Functional crosstalk between myeloid Foxo1–β-catenin axis and Hedgehog/Gli1 signaling in oxidative stress response

New insights in acetaminophen toxicity: HMGB1 contributes by itself to amplify hepatocyte necrosis in vitro through the TLR4-TRIF-RIPK3 axis

(2020) Charlotte Minsart et al.   Scientific Reports

Hippo signaling controls NLRP 3 Activation and governs immunoregulation of mesenchymal stem cells in mouse liver injury

(2019) Changyong Li et al.   HEPATOLOGY

High mobility group box 1 enables bacterial lipids to trigger receptor-interacting protein kinase 3 (RIPK3)-mediated necroptosis and apoptosis in mice

(2019) Ran Meng et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural mechanism for NEK7-licensed activation of NLRP3 inflammasome

(2019) Humayun Sharif et al.   NATURE

Jagged1-mediated myeloid Notch1 signaling activates HSF1/Snail and controls NLRP3 inflammasome activation in liver inflammatory injury

(2019) Yuting Jin et al.   Cellular & Molecular Immunology

Myeloid Notch1 deficiency activates the RhoA/ROCK pathway and aggravates hepatocellular damage in mouse ischemic livers

(2018) Ling Lu et al.   HEPATOLOGY

Mitochondria, Oxidative Stress and Innate Immunity

(2018) Yuxin Chen et al.   Frontiers in Physiology

Snail reprograms glucose metabolism by repressing phosphofructokinase PFKP allowing cancer cell survival under metabolic stress

(2017) Nam Hee Kim et al.   Nature Communications

RIP1 autophosphorylation is promoted by mitochondrial ROS and is essential for RIP3 recruitment into necrosome

(2017) Yingying Zhang et al.   Nature Communications

Anti-apoptotic effects of Sonic hedgehog signalling through oxidative stress reduction in astrocytes co-cultured with excretory-secretory products of larval Angiostrongylus cantonensis

(2017) Kuang-Yao Chen et al.   Scientific Reports

The myeloid heat shock transcription factor 1/β-catenin axis regulates NLR family, pyrin domain-containing 3 inflammasome activation in mouse liver ischemia/reperfusion injury

(2016) Shi Yue et al.   HEPATOLOGY

NEK7 is an essential mediator of NLRP3 activation downstream of potassium efflux

(2016) Yuan He et al.   NATURE

Necroptosis in development, inflammation and disease

(2016) Ricardo Weinlich et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

FOXO1 Deletion Reduces Dendritic Cell Function and Enhances Susceptibility to Periodontitis

(2015) Wenmei Xiao et al.   AMERICAN JOURNAL OF PATHOLOGY

Programmed Necrosis in the Cross Talk of Cell Death and Inflammation

(2015) Francis Ka-Ming Chan et al.   Annual Review of Immunology

FOXO1 Regulates Dendritic Cell Activity through ICAM-1 and CCR7

(2015) Guangyu Dong et al.   JOURNAL OF IMMUNOLOGY

NLRP3 activation and mitosis are mutually exclusive events coordinated by NEK7, a new inflammasome component

(2015) Hexin Shi et al.   NATURE IMMUNOLOGY

Roles for Hedgehog signaling in adult organ homeostasis and repair

(2014) R. Petrova et al.   DEVELOPMENT

The Transcription Factor GLI1 Modulates the Inflammatory Response during Pancreatic Tissue Remodeling

(2014) Esha Mathew et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

High-mobility group box-1 in sterile inflammation

(2014) A. Tsung et al.   JOURNAL OF INTERNAL MEDICINE

Mixed Lineage Kinase Domain-like Protein MLKL Causes Necrotic Membrane Disruption upon Phosphorylation by RIP3

(2014) Huayi Wang et al.   MOLECULAR CELL

RIP3: a molecular switch for necrosis and inflammation

(2013) K. Moriwaki et al.   GENES & DEVELOPMENT

Myofibroblastic cells function as progenitors to regenerate murine livers after partial hepatectomy

(2013) M Swiderska-Syn et al.   GUT

Kinase AKT controls innate immune cell development and function

(2013) Yan Zhang et al.   IMMUNOLOGY

Histones Activate the NLRP3 Inflammasome in Kupffer Cells during Sterile Inflammatory Liver Injury

(2013) H. Huang et al.   JOURNAL OF IMMUNOLOGY

Macrophage-Specific RNA Interference Targeting via “Click”, Mannosylated Polymeric Micelles

(2013) Shann S. Yu et al.   MOLECULAR PHARMACEUTICS

The mechanisms of Hedgehog signalling and its roles in development and disease

(2013) James Briscoe et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

PTEN-mediated akt/β-Catenin/foxo1 signaling regulates innate immune responses in mouse liver ischemia/reperfusion injury

(2012) Naoko Kamo et al.   HEPATOLOGY

β-catenin regulates innate and adaptive immunity in mouse liver ischemia-reperfusion injury

(2012) Bibo Ke et al.   HEPATOLOGY

The protective effect of sonic hedgehog is mediated by the propidium iodide 3-kinase/AKT/Bcl-2 pathway in cultured rat astrocytes under oxidative stress

(2012) Y.-P. Xia et al.   NEUROSCIENCE

Mammalian Target of Rapamycin Complex 2 (mTORC2) Negatively Regulates Toll-like Receptor 4-mediated Inflammatory Response via FoxO1

(2011) Jonathan Brown et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

HO-1–STAT3 axis in mouse liver ischemia/reperfusion injury: Regulation of TLR4 innate responses through PI3K/PTEN signaling

(2011) Bibo Ke et al.   JOURNAL OF HEPATOLOGY

Mechanisms and functions of Hedgehog signalling across the metazoa

(2011) Philip W. Ingham et al.   NATURE REVIEWS GENETICS

Pivotal role of JNK-dependent FOXO1 activation in downregulation of kallistatin expression by oxidative stress

(2010) Bo Shen et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

FoxO1 regulates Tlr4 inflammatory pathway signalling in macrophages

(2010) WuQiang Fan et al.   EMBO JOURNAL

FoxO Transcription Factors Promote Cardiomyocyte Survival upon Induction of Oxidative Stress

(2010) Arunima Sengupta et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A role for mitochondria in NLRP3 inflammasome activation

(2010) Rongbin Zhou et al.   NATURE

The Inflammasomes: Guardians of the Body

(2009) Fabio Martinon et al.   Annual Review of Immunology

Cancer Metastasis Is Accelerated through Immunosuppression during Snail-Induced EMT of Cancer Cells

(2009) Chie Kudo-Saito et al.   CANCER CELL

Wnt/β-Catenin Signaling: Components, Mechanisms, and Diseases

(2009) Bryan T. MacDonald et al.   DEVELOPMENTAL CELL

Foxo1 increases pro-inflammatory gene expression by inducing C/EBPβ in TNF-α-treated adipocytes

(2008) Yu Ito et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Structure/function relationships underlying regulation of FOXO transcription factors

(2008) T Obsil et al.   ONCOGENE