelet levels. Additionally, miR-146a-5p was found to regulate the expression of proteins involved in immune responses.
JOURNAL OF MEDICAL VIROLOGY
(2023)
