The Potential of Cylindromatosis (CYLD) as a Therapeutic Target in Oxidative Stress-Associated Pathologies: A Comprehensive Evaluation

CYLD deficiency enhances metabolic reprogramming and tumor progression in nasopharyngeal carcinoma via PFKFB3

(2022) Lingzhi Wang et al.   CANCER LETTERS

LncRNA FLG-AS1 Mitigates Diabetic Retinopathy by Regulating Retinal Epithelial Cell Inflammation, Oxidative Stress, and Apoptosis via miR-380-3p/SOCS6 Axis

(2022) Rong Luo et al.   INFLAMMATION

An Overview of Oxidative Stress, Neuroinflammation, and Neurodegenerative Diseases

(2022) Daniel Mihai Teleanu et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Deubiquitinase CYLD acts as a negative regulator of dopamine neuron survival in Parkinson’s disease

(2022) Sheila K. Pirooznia et al.   Science Advances

Genotoxicity-Stimulated and CYLD-Driven Malignant Transformation

(2022) Adnan Erol   Cancer Management and Research

The Met1-linked ubiquitin machinery in inflammation and infection

(2021) Berthe Katrine Fiil et al.   CELL DEATH AND DIFFERENTIATION

Podocyte RNF166 deficiency alleviates diabetic nephropathy by mitigating mitochondria impairment and apoptosis via regulation of CYLD signal

(2021) Ma Hongbo et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

CYLD mediates human pulmonary artery smooth muscle cell dysfunction in congenital heart disease‐associated pulmonary arterial hypertension

(2021) Jing‐jing Zhou et al.   JOURNAL OF CELLULAR PHYSIOLOGY

The 4-(Phenylsulfanyl) butan-2-one Improves Impaired Fear Memory Retrieval and Reduces Excessive Inflammatory Response in Triple Transgenic Alzheimer's Disease Mice

(2021) Peeraporn Varinthra et al.   Frontiers in Aging Neuroscience

Down-regulation of cylindromatosis protein phosphorylation by BTK inhibitor promotes apoptosis of non-GCB-diffuse large B-cell lymphoma

(2021) Xin Xu et al.   Cancer Cell International

STAT3/miR-135b/NF-κB axis confers aggressiveness and unfavorable prognosis in non-small-cell lung cancer

(2021) Jinlin Zhao et al.   Cell Death & Disease

Extracellular matrix: paving the way to the newest trends in atherosclerosis

(2021) Chrysostomi Gialeli et al.   CURRENT OPINION IN LIPIDOLOGY

Oxidative Stress and Osteoporosis

(2021) Jeff S. Kimball et al.   JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME

Oxidative stress in oocyte aging and female reproduction

(2021) Ling Wang et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Oxidative Stress in Mucopolysaccharidoses: Pharmacological Implications

(2021) Karolina Pierzynowska et al.   MOLECULES

Deficiency of the CYLD Impairs Fear Memory of Mice and Disrupts Neuronal Activity and Synaptic Transmission in the Basolateral Amygdala

(2021) Hui-dong Li et al.   Frontiers in Cellular Neuroscience

CYLD destabilizes NoxO1 protein by promoting ubiquitination and regulates prostate cancer progression

(2021) Saba Haq et al.   CANCER LETTERS

Antiparkinsonian-like effects of CPL500036, a novel selective inhibitor of phosphodiesterase 10A, in the unilateral rat model of Parkinson's disease

(2021) Tomasz Lenda et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

The K63 deubiquitinase CYLD modulates autism-like behaviors and hippocampal plasticity by regulating autophagy and mTOR signaling

(2021) Elisa Colombo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulation of CYLD activity and specificity by phosphorylation and ubiquitin-binding CAP-Gly domains

(2021) Paul R. Elliott et al.   Cell Reports

Genetic Testing in CYLD Cutaneous Syndrome: An Update

(2021) Nikoletta Nagy et al.   Application of Clinical Genetics

Reversal of CYLD phosphorylation as a novel therapeutic approach for adult T-cell leukemia/lymphoma (ATLL)

(2020) Xin Xu et al.   Cell Death & Disease

Autophagy promotes mammalian survival by suppressing oxidative stress and p53

(2020) Yang Yang et al.   GENES & DEVELOPMENT

Oxidative stress-based therapeutics in COPD

(2020) Peter J. Barnes   Redox Biology

CYLD mutation characterizes a subset of HPV-positive head and neck squamous cell carcinomas with distinctive genomics and frequent cylindroma-like histologic features

(2020) Erik A. Williams et al.   MODERN PATHOLOGY

Emerging functions of adipokines in linking the development of obesity and cardiovascular diseases

(2020) Xin Su et al.   MOLECULAR BIOLOGY REPORTS

Periodontitis is an inflammatory disease of oxidative stress: We should treat it that way

(2020) Fábio Sá Carneiro Sczepanik et al.   PERIODONTOLOGY 2000

The LINC01260 Functions as a Tumor Suppressor via the miR-562/CYLD/NF-κB Pathway in Non-Small Cell Lung Cancer

(2020) Yangming Chen et al.   OncoTargets and Therapy

Functional crosstalk between myeloid Foxo1–β-catenin axis and Hedgehog/Gli1 signaling in oxidative stress response

(2020) Changyong Li et al.   CELL DEATH AND DIFFERENTIATION

Perspectives of New Advances in the Pathogenesis of Vitiligo: From Oxidative Stress to Autoimmunity

(2019) Yinghan Wang et al.   MEDICAL SCIENCE MONITOR

CYLD Regulates Centriolar Satellites Proteostasis by Counteracting the E3 Ligase MIB1

(2019) Tiphaine Douanne et al.   Cell Reports

CENPV is a CYLD-interacting molecule regulating ciliary acetylated α-tubulin

(2019) Elena Chiticariu et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Rise and fall of elastic fibers from development to aging. Consequences on arterial structure-function and therapeutical perspectives

(2019) Wassim Fhayli et al.   MATRIX BIOLOGY

Oxidative Stress in Cardiovascular Diseases: Still a Therapeutic Target?

(2019) Thomas Senoner et al.   Nutrients

Loss of CYLD accelerates melanoma development and progression in the Tg(Grm1) melanoma mouse model

(2019) Miriam Martha de Jel et al.   Oncogenesis

Swiprosin-1 Promotes Mitochondria-Dependent Apoptosis of Glomerular Podocytes via P38 MAPK Pathway in Early-Stage Diabetic Nephropathy

(2018) Rong-Mei Wang et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Calcium Signaling and Reactive Oxygen Species in Mitochondria

(2018) Edoardo Bertero et al.   CIRCULATION RESEARCH

Oxidative stress: Major threat in traumatic brain injury

(2018) Nidhi Khatri et al.   CNS & Neurological Disorders-Drug Targets

Myeloid Notch1 deficiency activates the RhoA/ROCK pathway and aggravates hepatocellular damage in mouse ischemic livers

(2018) Ling Lu et al.   HEPATOLOGY

Ubiquitination: Friend and foe in cancer

(2018) Mohammed A. Mansour   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Frequent and differential mutations of the CYLD gene in basal cell salivary neoplasms: linkage to tumor development and progression

(2018) Miguel Rito et al.   MODERN PATHOLOGY

The deubiquitinating enzyme cylindromatosis mitigates nonalcoholic steatohepatitis

(2018) Yan-Xiao Ji et al.   NATURE MEDICINE

Incidence and Trend of Type 1 Diabetes and the Underlying Environmental Determinants

(2018) Ying Xia et al.   DIABETES-METABOLISM RESEARCH AND REVIEWS

Regulation of microRNA biogenesis and its crosstalk with other cellular pathways

(2018) Thomas Treiber et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Oxidative stress in chronic kidney disease

(2018) Kristien Daenen et al.   PEDIATRIC NEPHROLOGY

Neural circuits for a top-down control of fear and extinction

(2018) Roger Marek et al.   PSYCHOPHARMACOLOGY

Pathophysiological significance of cylindromatosis in the vascular endothelium and macrophages for the initiation of age-related atherogenesis

(2018) Yuki Imaizumi et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

CYLD deficiency promotes pancreatic cancer development by causing mitotic defects

(2018) Songbo Xie et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Nonalcoholic Fatty Liver Disease

(2018) Irene Pierantonelli et al.   TRANSPLANTATION

Oxidative stress and male infertility

(2017) Shilpa Bisht et al.   Nature Reviews Urology

Oxidative Stress and Endometriosis: A Systematic Review of the Literature

(2017) Gennaro Scutiero et al.   Oxidative Medicine and Cellular Longevity

Cardiovascular Disease and Long Noncoding RNAs

(2017) Elizabeth J. Hennessy   Circulation-Cardiovascular Genetics

Obesity-related glomerulopathy: pathogenesis, pathologic, clinical characteristics and treatment

(2017) Tianhua Xu et al.   Frontiers of Medicine

The myeloid heat shock transcription factor 1/β-catenin axis regulates NLR family, pyrin domain-containing 3 inflammasome activation in mouse liver ischemia/reperfusion injury

(2016) Shi Yue et al.   HEPATOLOGY

Motile and non-motile cilia in human pathology: from function to phenotypes

(2016) Hannah M Mitchison et al.   JOURNAL OF PATHOLOGY

Oxidative stress and metabolic disorders: Pathogenesis and therapeutic strategies

(2016) Vibha Rani et al.   LIFE SCIENCES

Inhibition of Ras/Raf/MEK/ERK Pathway Signaling by a Stress-Induced Phospho-Regulatory Circuit

(2016) Daniel A. Ritt et al.   MOLECULAR CELL

Loss of CYLD expression unleashes Wnt signaling in multiple myeloma and is associated with aggressive disease

(2016) H van Andel et al.   ONCOGENE

The role of oxidative stress in streptozotocin-induced diabetic nephropathy in rats

(2016) Sheila Marques Fernandes et al.   Archives of Endocrinology Metabolism

RPE necroptosis in response to oxidative stress and in AMD

(2015) Jakub Hanus et al.   AGEING RESEARCH REVIEWS

Deubiquitinating enzyme CYLD mediates pressure overload-induced cardiac maladaptive remodeling and dysfunction via downregulating Nrf2

(2015) Hui Wang et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

The Roles of PINK1, Parkin, and Mitochondrial Fidelity in Parkinson’s Disease

(2015) Alicia M. Pickrell et al.   NEURON

Wnt addiction of genetically defined cancers reversed by PORCN inhibition

(2015) B Madan et al.   ONCOGENE

CYLD Regulates Noscapine Activity in Acute Lymphoblastic Leukemia via a Microtubule-Dependent Mechanism

(2015) Yunfan Yang et al.   Theranostics

Dysregulated autophagy in the RPE is associated with increased susceptibility to oxidative stress and AMD

(2014) Sayak K Mitter et al.   Autophagy

CYLD mediates ciliogenesis in multiple organs by deubiquitinating Cep70 and inactivating HDAC6

(2014) Yunfan Yang et al.   CELL RESEARCH

Nrf2 enhances myocardial clearance of toxic ubiquitinated proteins

(2014) Wenjuan Wang et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

The Capable ABL: What Is Its Biological Function?

(2014) J. Y. J. Wang   MOLECULAR AND CELLULAR BIOLOGY

Nrf2 Deficiency Exaggerates Doxorubicin-Induced Cardiotoxicity and Cardiac Dysfunction

(2014) Siying Li et al.   Oxidative Medicine and Cellular Longevity

The deubiquitinating enzyme CYLD controls apical docking of basal bodies in ciliated epithelial cells

(2014) Thibaut Eguether et al.   Nature Communications

Oxidative stress in Alzheimer’s disease

(2014) Zhichun Chen et al.   Neuroscience Bulletin

Pharmacogenetic Inhibition of eIF4E-Dependent Mmp9 mRNA Translation Reverses Fragile X Syndrome-like Phenotypes

(2014) Christos G. Gkogkas et al.   Cell Reports

Adventitial fibroblasts from apoE(−/−) mice exhibit the characteristics of transdifferentiation into myofibroblasts

(2013) Fang Xu et al.   CELL BIOLOGY INTERNATIONAL

Targeting Wnt-driven cancer through the inhibition of Porcupine by LGK974

(2013) J. Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Oxidative stress and cancer: An overview

(2012) Venus Sosa et al.   AGEING RESEARCH REVIEWS

A pro-inflammatory role of deubiquitinating enzyme cylindromatosis (CYLD) in vascular smooth muscle cells

(2012) Shuai Liu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Cilia in vertebrate development and disease

(2012) E. C. Oh et al.   DEVELOPMENT

The complex world of WNT receptor signalling

(2012) Christof Niehrs   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Podocytopathy in Diabetes: A Metabolic and Endocrine Disorder

(2011) Ana Diez-Sampedro et al.   AMERICAN JOURNAL OF KIDNEY DISEASES

Up-regulation of p27kip1 contributes to Nrf2-mediated protection against angiotensin II-induced cardiac hypertrophy

(2011) Jinqing Li et al.   CARDIOVASCULAR RESEARCH

Diabetic Downregulation of Nrf2 Activity via ERK Contributes to Oxidative Stress-Induced Insulin Resistance in Cardiac Cells In Vitro and In Vivo

(2011) Y. Tan et al.   DIABETES

CYLD: a deubiquitination enzyme with multiple roles in cancer

(2011) Ramin Massoumi   Future Oncology

The contribution of endoplasmic reticulum stress to liver diseases

(2011) Lily Dara et al.   HEPATOLOGY

NF-κB Essential Modulator (NEMO) Interaction with Linear and Lys-63 Ubiquitin Chains Contributes to NF-κB Activation

(2011) Kamyar Hadian et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The role of tumour necrosis factor-  and tumour necrosis factor receptor signalling in inflammation-associated systemic genotoxicity

(2011) A. M. Westbrook et al.   MUTAGENESIS

CYLD regulates angiogenesis by mediating vascular endothelial cell migration

(2010) J. Gao et al.   BLOOD

Immunity, Inflammation, and Cancer

(2010) Sergei I. Grivennikov et al.   CELL

Nebivolol Attenuates Redox-Sensitive Glomerular and Tubular Mediated Proteinuria in Obese Rats

(2010) Javad Habibi et al.   ENDOCRINOLOGY

An inactivating CYLD mutation promotes skin tumor progression by conferring enhanced proliferative, survival and angiogenic properties to epidermal cancer cells

(2010) J P Alameda et al.   ONCOGENE

Nrf2 Protects Against Maladaptive Cardiac Responses to Hemodynamic Stress

(2009) Jinqing Li et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

CYLD: a tumor suppressor deubiquitinase regulating NF-κB activation and diverse biological processes

(2009) S-C Sun   CELL DEATH AND DIFFERENTIATION

Inflammation and oncogenesis: a vicious connection

(2009) Sergei I Grivennikov et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

CYLD negatively regulates cell-cycle progression by inactivating HDAC6 and increasing the levels of acetylated tubulin

(2009) Sara A Wickström et al.   EMBO JOURNAL

Targeting the Nrf2 pathway against cardiovascular disease

(2009) Jinqing Li et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

The NF-κB activation pathways, emerging molecular targets for cancer prevention and therapy

(2009) Yong Lin et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Phosphorylation of the Tumor Suppressor CYLD by the Breast Cancer Oncogene IKKɛ Promotes Cell Transformation

(2009) Jessica E. Hutti et al.   MOLECULAR CELL

Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling

(2009) Shih-Min A. Huang et al.   NATURE

Potential Role of CYLD (Cylindromatosis) as a Deubiquitinating Enzyme in Vascular Cells

(2008) Yoichi Takami et al.   AMERICAN JOURNAL OF PATHOLOGY

The Tumor Suppressor CYLD Regulates Microtubule Dynamics and Plays a Role in Cell Migration

(2008) Jinmin Gao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Deubiquitinating enzyme CYLD negatively regulates RANK signaling and osteoclastogenesis in mice

(2008) Wei Jin et al.   JOURNAL OF CLINICAL INVESTIGATION

The Structure of the CYLD USP Domain Explains Its Specificity for Lys63-Linked Polyubiquitin and Reveals a B Box Module

(2008) David Komander et al.   MOLECULAR CELL

Tracking the ends: a dynamic protein network controls the fate of microtubule tips

(2008) Anna Akhmanova et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

TTK/Mps1 controls nuclear targeting of c-Abl by 14-3-3-coupled phosphorylation in response to oxidative stress

(2008) K Nihira et al.   ONCOGENE

An Oncogene-Induced DNA Damage Model for Cancer Development

(2008) T. D. Halazonetis et al.   SCIENCE